Weixin Jing, Linna Long, Xiaorui Zhang, Xia Li, He Huang
{"title":"The research trends and hotspots of claudins in the field of cancer.","authors":"Weixin Jing, Linna Long, Xiaorui Zhang, Xia Li, He Huang","doi":"10.1080/19336918.2025.2520641","DOIUrl":null,"url":null,"abstract":"<p><p>Claudins (CLDNs), as the key components of tight junctions, have been implicated as key factors in carcinogenesis and metastasis. A total of 1720 publications on CLDNs in the field of cancer were published from January 2005 to December 2022. The United States dominates the research on CLDNs in cancer, followed by China. China Medical University is the most productive, and Johns Hopkins University has the most citations. Morin PJ is credited with initiating research on CLDNs in cancer. CLDN18, the intestinal barrier, and the intestinal microbiota are the focus and hotspots in this field. The mechanism of CLDN-mediated metastasis still needs further investigation, and the development of CLDN-targeted therapies also needs to be explored in the future.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"19 1","pages":"2520641"},"PeriodicalIF":3.3000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Adhesion & Migration","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/19336918.2025.2520641","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Claudins (CLDNs), as the key components of tight junctions, have been implicated as key factors in carcinogenesis and metastasis. A total of 1720 publications on CLDNs in the field of cancer were published from January 2005 to December 2022. The United States dominates the research on CLDNs in cancer, followed by China. China Medical University is the most productive, and Johns Hopkins University has the most citations. Morin PJ is credited with initiating research on CLDNs in cancer. CLDN18, the intestinal barrier, and the intestinal microbiota are the focus and hotspots in this field. The mechanism of CLDN-mediated metastasis still needs further investigation, and the development of CLDN-targeted therapies also needs to be explored in the future.
期刊介绍：
Cell Adhesion & Migration is a multi-disciplinary, peer reviewed open access journal that focuses on the biological or pathological implications of cell-cell and cell-microenvironment interactions. The main focus of this journal is fundamental science. The journal strives to serve a broad readership by regularly publishing review articles covering specific disciplines within the field, and by publishing focused issues that provide an overview on specific topics of interest within the field.
Cell Adhesion & Migration publishes relevant and timely original research, as well as authoritative overviews, commentaries, and perspectives, providing context for the work presented in Cell Adhesion & Migration and for key results published elsewhere. Original research papers may cover all topics important in the field of cell-cell and cell-matrix interactions. Cell Adhesion & Migration also publishes articles related to cell biomechanics, biomaterial, and development of related imaging technologies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
