Caspian Journal of Internal Medicine最新文献_第2页

Accuracy of angioboost software versus routine angiography for assessing the degree of coronary artery lesion occlusion. 在评估冠状动脉病变闭塞程度时，angioboost软件与常规血管造影的准确性。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.436

Farshad Shakerian, Vahid Akhondi, Ali Sarreshtehdari, Ebrahim Ghobadi, Maedeh Dastmardi

{"title":"Accuracy of angioboost software versus routine angiography for assessing the degree of coronary artery lesion occlusion.","authors":"Farshad Shakerian, Vahid Akhondi, Ali Sarreshtehdari, Ebrahim Ghobadi, Maedeh Dastmardi","doi":"10.22088/cjim.17.2.436","DOIUrl":"10.22088/cjim.17.2.436","url":null,"abstract":"Background: Accurate image extraction is essential for simplifying the diagnosis and treatment of coronary artery disease (CAD) and reducing the need for multiple imaging procedures. This study compared the diagnostic accuracy of AngioBoost knowledge-based software with routine angiography in assessing coronary artery lesions.Methods: This cross-sectional study included 174 patients undergoing coronary angiography at Shahid Rajaei Heart Hospital, Tehran. Patients with signs and symptoms of ischemic heart disease and an indication for coronary angiography were enrolled. All underwent angiography using the Seldinger method. Angiographic films were reviewed by two independent cardiologists. AngioBoost was then applied to the same images, and its findings were interpreted by two additional cardiologists.Results: Comparison of routine angiography and AngioBoost showed contingency coefficients of 74.7% (P = 0.01) and 90.1% (P = 0.01) for the first and second cardiologists, respectively. AngioBoost correctly identified 96.3% of patent vessels, 79.9% of mild lesions, 58.0% of moderate lesions, 91.2% of significant lesions, and 96.8% of occluded vessels. Overall diagnostic agreement was 88.2% (P = 0.01). Kappa coefficients for vascular occlusion were 46.8% for Left Main, 71.7% for LAD, 70.1% for LCX, and 77.8% for RCA (all P = 0.01).Conclusion: AngioBoost demonstrated acceptable diagnostic accuracy in assessing coronary artery occlusion, showing strong agreement (88.2%) with routine angiography. These findings suggest that AngioBoost may serve as a useful complementary tool for CAD diagnosis, potentially reducing physician workload and improving diagnostic efficiency.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"436-448"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crowned Dens Syndrome associated with rheumatoid arthritis: A case report of two patients with a systematic literature review. 类风湿性关节炎相关的冠状齿综合征：2例患者的病例报告并进行系统的文献回顾。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.255

Selma Bouden, Emna Razgallah, Rym Makhlouf, Leila Rouached, Aicha Ben Tekaya, Siwar Ben Dhia, Ines Mahmoud, Rawdha Tekaya, Olfa Saidane, Leila Abdelmoula

{"title":"Crowned Dens Syndrome associated with rheumatoid arthritis: A case report of two patients with a systematic literature review.","authors":"Selma Bouden, Emna Razgallah, Rym Makhlouf, Leila Rouached, Aicha Ben Tekaya, Siwar Ben Dhia, Ines Mahmoud, Rawdha Tekaya, Olfa Saidane, Leila Abdelmoula","doi":"10.22088/cjim.17.2.255","DOIUrl":"10.22088/cjim.17.2.255","url":null,"abstract":"Background: This study reported two cases of crowned dens syndrome (CDS) occurring in rheumatoid arthritis (RA) patients, along with a systematic literature review of similar cases, aiming to explore the association between RA and CDS within the context of calcium pyrophosphate deposition disease (CPPD disease).Methods: A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We performed an online systematic literature search using the PICO (Patient, Intervention, Comparison, Outcome) strategy, to identify articles reporting the association between RA and CDS. A total of five studies were included in the systematic review.Results: Most cases involved older adults aged between 60 and 80 years old. A marked predominance of female cases was observed in most cases. Clinical presentation typically included chronic or acute neck pain, stiffness, and headache. In all the studied cases, no neurological complications were reported. Standard radiographs identified atlanto-axial instability in two cases. CT imaging included calcifications of the transverse, alar, and apical ligaments encircling the odontoid process, as seen in most cases. CT might also reveal erosions, pseudotumors, or structural abnormalities. Management strategies combined colchicine, nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids, resulting in significant clinical and biological improvement.Conclusion: CDS is an uncommon condition that should be more frequently considered in patients with RA presenting with neck pain, headache, and fever. Further research studies are required to elucidate potential shared pathophysiological features between RA and CDS and to explore common treatment options.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"255-263"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic challenges and mimicking disorders of Wilson's Disease: A comprehensive review. 威尔逊氏病的诊断挑战和模拟疾病：全面回顾。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.229

Seyyed-Saleh Hashemi, Aida Gholoobi, Karim Naghipoor, Tayebeh Hamzehloei

{"title":"Diagnostic challenges and mimicking disorders of Wilson's Disease: A comprehensive review.","authors":"Seyyed-Saleh Hashemi, Aida Gholoobi, Karim Naghipoor, Tayebeh Hamzehloei","doi":"10.22088/cjim.17.2.229","DOIUrl":"10.22088/cjim.17.2.229","url":null,"abstract":"Wilson disease is classically defined as an autosomal recessive disorder of copper metabolism that leads to neurological and hepatic dysfunction. It is one of the most prevalent genetic liver disorders caused by pathogenic mutations in the ATP7B gene, leading to defective copper transport and toxic accumulation in tissues. Without timely diagnosis and appropriate treatment, Wilson disease can progress to life-threatening hepatic failure and severe neurological impairment, ultimately resulting in death. Clinically, Wilson disease exhibits marked phenotypic heterogeneity, presenting with a wide spectrum of hepatic, neurological, and psychiatric symptoms. Differential diagnosis can be complicated by other inherited metabolic disorders with overlapping clinical and biochemical features, collectively referred to as Wilson's mimicry disease. These disorders may contribute to diagnostic uncertainty, potentially delaying the identification of Wilson disease and timely initiation of effective therapy. In this review, we collated pertinent information on Wilson disease and its related differential diagnoses based on a broad review of the scientific literature. Our findings highlight disorders that closely mimic Wilson disease clinically and biochemically, outlining their distinguishing clinical, biochemical, and genetic features, which can be differentiated through specific diagnostic markers and genetic testing. Enhancing awareness and understanding of these entities is essential to improve diagnostic accuracy in pediatric neurology and hepatology.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"229-241"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Papillary thyroid carcinoma in a hyperfunctioning autonomous nodule : A diagnostic paradox challenging clinical guidelines. 甲状腺乳头状癌在功能亢进的自主结节：一个挑战临床指南的诊断悖论。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.464

José Paz-Ibarra, Marcio Concepción-Zavaleta, Jenyfer Fuentes-Mendoza, Hilder Herrera-Silvestre, Juan Eduardo Quiroz-Aldave, Paola Solis-Pazmino, Hubertino Díaz-Lazo, María Medrano-Huallanca, José Somocurcio-Peralta

{"title":"Papillary thyroid carcinoma in a hyperfunctioning autonomous nodule : A diagnostic paradox challenging clinical guidelines.","authors":"José Paz-Ibarra, Marcio Concepción-Zavaleta, Jenyfer Fuentes-Mendoza, Hilder Herrera-Silvestre, Juan Eduardo Quiroz-Aldave, Paola Solis-Pazmino, Hubertino Díaz-Lazo, María Medrano-Huallanca, José Somocurcio-Peralta","doi":"10.22088/cjim.17.2.464","DOIUrl":"10.22088/cjim.17.2.464","url":null,"abstract":"Background: Papillary thyroid carcinoma (PTC) is rarely found within hyperfunctioning (hot) thyroid nodules, which are typically considered benign. This case challenges the prevailing notion that functional autonomy excludes malignancy and underscores the need for a nuanced diagnostic approach.Methods: We report the case of a 63-year-old woman with clinical hyperthyroidism and a palpable right thyroid nodule. Biochemical tests confirmed thyrotoxicosis (TSH <0.005 µIU/mL, free T4 25.55 pmol/L and T3 7.69 pmol/L). Despite the hyperfunctioning profile, thyroid ultrasound showed high-risk features, including hypoechogenicity, microcalcifications, irregular margins, and elevated stiffness on shear wave elastography, classifying the lesion as ACR-TIRADS 5. A 99mTc scan confirmed a hyperfunctioning nodule. Fine-needle aspiration cytology (FNAC) revealed PTC. She subsequently underwent total thyroidectomy.Results: FNAC revealed PTC. Histopathology confirmed a 13 mm intrathyroidal papillary carcinoma with mixed classic (40%) and oncocytic (60%) subtypes, without capsular or extrathyroidal extension. The background thyroid tissue showed macrofollicular hyperplasia. The patient recovered uneventfully and did not require radioactive iodine ablation. Genetic testing was unavailable.Conclusion: This case illustrates that malignancy can coexist with hyperfunctioning thyroid nodules. Suspicious sonographic features should not be dismissed due to functional status. Cytological evaluation remains essential when ultrasound findings raise concern, supporting a shift toward integrated diagnostic decision-making in thyroid nodule assessment.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"464-469"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relapse-free survival and metastasis-free survival between patients with breast cancer receiving adjuvant or neoadjuvant therapy: A retrospective study in Iran. 接受辅助或新辅助治疗的乳腺癌患者的无复发生存期和无转移生存期：伊朗的一项回顾性研究

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.347

Mina Azarnia, Mehran Sharifi, Zahra Rezaeian, Saeedeh Arabzadeh, Shaghayegh Haghjooy Javanmard

{"title":"Relapse-free survival and metastasis-free survival between patients with breast cancer receiving adjuvant or neoadjuvant therapy: A retrospective study in Iran.","authors":"Mina Azarnia, Mehran Sharifi, Zahra Rezaeian, Saeedeh Arabzadeh, Shaghayegh Haghjooy Javanmard","doi":"10.22088/cjim.17.2.347","DOIUrl":"10.22088/cjim.17.2.347","url":null,"abstract":"Background: Breast cancer is the most common malignancy among women in Iran and worldwide. Although both neoadjuvant and adjuvant chemotherapies are widely used, their impact on relapse-free survival (RFS) and metastasis-free survival (MFS) in real-world settings remains unclear. This study aimed to compare RFS and MFS between neoadjuvant and adjuvant chemotherapy in breast cancer patients.Methods: A retrospective cohort study was conducted on patients who had received adjuvant or neoadjuvant therapy at Seyed Al-Shohada Hospital during July 2016 and July 2020. The cut-off date was July 202. Kaplan-Meier analysis and Cox regression models were used to evaluate RFS and MFS. To address potential confounding by indication due to non-randomized treatment assignment, inverse probability of treatment weighting (IPTW) was applied using propensity scores based on age, tumor grade, and molecular subtype.Results: Neoadjuvant therapy was significantly associated with increased relapse risk compared to adjuvant therapy in both multivariate (HR = 3.06, P = 0.030) and IPTW-weighted models (HR = 6.10, P = 0.002). No significant difference in MFS was observed between treatment groups. TNBC was identified as the strongest predictor of metastasis (HR = 6.45, P = 0.001). Subtype-specific analyses revealed better outcomes with adjuvant therapy in Luminal A and improved MFS/RFS with neoadjuvant therapy in TNBC.Conclusion: Adjuvant therapy was associated with better local disease control (RFS), while MFS was primarily influenced by tumor subtype. These findings highlighted the importance of subtype-tailored therapeutic strategies and supported the use of causal methods such as IPTW in observational oncology research.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"347-359"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gallstone disease as a clue for metabolic syndrome. 胆结石疾病是代谢综合征的线索。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.312

Valareza Alizadeh Bazrafshan, Alireza Rezapanah, Amin Dalili, Mojtaba Meshkat, Yalda Ravanshad, Tooraj Zandbaf

{"title":"Gallstone disease as a clue for metabolic syndrome.","authors":"Valareza Alizadeh Bazrafshan, Alireza Rezapanah, Amin Dalili, Mojtaba Meshkat, Yalda Ravanshad, Tooraj Zandbaf","doi":"10.22088/cjim.17.2.312","DOIUrl":"10.22088/cjim.17.2.312","url":null,"abstract":"Background: Nowadays, metabolic syndrome (MetS) is considered a global health concern. Patients with MetS are at 5- and 2-times higher risk of developing type 2 diabetes and gallstones, respectively. Although gallstone disease (GSD) and MetS are common, little is known about their association. This study aimed to compare the frequency of metabolic syndrome criteria between the GSD group and the control group.Methods: In this case-control study, we enrolled 432 subjects, including 216 with gallstones (184 females, 31 males) and 216 controls (187 females and 29 males without gallstones). Body mass index (BMI), waist and hip circumferences, fasting blood sugar (FBS), triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol, metabolic score for insulin resistance (METS-IR), and fibrosis score four index (FIB-4), were measured.Results: Out of 432 participants, 36% of the subjects had MetS documented. There were no significant differences between the case and control groups regarding age and gender (P=0.144 and P=0.674, respectively). The univariate analysis illustrated that individuals with GSD exhibited higher weight, BMI, hip and waist circumferences, waist-to-hip circumference ratio, total cholesterol, TG, LDL, FBS, METS-IR, and hypertension incidence than those without GSD. Conversely, HDL levels were significantly lower in subjects with GSD(P<0.05).Conclusion: Similar to cardiovascular diseases and type 2 diabetes mellitus, GSD seems strongly associated with MetS. Therefore, it is recommended that GSD patients be investigated and monitored for metabolic syndrome and its potential long-term consequences.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"312-318"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sama Vritti Pranayama breathing exercise on sleep disturbance and fatigue among hemodialysis patients: A quasi-experimental study. Sama vriti调息呼吸运动对血液透析患者睡眠障碍和疲劳的影响：一项准实验研究。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.457

Fariba Heydarian, Sepideh Mohammadi, Abbas Shamsalinia, Afsaneh Arzani

{"title":"Sama Vritti Pranayama breathing exercise on sleep disturbance and fatigue among hemodialysis patients: A quasi-experimental study.","authors":"Fariba Heydarian, Sepideh Mohammadi, Abbas Shamsalinia, Afsaneh Arzani","doi":"10.22088/cjim.17.2.457","DOIUrl":"10.22088/cjim.17.2.457","url":null,"abstract":"Background: Poor sleep quality and fatigue are common complications in hemodialysis patients. Although Sama Vritti pranayama breathing exercise as a yogic breathing is prescribed to improve sleep quality, its efficacy in this group of patients is not well established. The present study was conducted to examine the effects of Sama Vritti Pranayama applied to hemodialysis patients on sleep disturbance and fatigue.Methods: The pre-test/post-test quasi-experimental design was conducted in 60 hemodialysis patients. Data were collected from May to October 2023. A Sama Vritti pranayama breathing exercise was given to the experimental group (n= 30) twice a day for two months. Control group (n=30) received only routine hospital care. Sleep disturbance and fatigue were assessed by the Insomnia Severity Index (ISI) and Fatigue Assessment Scale (FAS), at baseline and after 2-month intervention.Results: The two groups were homogeneous in terms of demographic characteristics, insomnia severity (P=0.54) and fatigue score (P=0.74) at baseline. Following a 2-month intervention, insomnia severity (P=0.02) and fatigue score (P=0.00) were significantly better in the experimental group compared with the control group.Conclusion: A 2-month Sama Vritti pranayama breathing exercise can effectively reduce insomnia severity and minimize fatigue score of hemodialysis patients. Therefore, this breathing exercise as a feasible practice should be recommended for hemodialysis patients to manage sleep disturbance and fatigue.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"457-463"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red meat consumption: A comprehensive overview of the mechanistic evidence for the effects of oncogenes. 红肉消费：致癌基因影响的机制证据的全面概述。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.213

Erfan Mosharkesh, Neda Roshanravan

{"title":"Red meat consumption: A comprehensive overview of the mechanistic evidence for the effects of oncogenes.","authors":"Erfan Mosharkesh, Neda Roshanravan","doi":"10.22088/cjim.17.2.213","DOIUrl":"10.22088/cjim.17.2.213","url":null,"abstract":"Epidemiological studies have recently shown a very high correlation between consumption of red meat and meat products, the most important source of protein for humans, and cancer. The molecular basis of the red meat-cancer relationship is still poorly understood. The study of heme iron and N-nitroso metabolites, derived from the digestion of red meat, as possible inducers of oxidative stress and DNA damage, which is a major culprit of carcinogenic compounds and mutagenesis, has been pioneering. However, some other factors, like the time of cooking, temperature of cooking, and the direct or indirect contact of meat with flame during preparation, can also help in the formation and release of carcinogenic substances. This review aims to discuss the current evidence on the mechanistic associations between red meat intake and the activation of oncogenes that are central to tumorigenesis, and to generate new ideas for future studies. The synthesis and analysis of the existing evidence are a valuable resource for researchers and healthcare professionals trying to understand the complex interrelationships between dietary patterns, oncogenes, and the development of various cancers.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"213-228"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal histopathology spectrum in the biopsy-proven native kidney diseases of adult Iranian population, southern Iran: 2019-2024. 伊朗南部伊朗成年人群活检证实的原生肾脏疾病的肾脏组织病理学谱：2019-2024

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.403

Mohammadreza Akbari, Leila Malekmakan, Sahar Sanjarian, Maryam Pakfetrat

{"title":"Renal histopathology spectrum in the biopsy-proven native kidney diseases of adult Iranian population, southern Iran: 2019-2024.","authors":"Mohammadreza Akbari, Leila Malekmakan, Sahar Sanjarian, Maryam Pakfetrat","doi":"10.22088/cjim.17.2.403","DOIUrl":"10.22088/cjim.17.2.403","url":null,"abstract":"Background: Renal diseases strongly influence global health burden and healthcare costs, especially for countries with low and middle socio-demographic indices. This study aimed to provide data on kidney disorder patterns and compare results with our previous analysis of biopsy-proven renal diseases to determine how the pattern is changing in our region.Methods: This cross-sectional analysis of 2,392 native renal biopsies was performed from 2019 to 2024 at the Namazi Hospital, a tertiary referral healthcare center in Shiraz, Iran.Results: Of 2,392 native kidney biopsies, primary glomerulonephritis was the most common finding, with the leading diagnosis of membranous glomerulonephritis (MGN), followed by focal segmental glomerulosclerosis (FSGS), and mesangioproliferative GN (MesGN). For secondary GN, lupus nephritis (LN), diabetic nephropathy, and amyloidosis were prominent. Lupus nephritis was the only female-predominant subtype (p < 0.001). Significant male predominance was observed in MGN (p < 0.001), IgA nephropathy (p< 0.001), Amyloidosis (p< 0.05), and hypertensive nephropathy (p < 0.05), whereas most other renal biopsy subtypes showed no statistically significant gender differences (p > 0.05). Age-related analysis showed that LN was the predominant finding in patients <45 years, whereas MGN was the most common among older patients (P < 0.001).Conclusion: Comparing the proportions of biopsy results with our previous analysis revealed that FSGS and LN decreased dramatically, while MGN, Diabetic nephropathy, IgA nephropathy, and tubulointerstitial diseases showed increasing trends. These data provided essential clues for further studies on organizing renal health goals.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"403-411"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacillus Calmette-Guerin in controlling type 1 diabetes: A quasi-experimental randomized clinical trial. 卡介苗芽孢杆菌控制1型糖尿病：一项准实验随机临床试验。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.429

Mahtab Ordoei, Nasrin Behniafard, Nasim Namiranian, Samira Asadollahi, Saeede Jam-Ashkezari, Roghaye Razavi

{"title":"Bacillus Calmette-Guerin in controlling type 1 diabetes: A quasi-experimental randomized clinical trial.","authors":"Mahtab Ordoei, Nasrin Behniafard, Nasim Namiranian, Samira Asadollahi, Saeede Jam-Ashkezari, Roghaye Razavi","doi":"10.22088/cjim.17.2.429","DOIUrl":"10.22088/cjim.17.2.429","url":null,"abstract":"Background: T1DM is an autoimmune and chronic metabolic disorder characterized by the destruction of pancreatic beta cells. The Bacillus Calmette--Guérin (BCG) vaccine, originally used for tuberculosis prevention, has shown potential in modulating the immune response and improving beta-cell function. This study aimed to evaluate the therapeutic effects of two doses of BCG vaccine, administered four weeks apart, on glycemic control and selected immunological markers in patients with T1DM.Methods: In this single-center, double-blind randomized clinical trial, 33 patients with T1DM were enrolled and randomly assigned to intervention and control groups in a 1:1 ratio, matched by age and sex. The intervention group received two intradermal doses of the BCG vaccine, with a four-week interval. Fasting blood samples were collected at baseline and during follow-up to assess biochemical and immunological parameters. Patients were followed-up for 18 months. IRCT identifier: IRCT20201012049003N1; (date of registration: 2020/10/15).Results: The mean age of participants was 11.25±3.32 years in the control group and 10.69±3.22 years in the BCG group. Anti-ICA levels significantly decreased in the BCG group by the end of the follow-up period. Although there was no significant difference in fasting blood glucose levels between the two groups, a significant reduction in HbA1c was observed in the BCG group after 18 months.Conclusion: The findings suggest that BCG vaccination may contribute to improved long-term glycemic control, as evidenced by reduced HbA1c levels, in patients with T1DM. Additionally, the decrease in Anti-ICA levels indicates a potential immunomodulatory effect, supporting the therapeutic promise of BCG in autoimmune diabetes.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"429-435"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0