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Cell Adhesion & Migration最新文献

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Golgi α1,2-mannosidase I induces clustering and compartmentalization of CD147 during epithelial cell migration. 高尔基体α1,2-甘露糖苷酶 I 在上皮细胞迁移过程中诱导 CD147 的聚集和分区。
IF 3.3 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1764170
Miguel Gonzalez-Andrades, Supriya S Jalimarada, Maria Rodriguez-Benavente, Marissa N Feeley, Ashley M Woodward, Dina B AbuSamra, Pablo Argüeso
{"title":"Golgi α1,2-mannosidase I induces clustering and compartmentalization of CD147 during epithelial cell migration.","authors":"Miguel Gonzalez-Andrades, Supriya S Jalimarada, Maria Rodriguez-Benavente, Marissa N Feeley, Ashley M Woodward, Dina B AbuSamra, Pablo Argüeso","doi":"10.1080/19336918.2020.1764170","DOIUrl":"10.1080/19336918.2020.1764170","url":null,"abstract":"<p><p>CD147 is a widely expressed matrix metalloproteinase inducer involved in the regulation of cell migration. The high glycosylation and ability to undergo oligomerization have been linked to CD147 function, yet there is limited understanding on the molecular mechanisms behind these processes. The current study demonstrates that the expression of Golgi α1,2-mannosidase I is key to maintaining the cell surface organization of CD147 during cell migration. Using an in vitro model of stratified human corneal epithelial wound healing, we show that CD147 is clustered within lateral plasma membranes at the leading edge of adjacent migrating cells. This localization correlates with a surge in matrix metalloproteinase activity and an increase in the expression of α1,2-mannosidase subtype IC (MAN1C1). Global inhibition of α1,2-mannosidase I activity with deoxymannojirimycin markedly attenuates the glycosylation of CD147 and disrupts its surface distribution at the leading edge, concomitantly reducing the expression of matrix metalloproteinase-9. Likewise, treatment with deoxymannojirimycin or siRNA-mediated knockdown of MAN1C1 impairs the ability of the carbohydrate-binding protein galectin-3 to stimulate CD147 clustering in unwounded cells. We conclude that the mannose-trimming activity of α1,2-mannosidase I coordinates the clustering and compartmentalization of CD147 that follows an epithelial injury.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"14 1","pages":"96-105"},"PeriodicalIF":3.3,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37946691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The functions of kinesin and kinesin-related proteins in eukaryotes. 真核生物中运动蛋白及运动蛋白相关蛋白的功能。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1810939
Iftikhar Ali, Wei-Cai Yang
{"title":"The functions of kinesin and kinesin-related proteins in eukaryotes.","authors":"Iftikhar Ali,&nbsp;Wei-Cai Yang","doi":"10.1080/19336918.2020.1810939","DOIUrl":"https://doi.org/10.1080/19336918.2020.1810939","url":null,"abstract":"<p><p>Kinesins constitute a superfamily of ATP-driven microtubule motor enzymes that convert the chemical energy of ATP hydrolysis into mechanical work along microtubule tracks. Kinesins are found in all eukaryotic organisms and are essential to all eukaryotic cells, involved in diverse cellular functions such as microtubule dynamics and morphogenesis, chromosome segregation, spindle formation and elongation and transport of organelles. In this review, we explore recently reported functions of kinesins in eukaryotes and compare their specific cargoes in both plant and animal kingdoms to understand the possible roles of uncharacterized motors in a kingdom based on their reported functions in other kingdoms.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"14 1","pages":"139-152"},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1810939","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38402777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies. 流体剪切应力对成纤维细胞和干细胞平面和沟槽形貌的影响。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1713532
Xing Lei, Bin Liu, Hao Wu, Xiao Wu, Xiu-Li Wang, Yue Song, Shuai-Shuai Zhang, Jun-Qin Li, Long Bi, Guo-Xian Pei
{"title":"The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies.","authors":"Xing Lei,&nbsp;Bin Liu,&nbsp;Hao Wu,&nbsp;Xiao Wu,&nbsp;Xiu-Li Wang,&nbsp;Yue Song,&nbsp;Shuai-Shuai Zhang,&nbsp;Jun-Qin Li,&nbsp;Long Bi,&nbsp;Guo-Xian Pei","doi":"10.1080/19336918.2020.1713532","DOIUrl":"https://doi.org/10.1080/19336918.2020.1713532","url":null,"abstract":"<p><p>In this study, we aimed to study the effect of fluid shear stress on fibroblasts and BMSCs on plane and groove topographies. The results showed that 0.6-Hz stress had the greatest influence on the alignment, polarity, migration and adhesion of fibroblasts on plane by increasing the expression of reoriented actin and vinculin; whereas 1.0-Hz stress promoted differentiation of fibroblasts into myofibroblasts by increasing Col-I and α-SMA expression. Interestingly, under the given frequency stress, the groove structure strengthened the above characteristics of fibroblasts beyond adhesion, and promoted differentiation of BMSCs into myofibroblasts. The above results indicate that 0.6 Hz may improve the implant-tissue sealing, while 1.0-Hz stress probably causes the disordered fiber deposition around implants.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"14 1","pages":"12-23"},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1713532","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37548019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
EpCAM-claudin-tetraspanin-modulated ovarian cancer progression and drug resistance. epcam -claudin-tetraspanin调控卵巢癌进展及耐药。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1732761
Zehra Tavsan, Hülya Ayar Kayalı
{"title":"EpCAM-claudin-tetraspanin-modulated ovarian cancer progression and drug resistance.","authors":"Zehra Tavsan,&nbsp;Hülya Ayar Kayalı","doi":"10.1080/19336918.2020.1732761","DOIUrl":"https://doi.org/10.1080/19336918.2020.1732761","url":null,"abstract":"ABSTRACT Alterations of cell adhesion are involved in cancer progression, but the mechanisms underlying the progression and cell adhesion have remained poorly understood. Focusing on the complex between EpCAM, claudins and tetraspanins, we described a sequence of events by which of the molecules associate each other in ovarian cancer. The interactions between molecules were evaluated by immunoprecipitations and then immunoblotting. To identify the effects of complex formation on the ovarian cancer progression, the different types of ovarian cancer cell lines were compared. In this study, we report the identification of the EpCAM-claudin-4 or −7-CD82 complex in the ovarian cancer progression and metastasis in vitro. Additionally, we demonstrated palmitoylation and intra- or extra-cellular regions are critically required for the complex formation. These results represent the first direct evidence for the link between the dynamism of cell adhesion molecules and ovarian cancer progression.","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"14 1","pages":"57-68"},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1732761","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37671733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Short-term ex-vivo exposure to hydrogen sulfide enhances murine hematopoietic stem and progenitor cell migration, homing, and proliferation. 短期离体暴露于硫化氢可增强小鼠造血干细胞和祖细胞的迁移、归巢和增殖。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1842131
Anoushka Khanna, Namita Indracanti, Rina Chakrabarti, Prem Kumar Indraganti
{"title":"Short-term <i>ex-vivo</i> exposure to hydrogen sulfide enhances murine hematopoietic stem and progenitor cell migration, homing, and proliferation.","authors":"Anoushka Khanna, Namita Indracanti, Rina Chakrabarti, Prem Kumar Indraganti","doi":"10.1080/19336918.2020.1842131","DOIUrl":"10.1080/19336918.2020.1842131","url":null,"abstract":"<p><p>For successful transplantation of Hematopoietic Stem cells (HSCs), it is quite necessary that efficient homing, engraftment and retention of HSC self-renewal capacity takes place, which is often restricted due to inadequate number of adult HSCs. Here, we report that short-term <i>ex-vivo</i> treatment of mouse bone marrow mononuclear cells (BMMNCs) to Sodium Hydrogen Sulfide (NaHS, hydrogen sulfide-H<sub>2</sub>S donor) can be used as a possible strategy to overcome such hurdle. H<sub>2</sub>S increases the expression of CXCR4 on HSPCs, enhancing their migration toward SDF-1α in-vitro and thus homing to BM niche. . Additionally, <i>in-vitro</i> studies revealed that H<sub>2</sub>S has a role in activating mitochondria, thus, pushing quiescent HSCs into division. These results suggest a readily available and cost-effective method to facilitate efficient HSC transplantation.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"14 1","pages":"214-226"},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1842131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38659480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The anti-cancer properties of heparin and its derivatives: a review and prospect. 肝素及其衍生物的抗癌特性综述与展望。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1767489
Sai-Nan Ma, Zhi-Xiang Mao, Yang Wu, Ming-Xing Liang, Dan-Dan Wang, Xiu Chen, Ping-An Chang, Wei Zhang, Jin-Hai Tang
{"title":"The anti-cancer properties of heparin and its derivatives: a review and prospect.","authors":"Sai-Nan Ma,&nbsp;Zhi-Xiang Mao,&nbsp;Yang Wu,&nbsp;Ming-Xing Liang,&nbsp;Dan-Dan Wang,&nbsp;Xiu Chen,&nbsp;Ping-An Chang,&nbsp;Wei Zhang,&nbsp;Jin-Hai Tang","doi":"10.1080/19336918.2020.1767489","DOIUrl":"https://doi.org/10.1080/19336918.2020.1767489","url":null,"abstract":"<p><p>Heparin, including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and heparin derivatives, are commonly used in venous thromboembolism treatment and reportedly have beneficial effects on cancer survival. Heparin can affect the proliferation, adhesion, angiogenesis, migration and invasion of cancer cells via multiple mechanisms. The main mechanisms involve inhibition of heparanase, P-/L-selectin, angiogenesis, and interference with the CXCL12-CXCR4 axis. Here we summarize the current experimental evidence regarding the anti-cancer role of heparin and its derivatives, and conclude that there is evidence to support heparin's role in inhibiting cancer progression, making it a promising anti-cancer agent.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"14 1","pages":"118-128"},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1767489","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38046532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 46
FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer. FGFR1在FGFR1扩增的肺癌中通过靶向CCND1调控增殖和转移。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1766308
Ying Yang, Tingting Lu, Ziming Li, Shun Lu
{"title":"FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer.","authors":"Ying Yang,&nbsp;Tingting Lu,&nbsp;Ziming Li,&nbsp;Shun Lu","doi":"10.1080/19336918.2020.1766308","DOIUrl":"https://doi.org/10.1080/19336918.2020.1766308","url":null,"abstract":"<p><p><b>Aims</b>: The analysis of the online databases revealed that CCND1 expression is correlated with poor prognosis in LSCC. We aimed to explore the function of CCND1 in tumor progression in LSCC.<b>Main methods</b>: The expression of mRNA was measured using qRT-PCR. Protein expression was assessed by Western blot. Cell migration and invasion were assessed by transwell assay.<b>Key findings</b>: CCND1 was co-overexpressed with FGFR1 in lung cancer patients. Overexpression of CCND1 promoted LSCC cell proliferation and metastasis. FGFR1 promoted the processes of EMT through AKT/MAPK signaling by targeting CCND1 in FGFR1-amplification cell lines.<b>Significance</b>: IIn conclusion, our study demonstrated the regulatory mechanism between CCND1 and FGFR1 in FGFR1 amplified LSCC. Co-targeting CCND1 and FGFR1 could provide greater clinical benefits.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"14 1","pages":"82-95"},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1766308","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37912619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells. Amblyomin-X是一种重组kunitz型抑制剂，可调节人肿瘤细胞的粘附和迁移。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 Epub Date: 2018-09-25 DOI: 10.1080/19336918.2018.1516982
Mariana Costa Braga Schmidt, Katia L P Morais, Maíra Estanislau Soares de Almeida, Asif Iqbal, Mauricio Barbugiani Goldfeder, Ana Marisa Chudzinski-Tavassi
{"title":"Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells.","authors":"Mariana Costa Braga Schmidt,&nbsp;Katia L P Morais,&nbsp;Maíra Estanislau Soares de Almeida,&nbsp;Asif Iqbal,&nbsp;Mauricio Barbugiani Goldfeder,&nbsp;Ana Marisa Chudzinski-Tavassi","doi":"10.1080/19336918.2018.1516982","DOIUrl":"https://doi.org/10.1080/19336918.2018.1516982","url":null,"abstract":"<p><p>In a tumor microenvironment, endothelial cell migration and angiogenesis allow cancer to spread to other organs causing metastasis.  Indeed, a number of molecules that are involved in cytoskeleton re-organization and intracellular signaling have been investigated for their effects on tumor cell growth and metastasis. Alongside that, Amblyomin-X, a recombinant Kunitz-type protein, has been shown to reduce metastasis and tumor growth in in vivo experiments. In the present report, we provide a mechanistic insight to these antitumor effects, this is,  Amblyomin-X modulates Rho-GTPases and uPAR signaling, and reduces the release of MMPs, leading to disruption of the actin cytoskeleton and decreased cell migration of tumor cell lines. Altogether, our data support a role for Amblyomin-X as a novel potential antitumor drug.</p><p><strong>Abbreviations: </strong>Amb-X: Amblyomin-X; ECGF: endotelial cell growth factor; ECM: extracellular matrix; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; HUVEC: human umbilical vein endothelial cell; LRP1: low-density lipoprotein receptor-related protein; MMP: matrix metalloproteinase; HPI-4: hedgehog pathway inhibitor 4; PAI-1: plasminogen activator inhibitor 1; PMA: phorbol 12-myristate-13-acetate; TFPI: tissue factor pathway inhibitor; uPA: urokinase plasminogen activator; uPAR: uPA receptor.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"14 1","pages":"129-138"},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2018.1516982","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36509658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Fibronectin type III domain-containing 4 promotes the migration and differentiation of bovine skeletal muscle-derived satellite cells via focal adhesion kinase. 含纤维连接蛋白III型结构域4通过黏附激酶促进牛骨骼肌源卫星细胞的迁移和分化。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1810508
Zhao Wang, Zhiqi Wang, Yusheng Pang, Huili Tong, Yunqin Yan, Shuang Li, Shufeng Li
{"title":"Fibronectin type III domain-containing 4 promotes the migration and differentiation of bovine skeletal muscle-derived satellite cells via focal adhesion kinase.","authors":"Zhao Wang,&nbsp;Zhiqi Wang,&nbsp;Yusheng Pang,&nbsp;Huili Tong,&nbsp;Yunqin Yan,&nbsp;Shuang Li,&nbsp;Shufeng Li","doi":"10.1080/19336918.2020.1810508","DOIUrl":"https://doi.org/10.1080/19336918.2020.1810508","url":null,"abstract":"<p><p>FNDC4 is an anti-inflammatory factor that alters the activation state of macrophages; it is used to treat colitis in mice. However, its role in muscle formation and mechanism of function remains unknown. We found that FNDC4 promotes the bovine MDSCs migration and differentiation. Furthermore, we reported that it interacts with integrin β1 (ITGβ1). FAK, mediated by ITGβ1, regulates cell migration. Our results found FNDC4 to influence the expression of p-FAK, p-paxillin, and vinculin. Then, overexpressed or added FNDC4 protein could not influence migration and differentiation any more when the activated form of FAK was reduced. Therefore, we concluded that FNDC4 promotes the differentiation and migration of bovine MDSCs via the FAK, mediated by the ITGβ1 receptor.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"14 1","pages":"153-164"},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1810508","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38340662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Hypoxia regulates human mast cell adhesion to fibronectin via the PI3K/AKT signaling pathway. 缺氧通过PI3K/AKT信号通路调节人肥大细胞对纤维连接蛋白的粘附。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1764690
Joanna Pastwińska, Aurelia Walczak-Drzewiecka, Magdalena Łukasiak, Marcin Ratajewski, Jarosław Dastych
{"title":"Hypoxia regulates human mast cell adhesion to fibronectin via the PI3K/AKT signaling pathway.","authors":"Joanna Pastwińska,&nbsp;Aurelia Walczak-Drzewiecka,&nbsp;Magdalena Łukasiak,&nbsp;Marcin Ratajewski,&nbsp;Jarosław Dastych","doi":"10.1080/19336918.2020.1764690","DOIUrl":"https://doi.org/10.1080/19336918.2020.1764690","url":null,"abstract":"<p><p>A decrease in oxygen concentration is a hallmark of inflammatory reactions resulting from infection or homeostasis disorders. Mast cells interact with extracellular matrix and other cells by adhesion receptors. We investigated the effect of hypoxia on integrin-mediated mast cell adhesion to fibronectin. We found that it was mediated by the α5/β1 receptor and that hypoxia significantly upregulated this process. Hypoxia-mediated increases in mast cell adhesion occurred without increased surface expression of integrins, suggesting regulation by inside-out integrin signaling. Hypoxia also mediated an increase in phosphorylation of Akt, and PI3'kinase inhibitors abolished hypoxia-mediated mast cell adhesion. Hypoxia upregulates the function of integrin receptors by PI3' kinase-dependent signaling. This process might be important for the location of mast cells at inflammatory sites.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"14 1","pages":"106-117"},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1764690","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37952713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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