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引用次数: 0
摘要
本研究探讨全细胞色素c合成酶（Holocytochrome c synthase， HCCS）在肺腺癌（LUAD）中的表达及其对肿瘤免疫环境的影响。通过对多个肿瘤数据库的分析，本研究突出了HCCS在不同癌症类型中的表达模式，重点关注其与m2型巨噬细胞的相关性，而m2型巨噬细胞有助于肿瘤的进展。研究结果表明，LUAD中HCCS的高表达与m2型巨噬细胞的增加有关，HCCS水平的变化影响免疫细胞浸润和癌症治疗反应性。这表明HCCS显著地塑造肿瘤内的免疫景观，促进生长和扩散，并强调其作为LUAD和其他具有类似表达谱的癌症的治疗靶点的潜力。
Pathological significance and therapeutic prospects of HCCS expression patterns in lung adenocarcinoma.
This study examines Holocytochrome c synthase (HCCS) expression in lung adenocarcinoma (LUAD) and its impact on the tumor immune environment. By analyzing multiple tumor databases, the research highlights HCCS expression patterns across various cancer types, focusing on its correlation with M2-type macrophages, which aid tumor progression. Findings show that high HCCS expressionin LUAD is associated with increased M2-type macrophages, and variations in HCCS levels influence immune cell infiltration and cancer therapy responsiveness. It suggests that HCCS significantly shapes the immune landscape within tumors, promoting growth and spread, and underscores its potential as a therapeutic target in LUAD and other cancers with similar expression profiles.
期刊介绍：
Cell Adhesion & Migration is a multi-disciplinary, peer reviewed open access journal that focuses on the biological or pathological implications of cell-cell and cell-microenvironment interactions. The main focus of this journal is fundamental science. The journal strives to serve a broad readership by regularly publishing review articles covering specific disciplines within the field, and by publishing focused issues that provide an overview on specific topics of interest within the field.
Cell Adhesion & Migration publishes relevant and timely original research, as well as authoritative overviews, commentaries, and perspectives, providing context for the work presented in Cell Adhesion & Migration and for key results published elsewhere. Original research papers may cover all topics important in the field of cell-cell and cell-matrix interactions. Cell Adhesion & Migration also publishes articles related to cell biomechanics, biomaterial, and development of related imaging technologies.
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