Caspian Journal of Internal Medicine最新文献

Colon lesions in elderly individuals with positive and negative fecal immunochemical test results among PERSIAN Guilan cohort study (PGCS) population. 波斯桂兰队列研究（PGCS）人群中粪便免疫化学试验结果阳性和阴性的老年人结肠病变

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Caspian Journal of Internal Medicine Pub Date : 2025-12-24 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.451

Heydar Ali Balou, Farahnaz Joukar, Mahdi Orang Goorabzarmakhi, Milad Shahdkar, Soheil Hassanipour, Saman Maroufizadeh, Mehrnaz Asgharnezhad, Paridokht Karimian, Fariborz Mansour-Ghanaei

{"title":"Colon lesions in elderly individuals with positive and negative fecal immunochemical test results among PERSIAN Guilan cohort study (PGCS) population.","authors":"Heydar Ali Balou, Farahnaz Joukar, Mahdi Orang Goorabzarmakhi, Milad Shahdkar, Soheil Hassanipour, Saman Maroufizadeh, Mehrnaz Asgharnezhad, Paridokht Karimian, Fariborz Mansour-Ghanaei","doi":"10.22088/cjim.16.3.451","DOIUrl":"10.22088/cjim.16.3.451","url":null,"abstract":"Background: Early colorectal cancer (CRC) detection helps reduce the mortality rate. This study aimed to investigate colon lesions in individuals with positive and negative fecal immunochemical test (FIT) results among the (PERSIAN) Guilan cohort study (PGCS) population.Methods: This cross-sectional study was conducted on 1158 participants over 50 who were volunteers for the FIT stool test at the Endoscopy Department of Razi Hospital, Rasht, Iran, from 2021 to 2022. The FIT test was screened for all participants, and for 172 individuals (86 individuals from each group with positive and negative FIT results), a colonoscopy was performed to investigate the colon lesions. Demographic/clinical characteristics, FIT results, colonoscopy findings, and the Bristol Stool Chart were completed. All data were analyzed using SPSS Version 16, considering a significant level<0.05.Results: Out of 1,158 participants, 86 had positive FIT results, and 172 (52.3%) were females. The colonoscopy results showed that 34.3% of the patients had colon lesions. Individuals with positive FIT exhibited a significantly higher prevalence of colon lesions (p<0.001). No statistically significant differences were observed between positive and negative FIT results, demographic and clinical characteristics, and the location of lesions in individuals with colon lesions (p>0.05). Moreover, there was a significant difference in pathological findings and the presence of adenomatous polyps regarding the FIT results (p<0.001).Conclusion: The effectiveness of FIT in the initial stages of screening for early lesion detection is considerable, especially for individuals with upper age.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"451-457"},"PeriodicalIF":1.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between eosinopenia and neutrophil-lymphocyte ratio with sepsis-related mortality in the intensive care unit. 重症监护病房中嗜酸性粒细胞减少和中性粒细胞淋巴细胞比值与败血症相关死亡率的关系。

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Caspian Journal of Internal Medicine Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.444

Parviz Amri, Armin Nejadnaderi, Hemmat Gholinia, Fatemeh Heidarnia, Masomeh Bayani

{"title":"Relationship between eosinopenia and neutrophil-lymphocyte ratio with sepsis-related mortality in the intensive care unit.","authors":"Parviz Amri, Armin Nejadnaderi, Hemmat Gholinia, Fatemeh Heidarnia, Masomeh Bayani","doi":"10.22088/cjim.16.3.444","DOIUrl":"10.22088/cjim.16.3.444","url":null,"abstract":"Background: Early diagnosis of sepsis can lead to rapid initiation of treatment and reduced mortality. The aim of this study was to investigate the relationship between eosinopenia and neutrophil-lymphocyte ratio (NLR) with sepsis-related mortality in the intensive care unit.Results: Out of 100 patients studied, 59 patients survived and 41 patients died and the mean age of the patients was 63.27±16.13 years. Out of 40 patients with eosinopenia, 19(46.3%) died and out of 60 patients with normal eosinophil, 22(53.7%) died (P=0.28). The NLR on the first day in died patients was significantly higher than in the surviving patients (P=0.009). The increase in SOFA Score (p<0.001 and OR=1.49) and the increase in NLR (P=0.02 and OR=3.38) has a direct relationship with the mortality rate.Conclusion: The results of the present study in sepsis patients showed that patients who had a higher neutrophil-to-lymphocyte ratio had higher mortality and there was no relationship between eosinopenia and mortality rate.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"444-450"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seroepidemiology of toxoplasma gondii in kidney transplant patients. 肾移植患者刚地弓形虫血清流行病学研究。

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Caspian Journal of Internal Medicine Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.507

Marzieh Latifi, Habib Rahban, Elahe Pourhosein, Tannaz Hajialireza Tehrani, Parisa Mahjoobi, Sanaz Dehghani

{"title":"Seroepidemiology of toxoplasma gondii in kidney transplant patients.","authors":"Marzieh Latifi, Habib Rahban, Elahe Pourhosein, Tannaz Hajialireza Tehrani, Parisa Mahjoobi, Sanaz Dehghani","doi":"10.22088/cjim.16.3.507","DOIUrl":"10.22088/cjim.16.3.507","url":null,"abstract":"Background: Opportunistic infection after transplantation is a serious problem, with Toxoplasma Gondii (T.gondii) and cytomegalovirus being the most concerning infections. The objective of this research was to examine the seroepidemiology of the T. gondii virus among kidney transplant recipients at Sina Hospital in Tehran from 2017 to 2021.Methods: A total of 342 kidney transplant patients participated in this cross-sectional study using the census method after obtaining consent. Data were collected by reviewing medical records and the transplant database, including demographic characteristics and infectious tests related to kidney transplantation. The collected information was entered into SPSS18 software.Results: The age of the subjects ranged from 10 to 73 years, with 125 patients having kidney failure due to ERDS. The rate of exposure to T. gondii in kidney transplant patients was 54.2%. 125 patients experiencing kidney failure due to ERDS. In kidney transplant patients, the exposure rate to T. gondii was 54.2%. There is a positive correlation between TOX IgG and age (r= 0.12, P = 0.02). There is a positive correlation between CMV IgG and the time elapsed since kidney transplantation (r = 0.11, P = 0.03) and TOX IgG (r = 0.13, p < 0.01). Gender was found not to predict EBV.IgG (β = 0.787, p < 0.21), CMV.IgG (β = 4.752, p < 0.071), TOX.IgG (β = 1.154, p < 0.256) based on regression tests.Conclusion: Physicians should be aware of preventive measures and should consider early diagnosis in cases of compatible symptoms. Screening for anti-Toxoplasma IgM antibodies in potential donors is recommended.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"507-512"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum fibrinogen & total cholesterol: A significant primary biomarker and its interrelationship in stroke. 血清纤维蛋白原和总胆固醇：卒中中重要的主要生物标志物及其相互关系。

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Caspian Journal of Internal Medicine Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.525

Komal Rana, Tarunkumar Chavda, Sonal Chavda, Chetan Sonkar, Krishna Soni, Krina Patel, Nancy Vaja, Saniya Vahora, Amal Kumar Bhattacharya

{"title":"Serum fibrinogen & total cholesterol: A significant primary biomarker and its interrelationship in stroke.","authors":"Komal Rana, Tarunkumar Chavda, Sonal Chavda, Chetan Sonkar, Krishna Soni, Krina Patel, Nancy Vaja, Saniya Vahora, Amal Kumar Bhattacharya","doi":"10.22088/cjim.16.3.525","DOIUrl":"10.22088/cjim.16.3.525","url":null,"abstract":"Background: To study the association of plasma fibrinogen & total cholesterol levels, incidences, prevalence, and gender wise distribution in different etiologies of stroke.Methods: Fibrinogen & total cholesterol levels, prevalence, incidences, comorbidities, and different etiologies were assessed along with routine investigations and radiology inputs as per investigator's discretion. The overall median values were represented in graphically format in MS-Excel.Results: 292 Males: 218 females. Age 30 to 80 years. Among, 25.1% diabetic, 38.9 % hypertension (HTN) and 31% diabetes + HTN. 5 % diabetes + HTN + dyslipidemia and other comorbidities. Overall, 73% had ischemic stroke (IS) & 27 % have hemorrhagic stroke (HS). Hemiparesis in 76.5 %. Mean Fibrinogen elevated in 81% and range was 934±20 mg/dL. Total cholesterol level increased in 73.2% & range was 365±10 mg/dL. The HS patients were experienced headache 77 (19.60%) and vomiting 34 (24.6%) than IS patients. As per radiological finding, the territory of Middle Cerebral Artery was the ordinary location of arterial territory infarctions in the IS form that was present in 213 (57.2%) subjects following that in the anterior side of cerebral artery in 89 (23.92%) and posterior cerebral artery was 44 (11.82%). Arterial flutter found in 56 (10.9%), Structural heart disease present in 30 (5.88%), family history of stroke in 28 (5.49%).Conclusion: Elevated fibrinogen & total cholesterol levels are independent significant primary biomarkers elevated with incidences of CV stroke. Stroke was higher in ischemic stroke group.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"525-535"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Components of geriatric assessment and degree of sarcopenia on maintenance hemodialysis patients. 维持性血液透析患者的老年评估成分及骨骼肌减少程度。

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Caspian Journal of Internal Medicine Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.542

Ihdinal Mukti, Novira Widajanti, Hadiq Firdausi, Djoko Santoso

{"title":"Components of geriatric assessment and degree of sarcopenia on maintenance hemodialysis patients.","authors":"Ihdinal Mukti, Novira Widajanti, Hadiq Firdausi, Djoko Santoso","doi":"10.22088/cjim.16.3.542","DOIUrl":"10.22088/cjim.16.3.542","url":null,"abstract":"Background: Sarcopenia is a serious public health problem because of its impact on human health and health care system. The prevalence of sarcopenia in elderly undergoing maintenance hemodialysis is increasing, with various components underlying the geriatric assessment.Methods: This research used a cross-sectional study approach involving 40 samples taken by total sampling according to inclusion and exclusion criteria. The study population was the entire population aged ≥60 years, male dan female, who routinely undergo hemodialysis at the HD installation at Dr. Soetomo Hospital Surabaya. Data analysis was performed using SPSS Version 25.0.Results: The research subjects were dominated by 62.5% male elderly with a median age of 64 years (60-93 years). The median duration of hemodialysis was 4 years (0.5-21). The proportion of sarcopenia was 82.5%. From the results of bivariate analysis, it was found that nutritional status as measured by MNA was the only component of CGA associated with sarcopenia p=0,002 (OR 25; IK 95% 3,302-189,259).Conclusion: Nutritional status is an independent predictor of the incidence of sarcopenia to severe sarcopenia in geriatric patients with chronic kidney disease undergoing maintenance hemodialysis.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"542-552"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal sarcoidosis mimicking malignancy: A confusing scenario. 胃肠道结节病模拟恶性肿瘤：一个令人困惑的场景。

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Caspian Journal of Internal Medicine Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.584

Dilara Bulut Gökten, Rıdvan Mercan

引用次数: 0

Impact of HbA1c levels on coronary SYNTAX score in non-diabetic patients with ST-elevation myocardial infarction undergoing primary angioplasty: A cross-sectional study. 非糖尿病st段抬高型心肌梗死患者行原发性血管成形术时HbA1c水平对冠状动脉SYNTAX评分的影响：一项横断面研究

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Caspian Journal of Internal Medicine Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.519

Majid Saraei Koushki, Razieh Parizad, Ali Abdollahzadeh, Ahmad Separham

{"title":"Impact of HbA1c levels on coronary SYNTAX score in non-diabetic patients with ST-elevation myocardial infarction undergoing primary angioplasty: A cross-sectional study.","authors":"Majid Saraei Koushki, Razieh Parizad, Ali Abdollahzadeh, Ahmad Separham","doi":"10.22088/cjim.16.3.519","DOIUrl":"10.22088/cjim.16.3.519","url":null,"abstract":"Background: Glycated hemoglobin A1c (HbA1c) level is related to increased cardiovascular diseases (CVDs) and death, even in non-diabetic subjects. Although in ST-elevation myocardial infarction (STEMI) cases, the association between HbA1c and coronary artery disease (CAD) remains unclear.Methods: This cross-sectional study was conducted on 167 non-diabetic STEMI patients undergoing primary percutaneous coronary intervention (PCI). The SYNTAX score was utilized to evaluate CAD severity. Cases were categorized into three groups based on the HbA1c levels: <5%, 5.1-5.9%, and 6-6.5%.Results: SYNTAX scores significantly increased in the cases with 6 to 6.5 HbA1c levels compared to the other group (28.9±9.5 vs 21.2±5.2 vs 13.7±4.5, P=0.000). Additionally, death was more elevated in this group (4% vs 0% vs 0%, P=0.006).Conclusion: Higher HbA1c levels are strongly associated with coronary atherosclerosis in non-diabetic patients that present with non-diabetic STEMI. Consequently, in non-diabetic STEMI patients, HbA1c may be able to predict the severity of CAD.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"519-524"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leptin and thyroid hormones in beta-thalassemia major: A cross-sectional study. 乙型地中海贫血的瘦素和甲状腺激素：一项横断面研究。

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Caspian Journal of Internal Medicine Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.536

Noor Mohammad Noori, Alireza Teimouri, Ayoub Basham, Shahrokh Rajaei

{"title":"Leptin and thyroid hormones in beta-thalassemia major: A cross-sectional study.","authors":"Noor Mohammad Noori, Alireza Teimouri, Ayoub Basham, Shahrokh Rajaei","doi":"10.22088/cjim.16.3.536","DOIUrl":"10.22088/cjim.16.3.536","url":null,"abstract":"Background: Hypothyroidism and leptin deficiency are two common endocrinopathies in β-thalassemia major patients (β-TM). Changes in leptin levels may lead to changes in thyroid hormone levels in thalassemia patients through suppression of the hypothalamus-pituitary-thyroid axis. Hence, we aimed to evaluate their correlation in β-TM patients.Methods: A cross-sectional study was conducted on transfusion dependent β-thalassemia patients receiving chelation treatment between 2018 and 2019. Tri-iodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), and leptin were measured for each participant. Data analyzed by SPSS, p< 0.05 was considered as significant.Results: One hundred and twenty-six β-TM patients aged between 10 and 30 years old participated in the study, including 55 (43.7%) females and 71(56.3%) males. TSH abnormality was prevalent among 13 (23.6%) females and 10(14.1%) males. Leptin level was significantly lower in males (6.65±7.27 VS 2.41±2.79, p<0.01). TSH was correlated with leptin in all (r=0.393, p<0.01), females (r=0.387, p<0.01), males (r=0.387, p<0.01), adolescents (r=0.512, p<0.01), young adults (r=0.287, P=0.01), underweights (r=0.483, p<0.01) and normal weight (r=0.301, P=0.03) thalassemia patients. T4 was correlated with leptin in all (r=0.201, p=0.02), females (r=0.281, P=0.03), males (r=0.281, P=0.03), and adolescents (r=0.280, P=0.03) β-TM patients. T3 did not correlate with leptin in all groups of the patients.Conclusion: In summary, leptin levels were significantly lower in males, and TSH abnormality was common in both genders. Therefore, screening for endocrine issues may benefit these people. Furthermore, leptin exhibited a correlation with TSH and T4. This may support the role of leptin on thyroid function in β-TM patients.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"536-541"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognosis of multiple myeloma patients based on histopathological evaluation of bone marrow. 基于骨髓组织病理学评价的多发性骨髓瘤患者预后。

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Caspian Journal of Internal Medicine Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.562

Niloofar Arefi Sigaroudi, Mohsen Vakili Sadeghi, Housein Ghorbani, Davood Jahansouz, Hoda Shirafkan, Mohammad Ranaee

{"title":"Prognosis of multiple myeloma patients based on histopathological evaluation of bone marrow.","authors":"Niloofar Arefi Sigaroudi, Mohsen Vakili Sadeghi, Housein Ghorbani, Davood Jahansouz, Hoda Shirafkan, Mohammad Ranaee","doi":"10.22088/cjim.16.3.562","DOIUrl":"10.22088/cjim.16.3.562","url":null,"abstract":"Background: Multiple myeloma is still one of deadliest malignancies known. Although many attempts to prognosticate the disease have been done like the International Staging System (ISS), most of the proposed prognostic tools are based merely on laboratory tests and hence prone to analytical errors in large and high-volume centers. This study aims to evaluate the prognostic effectiveness of histopathologic components of bone marrow and compare it to the results of laboratory-based prognostic tools.Methods: This cross-sectional study, bone marrow specimens of 93 multiple myeloma patients underwent aspiration and biopsy evaluated. The primary outcome was overall survival (OS) based on plasma cell percentage. The secondary outcomes were also OS based on angiogenesis using IHC marker CD34, nuclear atypia level, BM involvement pattern and the presence of fibrosis in bone marrow specimens. All biopsy specimens assessed using light microscopy on Hematoxylin and Eosin and IHC staining. Giemsa staining assessed for aspirate specimens.Results: Of 93 patients, 63.4% were dead. Median survival was 34.0 months (95% CI [24.6; 43.3]) and the average age at diagnosis was 65 years (highest 84 and lowest 40). Patients with bone marrow plasma cell count of over 70%, had a hazard ratio (HR) of death of 4.7 times more than those with plasma cell count between 10-25%. Similarly, diffuse infiltration pattern (HR 4.67) and blastic morphology (HR 4.17) associated with a significant worse prognosis (p=0.03).Conclusion: Comparing to laboratory-based ISS, wider HR of death spectrum in this study proposes a potential more precise, robust and easy-to-use prognostication tool.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"562-569"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary alveolar microlithiasis: A case report and brief review of literature. 肺泡微石症1例报告及文献复习。

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Caspian Journal of Internal Medicine Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.570

Reza Mohseni Ahangar, Mohammad Golparvar Azizi, Sara Babazadeh, Seyed Ali Akbar Hosseini Nasab, Ali Tavakoli Pirzaman

{"title":"Pulmonary alveolar microlithiasis: A case report and brief review of literature.","authors":"Reza Mohseni Ahangar, Mohammad Golparvar Azizi, Sara Babazadeh, Seyed Ali Akbar Hosseini Nasab, Ali Tavakoli Pirzaman","doi":"10.22088/cjim.16.3.570","DOIUrl":"10.22088/cjim.16.3.570","url":null,"abstract":"Background: Pulmonary alveolar microlithiasis (PAM), a rare autosomal recessive pulmonary disease, is mainly characterized by extensive calcium phosphate microliths deposition in the alveoli. The major mutation, causing the characteristic of this disease, occurs in solute carrier family 34 members 2 (SLC34A2), which is placed on chromosome 4p15.2. SLC34A2 encodes sodium-phosphate cotransporter type IIb, NPT2b, which plays a critical role in the transportation of phosphate ions from pulmonary alveoli into type II pneumocytes.Case presentation: Herein, we have reported a 50-year-old male presented with recent sore throat, fever, and sweating. Radiological findings revealed bilateral micronodular pattern with diffuse ground glass attenuation in lower regions. Subsequent histologic examination of lung biopsy confirmed intra-alveolar accumulation of calculi and the diagnosis of PAM. In addition, we reviewed the literature narratively to clarify different aspects of PAM.Conclusion: In this paper, we presented a sporadic case of PAM which was suspected with chest x-ray and confirmed by HRCT and trans-bronchial lung biopsy. We hope that it can help clinicians to be more aware of this condition and make proper diagnosis.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"570-576"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0