Caspian Journal of Internal Medicine最新文献_第4页

Concurrent peritoneal and pleural tuberculosis in an adult: A case report and literature review. 一名成人并发腹膜和胸膜结核：病例报告和文献综述。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-09-07 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.735

Elham Barahimi, Zahra Ghaeini Hesarooeyeh, Ayoub Basham, Mohadeseh Karimi, Behnoush Heidari

{"title":"Concurrent peritoneal and pleural tuberculosis in an adult: A case report and literature review.","authors":"Elham Barahimi, Zahra Ghaeini Hesarooeyeh, Ayoub Basham, Mohadeseh Karimi, Behnoush Heidari","doi":"10.22088/cjim.15.4.735","DOIUrl":"10.22088/cjim.15.4.735","url":null,"abstract":"Background: The simultaneous involvement of the pleura and peritoneum with tuberculosis in the absence of pulmonary foci is an uncommon condition that may lead physicians to misdiagnose.Case presentation: Herein, we present a Persian male adult who manifested with epigastric pain, weakness, and a history of pleuritic chest pain two months prior to admission. The findings of the physical examination included vital signs within the normal range, unilateral fine crackle in the lung, abdominal distension with positive shifting dullness, and fluid wave test. Analysis of the ascitic fluid revealed a Serum-ascites albumin gradient (SAAG) of less than 1.1g/dl, indicating a non-portal condition. The results of the acid-fast bacilli (AFB) staining as well as the TB polymerase chain reaction (PCR) test were negative. However, the adenosine deaminase (ADA) level was 44 IU/L. A chest CT scan revealed mediastinal lymph node enlargement and pleural thickening with loculated pleural effusion. Three acid-fast bacilli smear of morning sputum were sent, and all three were negative. An abdominopelvic CT scan showed multiple periaortic and mesenteric lymph nodes of varying sizes with mesenteric haziness and accumulation of effusion in the peritoneal cavity. Eventually, peritoneal biopsy, the gold standard, was performed, which revealed multiple granulomatous lesions and areas of caseous necrosis surrounded by Langerhans giant cells and epithelioid cells.Conclusion: It is worth noting that in cases of ascites and pleural thickening, especially in patients with poor socioeconomic status, simultaneous pleural and peritoneal TB should be considered, especially in third-world countries.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"735-742"},"PeriodicalIF":0.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin-like growth factor (IGF) levels in pre-treatment plasma identifying breast cancer: A case control study. 乳腺癌治疗前血浆中的胰岛素样生长因子（IGF）水平：病例对照研究。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-09-07 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.706

Sarvin Alizadeh Sadighi, Nematollah Rostami, Maryam Tohidi, Mahbobeh Mashayekhi

{"title":"Insulin-like growth factor (IGF) levels in pre-treatment plasma identifying breast cancer: A case control study.","authors":"Sarvin Alizadeh Sadighi, Nematollah Rostami, Maryam Tohidi, Mahbobeh Mashayekhi","doi":"10.22088/cjim.15.4.706","DOIUrl":"10.22088/cjim.15.4.706","url":null,"abstract":"Background: Diabetes (primarily type 2) is linked to a higher risk of breast cancer. Insulin-like growth factor (IGF) is one of the most important factors that affects mitosis and thus inhibits apoptosis. The purpose of this study was to compare the pre-treatment insulin-like growth factor (IGF) levels in breast cancer against normal population.Methods: In this case-control study, 60 patients with breast cancer and 60 healthy controls were enrolled in 2017 and 2018 at Tehran's Shahid-Modarres Hospital. In this study, the blood sugar of the patients was examined before entering the study, and the age of the patients was also within the age limit of 18 to 70 years. They were studied to determine the relationship between insulin-like growth factor (ELISA method) and breast cancer.Results: Both groups have similar IGF-1 levels (Ctrl and Case) (P= 0.188). But, IGF-2 levels were significantly higher in breast cancer patients (373.4 vs. 317.3 ng/ml), (P=0.0001).Conclusion: According to our study, IGF-2 may serve as a prognostic biomarker and potential therapeutic target for breast cancer. However, further investigation is needed to validate this claim.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"706-712"},"PeriodicalIF":0.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum lipid profile in adolescents and adults with acne vulgaris receiving isotretinoin. 接受异维A酸治疗的青少年和成人寻常型痤疮患者的血脂状况。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-09-07 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.659

Kaveh Gharaei Nejad, Abbas Darjani, Narges Alizadeh, Seyede Tahoura Hakemzadeh, Afagh Hassanzadeh Rad, Ehsan Kazemnejad-Leili, Reyhaneh Ghadarjani, Hojat Eftekhari, Rana Rafiei, Setila Dalili

{"title":"Serum lipid profile in adolescents and adults with acne vulgaris receiving isotretinoin.","authors":"Kaveh Gharaei Nejad, Abbas Darjani, Narges Alizadeh, Seyede Tahoura Hakemzadeh, Afagh Hassanzadeh Rad, Ehsan Kazemnejad-Leili, Reyhaneh Ghadarjani, Hojat Eftekhari, Rana Rafiei, Setila Dalili","doi":"10.22088/cjim.15.4.659","DOIUrl":"10.22088/cjim.15.4.659","url":null,"abstract":"Background: Acne vulgaris is a chronic, inflammatory disease and one of the most common skin diseases. Isotretinoin is the best treatment for severe nodulocystic acne compared to other systemic medicine. Although serum lipids elevation is one of the side effects of this medicine; recent studies have shown controversial results. This study aimed to assess the serum lipid profile in adolescents and adults with acne vulgaris receiving isotretinoin.Methods: This is a cross-sectional study on 65 adolescents and adults older than 16 years old (55 females and 10 males) with moderate to severe degrees of acne vulgaris under a fixed low dose of 20 mg/day Isotretinoin treatment for 120 days. We analyzed the data using the SPSS software Version 16 using paired sample t-test, Wilcoxon, and ANCOVA test.Results: In this study, 65 records of patients with a mean age of 22.21±6.25 years were assessed. There was a significant elevation in Cholesterol and LDL levels, but in HDL and triglyceride levels no significant change occurred. A significant change in cholesterol levels was noticed in the adolescent age group, the female sex, and the normal weight group. Triglyceride had a significant change in the female sex and normal weight group and HDL significantly increased in male patients.Conclusion: Although a low dose of isotretinoin can be used with minimal concern for changes in lipid profile in acne vulgaris patients, in the long-term follow-up and treatment, it seems that we have to administer it cautiously.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"659-665"},"PeriodicalIF":0.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative study of the local effect of tranexamic acid and phenylephrine on the amount of bleeding in rhinoplasty: A randomized clinical trial. 氨甲环酸和苯肾上腺素对鼻整形术出血量的局部影响比较研究：随机临床试验。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-09-07 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.154.690

Hooshang Akbari, Ebrahim Nasiri Formi, Abbas Alipour, Hamed Delam, Esmaeil Kavi, Negar Shahkarami

{"title":"A comparative study of the local effect of tranexamic acid and phenylephrine on the amount of bleeding in rhinoplasty: A randomized clinical trial.","authors":"Hooshang Akbari, Ebrahim Nasiri Formi, Abbas Alipour, Hamed Delam, Esmaeil Kavi, Negar Shahkarami","doi":"10.22088/cjim.154.690","DOIUrl":"10.22088/cjim.154.690","url":null,"abstract":"Background: Bleeding during nose surgery is very important, because it can cause a problem in the surgeon's field of view and lead to an increase in the probability of surgical complications. The aim of this study was to compare the local effects of tranexamic acid and phenylephrine on bleeding in rhinoplasty.Methods: The present study is a double-blind clinical trial in which 98 patients who were candidates for rhinoplasty Shiraz were randomly divided into 49 groups of phenylephrine and tranexamic acid. In the first group, 1 cc of phenylephrine and in the second group, 1 cc of tranexamic acid was used locally and then the variables in the two groups were compared. The current study was approved by the Iranian Clinical Trial Registration Center with code IRCT20201205049602N1.Results: The average blood pressure and heart rate in the phenylephrine group first increased and then decreased, but in the tranexamic acid group decreased from the beginning to 30 minutes. Based on the results of the test, there was a difference between the two groups in terms of the amount of bleeding, and a statistically significant relationship was observed. The average bleeding volume was lower in the phenylephrine group (p<0.0001).Conclusion: Results of this study showed that the amount of bleeding in the phenylephrine group was lower than that of tranexamic acid. It is recommended to use phenylephrine in rhinoplasty surgery to reduce bleeding and improve the surgeon's vision.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"690-696"},"PeriodicalIF":0.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 associated lung cavitary lesions: A case series. 与 COVID-19 相关的肺空洞性病变：病例系列

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-09-07 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.713

Rama Bozorgmehr, Farzad Esmaili Tarki, Esmat Yazdi, Shahrzad Shahrokhi Nejad

{"title":"COVID-19 associated lung cavitary lesions: A case series.","authors":"Rama Bozorgmehr, Farzad Esmaili Tarki, Esmat Yazdi, Shahrzad Shahrokhi Nejad","doi":"10.22088/cjim.15.4.713","DOIUrl":"10.22088/cjim.15.4.713","url":null,"abstract":"Background: Our study discusses the probable etiologies and characteristics of pulmonary cavities in post-COVID-19 patients. A pulmonary cavity is a late complication of the disease, yet it has led to multiple referrals to our tertiary hospital in Tehran, Iran.Methods: We conducted a retrospective case-series study on 20 patients who were admitted to our center between April 2020 and September 2021. They were all diagnosed with COVID-19 and concomitantly developed pulmonary cavities. We assessed their electronic medical records in 2021 and compared their characteristics with other studies based on the available literature.Result: Of the 20 patients with cavities, 12 (60%) had been diagnosed with prior COVID-19, and 9 (45%) had type 2 diabetes mellitus. 9 patients (45%) had bacterial superinfections while 4 (44%) had fungal infections. All patients received corticosteroids, but only 4 (20%) were additionally administered Tocilizumab.Conclusion: COVID-19 patients can develop pulmonary cavities during recovery; however, this infrequent radiologic finding depends on specific risk factors.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"713-728"},"PeriodicalIF":0.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of brucellosis in Mazandaran, North of Iran in a nine-year period (2009-2017). 九年内（2009-2017 年）伊朗北部马赞达兰的布鲁氏菌病流行病学。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-09-07 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.666

Maryam Salmani Seraji, Jamshid Yazdani Charati, Farhang Baba Mahmoudi, Reza Ali Mohammadpour Tahamtan, Habib Vahedi, Jalil Shojaei

{"title":"Epidemiology of brucellosis in Mazandaran, North of Iran in a nine-year period (2009-2017).","authors":"Maryam Salmani Seraji, Jamshid Yazdani Charati, Farhang Baba Mahmoudi, Reza Ali Mohammadpour Tahamtan, Habib Vahedi, Jalil Shojaei","doi":"10.22088/cjim.15.4.666","DOIUrl":"10.22088/cjim.15.4.666","url":null,"abstract":"Background: Brucellosis is a common disease between humans and animals that still exists in most parts of Iran. This study investigated the epidemiology of brucellosis in Mazandaran province, Iran, during a nine-year period from the beginning of 2009 until the end of 2017.Methods: This descriptive-analytical study was conducted based on the guidelines of Iran's Ministry of Health and Medical Education on the data of 3732 brucellosis patients. The data were retrieved from the private and public laboratories gathered in a Ministry's database. We used the generalized estimating equation (GEE) for the Poisson regression model (Poisson GEE) to examine the disease incidence based on the studied variables.Results: The age-standardized incidence rate has been 13.2 per 100,000 people (15.6 in men and 21.3 in rural areas). The highest rate (17.2) was in 2012 and the lowest (10.6) was in 2014. The cities of Galugah (35.0) and Qaemshahr and Fereydunkenar (3.0) had the highest and lowest incidence rates. The patients' professions had been 30% housewives, 14.9% ranchers, and 14.4% livestock-related professions. The highest standard incidence was in people older than 55 years old. The results of the Poisson GEE regression model showed that the disease incidence has been higher in men compared to women and in rural compared to urban areas (risk ratio = 1.5, 3.4, P = 0.001).Conclusion: Mazandaran faces the risk of increased brucellosis incidence rate. Taking preventive measures, including educating people, are recommended for the near future.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"666-672"},"PeriodicalIF":0.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ifosfamide-induced nephrogenic diabetes insipidus and Fanconi syndrome in a patient with femur osteosarcoma. 一名股骨肉瘤患者因伊福酰胺诱发肾源性糖尿病和范可尼综合征。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-09-07 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.743

Marcio Concepción-Zavaleta, Guillermo Ramos-Torres, Juan Quiroz-Aldave, María Del Carmen Durand-Vásquez, Sofía Ildefonso-Najarro, Elena de Jesús Alvarado-León, Francisca Zavaleta-Gutiérrez, Luis Concepción-Urteaga, José Paz-Ibarra

{"title":"Ifosfamide-induced nephrogenic diabetes insipidus and Fanconi syndrome in a patient with femur osteosarcoma.","authors":"Marcio Concepción-Zavaleta, Guillermo Ramos-Torres, Juan Quiroz-Aldave, María Del Carmen Durand-Vásquez, Sofía Ildefonso-Najarro, Elena de Jesús Alvarado-León, Francisca Zavaleta-Gutiérrez, Luis Concepción-Urteaga, José Paz-Ibarra","doi":"10.22088/cjim.15.4.743","DOIUrl":"10.22088/cjim.15.4.743","url":null,"abstract":"Background: Ifosfamide-induced Fanconi syndrome is a relatively infrequent complication that generally occurs in young patients with a high cumulative dose of ifosfamide; and is commonly characterized by glycosuria, proteinuria, electrolyte abnormalities, and a normal anion gap metabolic acidosis.Case presentation: In this study, we present the case of a 16-year-old male patient with of osteosarcoma of the right femur with pulmonary metastasis, who received ifosfamide as part of chemotherapy 1 year and 2 months ago and required hospitalization for cellulitis. During inpatient management, he presented with hypokalemia, hypophosphatemia, polyuria, glycosuria, and proteinuria, by which he was diagnosed with Fanconi syndrome and nephrogenic diabetes insipidus, induced by ifosfamide. Management was focused on the control of the internal environment and use of potassium supplements and potassium-sparing diuretics.Conclusion: Patients receiving ifosfamide should be periodically monitored for kidney function and internal environment to detect any potential complications. It is thus important to carefully observe the cumulative dose of ifosfamide to prevent its associated nephrotoxicity, since its appearance can impoverish the prognosis in patients with neoplasms. Therefore, physicians should always be aware about the possibility of nephrotoxicity development.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"743-747"},"PeriodicalIF":0.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TIMI frame count as a predictor of major adverse cardiovascular events during the first month after primary PCI. TIMI 框计数作为一级 PCI 术后第一个月内主要不良心血管事件的预测指标。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-09-07 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.697

Kamyar Amin, Naghmeh Nematpour, Iraj Jafaripour, Seyedfarzad Jalali, Naghmeh Ziai

{"title":"TIMI frame count as a predictor of major adverse cardiovascular events during the first month after primary PCI.","authors":"Kamyar Amin, Naghmeh Nematpour, Iraj Jafaripour, Seyedfarzad Jalali, Naghmeh Ziai","doi":"10.22088/cjim.15.4.697","DOIUrl":"10.22088/cjim.15.4.697","url":null,"abstract":"Background: This study evaluated the correlation between corrected Thrombolysis in Myocardial Infarction (TIMI) frame count (CTFC) and major adverse cardiovascular events (MACE) within the first month following primary percutaneous coronary intervention (PPCI).Methods: Eighty patients who underwent PPCI at Ayatollah Rouhani teaching Hospital in Babol Eighty patients who underwent PPCI at Ayatollah Rouhani teaching Hospital in Babol were included. CTFC, a measure of coronary blood flow, was assessed. Demographic and clinical data, were collected. ST segment resolution, a criterion for successful PPCI, was evaluated. MACE, including cardiac deaths, need for repeat revascularization of culprit vessels, and recurrent non-fatal myocardial infarction, and CVA (cerebrovascular accident) were recorded. Statistical analyses were performed to assess the association between CTFC and demographic/clinical variables, as well as ST resolution and MACE.Results: The majority of patients were (78.8%) men and (81.2%) nonsmokers. No significant association was found between CTFC and demographic/clinical variables. The left anterior descending (LAD) artery was the most commonly involved vessel (48.8%). ST segment resolution of more than 50% was observed in 51.2% of patients. During the one-month follow-up, 13.7% of patients experienced MACE, including 7 cardiac deaths. However, there was no significant association between CTFC and MACE. (P=0.30).Conclusion: This study concludes that CTFC is not a reliable predictor of MACE within the first month after PPCI. Furthermore, ST segment resolution of more than 50% was associated with a lower prevalence of cardiovascular events.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"697-705"},"PeriodicalIF":0.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 infection after vaccination. 接种疫苗后感染 COVID-19。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.644

Mana Baziboroun, Sayareh Hosseinzadeh, Hemmat Gholinia, Farzin Sadeghi, Yousef Yahyapour

{"title":"COVID-19 infection after vaccination.","authors":"Mana Baziboroun, Sayareh Hosseinzadeh, Hemmat Gholinia, Farzin Sadeghi, Yousef Yahyapour","doi":"10.22088/cjim.15.4.644","DOIUrl":"10.22088/cjim.15.4.644","url":null,"abstract":"Background: Although vaccination is the most effective and specific approach for prevention of infectious diseases, but in a small percentage of vaccinated person's breakthrough infections can occur. This study aimed to determine the effectiveness of different common coronavirus vaccines in this area.Methods: 109 COVID-19 vaccinated patients were enrolled, with different types of vaccines (Sinopharm, AstraZeneca, Sputnic, Bharath, CovIran Barkat and Pasto-CoV) and time of administration in 2021 in Babol, Iran. Patients after 14 days of administration of the final dose of corona vaccines with positive COVID-19 RT-PCR test entered to study. Patients' data such as RT-PCR, type of vaccine, age, sex and outcome were collected using electronic medical records.Results: 47 patients were not fully vaccinated, 62 had two vaccine doses and 51 were fully vaccinated and considered to a breakthrough infection. Although, most of the patients with SARS-CoV-2 infection were either mild (n=18 [16.56%]), or moderate (n=86 [78.9%]), 5 (4.6%) patients had severe or critical illness, of whom 3 admitted in intensive care unit, 3 intubated, and 4 died. The average age of the participants with COVID-19 infections was 61.23 ± 19.91 years.Conclusion: Based on our results, the COVID-19 breakthrough occurring with two doses of current vaccines were mild and moderate.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"644-650"},"PeriodicalIF":0.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic value of Midkine and AFP in the detection of hepatocellular carcinoma: A systematic review and meta-analysis. Midkine 和 AFP 在检测肝细胞癌中的诊断价值：系统回顾和荟萃分析。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.559

Masrul Lubis, Darmadi Darmadi, Sem Samuel Surja, Cennikon Pakpahan

{"title":"Diagnostic value of Midkine and AFP in the detection of hepatocellular carcinoma: A systematic review and meta-analysis.","authors":"Masrul Lubis, Darmadi Darmadi, Sem Samuel Surja, Cennikon Pakpahan","doi":"10.22088/cjim.15.4.559","DOIUrl":"10.22088/cjim.15.4.559","url":null,"abstract":"Background: Hepatocellular carcinoma (HCC) posed significant health problems and deaths. There are various challenges in the management of HCC, including the late detection or diagnosis. The ongoing diagnostic method in HCC also hinders the detection on the early stages of the disease, thus biomarkers need to be explored further for HCC detection. Serum alpha fetoprotein (AFP) and Midkine (MDK) are two proteins which might be the biomarker of choice in the detection of HCC. This meta-analysis aims to analyze the accuracy of Midkine and AFP in the detection of HCC.Methods: The systematic review and meta-analysis was conducted by adhering to the Preferred Reporting System for Systematic Review and Meta-Analysis (PRISMA) guidelines. We conduct literature screening and selection followed by quality assessment from various databases such as PubMed, MEDLINE, SpringerLink, ProQuest, EBSCOhost, Cochrane, and EMBASE. The included studies were then extracted and analyzed cumulatively using MedCalc and MetaDTA with forest plot and ROC curve as outcome.Results: 12 studies were included in this study. The AFP biomarker yields sensitivity value of 62.5% (97.5% CI 0.442 - 0.778) and specificity value of 95% (97.5% CI 0.842 - 0.986), while the Midkine biomarker denotes sensitivity value of 91.6% (97.5% CI 0.83 - 0.961) and specificity value of 82.2% (97.5% CI 0.83 - 0.96).Conclusions: Both AFP and MDK are proven to be a good diagnostic tool or biomarker in the detection of HCC. The use of both in combination should provide high quality diagnostic marker for HCC suspected patients. Further studies on this should be conducted.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"559-569"},"PeriodicalIF":0.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0