Caspian Journal of Internal Medicine最新文献_第2页

Oligoclonal band on the 5-year prognosis of patients with multiple sclerosis. 寡克隆带对多发性硬化患者5年预后的影响。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.284

Masoud Ghiasian, Mojtaba Khazaei, Sajjad Daneshyar, Elham Khanlarzadeh, Mohammad Amin Habibi

{"title":"Oligoclonal band on the 5-year prognosis of patients with multiple sclerosis.","authors":"Masoud Ghiasian, Mojtaba Khazaei, Sajjad Daneshyar, Elham Khanlarzadeh, Mohammad Amin Habibi","doi":"10.22088/cjim.16.2.284","DOIUrl":"10.22088/cjim.16.2.284","url":null,"abstract":"Background: Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS). Prognostic markers are essential for predicting disease progression and managing its impact. Oligoclonal bands (OCBs) are significant laboratory findings in MS, yet their prognostic role remains uncertain. This study aimed to evaluate the role of OCBs in the short-term progression of MS.Methods: We enrolled patients diagnosed with Relapsing-Remitting MS and conducted a follow-up for five years, during which we monitored their Expanded Disability Status Scale (EDSS) scores. Clinical manifestations were compared between patients with positive and negative OCBs. Statistical analysis was performed using SPSS 26.Results: Among the 140 participants, 41 (29%) were OCB-negative and 99 (71%) were OCB-positive. No significant differences were found regarding sex, age, family history, associated disease, and EDSS scores between the two groups at the beginning of the study. Throughout the five-year duration of the study, there was no disparity in the EDSS scores of patients belonging to the two groups. Notably, the mean number of relapses was 1.37 in OCB-negatives compared to 1 in OCB-positives, which was statistically significant (P=0.03). In other words, after 5 years, despite the high rate of recurrence in patients with negative OCB compared to patients with positive OCB, there was no difference in terms of prognosis (EDSS progress) between the two groups.Conclusion: While the presence of OCBs in patients with MS does not demonstrate a significant prognostic impact over a five-year follow-up period, it could potentially influence the rate of recurrence.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"284-288"},"PeriodicalIF":0.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare neurological odyssey: Gastric adenocarcinoma and leptomeningeal carcinomatosis - A Peruvian case study. 罕见的神经系统漫游：胃腺癌和脑膜轻脑癌-秘鲁病例研究。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.369

Juan Eduardo Quiroz-Aldave, María Del Carmen Durand-Vásquez, Ramiro Herrera Cabezas, Rossana Jimenez Asto, Carlos Cerrón Aguilar, Julia Cristina Coronado-Arroyo, Francisca Zavaleta-Gutiérrez, Luis Alberto Concepción-Urteaga, Benjamín Alberto Leiva, Marcio José Concepción-Zavaleta

{"title":"A rare neurological odyssey: Gastric adenocarcinoma and leptomeningeal carcinomatosis - A Peruvian case study.","authors":"Juan Eduardo Quiroz-Aldave, María Del Carmen Durand-Vásquez, Ramiro Herrera Cabezas, Rossana Jimenez Asto, Carlos Cerrón Aguilar, Julia Cristina Coronado-Arroyo, Francisca Zavaleta-Gutiérrez, Luis Alberto Concepción-Urteaga, Benjamín Alberto Leiva, Marcio José Concepción-Zavaleta","doi":"10.22088/cjim.16.2.369","DOIUrl":"10.22088/cjim.16.2.369","url":null,"abstract":"Background: Leptomeningeal carcinomatosis involves the diffuse infiltration of neoplastic cells in the central nervous system, affecting 5-8% of leukemia, breast, and lung cancer cases. Gastric cancer instances are rare, mostly in poorly differentiated adenocarcinomas. We report the first Peruvian case, featuring gastric adenocarcinoma.Case presentation: A 51-year-old woman presented with severe headache, vomiting, dizziness, blurred vision, tinnitus, bradyphrenia, reduced verbal fluency, sixth cranial nerve paresis, and non-reactive anisocoric pupils. Pleocytosis was found, with positive cytology for metastatic adenocarcinoma in cerebrospinal fluid, and a solid gastric mass defined as poorly differentiated adenocarcinoma. Due to her condition, the patient did not receive oncological management, evolving unfavorably and passing away twenty days later. Leptomeningeal carcinomatosis should be considered in patients with advanced cancer and meningeal symptoms. It is more predominant in women, with an average age of 53.84 years. Clinical presentation of leptomeningeal carcinomatosis varies, and diagnosis involves neuroimaging and cerebrospinal fluid cytology. Prognosis is unfavorable, often leading to fatality. Treatment protocols lack standardization, and personalized approaches, including targeted and systemic therapies, are explored for improved outcomes. The exceptional aspect of our case lies in the unique diagnosis of an abdominal tumor following the manifestation of neurological symptoms.Conclusion: It is important to suspect this condition among the causes of meningitis, especially in the presence of an underlying malignancy.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"369-374"},"PeriodicalIF":0.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12194435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiofrequency catheter ablation of atrioventricular reentrant tachycardia in patient with interruption of inferior vena cava: A case report. 射频导管消融治疗下腔静脉中断的房室折返性心动过速1例。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.375

Mohammad Taghi Hedayati Godarzi, Saeed Abrotan, Fatemeh Younesi, Mohamad Rashid, Ali Bijani

{"title":"Radiofrequency catheter ablation of atrioventricular reentrant tachycardia in patient with interruption of inferior vena cava: A case report.","authors":"Mohammad Taghi Hedayati Godarzi, Saeed Abrotan, Fatemeh Younesi, Mohamad Rashid, Ali Bijani","doi":"10.22088/cjim.16.2.375","DOIUrl":"10.22088/cjim.16.2.375","url":null,"abstract":"Background: Congenital anomalies can pose challenges during electrophysiology (EP) procedures in patients with tachyarrhythmias, making diagnosis and management of these cases quite difficult. An interrupted inferior vena cava, an uncommon congenital defect, is especially rare without associated congenital heart disease. In this setting, catheter ablation from femoral vein access becomes more challenging.Case presentation: A 23-year-old male with no cardiovascular risk factors or prior cardiovascular disease presented with atrioventricular reentrant tachycardia that converted to sinus rhythm after adenosine administration. The patient was scheduled for an electrophysiology study with catheter ablation if indicated. During the procedure, catheter advancement into the right atrium was unsuccessful, raising suspicion of an interrupted inferior vena cava (IVC). Radiofrequency ablation was subsequently performed successfully via the subclavian vein approach. Post-procedural computed tomography (CT) imaging confirmed interruption of the IVC.Conclusion: Accessing via the subclavian vein can facilitate catheter ablation when an interrupted inferior vena cava is present.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"375-380"},"PeriodicalIF":0.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of critically Ill COVID-19 patients: Exploring the potential of morphine and assessing disadvantages of acetaminophen. COVID-19危重症患者的管理：探索吗啡的潜力和评估对乙酰氨基酚的缺点。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.381

Seyed Mohammadreza Hashemian, Ameneh Jafari, Parviz Amri Maleh

引用次数: 0

Incidence of multiple sclerosis (MS) relapse after COVID-19 infection: A systematic review and meta-analysis. COVID-19感染后多发性硬化症（MS）复发的发生率：系统回顾和荟萃分析

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.192

Amin Momeni Moghaddam, Mohsen Rastkar, Atena Soltanzadi, Saeed Vaheb, Mahsa Ghajarzadeh

{"title":"Incidence of multiple sclerosis (MS) relapse after COVID-19 infection: A systematic review and meta-analysis.","authors":"Amin Momeni Moghaddam, Mohsen Rastkar, Atena Soltanzadi, Saeed Vaheb, Mahsa Ghajarzadeh","doi":"10.22088/cjim.16.2.192","DOIUrl":"10.22088/cjim.16.2.192","url":null,"abstract":"Background: COVID-19 could exacerbate the symptoms of autoimmune diseases such as multiple sclerosis (MS). Literature shows an increase in the incidence of relapse in patients with MS after COVID-19. We designed this systematic review and meta-analysis to estimate the pooled incidence of MS-relapse after COVID-19.Methods: We performed a systematic search in PubMed, Scopus, EMBASE, Web of Science, and Google scholar. Gray literature including references of the references and conference abstracts were also searched to find relevant articles. We extracted data regarding the total number of participants, the name of the first author, publication year, country of origin, mean age, mean disease duration, mean Expanded Disability Status Scale (EDSS), and the number of patients with relapse after COVID.Results: A literature search revealed 5160 articles, after deleting duplicates, 2270 remained. After careful evaluation of the full texts, twelve studies were included for meta-analysis. Totally, 1595 patients with MS who had a history of COVID-19 were evaluated. Most studies were done in Iran. The mean age of included patients ranged between 35 and 49 years, and mean durations of the disease were between 7and 15.4 years. The incidence of relapse ranged between 2% and 20% in included studies.The pooled incidence of relapse after COVID-19 was 7% (95%CI:5-10%) (I2=64%, p<0.001).Conclusions: The results of this systematic review and meta-analysis show that the pooled incidence of MS-related relapse after COVID-19 is 7%.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"192-197"},"PeriodicalIF":0.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decreased plasma levels of sestrin-1 and sestrin-2 in patients with coronary artery disease and their association with the disease severity. 冠心病患者血浆凝血素-1和凝血素-2水平降低及其与疾病严重程度的关系

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.255

Somayeh Heidar Beygi, Gholamreza Namazi, Parastoo Asa, Raziyeh Salami, Alireza Mafi, Fariba Raygan

{"title":"Decreased plasma levels of sestrin-1 and sestrin-2 in patients with coronary artery disease and their association with the disease severity.","authors":"Somayeh Heidar Beygi, Gholamreza Namazi, Parastoo Asa, Raziyeh Salami, Alireza Mafi, Fariba Raygan","doi":"10.22088/cjim.16.2.255","DOIUrl":"10.22088/cjim.16.2.255","url":null,"abstract":"Background: Oxidative stress has been well established to participate in the pathology of coronary artery disease (CAD). Sestrin family of proteins have recently emerged as important suppressors of oxidative stress. However, only few studies have reported the levels of sestrins and their clinical significance in CAD patients.Methods: Participants were ninety patients referred to the cardiac angiography unit for cardiac angiography. Thirty-two subjects were diagnosed as having stable CAD, twenty patients had unstable CAD and thirty-eight subjects had no CAD. All patients underwent angiography and the severity of coronary stenosis was calculated by modified Gensini score. The levels of glucose, triglyceride, total cholesterol, HDL, LDL, hs-CRP and hematological parameters were determined in the fasting blood samples by routine methods. Plasma levels of sestrin-1 and sestrin-2 were measured by ELISA.Results: Although the plasma levels of sestrin-1 were significantly lower in both case groups compared with the control group (P<0.001), there were no significant differences in sestrin-1 levels between the two patient groups. The levels of sestrin-2 were also significantly lower in both CAD groups than in controls (P=0.001), but no significant difference was found between stable and unstable patients. In the whole study subjects, plasma sestrin-1 and sestrin-2 showed negative correlation with the coronary artery score. By multivariate analysis only sestrin-2 levels were significantly related to CAD severity.Conclusion: Our findings showed a negative association of sestrin levels and the coronary stenosis severity.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"255-262"},"PeriodicalIF":0.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical activity and elevated liver enzymes: A cross-sectional study from the PERSIAN Guilan cohort study. 体力活动和肝酶升高：来自波斯桂兰队列研究的横断面研究。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.246

Heydar Ali Balou, Farahnaz Joukar, Milad Shahdkar, Mahdi Orang Goorabzarmakhi, Saman Maroufizadeh, Fariborz Mansour-Ghanaei

{"title":"Physical activity and elevated liver enzymes: A cross-sectional study from the PERSIAN Guilan cohort study.","authors":"Heydar Ali Balou, Farahnaz Joukar, Milad Shahdkar, Mahdi Orang Goorabzarmakhi, Saman Maroufizadeh, Fariborz Mansour-Ghanaei","doi":"10.22088/cjim.16.2.246","DOIUrl":"10.22088/cjim.16.2.246","url":null,"abstract":"Background: Regular physical activity promotes health that can affect liver health, particularly modulating liver enzymes. The objective of this study was to assess the association between physical activities and elevated liver enzyme levels in the population of the Prospective Epidemiological Research Studies of the Iranian Adults (PERSIAN) Guilan cohort study (PGCS).Methods: This cross-sectional study was conducted on 10,519 individuals from the PGCS population. The demographical and clinical data of participants were collected. The study involved measuring the levels of physical activity and liver enzymes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and γ-glutamyl transferase (GGT). The study assessed physical activity intensity using standardized classification based on the energy costs of different activities, which was calculated through questionnaires administered in three tertiles. The relationship between physical activity and elevated liver enzymes was examined using the Cochran-Armitage test for trend and logistic regression.Results: The average age of individuals was 51.52±8.90 years, and 53.6% were women. The prevalence of elevated ALT, AST, and GGT decreased with increasing physical activity (p<0.001, 0.010, and <0.001, respectively). According to fully adjusted model, participants with low physical activity levels had higher odds for elevated ALT and GGT compared to the participants with high physical activity levels (OR=1.15, 95% CI: 1.04-1.31 and OR=1.37, 95% CI: 1.16-1.61, respectively) (p<0.05).Conclusion: Higher physical activity levels were associated with a lower prevalence of elevated liver enzymes, suggesting that regular physical activity may positively affect liver health.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"246-254"},"PeriodicalIF":0.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mucormycosis in patients infected with the delta strain of COVID-19 virus, effective of some factors in the prevalence and patient prognosis in Shahid Beheshti Hospital, Kashan, central Iran. 伊朗中部卡尚市Shahid Beheshti医院新冠病毒三角洲株感染患者的毛霉病及其影响患者预后的因素

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.239

Zahra Soleimani, Kamal Esalatmanesh, Hossein Hooshyar, Habibollah Rahimi, Mojtaba Reisee, Roozbeh Esalatmanesh

{"title":"Mucormycosis in patients infected with the delta strain of COVID-19 virus, effective of some factors in the prevalence and patient prognosis in Shahid Beheshti Hospital, Kashan, central Iran.","authors":"Zahra Soleimani, Kamal Esalatmanesh, Hossein Hooshyar, Habibollah Rahimi, Mojtaba Reisee, Roozbeh Esalatmanesh","doi":"10.22088/cjim.16.2.239","DOIUrl":"10.22088/cjim.16.2.239","url":null,"abstract":"Background: Opportunistic infections such as mucormycosis, are spread in COVID-19 patients due to the use of corticosteroids therapy. This study aimed to determine the prevalence of mucormycosis in patients infected with the delta strain of the COVID-19 virus and evaluated some effective factors in the prevalence and patient prognosis.Methods: This study was performed on 44 COVID patients with co-infection to mucormycosis who were admitted to Shahid Beheshti Hospital, Kashan in 2022. The COVID diagnosis was based on clinical signs and a positive PCR test, the diagnosis of mucormycosis was based on a positive laboratory report of fungi culture medium. The patient outcomes were recorded and CALL scoring system was used to determine the severity of the disease. The results were analyzed by descriptive statistics using SPSS 16 software.Results: Of 44 COVID patients infected with mucormycosis, 26 (59.1%) had diabetes. All 44 patients had a history of taking steroids with an average daily dose of 48.77±65.15 mg. Twenty-six (59.1%) patients were admitted to the ICU, 18 (40.9%) required intubation. Sixteen (36.4%) patients died. A significant decries observed in lymphopenia after treatment of patients (p<0.0001). CALL scores using showed that 33 (75%) patients had severe risk factors.Conclusion: Uncontrolled diabetes and hypertension are the two most common risk factors of mucormycosis in COVID patients. High use of glucocorticoid drugs and immune suppression are predisposing causes for opportunistic organisms. Accurate laboratory diagnosis of mucormycosis plays an important role in treatment of patients and in controlling the disease.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"239-245"},"PeriodicalIF":0.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive systematic review and meta-analysis of uterine cancer in Asian countries. 亚洲国家子宫癌的综合系统回顾和荟萃分析。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.215

Mohebat Vali, Zahra Maleki, Mohammad-Ali Jahani, Sina Nazemi, Mousa Ghelichi-Ghojogh, Soheil Hassanipour, Mostafa Javanian, Hossein-Ali Nikbakht

{"title":"A comprehensive systematic review and meta-analysis of uterine cancer in Asian countries.","authors":"Mohebat Vali, Zahra Maleki, Mohammad-Ali Jahani, Sina Nazemi, Mousa Ghelichi-Ghojogh, Soheil Hassanipour, Mostafa Javanian, Hossein-Ali Nikbakht","doi":"10.22088/cjim.16.2.215","DOIUrl":"10.22088/cjim.16.2.215","url":null,"abstract":"Background: Uterine cancer ranks among the leading causes of mortality in women, particularly prevalent in countries with low to moderate income levels. Present treatment and healthcare success rates are assessed by the survival rate index. This study aimed to determine the uterine cancer survival rate in Asia.Methods: Five international databases were analyzed to perform this systematic review: Medline/PubMed, ProQuest, Scopus, Web of Knowledge, and Google Scholar, until the end of August 2021. The Newcastle-Ottawa quality assessment form was utilized in the evaluation of quality for cohort studies. \"I2 statistic and Cochran test were used to check the analysis process and assess the heterogeneity among the studies. Also, the study year was used as the basis for a meta-regression analysis.Results: The study covered 75 papers in total. The survival rates of uterine cancer after one, three, five, and seven years are 76.68% (95% CI, 66.76-78.61), 63.56% (95% CI, 58.60-68.37), 59.04% (95% CI, 55.62-62.43), and 57.86% (95% CI, 51.16-64.42) according to the random model. Furthermore, according to the outcomes of the meta-regression, there was no correlation found between the study year and the survival rate.Conclusions: Compared to European and American countries, Asian countries have a poorer uterine cancer survival rate, which makes it crucial to improve the survival rate of patients through ensuring early diagnosis of the disease in its early stages and providing new diagnostic methods, modified surgical techniques, and targeted therapies.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"215-224"},"PeriodicalIF":0.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic value of serologic biomarkers for the detection of liver fibrosis in non-alcoholic fatty liver disease. 血清学生物标志物检测非酒精性脂肪肝肝纤维化的诊断价值

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.275

Mahsa Mohammadi, Keyvan Aminian, Farahnaz Joukar, Mohsen Rajabnia, Khaled Rahmani, Alireza Doostian, Fariborz Mansour-Ghanaei

{"title":"Diagnostic value of serologic biomarkers for the detection of liver fibrosis in non-alcoholic fatty liver disease.","authors":"Mahsa Mohammadi, Keyvan Aminian, Farahnaz Joukar, Mohsen Rajabnia, Khaled Rahmani, Alireza Doostian, Fariborz Mansour-Ghanaei","doi":"10.22088/cjim.16.2.275","DOIUrl":"10.22088/cjim.16.2.275","url":null,"abstract":"Background: The aim of this study was to evaluate the diagnostic accuracy of various non-invasive methods for Non-alcoholic fatty liver disease (NAFLD) diagnosis in an Iranian population. The methods studied included aspartate aminotransferase to platelet ratio index (APRI), fibrosis-4 (FIB-4) index, aspartate aminotransferase to alanine aminotransferase ratio (AAR), aspartate aminotransferase to platelet count index (AP index), fibrosis index (FI), NAFLD fibrosis score (NFS), Forns index, BARD score, BAAT score and PLALA score. The aim of the current study was to correlate these methods with liver stiffness measurement (LSM) and serum fibrosis markers, using FibroScan as the gold standard.Methods: In a cross-sectional study of 504 patients with NAFLD or non-alcoholic steatohepatitis (NASH), FibroScan examinations were performed and demographic, clinical and biochemical data were collected. Statistical analyses evaluated the performance of each diagnostic panel, calculating sensitivity, specificity, positive predictive value, negative predictive value and accuracy.Results: The APRI had high specificity (97.27%) but low sensitivity (4.12%) and limited discriminatory power AUC: 0.50) in the fibrosis panel. In contrast, Forns index and NFS had better AUC values (0.64 and 0.63, respectively), with the NFS having a sensitivity of 80%, indicating potential for broad-based screening. In the cirrhosis panel, the APRI was characterized by high specificity (98.21%) but had low sensitivity (4%) and limited discriminatory power (AUC: 0.51), while the FIB-4 had the highest AUC (0.67) and a sensitivity of 60%, suggesting its efficacy as a screening tool.Conclusion: NFS and FIB-4 showed promising performance among the evaluated panels for population screening.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"275-283"},"PeriodicalIF":0.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0