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Cell Adhesion & Migration最新文献

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Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity. Scribble, Lgl1和myosin IIA与α-/β-连环蛋白相互作用以维持上皮连接的完整性。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2023-12-01 Epub Date: 2023-09-24 DOI: 10.1080/19336918.2023.2260645
Maha Abedrabbo, Shirel Sloomy, Reham Abu-Leil, Einav Kfir-Cohen, Shoshana Ravid
{"title":"Scribble, Lgl1, and myosin IIA interact with α-/β-catenin to maintain epithelial junction integrity.","authors":"Maha Abedrabbo, Shirel Sloomy, Reham Abu-Leil, Einav Kfir-Cohen, Shoshana Ravid","doi":"10.1080/19336918.2023.2260645","DOIUrl":"10.1080/19336918.2023.2260645","url":null,"abstract":"<p><p>E-cadherin-catenin complex together with the cytoskeleton, builds the core of Adherens junctions (AJs). It has been reported that Scribble stabilizes the coupling of E-cadherin with catenins promoting epithelial cell adhesion, but the mechanism remains unknown. We show that Scribble, Lgl1, and NMII-A reside in a complex with E-cadherin-catenin complex. Depletion of either Scribble or Lgl1 disrupts the localization of E-cadherin-catenin complex to AJs. aPKCζ phosphorylation of Lgl1 regulates AJ localization of Lgl1 and E-cadherin-catenin complexes. Both Scribble and Lgl1 regulate the activation and recruitment of NMII-A at AJs. Finally, Scribble and Lgl1 are downregulated by TGFβ-induced EMT, and their re-expression during EMT impedes its progression. Our results provide insight into the mechanism regulating AJ integrity by Scribble, Lgl1, and NMII-A.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"17 1","pages":"1-23"},"PeriodicalIF":3.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41178136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell. 动态超低稀释的芦丁破坏质膜组织，减少黑色素瘤癌细胞的迁移。
IF 3.3 3区 生物学
Cell Adhesion & Migration Pub Date : 2023-12-01 DOI: 10.1080/19336918.2022.2154732
Camille Fuselier, Eleonore Dufay, Alexandre Berquand, Christine Terryn, Arnaud Bonnomet, Michael Molinari, Laurent Martiny, Christophe Schneider
{"title":"Dynamized ultra-low dilution of <i>Ruta graveolens</i> disrupts plasma membrane organization and decreases migration of melanoma cancer cell.","authors":"Camille Fuselier, Eleonore Dufay, Alexandre Berquand, Christine Terryn, Arnaud Bonnomet, Michael Molinari, Laurent Martiny, Christophe Schneider","doi":"10.1080/19336918.2022.2154732","DOIUrl":"10.1080/19336918.2022.2154732","url":null,"abstract":"<p><p>Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of <i>Ruta Graveolens</i> leads to an <i>in vitro</i> inhibition of migration on fibronectin of B16F10 melanoma cells, as well as a decrease in metastatic dissemination <i>in vivo</i>. These effects appear to be due to a disruption of plasma membrane organization, with a change in cell and membrane stiffness, associated with a disorganization of the actin cytoskeleton and a modification of the lipid composition of the plasma membrane. Together, these results demonstrate, in <i>in vitro</i> and <i>in vivo</i> models of cutaneous melanoma, an anti-cancer and anti-metastatic activity of ultra-low dynamized dilution of <i>Ruta graveolens</i> and reinforce its interest as complementary medicine in oncology.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"17 1","pages":"1-13"},"PeriodicalIF":3.3,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10657273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway. IL-13中和通过调节JAK-1/STAT-3信号通路减轻颈动脉内膜增生并增加内皮细胞迁移。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2023-12-01 Epub Date: 2023-10-09 DOI: 10.1080/19336918.2023.2265158
Qi Li, Yue Li, Fengjiao Wu, Jingyu Li, Zhongsha Li, Xiaoling Qin, Simeng Wei, Chang Chen
{"title":"IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway.","authors":"Qi Li,&nbsp;Yue Li,&nbsp;Fengjiao Wu,&nbsp;Jingyu Li,&nbsp;Zhongsha Li,&nbsp;Xiaoling Qin,&nbsp;Simeng Wei,&nbsp;Chang Chen","doi":"10.1080/19336918.2023.2265158","DOIUrl":"10.1080/19336918.2023.2265158","url":null,"abstract":"<p><p>The aim of this study was to investigate how the concentration of interleukin-13 (IL-13) affects the regulation of endothelial cell migration after injury. The incubation of recombinant human interleukin-13 (rhIL-13) strongly increased the content of reactive oxygen species (ROS) in HUVECs via the JAK-1/STAT-3/NOX-4 signaling pathway. Antagonizing the high intracellular ROS that was induced by rhIL-13 promoted the migration of HUVECs. Furthermore, IL-13 neutralization not only inhibited intimal hyperplasia, but also promoted the migration of endothelial cells (ECs) after injury. The results suggest that IL-13 inhibition is a potential means of stimulating endothelial cells recovery after injury. Therefore, the attenuation of IL-13 activation may have therapeutic value for vascular disease.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"17 1","pages":"1-10"},"PeriodicalIF":3.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/52/f9/KCAM_17_2265158.PMC10566387.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41182134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unravelling cell migration: defining movement from the cell surface. 解开细胞迁移：从细胞表面定义移动
IF 4.3 3区 生物学
Cell Adhesion & Migration Pub Date : 2022-12-01 DOI: 10.1080/19336918.2022.2055520
Francisco Merino-Casallo, Maria Jose Gomez-Benito, Silvia Hervas-Raluy, Jose Manuel Garcia-Aznar
{"title":"Unravelling cell migration: defining movement from the cell surface.","authors":"Francisco Merino-Casallo, Maria Jose Gomez-Benito, Silvia Hervas-Raluy, Jose Manuel Garcia-Aznar","doi":"10.1080/19336918.2022.2055520","DOIUrl":"10.1080/19336918.2022.2055520","url":null,"abstract":"<p><p>Cell motility is essential for life and development. Unfortunately, cell migration is also linked to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies on many actors. Cells change their migratory strategy based on their phenotype and the properties of the surrounding microenvironment. Cell migration is, therefore, an extremely complex phenomenon. Researchers have investigated cell motility for more than a century. Recent discoveries have uncovered some of the mysteries associated with the mechanisms involved in cell migration, such as intracellular signaling and cell mechanics. These findings involve different players, including transmembrane receptors, adhesive complexes, cytoskeletal components , the nucleus, and the extracellular matrix. This review aims to give a global overview of our current understanding of cell migration.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"16 1","pages":"25-64"},"PeriodicalIF":4.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41877505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Class I Myosins, molecular motors involved in cell migration and cancer. I类肌球蛋白，参与细胞迁移和癌症的分子马达。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2022-12-01 DOI: 10.1080/19336918.2021.2020705
Juan D Diaz-Valencia, Laura A Estrada-Abreo, Leonor Rodríguez-Cruz, Alfonso R Salgado-Aguayo, Genaro Patiño-López
{"title":"Class I Myosins, molecular motors involved in cell migration and cancer.","authors":"Juan D Diaz-Valencia,&nbsp;Laura A Estrada-Abreo,&nbsp;Leonor Rodríguez-Cruz,&nbsp;Alfonso R Salgado-Aguayo,&nbsp;Genaro Patiño-López","doi":"10.1080/19336918.2021.2020705","DOIUrl":"https://doi.org/10.1080/19336918.2021.2020705","url":null,"abstract":"<p><p>Class I Myosins are a subfamily of motor proteins with ATPase activity and a characteristic structure conserved in all myosins: A N-Terminal Motor Domain, a central Neck and a C terminal Tail domain. Humans have eight genes for these myosins. Class I Myosins have different functions: regulate membrane tension, participate in endocytosis, exocytosis, intracellular trafficking and cell migration. Cell migration is influenced by many cellular components including motor proteins, like myosins. Recently has been reported that changes in myosin expression have an impact on the migration of cancer cells, the formation of infiltrates and metastasis. We propose that class I myosins might be potential markers for future diagnostic, prognostic or even as therapeutic targets in leukemia and other cancers.<b>Abbreviations:</b> Myo1g: Myosin 1g; ALL: Acute Lymphoblastic Leukemia, TH1: Tail Homology 1; TH2: Tail Homology 2; TH3: Tail Homology 3.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"16 1","pages":"1-12"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10255785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Fluid shear stress induces cell migration via RhoA-YAP1-autophagy pathway in liver cancer stem cells. 流体剪切应力通过rhoa - yap1自噬途径诱导肝癌干细胞迁移。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2022-12-01 DOI: 10.1080/19336918.2022.2103925
Zhiping Yan, Danfeng Guo, Ruolin Tao, Xiao Yu, Jiacheng Zhang, Yuting He, Jiakai Zhang, Jie Li, Shuijun Zhang, Wenzhi Guo
{"title":"Fluid shear stress induces cell migration via RhoA-YAP1-autophagy pathway in liver cancer stem cells.","authors":"Zhiping Yan,&nbsp;Danfeng Guo,&nbsp;Ruolin Tao,&nbsp;Xiao Yu,&nbsp;Jiacheng Zhang,&nbsp;Yuting He,&nbsp;Jiakai Zhang,&nbsp;Jie Li,&nbsp;Shuijun Zhang,&nbsp;Wenzhi Guo","doi":"10.1080/19336918.2022.2103925","DOIUrl":"https://doi.org/10.1080/19336918.2022.2103925","url":null,"abstract":"<p><p>Fluid shear stress (FSS) regulates the metastasis of hepatocellular carcinoma (HCC), but the role of the RhoA-YAP1-autophagy pathway in HCC remains unclear. Due to the core role of liver cancer stem cells (LCSCs) in HCC metastasis and recurrence, we explored the RhoA-YAP1-autophagy pathway in LCSCs under FSS. Our results indicate that LCSCs have stronger proliferation and cell spheroidization abilities. FSS (1 dyn/cm<sup>2</sup>) upregulated the migration of LCSCs and autophagy protein markers, inducing LC3B aggregation and autophagosome formation in LCSCs. Mechanistically, FSS promoted YAP1 dephosphorylation and transport to the nucleus, which is mediated by RhoA, inducing autophagy. Finally, inhibition of autophagy suppressed cell migration in LCSCs under FSS. In conclusion, FSS promoted the migration of LCSCs via the RhoA-YAP1-autophagy pathway.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"16 1","pages":"94-106"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/92/d5/KCAM_16_2103925.PMC9331214.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10623073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Activation of GRP78 ATPase suppresses A549 lung cancer cell migration by promoting ITGB4 degradation. 激活GRP78 atp酶通过促进ITGB4降解抑制A549肺癌细胞迁移。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2022-12-01 DOI: 10.1080/19336918.2022.2130415
Junya Ning, Xiaoling Cui, Nan Li, Na Li, Baoxiang Zhao, Junying Miao, Zhaomin Lin
{"title":"Activation of GRP78 ATPase suppresses A549 lung cancer cell migration by promoting ITGB4 degradation.","authors":"Junya Ning,&nbsp;Xiaoling Cui,&nbsp;Nan Li,&nbsp;Na Li,&nbsp;Baoxiang Zhao,&nbsp;Junying Miao,&nbsp;Zhaomin Lin","doi":"10.1080/19336918.2022.2130415","DOIUrl":"https://doi.org/10.1080/19336918.2022.2130415","url":null,"abstract":"<p><p>Hypochlorous acid (HOCl) is an essential signal molecule in cancer cells. Activated GRP78 ATPase by a HOCl probe named ZBM-H inhibits lung cancer cell growth. However, the role and underlying mechanism of GRP78 ATPase in lung cancer cell migration have not been established. Here, we reported that activation of GRP78 ATPase by ZBM-H suppressed A549 cell migration and inhibited EMT process. Notably, ZBM-H time-dependently decreased the protein level of integrin β4 (ITGB4) in A549 cells. Combinatorial treatment of 3BDO (an autophagy inhibitor) and ZBM-H partially rescued the protein level of ITGB4. Consistently, 3BDO partially reversed ZBM-H-inhibited cell migration. Furthermore, ZBM-H promoted the interaction between ANXA7 and Hsc70, which participated in the regulation of selective autophagy and degradation of ITGB4.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"16 1","pages":"107-114"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9542429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10637614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
TNF-α regulates the composition of the basal lamina and cell-matrix adhesions in gingival epithelial cells. TNF-α调节牙龈上皮细胞基底膜组成及细胞-基质黏附。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2022-12-01 DOI: 10.1080/19336918.2022.2029237
Masaru Mezawa, Yuto Tsuruya, Arisa Yamaguchi, Mizuho Yamazaki-Takai, Tetsuro Kono, Hiroyuki Okada, Christopher A McCulloch, Yorimasa Ogata
{"title":"TNF-α regulates the composition of the basal lamina and cell-matrix adhesions in gingival epithelial cells.","authors":"Masaru Mezawa,&nbsp;Yuto Tsuruya,&nbsp;Arisa Yamaguchi,&nbsp;Mizuho Yamazaki-Takai,&nbsp;Tetsuro Kono,&nbsp;Hiroyuki Okada,&nbsp;Christopher A McCulloch,&nbsp;Yorimasa Ogata","doi":"10.1080/19336918.2022.2029237","DOIUrl":"https://doi.org/10.1080/19336918.2022.2029237","url":null,"abstract":"<p><p>Laminin 5, type 4 collagen, and α6β4 integrin contribute to the formation of hemidesmosomes in the epithelia of periodontal tissues, which is critical for the development and maintenance of the dentogingival junction. As it is not known whether TNF-α alters the composition of the epithelial pericellular matrix, human gingival epithelial cells were cultured in the presence or absence of TNF-α. Treatment with TNF-α accelerated epithelial cell migration and closure of in vitro wounds. These data indicate unexpectedly, that TNF-α promotes the formation of the pericellular matrix around epithelial cells and enhances adhesion of epithelial cells to the underlying matrix, properties which are important for cell migration and the integrity of the dentogingival junction.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":" ","pages":"13-24"},"PeriodicalIF":3.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39764444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Novel role of Dipterocarpus tuberculatus as a stimulator of focal cell adhesion through the regulation of MLC2/FAK/Akt signaling pathway 通过调控MLC2/FAK/Akt信号通路刺激局灶细胞粘附的新作用
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2022-05-26 DOI: 10.1080/19336918.2022.2073002
Su jin Lee, Ji Eun Kim, J. W. Jung, Y. Choi, J. Gong, Bounleuane Douangdeuane, Onevilay Souliya, Y. Choi, Sung Baek Seo, D. Hwang
{"title":"Novel role of Dipterocarpus tuberculatus as a stimulator of focal cell adhesion through the regulation of MLC2/FAK/Akt signaling pathway","authors":"Su jin Lee, Ji Eun Kim, J. W. Jung, Y. Choi, J. Gong, Bounleuane Douangdeuane, Onevilay Souliya, Y. Choi, Sung Baek Seo, D. Hwang","doi":"10.1080/19336918.2022.2073002","DOIUrl":"https://doi.org/10.1080/19336918.2022.2073002","url":null,"abstract":"ABSTRACT To investigate a novel function of Dipterocarpus tuberculatus on focal cell adhesion stimulation, alterations to the regulation of focal cell adhesion-related factors were analyzed in NHDF cells and a calvarial defect rat model after treatment with methanol extracts of D. tuberculatus (MED). MED contained gallic acid, caffeic acid, ellagic acid, and naringenin in high concentrations. The proliferation activity, focal cell adhesion ability, adhesion receptors-mediated signaling pathway in NHDF cells were increased by MED. Also, a dense adhered tissue layer and adherent cells on MED-coated titanium plate (MEDTiP) surfaces were detected during regeneration of calvarial bone. The results of the present study provide novel evidence that MED may stimulate focal cell adhesion in NHDF cells and a calvarial defect rat model.","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"16 1","pages":"72 - 93"},"PeriodicalIF":3.2,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46930438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Triple-negative and triple-positive breast cancer cells reciprocally control their growth and migration via the S100A4 pathway 三阴性和三阳性乳腺癌细胞通过S100A4途径相互控制其生长和迁移
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2022-05-12 DOI: 10.1080/19336918.2022.2072554
E. Dukhanina, T. Portseva, A. Dukhanin, S. Georgieva
{"title":"Triple-negative and triple-positive breast cancer cells reciprocally control their growth and migration via the S100A4 pathway","authors":"E. Dukhanina, T. Portseva, A. Dukhanin, S. Georgieva","doi":"10.1080/19336918.2022.2072554","DOIUrl":"https://doi.org/10.1080/19336918.2022.2072554","url":null,"abstract":"ABSTRACT The study’s aim was to investigate the S100A4-mediated mechanisms of the regulation of tumor cell proliferation and migration in the human triple-positive breast carcinoma cell line MCF-7 (TPBC) and triple-negative breast carcinoma cell line MDA-MB-231 (TNBC). The proliferative activity of TNBC more than doubled during the incubation in the conditioned medium of TPBC. Extracellular S100A4 dose-dependently decreased the proliferative response of TPBC. TPBC negatively impacted the growth of TNBCs during their co-culturing. TPBC significantly decreased the migration activity of the TNBC cells while the S100A4 intracellular level in the TNBC was also decreasing. The decrease in the S100A4 intracellular level occurred due to the protein’s monomeric form while the contribution of the dimeric form into the overall S100A4 concentration in TNBC cells increased 1.5-2-fold. The S100A4 pathway in the intercellular communication between TNBC and TPBCs also included the dexamethasone-sensitive mechanisms of S100A4 intra- and extracellular pools regulation.","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"16 1","pages":"65 - 71"},"PeriodicalIF":3.2,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49213300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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