Caspian Journal of Internal Medicine最新文献

{"title":"Effect of laparoscopic sleeve gastrectomy on heart remodeling and right ventricular function.","authors":"Kağan Gökçe, Hidayet Demir, Mehmet Altuğ Tunçer, Mehrdad Sheikhvatan, Hanie Abbasi","doi":"10.22088/cjim.17.1.121","DOIUrl":"https://doi.org/10.22088/cjim.17.1.121","url":null,"abstract":"<p><strong>Background: </strong>Weight loss following bariatric surgery reduces cardiovascular workload and may improve cardiac structure and function. This study aimed to assess changes in right heart echocardiographic parameters and cardiac remodeling six months after laparoscopic sleeve gastrectomy (LSG).</p><p><strong>Methods: </strong>In this cross-sectional study, patients who underwent LSG between 2022 and 2024 were evaluated before surgery and at six-month follow-up. Demographic data, clinical variables, and comprehensive echocardiographic indices of cardiac function were recorded and compared.</p><p><strong>Results: </strong>Twenty-two patients (mean age 38.09±9.47 years) were included. Significant postoperative improvements were observed in left ventricular ejection fraction (55.84±6.49% to 62.86 ± 4.41%, p<0.001), right ventricular peak systolic myocardial velocity (12.22±2.59 to 14.24±2.38 cm/s, p<0.001), tricuspid annular plane systolic excursion (22.95±3.03 to 24.18±2.82 mm, p=0.04), E wave velocity (7.35±2.01 to 9.54±1.98 cm/s, p<0.001), and left ventricular global longitudinal strain (15.42±3.86 to 18.24±2.93, p<0.001). Significant reductions were noted in right ventricular diameter, left ventricular end-diastolic and end-systolic volumes, and pulmonary artery pressure (all p<0.01). The prevalence of diastolic dysfunction decreased markedly from 63.6% preoperatively to 13.6% postoperatively (p<0.001).</p><p><strong>Conclusion: </strong>Laparoscopic sleeve gastrectomy is associated with significant improvement in cardiac remodeling and both left and right ventricular function, with notable enhancement of right heart echocardiographic parameters.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"121-127"},"PeriodicalIF":1.0,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can dobutamine stress echocardiography predict improvement of left ventricular dyssynchrony after coronary artery bypass grafting?","authors":"Rezvanieh Salehi, Zahra Jabbary, Fariba Abaszadeh, Maryam Chenaghlou","doi":"10.22088/cjim.17.1.158","DOIUrl":"https://doi.org/10.22088/cjim.17.1.158","url":null,"abstract":"<p><strong>Background: </strong>For patients with advanced, diffuse Coronary artery disease (CAD), surgical myocardial revascularization via coronary artery bypass grafting (CABG) continues to represent the gold standard therapeutic approach. Given the paucity of studies demonstrating CABG benefits in patients with significant left intraventricular dyssynchrony (LVD), we conducted this study to evaluate how viable myocardial tissue volume, quantified by dobutamine stress echocardiography (DSE), predicts postoperative LVD improvement.</p><p><strong>Methods: </strong>This investigation employed a cross-sectional analytical design to assess 30 CABG candidates with moderate-severe ischemic cardiomyopathy. Myocardial viability evaluation utilized dobutamine stress echocardiography, complemented by tissue Doppler Imaging for synchronized assessment of regional LV contractility.</p><p><strong>Results: </strong>Demographic analysis revealed a study population aged 61.5±7.9 years (range: 47 to 85 years), comprising 73.3% males. Left ventricular ejection fraction (LVEF) measurements improved from 32.2±4.6% at baseline to 39.6±5.2 % following surgical revascularization (p<0.001). Postoperative resolution of left ventricular dyssynchrony occurred in 9 patients (30.0 %), whereas 19 patients (63.3 %) showed no improvement (p<0.001). Two patients (6.6 %) died due to progressive heart failure and inadequate revascularization.</p><p><strong>Conclusion: </strong>Our current study demonstrates significant postoperative improvements in LVEF, LVEDD, and left ventricular dyssynchrony. However, given that approximately two-thirds of cases showed only minimal improvement in dyssynchrony, it would be reasonable to consider cardiac resynchronization therapy (CRT) for these patients.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"158-162"},"PeriodicalIF":1.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary phytochemical index with sleep quality in older adults of Amirkola city.","authors":"Masooumeh Rabipour, Angela Hamidia, Reza Ghadimi, Seyed Reza Hosseini, Ali Bijani, Parvin Sajadi","doi":"10.22088/cjim.17.1.181","DOIUrl":"https://doi.org/10.22088/cjim.17.1.181","url":null,"abstract":"<p><strong>Background: </strong>Diet can play a significant role in sleep regulation, particularly in older adults. This study aimed to investigate the association between the Dietary Phytochemical Index (DPI) and sleep quality among the elderly in Amirkola City.</p><p><strong>Methods: </strong>This case-control study was part of the second phase of the Amirkola Cohort Study on aging. A total of 800 elderly individuals aged ≥60 years (400 with good sleep quality and 400 with poor sleep quality, matched for age and sex) were randomly selected. Inclusion criteria comprised having complete demographic data in the cohort profile, no known history of malignancy (including gastric and intestinal cancers), absence of psychiatric or cognitive disorders (such as psychiatric hospitalization), and no drug addiction. Data were collected using the Pittsburgh Sleep Quality Index (PSQI) and a semi-quantitative food frequency questionnaire (SQ-FFQ), which were then analyzed statistically.</p><p><strong>Results: </strong>Total energy intake and the number of chronic diseases significantly impacted sleep quality (OR=1.002, 95% CI: 1.001-1.003, P = 0.004 and OR=1.257, 95% CI:1.170-1.352, p < 0.001, respectively). Furthermore, Poorer sleep quality was significantly associated with a higher number of chronic diseases in both gender, male and female (OR=1.244, 95% CI: 1.097-1.411, P = 0.001 and OR=1.225, 95% CI: 1.106-1.357, P < 0.001). However, Dietary Phytochemical Index (DPI) and Energy intake from plant sources did not show a significant effect on sleep quality.</p><p><strong>Conclusion: </strong>Dietary modifications and management of chronic diseases could be effective in improving sleep quality among the elderly. However, further research is recommended.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"181-190"},"PeriodicalIF":1.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effect of pirfenidone on lung CT scans in patients with severe COVID-19 Hospitalized at Shahid Sadoughi Hospital, Yazd, Iran.","authors":"Sakineh Khatoon Gholamrezaei, Mohammad Samet, Amir Pasha Amelshahbaz, Nasim Namiranian, Fatemeh Al-Sadat Aghaei Meybodi","doi":"10.22088/cjim.17.1.163","DOIUrl":"https://doi.org/10.22088/cjim.17.1.163","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the effect of pirfenidone on lung CT scan lesions in patients with severe COVID-19.</p><p><strong>Methods: </strong>In this cross-sectional study, data were extracted from the electronic medical records of patients with severe COVID-19 who received one of the following treatments: pirfenidone alone (n= 40), prednisolone alone (n= 55), pirfenidone combined with methylprednisolone (n= 18), or supportive care only (n= 32). Chest CT images taken at baseline and two months post-treatment were assessed by a trained radiologist. p< 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The distribution of initial CT scan findings, Comparison of CT scan findings at admission and two months post-discharge, as well as the extent of pulmonary fibrosis and ground-glass opacity (GGO) grades across the groups, showed no statistically significant differences. However, significant differences were observed in CT scan findings and GGO grades between the four study groups at two months post-discharge. Moreover, in both the pirfenidone (p= 0.00) and supportive care (p= 0.01) groups, the extent of pulmonary fibrosis between admission and two months post-discharge showed statistically significant changes.</p><p><strong>Conclusion: </strong>In summary, although antifibrotic agents such as pirfenidone may not lead to significant improvement in lung CT scan findings in patients with severe COVID-19, they may help slow the progression of pulmonary fibrosis following the acute phase of the disease.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"163-172"},"PeriodicalIF":1.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional status impact on engraftment time in hematopoietic stem cell transplants (HSCT) in Semarang, Indonesia: A cross-sectional study.","authors":"Damai Santosa, Daniel Rizky, Kevin Tandarto, Ika Kartiyani, Vina Yunarvika, Desta Nur Ewika Ardini, Budi Setiawan, Eko Adhi Pangarsa, Catharina Suharti","doi":"10.22088/cjim.17.1.152","DOIUrl":"https://doi.org/10.22088/cjim.17.1.152","url":null,"abstract":"<p><strong>Background: </strong>Nutritional support is a critical consideration in the care of individuals undergoing hematopoietic stem cell transplantation (HSCT), given the metabolic alterations induced by intensive treatments. This study aimed to explore the correlation between nutritional status and the time to engraftment in HSCT patients at Dr. Kariadi General Hospital, Semarang, Indonesia.</p><p><strong>Methods: </strong>This study included adult patients with malignant diseases who underwent autologous or allogeneic HSCT at Dr. Kariadi General Hospital between 2013 and 2023. Nutritional status was evaluated using body mass index (BMI), energy intake, and the type and duration of nutritional support. Neutrophil and platelet engraftment were defined as the time to sustained absolute neutrophil count (ANC) ≥500 cells/mm³ and platelet count ≥20 × 10⁹/L, respectively, and correlations between numerical variables were analyzed using Pearson's test.</p><p><strong>Results: </strong>A total of 45 HSCT patients were involved in this study. There was a significant negative correlation between nutritional intake and neutrophil engraftment (r = -0.776, p <0.001) and platelet engraftment (r= -0.72, P = 0.00), indicating that as the engraftment time increased, nutritional intake decreased. Furthermore, a positive but weak correlation (r = 0.24, P = 0.10) was found between BMI and time to engraftment.</p><p><strong>Conclusion: </strong>The study highlights that nutritional status significantly influences engraftment time in HSCT patients, supporting the importance of comprehensive nutritional support to improve outcomes and shorten engraftment.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"152-157"},"PeriodicalIF":1.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Culturable bacteria in the gastric tissue and diversity of antimicrobial resistance in adults with gastritis.","authors":"Masoud Alebouyeh, Malihe Aminzadeh, Mohammad Reza Pourmand, Masoumeh Bahiraee, Seyedeh Zohre Mirbagheri, Ronak Bakhtiari","doi":"10.22088/cjim.17.1.143","DOIUrl":"https://doi.org/10.22088/cjim.17.1.143","url":null,"abstract":"<p><strong>Background: </strong>Despite growing knowledge in microbiome studies data about the diversity of cultivable bacteria and their drug resistance patterns in patients with gastritis are scant.</p><p><strong>Methods: </strong>Two gastric biopsies of 171 symptomatic patients were collected and examined by histological and microbiological methods. Viable bacteria were characterized using conventional techniques, and antimicrobial susceptibility of the isolates was detected.</p><p><strong>Results: </strong>Acute gastritis, chronic gastritis, and peptic ulcers were detected in 3.5%, 86.5%, and 5.8% of the patients, respectively. Culturable bacteria were isolated from 71.3% of the patients, including <i>Helicobacter pylori</i> (<i>H. pylori)</i> (26.9%), <i>Staphylococcus epidermidis</i> (19.8%), <i>Micrococcus</i> (1.1%), <i>Streptococcus viridans</i> (<i>S. viridans</i>) (13.4%), <i>Enterococcus faecalis</i> (<i>E. faecalis</i>) (4.6%), <i>Staphylococcus aureus</i> (<i>S. aureus</i>) (1.7%), and Group D <i>Streptococcus</i> (7.1%). Single infection and coexistence of two and three types of bacteria were detected in 43.2%, 15.2%, and 5.2% of the patients, respectively. An odd ratio of 4.4 was measured for <i>Staphylococcus</i> spp. in patients with acute gastritis (<i>P-value</i> = 0.08). <i>E</i>-test results showed intermediate resistance to penicillin in 66.6% of the <i>S. aureus</i> isolates, while resistance to vancomycin was detected only in the <i>S. viridans</i> (30.4%). Resistance to linezolid was detected in 100%, 17.4%, and 16.7% of <i>E. faecalis</i>, <i>S. viridans</i>, and group D <i>Streptococci</i> isolates, respectively. A high frequency of resistance to penicillin, clindamycin, linezolid, erythromycin, and tetracycline was detected in <i>S. epidermidis</i> strains.</p><p><strong>Conclusion: </strong>Our results highlighted the importance of Gram-positive bacteria in the etiology of gastritis. Resistance of these bacteria to different classes of antibiotics should be considered in the clinical setting.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"143-151"},"PeriodicalIF":1.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of thrombin generation assay in patients with acute myocardial infarction.","authors":"Omid Reza Zekavat, Mohammad Shojaie, Hoda Sezavarian, Sonia Rostami Ghorbani, Seyed Javad Dehghani, Javad Gerdabi, Peyman Izadpanah, Shirin Parand, Sezaneh Haghpanah","doi":"10.22088/cjim.17.1.82","DOIUrl":"https://doi.org/10.22088/cjim.17.1.82","url":null,"abstract":"<p><strong>Background: </strong>Thrombin generation (TG) assays have been developed to assess the overall coagulability of blood, as thrombin plays a pivotal role in hemostasis and thrombosis. Although increased TG has been associated with acute myocardial infarction (MI) in some previous reports, the results have been inconsistent. This study aimed to evaluate TG in platelet-poor plasma specimens from patients with confirmed acute MI.</p><p><strong>Methods: </strong>In this case-control study, we enrolled a total of 50 patients diagnosed with acute MI using convenience sampling, along with 50 healthy individuals. TG assays were performed in both groups, and the calculated TG indices were compared.</p><p><strong>Results: </strong>Forty-one patients with confirmed acute MI (24 males, 17 females; mean age 62.7±14.9 years) and 50 healthy controls (40 males, 10 females; mean age 57.5±12.9) were included in the analysis. TG assay indices were not significantly different in acute MI patients compared to healthy subjects (p >0.05). In terms of the diagnostic utility of TG assays, a five-variable panel yielded an AUC of 0.659 [95% CI: 0.547-0.770, P=0.010], with a sensitivity of 65.9% and specificity of 62% for identifying acute MI.</p><p><strong>Conclusion: </strong>All TG parameters taken together appear to have a predictive value in detecting acute MI. However, further studies with larger sample sizes are needed to confirm this finding.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"82-89"},"PeriodicalIF":1.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-38 serum levels in breast cancer: A comparative analysis of women under 40 and over 50.","authors":"Seyedeh Niloufar Mousavi, Aida Khademolhosseini, Mohammad Javad Fattahi, Soolmaz Khansalar, Sedigheh Tahmasebi, Abbas Ghaderi, Mohammad Reza Haghshenas","doi":"10.22088/cjim.17.1.90","DOIUrl":"https://doi.org/10.22088/cjim.17.1.90","url":null,"abstract":"<p><strong>Background: </strong>Interleukin-38 (IL-38) is an anti-inflammatory cytokine with immunomodulatory properties, but its role in breast cancer (BC) is unclear. This study aimed to evaluate IL-38 serum levels in BC patients aged ≤40 and ≥50 years and to correlate the findings with clinicopathological features.</p><p><strong>Methods: </strong>IL-38 levels were measured using an enzyme-linked immunosorbent assay (ELISA) in the serum of 30 BC patients aged ≤40, 30 aged ≥50, and 30 healthy controls. Non-parametric tests were used for statistical comparisons, and Spearman's correlation was used to examine the correlation between IL-38 and age and tumor size.</p><p><strong>Results: </strong>There was no significant difference in serum IL-38 levels between patients aged ≥50 and those aged ≤40 or their age-matched controls. However, patients aged ≤40 years had significantly lower IL-38 levels than healthy individuals of the same age (P=0.003). In addition, serum IL-38 levels were significantly different between healthy individuals aged ≤40 and ≥50 years. Patients with stage I and II BC had significantly lower serum IL-38 levels than healthy controls (P=0.04 and P=0.003, respectively). However, there were no significant associations between IL-38 serum levels and histological grade (P=0.09), nuclear grade (P=0.11), lymphovascular invasion (P=0.72), perineural invasion (P=0.21), lymph node involvement (P=0.71) and tumor size (P=0.70).</p><p><strong>Conclusion: </strong>Our results suggest that any change in IL-38 serum levels is likely to affect the anti-inflammatory response in BC patients, especially those under 40 years of age. However, this is a preliminary study, and further studies with larger cohorts are needed to validate these findings.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"90-96"},"PeriodicalIF":1.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating subclinical myocardial ischemia by measuring carotid intima-media thickness using Doppler Ultrasound in patients with acute cardiac ischemia.","authors":"Yasaman Zeid Shafiei, Mahsa Akhavan Sabagh, Habib Haybar, Shirin Azizidoost","doi":"10.22088/cjim.17.1.97","DOIUrl":"https://doi.org/10.22088/cjim.17.1.97","url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to evaluate the relationship between Carotid intima-media thickening (CIMT) with subclinical myocardial ischemia in acute cardiac ischemia (ACI) patients.</p><p><strong>Methods: </strong>This prospective, observational study was conducted on 75 ACI patients referred to Golestan and Imam Khomeini hospitals of Ahvaz in 2023. The patients in healthy (CIMT≤0.8mm) and at risk of cardiac ischemia (CIMT>0.8mm) groups underwent carotid Doppler ultrasound to check CIMT and the presence of carotid plaque.</p><p><strong>Results: </strong>CIMT mean was 1.07±0.12 mm in healthy ACI patients and 1.4±0.19 mm in those at risk of cardiac ischemia. Among patients at risk of CIMT and carotid plaque, 85.1% and 80.8% had at least one cardiovascular risk factor, respectively. However, no significant differences were found between CIMT, carotid plaque, and patients' risk factor profiles (P = 0.129 vs. P = 0.515). The adjusted odds ratio (OR) for CIMT was 1.50 (95% CI: 0.58-3.94, P = 0.400), indicating no significant association with the outcome. No significant associations were observed for age, sex, diabetes, hypertension, LDL, or HDL. While the prevalence of vessel disease was higher in at-risk group than healthy CIMT group, no dramatic differences were observed between CIMT and vessel involvement (P = 0.136).</p><p><strong>Conclusion: </strong>The presence of one or more cardiovascular risk factors combined with increased CIMT may increase heart attack susceptibility, highlighting the potential of CIMT as an effective screening tool for predicting coronary artery disease. Further large-scale studies are needed to define its role in clinical practice more definitively.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"97-105"},"PeriodicalIF":1.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of breast cancer in women referring to the surgical clinic of northern Iran Hospitals over a ten-year period (2011-2021).","authors":"Melika Hendukolai, Khadijeh Ezoji, Yasser Asghari, Majid Nabipour, Sana Keshtegar, Aref Gholami Languri, Mohammad Amin Afshar, Abolhasan Alijanpour","doi":"10.22088/cjim.17.1.128","DOIUrl":"https://doi.org/10.22088/cjim.17.1.128","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is a major global health concern, with the highest incidence in women and the main cause of cancer-related deaths in them worldwide. The purpose of this study was to investigate the risk factors related to breast cancer in women.</p><p><strong>Methods: </strong>This is a case-control study on breast cancer patients referred to the Surgery Clinic during the years 2011 to 2021. There were 131 participants in the case group and 131 in the control group. Patient information was collected through medical records, face-to-face or telephone interviews. This study has the ethics code IR.MUBABOL.HRI.REC.1401.226 from the National Organization for Ethics in Biomedical Research of the Ministry of Health and Medical Education of Iran.</p><p><strong>Results: </strong>262 participants were included in the study, 50% were in the case group (breast cancer) and 131 (50%) were in the control group. Between the case and control group in terms of demographic variables, age (P=0.289), height (P=0.254), education level (P=0.785), marital status (P=0.421), place of birth (P=0.668) and place of residence (P=0.454) have been no statistically significant difference. Presence of underlying disease (P=0.005), less physical activity (p<0.001), older age at first delivery (P=0.003), lower menstrual age (P=0.001), history of breastfeeding for at least one year (P=0.002) and use of oral contraceptives (P=0.015) can significantly predict the incidence of breast cancer.</p><p><strong>Conclusion: </strong>OCP use, underlying disease, less physical activity, older age at first delivery, younger age at menstruation, and history of breastfeeding for at least one year are associated with the incidence of breast cancer.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"128-135"},"PeriodicalIF":1.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}