流体剪切应力对成纤维细胞和干细胞平面和沟槽形貌的影响。

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Xing Lei, Bin Liu, Hao Wu, Xiao Wu, Xiu-Li Wang, Yue Song, Shuai-Shuai Zhang, Jun-Qin Li, Long Bi, Guo-Xian Pei
{"title":"流体剪切应力对成纤维细胞和干细胞平面和沟槽形貌的影响。","authors":"Xing Lei,&nbsp;Bin Liu,&nbsp;Hao Wu,&nbsp;Xiao Wu,&nbsp;Xiu-Li Wang,&nbsp;Yue Song,&nbsp;Shuai-Shuai Zhang,&nbsp;Jun-Qin Li,&nbsp;Long Bi,&nbsp;Guo-Xian Pei","doi":"10.1080/19336918.2020.1713532","DOIUrl":null,"url":null,"abstract":"<p><p>In this study, we aimed to study the effect of fluid shear stress on fibroblasts and BMSCs on plane and groove topographies. The results showed that 0.6-Hz stress had the greatest influence on the alignment, polarity, migration and adhesion of fibroblasts on plane by increasing the expression of reoriented actin and vinculin; whereas 1.0-Hz stress promoted differentiation of fibroblasts into myofibroblasts by increasing Col-I and α-SMA expression. Interestingly, under the given frequency stress, the groove structure strengthened the above characteristics of fibroblasts beyond adhesion, and promoted differentiation of BMSCs into myofibroblasts. The above results indicate that 0.6 Hz may improve the implant-tissue sealing, while 1.0-Hz stress probably causes the disordered fiber deposition around implants.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"14 1","pages":"12-23"},"PeriodicalIF":3.3000,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1713532","citationCount":"9","resultStr":"{\"title\":\"The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies.\",\"authors\":\"Xing Lei,&nbsp;Bin Liu,&nbsp;Hao Wu,&nbsp;Xiao Wu,&nbsp;Xiu-Li Wang,&nbsp;Yue Song,&nbsp;Shuai-Shuai Zhang,&nbsp;Jun-Qin Li,&nbsp;Long Bi,&nbsp;Guo-Xian Pei\",\"doi\":\"10.1080/19336918.2020.1713532\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In this study, we aimed to study the effect of fluid shear stress on fibroblasts and BMSCs on plane and groove topographies. The results showed that 0.6-Hz stress had the greatest influence on the alignment, polarity, migration and adhesion of fibroblasts on plane by increasing the expression of reoriented actin and vinculin; whereas 1.0-Hz stress promoted differentiation of fibroblasts into myofibroblasts by increasing Col-I and α-SMA expression. Interestingly, under the given frequency stress, the groove structure strengthened the above characteristics of fibroblasts beyond adhesion, and promoted differentiation of BMSCs into myofibroblasts. The above results indicate that 0.6 Hz may improve the implant-tissue sealing, while 1.0-Hz stress probably causes the disordered fiber deposition around implants.</p>\",\"PeriodicalId\":9680,\"journal\":{\"name\":\"Cell Adhesion & Migration\",\"volume\":\"14 1\",\"pages\":\"12-23\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2020-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/19336918.2020.1713532\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell Adhesion & Migration\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1080/19336918.2020.1713532\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Adhesion & Migration","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/19336918.2020.1713532","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 9

摘要

在这项研究中,我们旨在研究流体剪切应力对成纤维细胞和骨髓间充质干细胞平面和沟槽形貌的影响。结果表明,0.6 hz胁迫对成纤维细胞在平面上的排列、极性、迁移和粘附的影响最大,可通过增加重定向肌动蛋白和血管蛋白的表达来实现;而1.0 hz应激通过增加col - 1和α-SMA表达促进成纤维细胞向肌成纤维细胞分化。有趣的是,在给定的频率应力下,沟槽结构强化了成纤维细胞的上述特性,并促进了骨髓间充质干细胞向肌成纤维细胞的分化。以上结果表明,0.6 Hz应力可改善种植体与组织的密封性,而1.0 Hz应力可能导致种植体周围纤维沉积紊乱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies.

The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies.

The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies.

The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies.

In this study, we aimed to study the effect of fluid shear stress on fibroblasts and BMSCs on plane and groove topographies. The results showed that 0.6-Hz stress had the greatest influence on the alignment, polarity, migration and adhesion of fibroblasts on plane by increasing the expression of reoriented actin and vinculin; whereas 1.0-Hz stress promoted differentiation of fibroblasts into myofibroblasts by increasing Col-I and α-SMA expression. Interestingly, under the given frequency stress, the groove structure strengthened the above characteristics of fibroblasts beyond adhesion, and promoted differentiation of BMSCs into myofibroblasts. The above results indicate that 0.6 Hz may improve the implant-tissue sealing, while 1.0-Hz stress probably causes the disordered fiber deposition around implants.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
6.40
自引率
0.00%
发文量
7
审稿时长
53 weeks
期刊介绍: Cell Adhesion & Migration is a multi-disciplinary, peer reviewed open access journal that focuses on the biological or pathological implications of cell-cell and cell-microenvironment interactions. The main focus of this journal is fundamental science. The journal strives to serve a broad readership by regularly publishing review articles covering specific disciplines within the field, and by publishing focused issues that provide an overview on specific topics of interest within the field. Cell Adhesion & Migration publishes relevant and timely original research, as well as authoritative overviews, commentaries, and perspectives, providing context for the work presented in Cell Adhesion & Migration and for key results published elsewhere. Original research papers may cover all topics important in the field of cell-cell and cell-matrix interactions. Cell Adhesion & Migration also publishes articles related to cell biomechanics, biomaterial, and development of related imaging technologies.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信