Caspian Journal of Internal Medicine最新文献

{"title":"Pulmonary function test and carotid intima-media thickness in chronic obstructive pulmonary disease.","authors":"Shahabaddin Sorouri, Maryam Naseri, Sepideh Hejazi","doi":"10.22088/cjim.16.3.487","DOIUrl":"10.22088/cjim.16.3.487","url":null,"abstract":"<p><strong>Background: </strong>Studies have shown that carotid intima-media thickness (CIMT) is an indicator of cardiovascular events and mortality and its increase has correlation with severe airflow obstruction in patients with COPD. The aim of this study was to investigate the association between pulmonary function and CIMT in COPD patients.</p><p><strong>Methods: </strong>This study was performed on two groups of patients with and without COPD (cases & controls) who were referred to pulmonary clinics. Demographic, clinical, and laboratory tests were recorded in questionnaire. Spirometry was performed in cases and FVC, FEV1, and FEV1/FVC were measured. CIMT was determined via ultrasound.</p><p><strong>Results: </strong>Our results indicated that right carotid IMT was 0.51±0.112 mm and 0.65±0.131 mm in the control and case groups, respectively (p< 0.001). Left CIMT was 0.48±0.089 mm and 0.68±0.113 mm in the control and case groups, respectively (p< 0.001). FEV1 and FEV1/FVC had an inverse and significant correlation with IMT of the carotid (both right and left carotid).</p><p><strong>Conclusion: </strong>The results indicated an inverse association between carotid IMT and lung function test in COPD patients.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"487-492"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rituximab versus azathioprine in maintenance therapy of patients with granulomatosis with polyangiitis.","authors":"Samira Alesaeidi, Masoud Radnia, Soheil Tavakolpour, Seyed Behnam Jazayeri, Shima Loni","doi":"10.22088/cjim.16.3.480","DOIUrl":"10.22088/cjim.16.3.480","url":null,"abstract":"<p><strong>Background: </strong>Granulomatosis with polyangiitis (GPA) is a rare disease affecting medium-small vessels, causing granuloma formation and inflammation. This study aimed to assess the efficacy and safety of RTX versus Azathioprine (AZA) for maintenance treatment in GPA patients.</p><p><strong>Methods: </strong>This retrospective cohort study involved a review of medical records of recently diagnosed GPA patients undergoing maintenance treatment with RTX or AZA. The main variable was the frequency of relapses within an 18-month follow-up period. Additionally, the study compared changes in BVAS.WG score (The Birmingham Vasculitis Activity Score-Wegner specific) and Damage (vasculitis damage index (VDI)), mortality, and treatment complications between the two groups.</p><p><strong>Results: </strong>Among the 43 patients receiving RTX maintenance treatment, 8 (18.6%) experienced relapses during 24 months follow-up, while 14 (66.6%) out of the 21 patients receiving AZA relapsed (Hazard Ratio = 6.9 and 95% confidence interval = 1.95-19.3, p <001). Notably, the increase in the BVAS-WG score was significantly lower in the RTX group compared to the AZA group (p <001). The cumulative steroid dose was 143±21 mg in the RTX group and 125±25 mg in the AZA group (P = 0.1). Treatment side effects were similar in both groups (p >0.05).</p><p><strong>Conclusion: </strong>Maintenance treatment with RTX is associated with better treatment response and lower relapse rate compared to AZA. There was no difference in treatment complications between AZA or RTX in maintenance treatment.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"480-486"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between serum irisin levels and renal function in patients with type 2 diabetes mellitus.","authors":"Robab Aboutorabi, Golrokh Hariri, Zahra Mazloum Khorasani, Hassan Mehrad-Majd","doi":"10.22088/cjim.16.3.493","DOIUrl":"10.22088/cjim.16.3.493","url":null,"abstract":"<p><strong>Background: </strong>Irisin, a myokine implicated in metabolic hemostasis, have been investigated in relation to type 2 diabetes mellitus (T2DM), yet findings on its serum levels and association with diabetic complications such as nephropathy remain inconsistent. This study aimed to assess the relationship between serum irisin levels and renal function in T2DM patients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted involving 140 individuals diagnosed with T2DM. Demographic, anthropometric, and clinical data were recorded. Fasting blood samples were collected to determine serum irisin levels using the ELISA method. Additional biochemical measurements included fasting blood glucose, creatinine, HDL, LDL, triglycerides, HbA1c, and urinary albumin. Correlations between irisin levels and these parameters were analyzed. Patients were divided into two groups based on glomerular filtration rate (GFR) and albumin-to-creatinine ratio (ACR) to assess associations between irisin levels and renal function.</p><p><strong>Results: </strong>No statistically significant difference in serum irisin levels was observed between patients with reduced renal function (GFR≤60) and those with GFR>60 (10.45±6.54 vs. 13.32±10.59 ng/ml, P=0.08). In stratified analysis by ACR, patients with nephropathy displayed a non-significantly lower irisin level than those without (11.70±8.18 vs. 13.38±11.51, P=0.33). Serum irisin showed no significant correlations with FBS (P=0.05), insulin (P=0.06), LDL (P=0.96), HDL (P=0.61), or BMI (P=0.42).</p><p><strong>Conclusion: </strong>Lower irisin levels in T2DM patients with reduced renal function or nephropathy may indicate a potential role for irisin in diabetic renal disease progression. Serum irisin could serve as a prognostic biomarker for diabetic nephropathy pending further validation.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"493-499"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyoderma gangrenosum, as the first clinical presentation of systemic lupus erythematous, a case report and comprehensive literature review.","authors":"Shahrzad Rahmani, Azadeh Goodarzi, Amirhossein Akbarzadehpasha, Homa Abri, Amir Mohamad Sadeghian, Elham Behrangi, Azadeh Laali, Nasrin Shayanfar, Shiva Lotfi","doi":"10.22088/cjim.16.3.577","DOIUrl":"10.22088/cjim.16.3.577","url":null,"abstract":"<p><strong>Background: </strong>Pyoderma gangrenosum (PG) can be related to a range of systemic and hematologic diseases. The relationship between systemic lupus erythematosus (SLE) and PG has rarely been discussed.</p><p><strong>Case presentation: </strong>In this case study, we report on an SLE patient who presented with PG. The patient is a 53-year-old woman with the chief complaint of developing painful erythematous pustules on her right flank 3 days after hysterectomy surgery. In the span of 3 months, the patient was treated with antibiotics and intra-lesional corticosteroids with no improvement. Meanwhile, she developed symptoms such as polyarthralgia, pleural effusion, hemolytic anemia, and thrombocytopenia, while anti-dsDNA came out positive.</p><p><strong>Result: </strong>Based on pathology results in combination with clinical and para-clinical findings according to the SLICC criteria for SLE 2012, our patient was diagnosed as an active case of SLE presenting with PG. We also searched for and gathered the latest articles on this issue (from 2017 until 2022) to present the most updated review study on the topic in this article.</p><p><strong>Conclusion: </strong>Considering the abundance of PG and SLE concomitance reported cases (more than 30), it might be time to pay more attention to SLE as the underlying cause of PG and keep in mind that any unhealing ulcer in patients with connective tissue disorders should be evaluated for PG. Considering the various treatment options for PG, it is essential that the treatment of choice should cover symptoms of both PG and the underlying disease.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"577-583"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"99mTc-pertechnetate cut-off to distinguish Graves' disease from subacute thyroiditis.","authors":"Amir Gholami, Mahsa Sabbaghi, Hoda Shirafkan, Seyyed Hossein Mousavie Anijdan","doi":"10.22088/cjim.16.3.513","DOIUrl":"10.22088/cjim.16.3.513","url":null,"abstract":"<p><strong>Background: </strong>The cause of thyrotoxicosis can be determined through the thyroid uptake of 99mTc-pertechnetate<b>.</b> The goal of the study was to calculate the cut-off value of 99mTc-pertechnetate of the thyroid gland for the differential diagnosis of Graves' disease from subacute thyroiditis.</p><p><strong>Methods: </strong>A total of 60 patients were included in the study<b>.</b> Based on thyroid scan findings, 30 patients were in the Graves group and 30 of them had been diagnosed as subacute thyroiditis. Biochemical parameters, thyroid scintigraphy, and the percentage thyroidal 99mTc-pertechnetate uptake results were thoroughly assessed.</p><p><strong>Results: </strong>The mean percentage 99mTc-pertechnetate uptake in Graves group was much higher than that of the subacute thyroiditis group, which was statistically significant (P <0.001). Receiver operating characteristic (ROC) analysis revealed that the uptake cut-off value of 1.1% had the sensitivity and specificity of 97% and 95%, respectively.</p><p><strong>Conclusion: </strong>The findings depicted that the cutoff value of 1.1% for 99mTc-pertechnetate uptake could be a helpful index to differentiate Graves' disease from subacute thyroiditis, especially when it is difficult to distinguish between the two diseases using conventional diagnostic methods.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"513-518"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to dietary approaches to stop hypertension (DASH), Mediterranean diet, and plant-based dietary pattern with systolic and diastolic blood pressure: A cross-sectional analysis.","authors":"Zahra Hassanzadeh-Rostami, Mahsa Moazen, Maryam Ranjbar Zahedani, Seyed Jalil Masoumi","doi":"10.22088/cjim.16.3.468","DOIUrl":"10.22088/cjim.16.3.468","url":null,"abstract":"<p><strong>Background: </strong>Dietary patterns based on plant foods are proposed as a means of controlling blood pressure. This study aimed to assess the adherence to Dietary Approaches to Stop Hypertension (DASH), Mediterranean, and plant-based dietary pattern and their association with systolic (SBP) and diastolic (DBP) blood pressure among patients with hypertension participated in the SUMS Employees Health Cohort Study (SUMS EHCS).</p><p><strong>Methods: </strong>This cross-sectional study included 226 adults with hypertension, enrolled in the SUMS EHCS. The score of DASH, Mediterranean, and plant-based dietary patterns were measured, using a- 116 item food frequency questionnaire (FFQ). Plant-based dietary indices were measured and comprised of total (t-PDI), healthy (h-PDI), and unhealthy (u-PDI) plant-based dietary index. The association of each dietary score with SBP and DBP were analyzed by multivariate linear regression after adjusting for age, sex, educational level, marital status, smoking, BMI, energy intake, physical activity, having other diseases, and family history of hypertension.</p><p><strong>Results: </strong>The means of SBP and DBP were 127.82±15.87 and 83.51±11.22 mmHg, respectively. No significant association was seen between DASH or Mediterranean score with SBP and DBP after controlling the confounders. Although, t-PDI was significantly associated with both SBP (β; -0.53, 95% CI; -0.91, -0.15) and DBP (β; -0.30, 95% CI; -0.54, -0.03), h-PDI and u-PDI was not significantly associated with blood pressure after taking all the potential confounders into account.</p><p><strong>Conclusion: </strong>No significant associations could be found between DASH, Mediterranean, and healthy or unhealthy plant-based dietary index, and blood pressure levels among hypertensive individuals.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"468-479"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An investigation of the Effect of Antihypertensive drugs on Arteriovenous Fistula Maturation in Patients with Hemodialysis.","authors":"Fatemeh Mahmoudlou, Pouya Tayebi, Ali Akbar Moghadamnia, Ali Bijani","doi":"10.22088/cjim.16.3.500","DOIUrl":"10.22088/cjim.16.3.500","url":null,"abstract":"<p><strong>Background: </strong>The maturation of the arteriovenous fistula (AVF) is necessary for successful hemodialysis treatment. However, the role of antihypertensive drugs in influencing AVF maturation remains uncertain. This study investigated the AVF maturation in patients with renal failure treated with antihypertensive medications.</p><p><strong>Methods: </strong>A prospective cohort study was conducted on 73 patients who needed to be treated with hemodialysis through AVF. Demographic information, medication, underlying diseases, blood pressure changes, surgical information, and the time of AVF maturation were collected during the study. Descriptive statistics and survival analysis were employed to assess the outcomes.</p><p><strong>Results: </strong>The mean age of patients was 53.96±13.65 years, with 38 (52.1%) males and 35 (47.9%) females. The mean AVF maturation time was 104.87±1.02 days, and the rate of AVF maturation was 87.7%. Among the comorbidities, the rate of AVF maturation in diabetic patients (78.4%) versus non-diabetic (97.2%) exhibited a notably diminished effect (P = 0.028). There was a significant association between mean intraoperative arterial blood pressure (123.45±2.89 mmHg) and AVF maturation time (P = 0.033). Furthermore, there were not any significant differences in the use of antihypertensive medications on AVF maturation time or rates.</p><p><strong>Conclusion: </strong>Our study findings suggest that the administration of antihypertensive medications did not demonstrate a significant correlation with either the AVF maturation outcome or the time required for maturation.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"500-506"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spirulina-fortified salad dressing on body composition and anthropometric indices in hypertensive patients: A tipple-blind randomized placebo-controlled trial.","authors":"Elnaz Ghaem Far, Siavash Babajafari, Zohreh Ghaem Far, Salman Mohammadi, Mehran Nouri, Javad Kojuri, Elham Ashrafi-Dehkordi, Mohammad Hossein Rahmani, Seyed Mohammad Mazloomi","doi":"10.22088/cjim.16.3.553","DOIUrl":"10.22088/cjim.16.3.553","url":null,"abstract":"<p><strong>Background: </strong>Numerous studies have demonstrated that improving anthropometric indices through a healthy diet and exercise can aid individuals with high blood pressure. Additionally, research suggests that consuming Spirulina, a type of microalga, could positively impact body composition and anthropometric indices. The purpose of this study was to determine the effects of spirulina-fortified salad dressing on anthropometric indices and body composition in patients with hypertension.</p><p><strong>Methods: </strong>Forty-eight (19 men and 22 women) patients with hypertension randomly received either spirulina-fortified salad dressing containing 2 gr spirulina (SSD, n = 22) or a placebo salad dressing (PSD, n = 19) daily for eight weeks. This study was registered at https://www.irct.ir/ (the Iranian registry of clinical trials identifier: IRCT20200404046940N1).</p><p><strong>Results: </strong>There was a change in body composition and anthropometric indices from baseline to 8 weeks. We observed that the mean change±SD of waist circumference after the SSD intervention (-2.86±4.02 cm) was significantly different from that of the PSD intervention (0.38±9.47 cm). Although no between-group difference was observed, a statistically significant reduction in body fat-free mass (FFM) occurred in the PSD group after the intervention. Meanwhile, within-group mean change±SD of body fat-free mass (FFM, 1.04±5.39 kg) and body fat mass (FM, -0.73±1.83 kg) was significant only in the SSD group. However, no significance between-group difference was observed in terms of FFM and FM changes.</p><p><strong>Conclusion: </strong>The present study's findings suggest that consuming spirulina-fortified dressing can improve the status of risk factors associated with hypertension and cardiovascular diseases.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"553-561"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of patient-oriented intervention in primary prevention of cardiovascular diseases with statins: Open-label randomized study.","authors":"Elena V Bochkareva, Sergey A Boytsov, Oxana M Drapkina, Oleg G Melikhov, Ekaterina K Butina, Irina V Kim","doi":"10.22088/cjim.16.3.458","DOIUrl":"10.22088/cjim.16.3.458","url":null,"abstract":"<p><strong>Background: </strong>Poor adherence to treatment is an obstacle to reach the target level of lipids. The purpose of the study was to investigate the impact of patient-oriented intervention with primary focus on patients' adherence to lipid-lowering therapy on low-density lipoprotein cholesterol (LDL-C) in patients with dyslipidemia and receiving statins for primary prevention of cardiovascular diseases (CVD).</p><p><strong>Methods: </strong>A prospective, open-label, randomized, multicenter study in parallel groups. Data was collected from 11 study sites. 2,912 patients were recruited between June 2018 and August 2019. Test Intervention: extended consultation on drug compliance, patient-oriented printed materials about CVD prevention, SMS- and phone reminders. The primary endpoint was LDL-C. Chi-square test or Fisher's exact test was used for qualitative variables. Paired Wilcoxon test was used to compare the variables between patient visits. The odds ratio (OR) at 95% confidence interval (CI) was defined as the ratio of the chance of fulfilling the criterion in the group or subgroup (subpopulation).</p><p><strong>Results: </strong>At 12 month, the number of patients achieving target levels of LDL-C, total cholesterol (TC) and blood pressure (BP) was significantly higher in the intervention group vs control (LDL-C: 80% vs. 70%, OR: 1.68, 95% CI: 1.40 to 2.01, p<0.001; TC: 80% vs. 67%, OR: 1.92, 95% CI: 1.60 to 2.29, p<0.001; BP: 85% vs 79%, OR: 1.49, 95% CI:1.22 to 1.83, p=0.0001).</p><p><strong>Conclusion: </strong>Proposed patient-oriented intervention helps to achieve the target level of LDL-C, TC and supports better control of BP in patients receiving statins for primary prevention of CVD.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"458-467"},"PeriodicalIF":1.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the results of knee osteoarthritis treatment with intra-articular injection of steroid (methylprednisolone) and hyaluronic acid.","authors":"Seyyed Reza Aghapour, Hamid Mohammadi, Seyyed Poyan Aghapour, Khashayar Farnoud, Yasin Sharifzadeh","doi":"10.22088/cjim.16.3.437","DOIUrl":"10.22088/cjim.16.3.437","url":null,"abstract":"<p><strong>Background: </strong>Treatments for osteoarthritis, including steroids and nonsteroidal anti-inflammatory drugs, are not very satisfactory. Therefore, we decided to compare the therapeutic results of intra-articular injection of hyaluronic acid and methylprednisolone.</p><p><strong>Methods: </strong>In this single-blind clinical trial, 132 patients with osteoarthritis of the knee were randomly assigned to two treatment groups; hyaluronic acid and methylprednisolone. Treatment results were measured based on the standard McMaster Universities Arthritis Index (WOMAC) questionnaire.</p><p><strong>Results: </strong>Although the desired level of satisfaction was higher in the short-term in the methylprednisolone group and in the long-term in the hyaluronic acid group, however, these differences were not significant.</p><p><strong>Conclusion: </strong>The recovery of patients is better with methylprednisolone injection in the short term and hyaluronic acid in the long term. However, since methylprednisolone has complications, it is recommended to consider hyaluronic acid as a suitable drug in the treatment process.</p>","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"437-443"},"PeriodicalIF":1.0,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}