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Cell Adhesion & Migration最新文献

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A toolbox to analyze collective cell migration, proliferation and cellular organization simultaneously. 同时分析集体细胞迁移、增殖和细胞组织的工具箱。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2023-12-01 Epub Date: 2023-11-08 DOI: 10.1080/19336918.2023.2276615
Urszula Hohmann, Chalid Ghadban, Julian Prell, Christian Strauss, Faramarz Dehghani, Tim Hohmann
{"title":"A toolbox to analyze collective cell migration, proliferation and cellular organization simultaneously.","authors":"Urszula Hohmann, Chalid Ghadban, Julian Prell, Christian Strauss, Faramarz Dehghani, Tim Hohmann","doi":"10.1080/19336918.2023.2276615","DOIUrl":"10.1080/19336918.2023.2276615","url":null,"abstract":"<p><strong>Background: </strong>Analyses of collective cell migration and orientation phenomena are needed to assess the behavior of multicellular clusters. While some tools to the authors' knowledge none is capable to analyze collective migration, cellular orientation and proliferation in phase contrast images simultaneously.</p><p><strong>Methods: </strong>We provide a tool based to analyze phase contrast images of dense cell layers. PIV is used to calculatevelocity fields, while the structure tensor provides cellular orientation. An artificial neural network is used to identify cell division events, allowing to correlate migratory and organizational phenomena with cell density.</p><p><strong>Conclusion: </strong>The presented tool allows the simultaneous analysis of collective cell behavior from phase contrast images in terms of migration, (self-)organization and proliferation.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10773533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71520580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphangiogenic responses of lymphatic endothelial cells to steady direct-current electric fields. 淋巴管内皮细胞对稳定直流电场的淋巴管生成反应。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2023-12-01 Epub Date: 2023-10-27 DOI: 10.1080/19336918.2023.2271260
Linbo Guan, Ping Fan, Yufeng Wang, Xinghui Liu, Rui Liu, Wandi Ma, Huai Bai
{"title":"Lymphangiogenic responses of lymphatic endothelial cells to steady direct-current electric fields.","authors":"Linbo Guan, Ping Fan, Yufeng Wang, Xinghui Liu, Rui Liu, Wandi Ma, Huai Bai","doi":"10.1080/19336918.2023.2271260","DOIUrl":"10.1080/19336918.2023.2271260","url":null,"abstract":"<p><p>Lymphangiogenesis plays pivotal roles in diverse physiological and pathological conditions. Steady direct-current electric fields (DC EFs) induce vascular endothelial behaviors related to angiogenesis have been observed. This study investigated the effects of DC EFs on the lymphangiogenic response of lymphatic endothelial cells (LECs). We demonstrated that EFs stimulation induced directional migration, reorientation, and elongation of human LECs in culture. These lymphangiogenic responses required VEGF receptor 3 (VEGFR-3) activation and were mediated through the PI3K-Akt, Erk1/2, and p38 MAPK signaling pathways in relation to the reorganization of the actin cytoskeleton. Our results indicate that endogenous EFs may play a role in lymphangiogenesis in vivo, and VEGFR-3 signaling activation may be involved in the cellular function of LECs driven by EFs.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54227795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MST1/2 in inflammation and immunity. MST1/2在炎症和免疫中的作用。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2023-12-01 Epub Date: 2023-11-01 DOI: 10.1080/19336918.2023.2276616
Tongfen Li, Yiqiong Wen, Qiongfen Lu, Shu Hua, Yunjiao Hou, Xiaohua Du, Yuanyuan Zheng, Shibo Sun
{"title":"MST1/2 in inflammation and immunity.","authors":"Tongfen Li, Yiqiong Wen, Qiongfen Lu, Shu Hua, Yunjiao Hou, Xiaohua Du, Yuanyuan Zheng, Shibo Sun","doi":"10.1080/19336918.2023.2276616","DOIUrl":"10.1080/19336918.2023.2276616","url":null,"abstract":"<p><p>The mammalian Sterile 20-like kinase 1/2 (MST1/2) belongs to the serine/threonine (GC) protein kinase superfamily. Collective studies confirm the vital role MST1/2 in inflammation and immunity. MST1/2 is closely related to the progress of inflammation. Generally, MST1/2 aggravates the inflammatory injury through MST1-JNK, MST1-mROS, MST1-Foxo3, and NF-κB pathways, as well as several regulatory factors such as tumor necrosis factor-α (TNF-α), mitochondrial extension factor 1 (MIEF1), and lipopolysaccharide (LPS). Moreover, MST1/2 is also involved in the regulation of immunity to balance immune activation and tolerance by regulating MST1/2-Rac, MST1-Akt1/c-myc, MST1-Foxos, MST1-STAT, Btk pathways, and lymphocyte function-related antigen 1 (LFA-1), which subsequently prevents immunodeficiency syndrome and autoimmune diseases. This article reviews the effects of MST1/2 on inflammation and immunity.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in β2-integrin activation and signaling. 肉豆蔻酰化富含丙氨酸的C激酶底物（MARCKS）抑制剂肽在β2-整合素激活和信号传导中减弱中性粒细胞。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2023-12-01 DOI: 10.1080/19336918.2023.2233204
Haleigh Conley, Rebecca L Till, Alix K Berglund, Samuel L Jones, M Katie Sheats
{"title":"A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in β<sub>2</sub>-integrin activation and signaling.","authors":"Haleigh Conley, Rebecca L Till, Alix K Berglund, Samuel L Jones, M Katie Sheats","doi":"10.1080/19336918.2023.2233204","DOIUrl":"10.1080/19336918.2023.2233204","url":null,"abstract":"<p><p>MARCKS is an actin and PIP2-binding protein that plays an essential role in neutrophil migration and adhesion; however, the molecular details regarding MARCKS function in these processes remains unclear. Neutrophil adhesion and migration also require the cell surface receptors β<sub>2</sub>-integrins. We hypothesized that MARCKS inhibition would alter neutrophil β<sub>2</sub>-integrin activation and signaling. We utilized a MARCKS-targeting peptide to inhibit MARCKS in inside-out and outside-in β<sub>2</sub>-integrin activation in neutrophils. MANS-mediated MARCKS inhibition had no significant effect on inside-out β<sub>2</sub>-integrin activation. MANS treatment significantly attenuated ICAM-1/Mn<sup>2+</sup>-stimulated static adhesion, cell spreading and β<sub>2</sub>-integrin clustering, suggesting a role for MARCKS function in outside-in β<sub>2</sub>-integrin activation. Additional work is needed to better understand the molecular mechanisms of MARCKS role in outside-in β<sub>2</sub>-integrin activation and signaling.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/1c/KCAM_17_2233204.PMC10348033.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9893102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity. Scribble, Lgl1和myosin IIA与α-/β-连环蛋白相互作用以维持上皮连接的完整性。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2023-12-01 Epub Date: 2023-09-24 DOI: 10.1080/19336918.2023.2260645
Maha Abedrabbo, Shirel Sloomy, Reham Abu-Leil, Einav Kfir-Cohen, Shoshana Ravid
{"title":"Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity.","authors":"Maha Abedrabbo, Shirel Sloomy, Reham Abu-Leil, Einav Kfir-Cohen, Shoshana Ravid","doi":"10.1080/19336918.2023.2260645","DOIUrl":"10.1080/19336918.2023.2260645","url":null,"abstract":"<p><p>E-cadherin-catenin complex together with the cytoskeleton, builds the core of Adherens junctions (AJs). It has been reported that Scribble stabilizes the coupling of E-cadherin with catenins promoting epithelial cell adhesion, but the mechanism remains unknown. We show that Scribble, Lgl1, and NMII-A reside in a complex with E-cadherin-catenin complex. Depletion of either Scribble or Lgl1 disrupts the localization of E-cadherin-catenin complex to AJs. aPKCζ phosphorylation of Lgl1 regulates AJ localization of Lgl1 and E-cadherin-catenin complexes. Both Scribble and Lgl1 regulate the activation and recruitment of NMII-A at AJs. Finally, Scribble and Lgl1 are downregulated by TGFβ-induced EMT, and their re-expression during EMT impedes its progression. Our results provide insight into the mechanism regulating AJ integrity by Scribble, Lgl1, and NMII-A.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41178136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway. IL-13中和通过调节JAK-1/STAT-3信号通路减轻颈动脉内膜增生并增加内皮细胞迁移。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2023-12-01 Epub Date: 2023-10-09 DOI: 10.1080/19336918.2023.2265158
Qi Li, Yue Li, Fengjiao Wu, Jingyu Li, Zhongsha Li, Xiaoling Qin, Simeng Wei, Chang Chen
{"title":"IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway.","authors":"Qi Li,&nbsp;Yue Li,&nbsp;Fengjiao Wu,&nbsp;Jingyu Li,&nbsp;Zhongsha Li,&nbsp;Xiaoling Qin,&nbsp;Simeng Wei,&nbsp;Chang Chen","doi":"10.1080/19336918.2023.2265158","DOIUrl":"10.1080/19336918.2023.2265158","url":null,"abstract":"<p><p>The aim of this study was to investigate how the concentration of interleukin-13 (IL-13) affects the regulation of endothelial cell migration after injury. The incubation of recombinant human interleukin-13 (rhIL-13) strongly increased the content of reactive oxygen species (ROS) in HUVECs via the JAK-1/STAT-3/NOX-4 signaling pathway. Antagonizing the high intracellular ROS that was induced by rhIL-13 promoted the migration of HUVECs. Furthermore, IL-13 neutralization not only inhibited intimal hyperplasia, but also promoted the migration of endothelial cells (ECs) after injury. The results suggest that IL-13 inhibition is a potential means of stimulating endothelial cells recovery after injury. Therefore, the attenuation of IL-13 activation may have therapeutic value for vascular disease.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/52/f9/KCAM_17_2265158.PMC10566387.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41182134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell. 动态超低稀释的芦丁破坏质膜组织，减少黑色素瘤癌细胞的迁移。
IF 3.3 3区 生物学
Cell Adhesion & Migration Pub Date : 2023-12-01 DOI: 10.1080/19336918.2022.2154732
Camille Fuselier, Eleonore Dufay, Alexandre Berquand, Christine Terryn, Arnaud Bonnomet, Michael Molinari, Laurent Martiny, Christophe Schneider
{"title":"Dynamized ultra-low dilution of <i>Ruta graveolens</i> disrupts plasma membrane organization and decreases migration of melanoma cancer cell.","authors":"Camille Fuselier, Eleonore Dufay, Alexandre Berquand, Christine Terryn, Arnaud Bonnomet, Michael Molinari, Laurent Martiny, Christophe Schneider","doi":"10.1080/19336918.2022.2154732","DOIUrl":"10.1080/19336918.2022.2154732","url":null,"abstract":"<p><p>Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of <i>Ruta Graveolens</i> leads to an <i>in vitro</i> inhibition of migration on fibronectin of B16F10 melanoma cells, as well as a decrease in metastatic dissemination <i>in vivo</i>. These effects appear to be due to a disruption of plasma membrane organization, with a change in cell and membrane stiffness, associated with a disorganization of the actin cytoskeleton and a modification of the lipid composition of the plasma membrane. Together, these results demonstrate, in <i>in vitro</i> and <i>in vivo</i> models of cutaneous melanoma, an anti-cancer and anti-metastatic activity of ultra-low dynamized dilution of <i>Ruta graveolens</i> and reinforce its interest as complementary medicine in oncology.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10657273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unravelling cell migration: defining movement from the cell surface. 解开细胞迁移：从细胞表面定义移动
IF 3.3 3区 生物学
Cell Adhesion & Migration Pub Date : 2022-12-01 DOI: 10.1080/19336918.2022.2055520
Francisco Merino-Casallo, Maria Jose Gomez-Benito, Silvia Hervas-Raluy, Jose Manuel Garcia-Aznar
{"title":"Unravelling cell migration: defining movement from the cell surface.","authors":"Francisco Merino-Casallo, Maria Jose Gomez-Benito, Silvia Hervas-Raluy, Jose Manuel Garcia-Aznar","doi":"10.1080/19336918.2022.2055520","DOIUrl":"10.1080/19336918.2022.2055520","url":null,"abstract":"<p><p>Cell motility is essential for life and development. Unfortunately, cell migration is also linked to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies on many actors. Cells change their migratory strategy based on their phenotype and the properties of the surrounding microenvironment. Cell migration is, therefore, an extremely complex phenomenon. Researchers have investigated cell motility for more than a century. Recent discoveries have uncovered some of the mysteries associated with the mechanisms involved in cell migration, such as intracellular signaling and cell mechanics. These findings involve different players, including transmembrane receptors, adhesive complexes, cytoskeletal components , the nucleus, and the extracellular matrix. This review aims to give a global overview of our current understanding of cell migration.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41877505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Class I Myosins, molecular motors involved in cell migration and cancer. I类肌球蛋白，参与细胞迁移和癌症的分子马达。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2022-12-01 DOI: 10.1080/19336918.2021.2020705
Juan D Diaz-Valencia, Laura A Estrada-Abreo, Leonor Rodríguez-Cruz, Alfonso R Salgado-Aguayo, Genaro Patiño-López
{"title":"Class I Myosins, molecular motors involved in cell migration and cancer.","authors":"Juan D Diaz-Valencia,&nbsp;Laura A Estrada-Abreo,&nbsp;Leonor Rodríguez-Cruz,&nbsp;Alfonso R Salgado-Aguayo,&nbsp;Genaro Patiño-López","doi":"10.1080/19336918.2021.2020705","DOIUrl":"https://doi.org/10.1080/19336918.2021.2020705","url":null,"abstract":"<p><p>Class I Myosins are a subfamily of motor proteins with ATPase activity and a characteristic structure conserved in all myosins: A N-Terminal Motor Domain, a central Neck and a C terminal Tail domain. Humans have eight genes for these myosins. Class I Myosins have different functions: regulate membrane tension, participate in endocytosis, exocytosis, intracellular trafficking and cell migration. Cell migration is influenced by many cellular components including motor proteins, like myosins. Recently has been reported that changes in myosin expression have an impact on the migration of cancer cells, the formation of infiltrates and metastasis. We propose that class I myosins might be potential markers for future diagnostic, prognostic or even as therapeutic targets in leukemia and other cancers.<b>Abbreviations:</b> Myo1g: Myosin 1g; ALL: Acute Lymphoblastic Leukemia, TH1: Tail Homology 1; TH2: Tail Homology 2; TH3: Tail Homology 3.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10255785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Fluid shear stress induces cell migration via RhoA-YAP1-autophagy pathway in liver cancer stem cells. 流体剪切应力通过rhoa - yap1自噬途径诱导肝癌干细胞迁移。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2022-12-01 DOI: 10.1080/19336918.2022.2103925
Zhiping Yan, Danfeng Guo, Ruolin Tao, Xiao Yu, Jiacheng Zhang, Yuting He, Jiakai Zhang, Jie Li, Shuijun Zhang, Wenzhi Guo
{"title":"Fluid shear stress induces cell migration via RhoA-YAP1-autophagy pathway in liver cancer stem cells.","authors":"Zhiping Yan,&nbsp;Danfeng Guo,&nbsp;Ruolin Tao,&nbsp;Xiao Yu,&nbsp;Jiacheng Zhang,&nbsp;Yuting He,&nbsp;Jiakai Zhang,&nbsp;Jie Li,&nbsp;Shuijun Zhang,&nbsp;Wenzhi Guo","doi":"10.1080/19336918.2022.2103925","DOIUrl":"https://doi.org/10.1080/19336918.2022.2103925","url":null,"abstract":"<p><p>Fluid shear stress (FSS) regulates the metastasis of hepatocellular carcinoma (HCC), but the role of the RhoA-YAP1-autophagy pathway in HCC remains unclear. Due to the core role of liver cancer stem cells (LCSCs) in HCC metastasis and recurrence, we explored the RhoA-YAP1-autophagy pathway in LCSCs under FSS. Our results indicate that LCSCs have stronger proliferation and cell spheroidization abilities. FSS (1 dyn/cm<sup>2</sup>) upregulated the migration of LCSCs and autophagy protein markers, inducing LC3B aggregation and autophagosome formation in LCSCs. Mechanistically, FSS promoted YAP1 dephosphorylation and transport to the nucleus, which is mediated by RhoA, inducing autophagy. Finally, inhibition of autophagy suppressed cell migration in LCSCs under FSS. In conclusion, FSS promoted the migration of LCSCs via the RhoA-YAP1-autophagy pathway.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/92/d5/KCAM_16_2103925.PMC9331214.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10623073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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