Acyl-CoA dehydrogenase long chain acts as a tumor-suppressive factor in lung adenocarcinoma progression.

IF 3.3 3区生物学 Q3 CELL BIOLOGY

Cell Adhesion & Migration Pub Date : 2025-12-01 Epub Date: 2025-04-22 DOI:10.1080/19336918.2025.2495676

Tingju Wei, Guowei Fu, Junjie Zhao, Fengan Cao, Danfeng Guo

引用次数: 0

Abstract

This study investigated the role of long-chain acyl-CoA dehydrogenase (ACADL) in lung adenocarcinoma (LUAD). ACADL was significantly downregulated in human LUAD tissues compared to normal lung tissues. In vitro, ectopic expression of ACADL in murine LLC cells decreased cell viability, migration, and invasion, while ACADL knockdown exhibited the opposite effect. In vivo, ACADL overexpression impeded tumor growth and metastasis. Mechanistically, ACADL hindered tumor progression by inducing cell cycle arrest, promoting apoptosis, and suppressing the epithelial-mesenchymal transition (EMT) process. These findings suggest ACADL acts as a tumor suppressor in LUAD progression.

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酰基辅酶a脱氢酶长链在肺腺癌进展中作为肿瘤抑制因子。

本研究探讨了长链酰基辅酶a脱氢酶（ACADL）在肺腺癌（LUAD）中的作用。与正常肺组织相比，人LUAD组织中的ACADL显著下调。在体外，ACADL在小鼠LLC细胞中的异位表达降低了细胞活力、迁移和侵袭，而ACADL敲低则表现出相反的效果。在体内，ACADL过表达可抑制肿瘤生长和转移。从机制上讲，ACADL通过诱导细胞周期阻滞、促进细胞凋亡和抑制上皮-间质转化（EMT）过程来阻碍肿瘤进展。这些发现表明ACADL在LUAD进展中起肿瘤抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Adhesion & Migration CELL BIOLOGY-

CiteScore

6.40

自引率

0.00%

发文量

审稿时长

53 weeks

期刊介绍： Cell Adhesion & Migration is a multi-disciplinary, peer reviewed open access journal that focuses on the biological or pathological implications of cell-cell and cell-microenvironment interactions. The main focus of this journal is fundamental science. The journal strives to serve a broad readership by regularly publishing review articles covering specific disciplines within the field, and by publishing focused issues that provide an overview on specific topics of interest within the field. Cell Adhesion & Migration publishes relevant and timely original research, as well as authoritative overviews, commentaries, and perspectives, providing context for the work presented in Cell Adhesion & Migration and for key results published elsewhere. Original research papers may cover all topics important in the field of cell-cell and cell-matrix interactions. Cell Adhesion & Migration also publishes articles related to cell biomechanics, biomaterial, and development of related imaging technologies.