Caspian Journal of Internal Medicine最新文献

Effect of laparoscopic sleeve gastrectomy on heart remodeling and right ventricular function. 腹腔镜袖胃切除术对心脏重构及右心室功能的影响。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-05-28 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.121

Kağan Gökçe, Hidayet Demir, Mehmet Altuğ Tunçer, Mehrdad Sheikhvatan, Hanie Abbasi

{"title":"Effect of laparoscopic sleeve gastrectomy on heart remodeling and right ventricular function.","authors":"Kağan Gökçe, Hidayet Demir, Mehmet Altuğ Tunçer, Mehrdad Sheikhvatan, Hanie Abbasi","doi":"10.22088/cjim.17.1.121","DOIUrl":"10.22088/cjim.17.1.121","url":null,"abstract":"Background: Weight loss following bariatric surgery reduces cardiovascular workload and may improve cardiac structure and function. This study aimed to assess changes in right heart echocardiographic parameters and cardiac remodeling six months after laparoscopic sleeve gastrectomy (LSG).Methods: In this cross-sectional study, patients who underwent LSG between 2022 and 2024 were evaluated before surgery and at six-month follow-up. Demographic data, clinical variables, and comprehensive echocardiographic indices of cardiac function were recorded and compared.Results: Twenty-two patients (mean age 38.09±9.47 years) were included. Significant postoperative improvements were observed in left ventricular ejection fraction (55.84±6.49% to 62.86 ± 4.41%, p<0.001), right ventricular peak systolic myocardial velocity (12.22±2.59 to 14.24±2.38 cm/s, p<0.001), tricuspid annular plane systolic excursion (22.95±3.03 to 24.18±2.82 mm, p=0.04), E wave velocity (7.35±2.01 to 9.54±1.98 cm/s, p<0.001), and left ventricular global longitudinal strain (15.42±3.86 to 18.24±2.93, p<0.001). Significant reductions were noted in right ventricular diameter, left ventricular end-diastolic and end-systolic volumes, and pulmonary artery pressure (all p<0.01). The prevalence of diastolic dysfunction decreased markedly from 63.6% preoperatively to 13.6% postoperatively (p<0.001).Conclusion: Laparoscopic sleeve gastrectomy is associated with significant improvement in cardiac remodeling and both left and right ventricular function, with notable enhancement of right heart echocardiographic parameters.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"121-127"},"PeriodicalIF":1.2,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of body composition with bone mineral density and fracture in diabetic elderly: Results from AHAP study. 老年糖尿病患者身体成分与骨密度和骨折的关系：来自AHAP研究的结果。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.302

Seyed Amirhossein Hosseini, Neda Meftah, Mansor Babaei, Ali Bijani, Reza Ghadimi, Hajighorban Noreddini, Seyed Reza Hosseini

{"title":"Association of body composition with bone mineral density and fracture in diabetic elderly: Results from AHAP study.","authors":"Seyed Amirhossein Hosseini, Neda Meftah, Mansor Babaei, Ali Bijani, Reza Ghadimi, Hajighorban Noreddini, Seyed Reza Hosseini","doi":"10.22088/cjim.17.2.302","DOIUrl":"10.22088/cjim.17.2.302","url":null,"abstract":"Background: Diabetes is a common metabolic disorder and one of its comorbidities is osteoporosis. In previous studies, the effect of lean mass and fat mass on bone has been investigated separately. Therefore, the aim of this study was to investigate the association between body composition with bone mineral density (BMD) and fractures in diabetic elderly.Methods: This population based cross-sectional study is part of the second phase of the Amirkola Health and Ageing Cohort Project (AHAP). Diabetes was diagnosed by fasting blood glucose level twice greater than or equal to 126 mg/dl. BMD and body composition were measured by Hologic Horizon-WI densitometer. History of fracture was obtained by asking the elderly individual. Then data were analyzed using statistical tests and ROC curve.Results: Out of 469 elderly diabetics, 270 (57.57%) were women. The mean age was 68.70±6.18. Older people with osteopenia, osteoporosis and fracture had lower visceral fat mass (VFM), lean mass (LM) and waist circumference (WC) than normal people. The mean BMD in elderly with less than 10 years of diabetes history was greater and the percentage of fractures in elderly individuals with more than 10 years of diabetes was higher. In Roc analysis, the highest area under the curve was related to LM 78% (0.78±0.02), WC 67% (0.67±0.03) and VFM 62% (0.62±0.03) for estimation of osteoporosis.Conclusion: In this study, LM, WC and VFM had the greatest effect on BMD and fracture in elderly diabetic.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"302-311"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The correlation between clinical and pathological features of renal cancer patients with survival after surgical intervention. 肾癌患者手术干预后临床及病理特征与生存的关系。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.360

Mohammad Sadri, Sima Masudi, Saman Farshid, Mohammad Mehdi Nemati Oskuii

{"title":"The correlation between clinical and pathological features of renal cancer patients with survival after surgical intervention.","authors":"Mohammad Sadri, Sima Masudi, Saman Farshid, Mohammad Mehdi Nemati Oskuii","doi":"10.22088/cjim.17.2.360","DOIUrl":"10.22088/cjim.17.2.360","url":null,"abstract":"Background: Renal cell carcinoma (RCC) is a prevalent malignancy with a steadily increasing incidence. This study examined the association between clinical and pathological factors and RCC patient survival outcomes.Methods: This retrospective cohort study enrolled patients diagnosed with malignant renal tumors who underwent surgical resection at Urmia Imam Khomeini Hospital between April 2017 and March 2022. Eligible patients were identified through a review of medical records and recruited using a convenience sampling method. Demographic, clinical, and pathological data were collected for each patient.Results: Of the 171 patients, 104 were males and 67 were females with a mean age of 57.9 years (SD±14.5). The one-, three, and five-year overall survival rates were 84.7%, 72.4%, and 70.5%, respectively. Univariate regression analysis revealed that five-year mortality following surgical intervention was strongly associated with moderate-to-severe anemia HR: 6.495, 95%CI: 3.618-11.660, p<0.001), elevated ESR (HR: 6.690, 95%CI: 3.122-14.335, p<0.001), presence of necrosis (HR 13.216, 95% CI 5.213-33.509, p < 0.001), and lymphovascular invasion (HR 7.988, 95% CI 4.184-15.251, p < 0.001). Multivariate regression analysis identified moderate-to-severe anemia, lymphovascular invasion, and stage III &IV, high ESR and eGFR<45 as strong predictors of five-year mortality.Conclusion: These findings highlight the importance of considering clinical and pathological features in the management and prognosis of RCC patients.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"360-373"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin C intake is a novel potential therapeutic approach in the secretion of adiponectin and in the treatment of abdominal obesity. 维生素C的摄入在脂联素分泌和腹部肥胖的治疗中是一种新的潜在的治疗方法。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.422

Ganesh H Ghanwat, Anup S Hendre, Ajit V Sontakke, Bhagyashri Yadav, Rohan S Phatak, Amar R Mohite

{"title":"Vitamin C intake is a novel potential therapeutic approach in the secretion of adiponectin and in the treatment of abdominal obesity.","authors":"Ganesh H Ghanwat, Anup S Hendre, Ajit V Sontakke, Bhagyashri Yadav, Rohan S Phatak, Amar R Mohite","doi":"10.22088/cjim.17.2.422","DOIUrl":"10.22088/cjim.17.2.422","url":null,"abstract":"Background: The prevalence of abdominal obesity is increasing rapidly worldwide and is a leading cause of morbidities and mortalities. Abdominal obesity is associated with various health complications including insulin resistance (IR), type 2 diabetes etc. The present research studied the outcome of VC intake on adiponectin (ACRP30) levels and its relationship with waist circumference (WC) and IR.Methods: The present study was carried out on a total of 80 subjects. 42 obese (20 males and 22 females) and 38 non-obese (19 males and 19 females) were enrolled into two groups. Vitamin C (500 mg) was provided to all study subjects and instructed to consume it three times a day over a period of 90 consecutive days. Fasting blood samples were collected at the baseline and end of the study. Adiponectin levels were measured. Data were analyzed by using a two-tailed Student's t-test.Results: Vitamin C supplementation significantly increased serum adiponectin (ACRP30) levels in obese males (P = 0.0485), obese females (P = 0.0235), non-obese males (0.0457), and non-obese females (0.0245). Adiponectin is inversely correlated with WC and IR. No significant differences were found in the levels of serum adiponectin between study participants gender-wise.Conclusion: 500 mg of vitamin C intake, three times a day for 90 days, is a novel potential therapeutic approach to restore the capacity of adipose tissue in secreting adiponectin and for the treatment of abdominal obesity and allied complications.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"422-428"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The signaling pathway of PPAR-γ and its protective role in various diseases. PPAR-γ信号通路及其在多种疾病中的保护作用。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.264

Amin Hasanvand, Peyman Amanolahi Baharvand, Hamid Nasri, Kamran Shirbache

{"title":"The signaling pathway of PPAR-γ and its protective role in various diseases.","authors":"Amin Hasanvand, Peyman Amanolahi Baharvand, Hamid Nasri, Kamran Shirbache","doi":"10.22088/cjim.17.2.264","DOIUrl":"10.22088/cjim.17.2.264","url":null,"abstract":"The peroxisome proliferator-activated receptor gamma (PPARγ) signaling pathway is one of the most important physiological pathways in the body, which is known for its beneficial role in regulating metabolism and modulating disease processes. This ligand-activated nuclear receptor significantly influences glucose and lipid metabolism, and is involved in various cellular functions, including anti-inflammatory, antioxidant, and anti-apoptotic responses. PPARγ activity can be regulated through multiple post-translational modifications such as acetylation, glycosylation, and phosphorylation, which underscores its complexity and therapeutic potential. In this review, we examined numerous studies investigating the role of the PPAR-γ signaling pathway in a wide range of diseases. Particular emphasis was placed on its involvement in the cardiovascular system, central nervous system (CNS), digestive system, respiratory as well as urinary systems, and allergic diseases. Accumulating evidence has shown that activation of this pathway can modulate inflammatory and oxidative responses, enhance insulin sensitivity, and provide neuroprotective and organ-protective effects. To conduct this review, we searched PubMed, Web of Science, EBSCO, Scopus, Google Scholar, Directory of Open Access Journals (DOAJ), and Embase, using keywords such as \"PPAR-γ,\" \"Signaling Pathway,\" \"Anti-inflammatory,\" \"Antioxidant,\" and \"Diseases.\" These searches revealed consistent findings supporting the therapeutic potential of PPARγ activation in diverse pathological conditions. The evidence suggests that targeting the PPARγ pathway may offer novel strategies for preventing and treating a variety of metabolic, inflammatory and degenerative diseases.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"264-277"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strongyloides steroralis: A case report to manifest the diagnosis and treatment. 粪类圆线虫1例，探讨其诊断与治疗。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.470

Faezeh Firuzpour, Pedram Beigvand, Niloofar Moradi, Hadis Zaboli, Fatemeh Jafarpour, Zahra Naghdizadeh, Maryam Adabi

{"title":"Strongyloides steroralis: A case report to manifest the diagnosis and treatment.","authors":"Faezeh Firuzpour, Pedram Beigvand, Niloofar Moradi, Hadis Zaboli, Fatemeh Jafarpour, Zahra Naghdizadeh, Maryam Adabi","doi":"10.22088/cjim.17.2.470","DOIUrl":"10.22088/cjim.17.2.470","url":null,"abstract":"Background: Strongyloides stercoralis is a soil-transmitted intestinal nematode capable of establishing chronic autoinfection, allowing infection to persist for decades. Its nonspecific clinical manifestations and variable presentation often result in delayed diagnosis, particularly in older adults and in endemic regions, where unrecognized infection may progress to severe complications.Case report: A 78-year-old man presented with progressive bilateral lower-extremity edema lasting four months, accompanied by functional class II dyspnea, fever, chills, night sweats, nausea, lethargy, and an unintentional 20-kg weight loss over eight months. Laboratory and imaging investigations failed to identify a clear etiology, prompting further diagnostic evaluation. Histopathological examination together with stool analysis ultimately confirmed Strongyloides stercoralis infection associated with protein-losing enteropathy. The patient was treated with albendazole for seven days, leading to marked clinical improvement and complete resolution of symptoms during follow-up, with recovery of nutritional status and no evidence of recurrence.Conclusion: This case highlights the diagnostic challenge posed by strongyloidiasis in elderly patients presenting with nonspecific constitutional symptoms and protein-losing enteropathy. Clinicians practicing in endemic settings or caring for individuals with relevant epidemiologic risk factors should maintain a high index of suspicion, even in the absence of classic gastrointestinal manifestations or eosinophilia. Early recognition, appropriate parasitological and histopathological investigations, and timely antiparasitic therapy are essential to achieve favorable outcomes and prevent potentially life-threatening complications, including hyperinfection syndrome and disseminated disease.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"470-475"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological pattern of tuberculosis in Babol City, northern Iran (2015-2021). 伊朗北部巴博勒市结核病流行病学模式（2015-2021年）

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.392

Amir Ghorbanzade, Mostafa Javanian, Mohsen Karami, Roghaye Vaseghi-Amiri, Saman Sedighi, Zainab Roshani, Hossein-Ali Nikbakht

{"title":"Epidemiological pattern of tuberculosis in Babol City, northern Iran (2015-2021).","authors":"Amir Ghorbanzade, Mostafa Javanian, Mohsen Karami, Roghaye Vaseghi-Amiri, Saman Sedighi, Zainab Roshani, Hossein-Ali Nikbakht","doi":"10.22088/cjim.17.2.392","DOIUrl":"10.22088/cjim.17.2.392","url":null,"abstract":"Background: Tuberculosis (TB) continues to persist being the most important cause of death and disability in developing countries. Prioritizing the analysis of the current situation is the most effective approach to managing and intervening in any health issue. Therefore, this study aimed to investigate the epidemiological patterns of TB in Babol City over seven years.Methods: This study was performed from 2015 to 2021. For data collection, the information of all cases of TB patients registered in the system of the Tuberculosis Inventory of the health department of Babol Medical Sciences was examined.Results: A total of 307 individuals diagnosed with TB were included in the study. More than 60 percent were under 50 years old and the highest number was observed in the 30-39 years old age group. Most of the patients were males (67.4%) and more than 90% were new cases of TB. 73.9% were pulmonary patients and 85.9% were smear-positive. The prevalence of tuberculosis (TB) had a notable decline, dropping from 7.05 per 100,000 individuals in 2015 to 5.26 per 100,000 individuals in 2021, which indicates a significant decreasing trend (P=0.012). Besides, there was a relationship between the type of disease (pulmonary/non-pulmonary) and age, gender, BMI, case of disease and history of TB-related hospitalization (p<0.05).Conclusion: The trends and factors identified in this study can enhance public awareness, reduce risk factors, and support effective patient screening programs. Additionally, these findings can help health policymakers assess regional disease status and develop future strategies.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"392-402"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastric cancer patients' survival with neoadjuvant chemotherapy versus direct surgery. 胃癌患者新辅助化疗与直接手术的生存率比较。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.334

Vahid Zangouri, Masoumeh Molanorouzi, Saba Ebrahimian

{"title":"Gastric cancer patients' survival with neoadjuvant chemotherapy versus direct surgery.","authors":"Vahid Zangouri, Masoumeh Molanorouzi, Saba Ebrahimian","doi":"10.22088/cjim.17.2.334","DOIUrl":"10.22088/cjim.17.2.334","url":null,"abstract":"Background: Despite these theoretical advantages, there is still a lack of evidence to answer whether NeoAdjuvant Chemotherapy (NAC) can further improve the survival of Locally Advanced Gastric Cancer (LAGC) patients on the basis of Adjuvant Chemotherapy (AC) following curative gastrectomy. The present research assessed the 36-month survival of gastric cancer patients treated in our center with and without NAC and over-all 36-month survival.Methods: The present research assessed the 36-month survival of gastric cancer patients treated in our center with and without NAC and over-all 36-month survival. 79 patients entered this study, of whom 64 received NAC and 15 underwent direct surgery.Results: Generally, the three-year survival rate in the groups was statistically different based on the Wilcoxon test (P 0.004). NAC was effective in increasing survival in the groups with lymph o vascular invasion, higher stage and all pathologic groups. However, age, type of surgery (TG vs DG), number of positive lymph nodes, and positive margin after surgery were not effective in interfering with survival in both groups. Neoadjuvant chemotherapy can positively increase OS and DFS in locally advanced gastric cancer. NAC was effective in increasing survival in the groups with lymph o vascular invasion, higher stage and all pathologic groups.Conclusion: Considering the similar results in previous studies, larger prospective studies with accurate information can effectively achieve definitive results. However, age, type of surgery (TG vs DG), number of positive lymph nodes, positive margin after surgery were not effective interfering with survival in both groups.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"334-346"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Initial treatment for uncontrolled type 2 diabetes: A clinical trial comparing basal insulin and modified-release gliclazide. 未控制2型糖尿病的初始治疗：一项比较基础胰岛素和改良释放格列齐特的临床试验。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.319

Ebrahim Mohammadi, Laya Hooshmand Gharebagh, Maryam Hajiesmaello

{"title":"Initial treatment for uncontrolled type 2 diabetes: A clinical trial comparing basal insulin and modified-release gliclazide.","authors":"Ebrahim Mohammadi, Laya Hooshmand Gharebagh, Maryam Hajiesmaello","doi":"10.22088/cjim.17.2.319","DOIUrl":"10.22088/cjim.17.2.319","url":null,"abstract":"Background: The global rise of type 2 diabetes (T2D) presents significant healthcare challenges in diagnosis, prevention, and treatment. This study compares basal insulin and modified-release gliclazide to assess their effectiveness in managing glycemic control and other clinical factors in T2D patients.Methods: This open-label, randomized controlled trial included 90 patients with type 2 diabetes mellitus (T2DM) exhibiting poorly controlled glycemic levels (HbA1c > 10%), referred to endocrinology clinic of Imam Khomeini Hospital, Urmia, Iran, between 2023 and 2024. The patients were randomly assigned into one of two intervention groups: the Gliclazide-MR group (n=45), receiving 30 mg of modified-release gliclazide twice daily, or the Basal Insulin group (n=45), receiving basal insulin (detemir or glargine) at a dosage of 0.1--0.3 units per kilogram of body weight.Results: The mean age of participants was 56.4±11.48 years in the gliclazide-MR group and 55.5±13.48 years in the basal insulin group. Baseline demographic characteristics and pre-intervention variables demonstrated no statistically significant differences between the groups (p > 0.05). Both intervention groups exhibited statistically significant reductions in three glycemic indices HbA1c, fasting blood glucose (FBS), and 2-hour postprandial blood glucose (BS2hpp) at the 3-month follow-up compared to baseline (p < 0.001). The gliclazide-MR group demonstrated comparable efficacy to the basal insulin group in reducing these glycemic indices.Conclusion: Both basal insulin and modified-release gliclazide demonstrated efficacy in improving glycemic control in patients with severe hyperglycemia. The optimal treatment choice should be individualized based on patient-specific factors and treatment goals.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"319-327"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival rate in patients with pancreatic cancer in Guilan province, Iran. 伊朗桂兰地区胰腺癌患者的生存率。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.449

Mohammad Almasi, Niloofar Faraji, Farahnaz Joukar, Narges Eslami, Saman Maroufizadeh, Amineh Hojati, Fariborz Mansour-Ghanaei

{"title":"Survival rate in patients with pancreatic cancer in Guilan province, Iran.","authors":"Mohammad Almasi, Niloofar Faraji, Farahnaz Joukar, Narges Eslami, Saman Maroufizadeh, Amineh Hojati, Fariborz Mansour-Ghanaei","doi":"10.22088/cjim.17.2.449","DOIUrl":"10.22088/cjim.17.2.449","url":null,"abstract":"Background: Pancreatic cancer is among the deadliest malignancies globally, marked by poor prognosis and limited survival. This research investigated the demographic and clinical determinants affecting overall survival in patients diagnosed with pancreatic cancer in Guilan Province, Iran.Methods: A total of 50 pathologically and radiologically confirmed cases of pancreatic cancer were analyzed. Demographic, anthropometric, and clinical data were extracted from medical records. Survival probabilities were estimated using the Kaplan--Meier method, and intergroup differences were tested using the log-rank test. Cox proportional hazards modeling identified predictors of mortality, with significance defined at p < 0.05. Statistical analyses were conducted in SPSS (v16) and GraphPad Prism (v8).Results: The majority of patients were male (60%) and over 60 years old (58%), while 46% had normal BMI and 40% had blood group O. Comorbidities were present in 42%, and 32% were diagnosed at stage IV. Mean and median survival were 39.6 and 9.0 months, respectively. One-, three-, and five-year survival rates were 45.2%, 31.3%, and 23.5%. Advanced tumor stage (III/IV) significantly predicted shorter survival (p < 0.001). Underweight individuals had higher mortality risk (HR = 2.79; 95% CI: 1.21--6.42; P = 0.016). In multivariate models, male gender, blood group O, and advanced disease remained independent negative prognostic indicators.Conclusion: Male sex, advanced stage, low BMI, and blood group O were major determinants of poorer survival in pancreatic cancer. These results emphasize the need for individualized treatment and closer follow-up among high-risk groups.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"449-456"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0