Caspian Journal of Internal Medicine最新文献

{"title":"Culturable bacteria in the gastric tissue and diversity of antimicrobial resistance in adults with gastritis.","authors":"Masoud Alebouyeh, Malihe Aminzadeh, Mohammad Reza Pourmand, Masoumeh Bahiraee, Seyedeh Zohre Mirbagheri, Ronak Bakhtiari","doi":"10.22088/cjim.17.1.143","DOIUrl":"10.22088/cjim.17.1.143","url":null,"abstract":"<p><strong>Background: </strong>Despite growing knowledge in microbiome studies data about the diversity of cultivable bacteria and their drug resistance patterns in patients with gastritis are scant.</p><p><strong>Methods: </strong>Two gastric biopsies of 171 symptomatic patients were collected and examined by histological and microbiological methods. Viable bacteria were characterized using conventional techniques, and antimicrobial susceptibility of the isolates was detected.</p><p><strong>Results: </strong>Acute gastritis, chronic gastritis, and peptic ulcers were detected in 3.5%, 86.5%, and 5.8% of the patients, respectively. Culturable bacteria were isolated from 71.3% of the patients, including <i>Helicobacter pylori</i> (<i>H. pylori)</i> (26.9%), <i>Staphylococcus epidermidis</i> (19.8%), <i>Micrococcus</i> (1.1%), <i>Streptococcus viridans</i> (<i>S. viridans</i>) (13.4%), <i>Enterococcus faecalis</i> (<i>E. faecalis</i>) (4.6%), <i>Staphylococcus aureus</i> (<i>S. aureus</i>) (1.7%), and Group D <i>Streptococcus</i> (7.1%). Single infection and coexistence of two and three types of bacteria were detected in 43.2%, 15.2%, and 5.2% of the patients, respectively. An odd ratio of 4.4 was measured for <i>Staphylococcus</i> spp. in patients with acute gastritis (<i>P-value</i> = 0.08). <i>E</i>-test results showed intermediate resistance to penicillin in 66.6% of the <i>S. aureus</i> isolates, while resistance to vancomycin was detected only in the <i>S. viridans</i> (30.4%). Resistance to linezolid was detected in 100%, 17.4%, and 16.7% of <i>E. faecalis</i>, <i>S. viridans</i>, and group D <i>Streptococci</i> isolates, respectively. A high frequency of resistance to penicillin, clindamycin, linezolid, erythromycin, and tetracycline was detected in <i>S. epidermidis</i> strains.</p><p><strong>Conclusion: </strong>Our results highlighted the importance of Gram-positive bacteria in the etiology of gastritis. Resistance of these bacteria to different classes of antibiotics should be considered in the clinical setting.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"143-151"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of thrombin generation assay in patients with acute myocardial infarction.","authors":"Omid Reza Zekavat, Mohammad Shojaie, Hoda Sezavarian, Sonia Rostami Ghorbani, Seyed Javad Dehghani, Javad Gerdabi, Peyman Izadpanah, Shirin Parand, Sezaneh Haghpanah","doi":"10.22088/cjim.17.1.82","DOIUrl":"10.22088/cjim.17.1.82","url":null,"abstract":"<p><strong>Background: </strong>Thrombin generation (TG) assays have been developed to assess the overall coagulability of blood, as thrombin plays a pivotal role in hemostasis and thrombosis. Although increased TG has been associated with acute myocardial infarction (MI) in some previous reports, the results have been inconsistent. This study aimed to evaluate TG in platelet-poor plasma specimens from patients with confirmed acute MI.</p><p><strong>Methods: </strong>In this case-control study, we enrolled a total of 50 patients diagnosed with acute MI using convenience sampling, along with 50 healthy individuals. TG assays were performed in both groups, and the calculated TG indices were compared.</p><p><strong>Results: </strong>Forty-one patients with confirmed acute MI (24 males, 17 females; mean age 62.7±14.9 years) and 50 healthy controls (40 males, 10 females; mean age 57.5±12.9) were included in the analysis. TG assay indices were not significantly different in acute MI patients compared to healthy subjects (p >0.05). In terms of the diagnostic utility of TG assays, a five-variable panel yielded an AUC of 0.659 [95% CI: 0.547-0.770, P=0.010], with a sensitivity of 65.9% and specificity of 62% for identifying acute MI.</p><p><strong>Conclusion: </strong>All TG parameters taken together appear to have a predictive value in detecting acute MI. However, further studies with larger sample sizes are needed to confirm this finding.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"82-89"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating subclinical myocardial ischemia by measuring carotid intima-media thickness using Doppler Ultrasound in patients with acute cardiac ischemia.","authors":"Yasaman Zeid Shafiei, Mahsa Akhavan Sabagh, Habib Haybar, Shirin Azizidoost","doi":"10.22088/cjim.17.1.97","DOIUrl":"10.22088/cjim.17.1.97","url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to evaluate the relationship between Carotid intima-media thickening (CIMT) with subclinical myocardial ischemia in acute cardiac ischemia (ACI) patients.</p><p><strong>Methods: </strong>This prospective, observational study was conducted on 75 ACI patients referred to Golestan and Imam Khomeini hospitals of Ahvaz in 2023. The patients in healthy (CIMT≤0.8mm) and at risk of cardiac ischemia (CIMT>0.8mm) groups underwent carotid Doppler ultrasound to check CIMT and the presence of carotid plaque.</p><p><strong>Results: </strong>CIMT mean was 1.07±0.12 mm in healthy ACI patients and 1.4±0.19 mm in those at risk of cardiac ischemia. Among patients at risk of CIMT and carotid plaque, 85.1% and 80.8% had at least one cardiovascular risk factor, respectively. However, no significant differences were found between CIMT, carotid plaque, and patients' risk factor profiles (P = 0.129 vs. P = 0.515). The adjusted odds ratio (OR) for CIMT was 1.50 (95% CI: 0.58-3.94, P = 0.400), indicating no significant association with the outcome. No significant associations were observed for age, sex, diabetes, hypertension, LDL, or HDL. While the prevalence of vessel disease was higher in at-risk group than healthy CIMT group, no dramatic differences were observed between CIMT and vessel involvement (P = 0.136).</p><p><strong>Conclusion: </strong>The presence of one or more cardiovascular risk factors combined with increased CIMT may increase heart attack susceptibility, highlighting the potential of CIMT as an effective screening tool for predicting coronary artery disease. Further large-scale studies are needed to define its role in clinical practice more definitively.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"97-105"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-38 serum levels in breast cancer: A comparative analysis of women under 40 and over 50.","authors":"Seyedeh Niloufar Mousavi, Aida Khademolhosseini, Mohammad Javad Fattahi, Soolmaz Khansalar, Sedigheh Tahmasebi, Abbas Ghaderi, Mohammad Reza Haghshenas","doi":"10.22088/cjim.17.1.90","DOIUrl":"10.22088/cjim.17.1.90","url":null,"abstract":"<p><strong>Background: </strong>Interleukin-38 (IL-38) is an anti-inflammatory cytokine with immunomodulatory properties, but its role in breast cancer (BC) is unclear. This study aimed to evaluate IL-38 serum levels in BC patients aged ≤40 and ≥50 years and to correlate the findings with clinicopathological features.</p><p><strong>Methods: </strong>IL-38 levels were measured using an enzyme-linked immunosorbent assay (ELISA) in the serum of 30 BC patients aged ≤40, 30 aged ≥50, and 30 healthy controls. Non-parametric tests were used for statistical comparisons, and Spearman's correlation was used to examine the correlation between IL-38 and age and tumor size.</p><p><strong>Results: </strong>There was no significant difference in serum IL-38 levels between patients aged ≥50 and those aged ≤40 or their age-matched controls. However, patients aged ≤40 years had significantly lower IL-38 levels than healthy individuals of the same age (P=0.003). In addition, serum IL-38 levels were significantly different between healthy individuals aged ≤40 and ≥50 years. Patients with stage I and II BC had significantly lower serum IL-38 levels than healthy controls (P=0.04 and P=0.003, respectively). However, there were no significant associations between IL-38 serum levels and histological grade (P=0.09), nuclear grade (P=0.11), lymphovascular invasion (P=0.72), perineural invasion (P=0.21), lymph node involvement (P=0.71) and tumor size (P=0.70).</p><p><strong>Conclusion: </strong>Our results suggest that any change in IL-38 serum levels is likely to affect the anti-inflammatory response in BC patients, especially those under 40 years of age. However, this is a preliminary study, and further studies with larger cohorts are needed to validate these findings.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"90-96"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting coronary artery disease among the individuals with left-sided dominant coronary circulation.","authors":"Majid Saraei Koushki, Bahram Sohrabi, Razieh Parizad","doi":"10.22088/cjim.17.1.173","DOIUrl":"10.22088/cjim.17.1.173","url":null,"abstract":"<p><strong>Background: </strong>Investigating the importance of exercise tolerance test (ETT) in the diagnosis of coronary artery disease (CAD) among people with left-sided dominant coronary circulation is very important.</p><p><strong>Methods: </strong>This retrospective study aimed to explore the relevance of ETT in CAD diagnosis by analyzing medical records of 2084 patients who underwent ETT and coronary angiography in Urmia's educational therapeutic hospitals between 2018 and 2019. SPSS Version 16 was used for data analysis.</p><p><strong>Results: </strong>The study included 5.58% males and 5.41% females. The prevalence of co-dominancy was 10.2%, right coronary dominance (RD) was 65%, and left coronary dominance (LD) was 24.8%. There were no significant differences between gender, age, smoking, blood pressure, diabetes mellitus (DM), the prevalence of hyperlipidemia (HLP), family history (FH) and left ventricular ejection fraction (LVEF). The frequency of non-significant CAD was higher in women than in men. Additionally, the frequency of women with LD was significantly higher than that of men. The results of angiography in normal cases, it was observed that the highest frequency was related to female patients with a history of DM. The sensitivity of the ETT was 94%, and the accuracy and diagnostic power of the exercise test for the presence of CAD in individuals with LD were 53% (p = 0.03).</p><p><strong>Conclusion: </strong>The study highlights the potential for false-positive exercise tests in diabetic individuals with left coronary dominance, providing valuable insights into the nuanced interplay of gender, cardiovascular health, and coronary circulation patterns in CAD risk.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"173-180"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of breast cancer in women referring to the surgical clinic of northern Iran Hospitals over a ten-year period (2011-2021).","authors":"Melika Hendukolai, Khadijeh Ezoji, Yasser Asghari, Majid Nabipour, Sana Keshtegar, Aref Gholami Languri, Mohammad Amin Afshar, Abolhasan Alijanpour","doi":"10.22088/cjim.17.1.128","DOIUrl":"10.22088/cjim.17.1.128","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is a major global health concern, with the highest incidence in women and the main cause of cancer-related deaths in them worldwide. The purpose of this study was to investigate the risk factors related to breast cancer in women.</p><p><strong>Methods: </strong>This is a case-control study on breast cancer patients referred to the Surgery Clinic during the years 2011 to 2021. There were 131 participants in the case group and 131 in the control group. Patient information was collected through medical records, face-to-face or telephone interviews. This study has the ethics code IR.MUBABOL.HRI.REC.1401.226 from the National Organization for Ethics in Biomedical Research of the Ministry of Health and Medical Education of Iran.</p><p><strong>Results: </strong>262 participants were included in the study, 50% were in the case group (breast cancer) and 131 (50%) were in the control group. Between the case and control group in terms of demographic variables, age (P=0.289), height (P=0.254), education level (P=0.785), marital status (P=0.421), place of birth (P=0.668) and place of residence (P=0.454) have been no statistically significant difference. Presence of underlying disease (P=0.005), less physical activity (p<0.001), older age at first delivery (P=0.003), lower menstrual age (P=0.001), history of breastfeeding for at least one year (P=0.002) and use of oral contraceptives (P=0.015) can significantly predict the incidence of breast cancer.</p><p><strong>Conclusion: </strong>OCP use, underlying disease, less physical activity, older age at first delivery, younger age at menstruation, and history of breastfeeding for at least one year are associated with the incidence of breast cancer.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"128-135"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of interleukin-8 and neutrophil-to-lymphocyte ratio with clinical indices in diabetic nephropathy.","authors":"Mahboobeh Freidoon, Hadi Kazemzadehghadim, Sara Assadiasl, Naghmeh Sayadi, Narjes Soleimanifar, Maryam Sadr, Hanieh Mojtahedi, Mohammad Hossein Nicknam","doi":"10.22088/cjim.17.1.191","DOIUrl":"10.22088/cjim.17.1.191","url":null,"abstract":"<p><strong>Background: </strong>Diabetic nephropathy (DN) is the most prevalent reason for chronic kidney diseases that end up with renal failure if it is not diagnosed and treated at early stages. Therefore, low-cost, non-invasive, and easy-to-use tests are necessary for efficient follow-up and early diagnosis of DN in diabetic patients. Interleukin-8 (IL-8) as the main recruiter of neutrophils may play a role in inflammatory responses that end up with renal damage and dysfunction in DN.</p><p><strong>Methods: </strong>In a case-control study, serum levels of IL-8 and neutrophil-to-lymphocyte ratios (NLR) were evaluated in correlation with clinical findings in 60 patients with DN, 60 type 2 diabetic patients without renal involvement, and 60 age and sex-matched healthy subjects.</p><p><strong>Results: </strong>IL-8 levels were significantly higher in diabetic nephropathy patients than in diabetic patients without nephropathy and healthy controls (both p-value<0.0001). However, the frequency of neutrophils in both groups of patients was higher than that of healthy individuals. Despite increased NLRs in diabetic patients, the difference was only significant between DN and healthy groups (P-value: 0.03). A direct correlation was observed between IL-8 levels and NLR (P-value: 0.02), and a negative correlation between IL-8 and eGFR (P-value: 0.01). In addition, UACR was associated with IL-8 concentrations (P-value: 0.04) in DN patients. IL-8 level showed a higher diagnostic value for diabetic nephropathy [AUC: 0.87 (p<0.0001)] than NLR and neutrophil count.</p><p><strong>Conclusion: </strong>Increased level of IL-8 in DN is associated with elevated NLR and UACR, and reduced eGFR. Therefore, IL-8 levels might be considered a diagnostic or prognostic biomarker for DN.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"191-199"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium-glucose transport 2 inhibitors: Practical management of the venetoclax-induced adverse events.","authors":"Zahra Nazari Taloki","doi":"10.22088/cjim.17.1.211","DOIUrl":"10.22088/cjim.17.1.211","url":null,"abstract":"","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"211-212"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between appendicular skeletal muscle index and liver steatosis and fibrosis: A cross-sectional study.","authors":"Ayoub Basham, Saeed Hosseini Teshnizi, Ebrahim Evazi, Seyed Moayed Alavian, Alireza Khajehpour, Farkhondeh Razmpour","doi":"10.22088/cjim.17.1.113","DOIUrl":"10.22088/cjim.17.1.113","url":null,"abstract":"<p><strong>Background: </strong>Skeletal muscle index (SMI) is a measure for evaluating skeletal muscle status. However, its specific association with liver steatosis and fibrosis remains unclear. The aim of this study was to investigate the association between SMI and liver steatosis and fibrosis.</p><p><strong>Methods: </strong>We conducted a cross-sectional study with a random selection of 328 participants over the age of 18, with no history of alcohol consumption or liver disease, from a nutrition clinic in Iran. Waist circumference (WC) and hip circumference (HC) were measured using a tape measure according to standards. Total fat mass, SMI, and other body composition parameters were obtained via bioelectrical impedance analysis. Liver status was assessed in all participants using elastography (FibroScan®).</p><p><strong>Results: </strong>The participants included 64.0% males and 36.0% females, with a median age of 41 (IQR:14) years. After adjusting for confounders, SMI had no significant association with liver steatosis (P=0.647). Indeed, body mass index (BMI) (P=0.028), WC (P=0.038), and HC (P=0.007) were the significant predictors of liver steatosis. Conversely, each unit increase in SMI value decreased the chance of liver fibrosis by 48% after controlling the confounders (aOR=0.519, 95%CI: 0.283-0.951, P=0.034). Additionally, BMI (P=001), WC (P=0.006), and HC (P=0.026) were other significant predictors of liver fibrosis.</p><p><strong>Conclusion: </strong>In conclusion, while a higher SMI did not mitigate obesity-linked liver steatosis risk, it independently lowered the odds of fibrosis. Furthermore, increased waist circumference was a stronger predictor of both steatosis and fibrosis than increased trunk fat mass.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"113-120"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of cystic brain metastasis from lung adenocarcinoma.","authors":"Danial Fazilat-Panah, Habibollah Hasani, Ali Alizadeh Khatir, Ali Shabestani Monfared, Hamid Fallah Tafti, Nahid Ahmadi, Siamak Kazemi Soufi, Ali Emadi Torghabeh, Babak PeyroShabany, Hassan Younesi Ghale, Sara Rasta, Seyed Alireza Javadinia, Maedeh Alsadat Fatemi","doi":"10.22088/cjim.17.1.200","DOIUrl":"10.22088/cjim.17.1.200","url":null,"abstract":"<p><strong>Background: </strong>Multiple cystic brain metastases are a rare form of cancer dissemination and usually originate from adenocarcinomas of the lung and breast. Managing these lesions is challenging, and cyst drainage plays an essential role in reducing intracranial pressure. This article presents a case of multiple cystic brain metastases from lung adenocarcinoma.</p><p><strong>Case presentation: </strong>A 40-year-old female with a two-year history of stage IV lung adenocarcinoma presented with debilitating progressive neurologic symptoms. Imaging studies showed multiple cystic lesions on brain MRI most consistent with brain metastases. She underwent a craniotomy to drain the biggest cysts, followed by whole-brain radiotherapy (WBRT). The patient experienced dramatic alleviation of symptoms. Following a year of follow-up, she had no neurological symptoms.</p><p><strong>Conclusion: </strong>Despite the rarity of cystic brain metastases, these lesions should be ruled out in case of signs of increased intracranial pressure in a patient with a history of malignant disease.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"200-204"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}