{"title":"长链非编码RNA ENST00000508435通过fxr1促进乳腺癌迁移","authors":"Luying Li, Youping Jin, Xue Wang, Li Wang, Yangbai Sun, Yihong Luo, Xiaojian Ni, Qi Lu, Wenbo Wei, Xiuling Zhi, Jerry Yu, Wei Zhu, Ping Zhou","doi":"10.1080/19336918.2021.1921402","DOIUrl":null,"url":null,"abstract":"<p><p>LncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, <i>ENST00000508435</i>, which could be remarkably up-regulated in breast cancer cells and tissues. We found that the expression of <i>ENST00000508435</i> was positively correlated with tumor size, lymph node metastasis and HER2. More interesting, overexpression of <i>ENST00000508435</i> significantly increased cell migration, while specific knockdown led to the opposite. RNA pull-down and RNA immunoprecipitation assays demonstrated that <i>ENST00000508435</i> could directly bind to FXR1 to promote tumor metastasis. <i>ENST00000508435</i> and FXR1 were positively correlated. FXR1 was also significantly up-regulated in breast tumors. Taken together, we propose that <i>ENST00000508435</i> regulates FXR1 to promote breast cancer metastasis.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2021.1921402","citationCount":"2","resultStr":"{\"title\":\"Long noncoding RNA <i>ENST00000508435</i> promotes migration of breast cancer via FXR 1.\",\"authors\":\"Luying Li, Youping Jin, Xue Wang, Li Wang, Yangbai Sun, Yihong Luo, Xiaojian Ni, Qi Lu, Wenbo Wei, Xiuling Zhi, Jerry Yu, Wei Zhu, Ping Zhou\",\"doi\":\"10.1080/19336918.2021.1921402\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>LncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, <i>ENST00000508435</i>, which could be remarkably up-regulated in breast cancer cells and tissues. We found that the expression of <i>ENST00000508435</i> was positively correlated with tumor size, lymph node metastasis and HER2. More interesting, overexpression of <i>ENST00000508435</i> significantly increased cell migration, while specific knockdown led to the opposite. RNA pull-down and RNA immunoprecipitation assays demonstrated that <i>ENST00000508435</i> could directly bind to FXR1 to promote tumor metastasis. <i>ENST00000508435</i> and FXR1 were positively correlated. FXR1 was also significantly up-regulated in breast tumors. Taken together, we propose that <i>ENST00000508435</i> regulates FXR1 to promote breast cancer metastasis.</p>\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/19336918.2021.1921402\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1080/19336918.2021.1921402\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/19336918.2021.1921402","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1.
LncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, ENST00000508435, which could be remarkably up-regulated in breast cancer cells and tissues. We found that the expression of ENST00000508435 was positively correlated with tumor size, lymph node metastasis and HER2. More interesting, overexpression of ENST00000508435 significantly increased cell migration, while specific knockdown led to the opposite. RNA pull-down and RNA immunoprecipitation assays demonstrated that ENST00000508435 could directly bind to FXR1 to promote tumor metastasis. ENST00000508435 and FXR1 were positively correlated. FXR1 was also significantly up-regulated in breast tumors. Taken together, we propose that ENST00000508435 regulates FXR1 to promote breast cancer metastasis.
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