Caspian Journal of Internal Medicine最新文献_第3页

Prognostic role of monocyte-to-high-density lipoprotein ratio in mortality of VTE patients at Ardabil (2023-2024). 单核细胞与高密度脂蛋白比值在静脉血栓栓塞（VTE）患者死亡率中的预后作用（2023-2024）。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.328

Reza Aghah, Sevda Mikaeili Mirak, Nazli Javaheri, Atabak Sedigh-Namin, Shafagh Aliasgharzadeh

{"title":"Prognostic role of monocyte-to-high-density lipoprotein ratio in mortality of VTE patients at Ardabil (2023-2024).","authors":"Reza Aghah, Sevda Mikaeili Mirak, Nazli Javaheri, Atabak Sedigh-Namin, Shafagh Aliasgharzadeh","doi":"10.22088/cjim.17.2.328","DOIUrl":"10.22088/cjim.17.2.328","url":null,"abstract":"Background: Venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE), is a leading cause of cardiovascular mortality. The monocyte-to-high-density lipoprotein ratio (MHR) is a novel inflammatory biomarker with potential prognostic value in VTE.Methods: Venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE), is a leading cause of cardiovascular mortality. The monocyte-to-high-density lipoprotein ratio (MHR) is a novel inflammatory biomarker with potential prognostic value in VTE.Results: The mortality rate was 9%. Higher MHR was significantly associated with mortality (adjusted OR: 1.102, 95% CI: 1.013-1.199, P = 0.023), indicating a 10.2% increased mortality risk per unit increase in MHR. No significant associations were found with hospital stay duration (P = 0.238, R² = 0.007), CT-scan findings (P = 0.60), or echocardiography results (P = 0.40).Conclusion: MHR may serve as a predictor of mortality in patients with VTE, offering a cost-effective tool for risk stratification. These findings support its potential use in identifying high-risk patients for targeted interventions. Prospective studies are needed to validate and extend these results.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"328-333"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep learning in imaging analysis for multiple sclerosis: Diagnosis and monitoring. 深度学习在多发性硬化成像分析中的应用：诊断和监测。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.242

Abdorreza Naser Moghadasi, Mahsa Owji, Nasim Rezaeimanesh

引用次数: 0

Viral respiratory infections and their co-occurrence among patients hospitalized in Ayatollah Rouhani Hospital, Babol, 2021-2024. 2021-2024年巴博尔阿亚图拉鲁哈尼医院住院患者的病毒性呼吸道感染及其合并症

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.412

Alireza Firouzjahi, Samaneh Rouhi, Mohammad Ranaee, Zahra Ahmadnia, Mahdieh Taheri, Sara Ghofrani Tabari, Somayeh Ahmadi Gooraji, Hossein Ghorbani

{"title":"Viral respiratory infections and their co-occurrence among patients hospitalized in Ayatollah Rouhani Hospital, Babol, 2021-2024.","authors":"Alireza Firouzjahi, Samaneh Rouhi, Mohammad Ranaee, Zahra Ahmadnia, Mahdieh Taheri, Sara Ghofrani Tabari, Somayeh Ahmadi Gooraji, Hossein Ghorbani","doi":"10.22088/cjim.17.2.412","DOIUrl":"10.22088/cjim.17.2.412","url":null,"abstract":"Background: Vaccination has reduced the viral respiratory diseases in the community, but it has not ended. This study was conducted to determine the distribution of COVID-19, the influenza virus, and the human respiratory syncytial virus (RSV).Methods: This retrospective, descriptive-analytical study was conducted based on patient file information in Babol City (2021-2024). Clinical examination of the patient, computed tomography (CT), and real-time polymerase chain reaction (PCR) were used to identify the viruses in 10,567 patients. Mean, standard deviation (SD), distribution (%), and logistic regression were used to analyze the data using SPSS-23 (p<0.05).Results: 83.34% and 16.65% of patients suffered from COVID-19 (12.95% ≥ 50 years old) and influenza (15.42%, ≤ 50 years old), respectively. The most underlying diseases were related to cardiovascular disease (17.47%). Female patients suspected of COVID-19 (females; 14.14% versus (vs) males; 11.87%) and influenza (females; 14.90% vs males; 15.62%) were more than male patients. COVID-19 (12.91%) and influenza (15.27%) in 2022 and 2023 showed a high distribution, respectively. Co-occurrence of COVID-19 and influenza was observed in one female. Gender, season, and year (each with a P-value of P=0.00) was associated in this descriptive analysis with the distribution of COVID-19. A significant relationship between season and year with the distribution of influenza was observed.Conclusion: A high distribution of COVID-19 was diagnosed among patients. Gender and year of study had a significant effect on COVID-19. Diagnosis and differentiation of the viral agent by molecular methods should be performed in a patient.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"412-421"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential impact of two functional variants in the VEGF gene on the risk and clinical characteristics of granulomatosis with polyangiitis: A case-control study. VEGF基因的两种功能变异对肉芽肿合并多血管炎的风险和临床特征的潜在影响：一项病例对照研究

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.374

Amirali Pourebrahimi, Mozhdeh Saghaei, Naeim Ehtesham, Huriyeh Hashemi, Seyed Amirhosein Mazhari, Hamidreza Karbalaei-Musa, Mohammad Javad Broujerdi, Meysam Mosallaei

{"title":"Potential impact of two functional variants in the VEGF gene on the risk and clinical characteristics of granulomatosis with polyangiitis: A case-control study.","authors":"Amirali Pourebrahimi, Mozhdeh Saghaei, Naeim Ehtesham, Huriyeh Hashemi, Seyed Amirhosein Mazhari, Hamidreza Karbalaei-Musa, Mohammad Javad Broujerdi, Meysam Mosallaei","doi":"10.22088/cjim.17.2.374","DOIUrl":"10.22088/cjim.17.2.374","url":null,"abstract":"Background: Granulomatosis with polyangiitis (GPA) is an autoimmune disorder that results from an interplay of genetic factors and environmental influences. We investigated the association between two polymorphisms in the VEGF gene, specifically rs2010963 and rs833061, and the likelihood of developing GPA.Methods: A case-control study involving 224 participants was conducted, comprising 104 individuals diagnosed with GPA and 120 control subjects. The high-resolution melting (HRM) technique was employed for genotyping these polymorphisms.Results: The findings revealed a significant difference in the distribution of the CC genotype and C allele for rs2010963 between the control and case groups (CC vs GG; OR: 2.687; 95% CI [1.185-6.264], P: 0.014; C vs G; OR: 1.628; 95% CI [1.097-2.421], P: 0.012). Moreover, patients with the GC + CC genotype exhibited elevated mean levels of creatinine, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), as well as a higher incidence of alveolar hemorrhage compared to those with the GG genotype. Concerning rs833061, no association with GPA risk was identified; however, correlations were noted with certain laboratory and clinical parameters, including PR3-ANCA levels, septal perforation, alveolar hemorrhage, renal involvement, and rapidly progressive glomerulonephritis (RPGN).Conclusion: The C allele of rs2010963 is linked to an increased risk of developing GPA and certain laboratory and clinical parameters, while the rs833061 polymorphism does not appear to be associated with GPA risk but is correlated with various laboratory and clinical indices.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"374-384"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RUNX1-IT1 and AK026392.1 long non-coding RNAs as early predictors of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in acute leukemia. RUNX1-IT1和AK026392.1长链非编码rna作为急性白血病患者异基因造血干细胞移植后急性移植物抗宿主病的早期预测因子

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.385

Mahsa Dabir, Shervin Manteghi, Mehrdad Payandeh, Amir Abass Rashidi, Fakhredin Saba

{"title":"RUNX1-IT1 and AK026392.1 long non-coding RNAs as early predictors of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in acute leukemia.","authors":"Mahsa Dabir, Shervin Manteghi, Mehrdad Payandeh, Amir Abass Rashidi, Fakhredin Saba","doi":"10.22088/cjim.17.2.385","DOIUrl":"10.22088/cjim.17.2.385","url":null,"abstract":"Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) offers curative potential for hematologic malignancies, yet acute graft-versus-host disease (aGVHD) remains a major complication. Long non-coding RNAs (lncRNAs) regulate immune responses and T-cell differentiation, raising interest in their possible role as biomarkers. This study aimed to evaluate the expression of RUNX1-IT1 and AK026392.1 in peripheral CD4⁺ T cells of allo-HSCT recipients with and without aGVHD.Methods: In a case--control design, 30 acute leukemia patients undergoing allo-HSCT were enrolled. Peripheral blood samples were obtained on day +7 post-transplantation. Patients were monitored for 100 days and classified as aGVHD (n=14) or non-GVHD (n=16) according to NIH criteria. Expression levels of RUNX1-IT1 and AK026392.1 were quantified using qRT-PCR and normalized to ABL. Statistical comparisons and ROC curve analyses were performed to assess diagnostic performance.Results: RUNX1-IT1 expression was significantly elevated in the aGVHD group (~14-fold increase, P=0.012) with an AUC of 0.75, sensitivity 64.3%, and specificity 75%. AK026392.1 showed no statistically significant difference (P=0.114) but demonstrated relatively high specificity (87.5%) with an AUC of 0.67. No significant differences in baseline demographic or clinical characteristics were observed between groups.Conclusion: RUNX1-IT1 upregulation in aGVHD patients supports its potential role in Th1-driven immune responses post-allo-HSCT. While AK026392.1 alone was not significant, its high specificity suggests value in combination with RUNX1-IT1 within multi-marker biomarker panels for aGVHD.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"385-391"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collagen-based dressings for diabetic foot ulcers: A systematic review. 胶原蛋白敷料治疗糖尿病足溃疡：系统综述。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-03-10 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.2.278

Shakiba Rahimi, Mahsa Hosseingholizade, Nahid Hashemi-Madani, Zahra Emami, Mohammad E Khamseh, Zahra Nadia Sharifi

{"title":"Collagen-based dressings for diabetic foot ulcers: A systematic review.","authors":"Shakiba Rahimi, Mahsa Hosseingholizade, Nahid Hashemi-Madani, Zahra Emami, Mohammad E Khamseh, Zahra Nadia Sharifi","doi":"10.22088/cjim.17.2.278","DOIUrl":"10.22088/cjim.17.2.278","url":null,"abstract":"Background: To evaluate the efficacy and safety of collagen-based dressings in the management of diabetic foot ulcers (DFUs), compared to standard wound care (SWC), human amniotic membrane allografts (hAMA), and decellularized extracellular matrix (dECM) products.Methods: A systematic review of randomized controlled trials (RCTs) and cohort studies published between December 2013 and March 2025 was conducted using PubMed, Scopus, and Web of Science. Eligible studies assessed collagen-based dressings for DFUs, with primary outcomes including wound area reduction, closure rates, and healing time. Adverse events were considered secondary outcomes. Due to heterogeneity, findings were narratively synthesized by dressing type.Results: Twenty-two studies (15 RCTs, 7 cohort studies) were included. Collagen-based dressings consistently outperformed SWC, achieving greater wound reduction (54.5--88.2%), higher closure rates (22.2--82.4%), and shorter healing times (21--83.5 days), with no serious treatment-related adverse events. Helicoll showed superior performance (wound reduction: 84--86.5%; closure: 50--71.4%). Comparisons with hAMA and dECM yielded mixed and heterogeneous results, without consistent evidence of superiority. RCTs favored hAMA over Apligraf, while some real-world studies reported the opposite. Findings on collagen/ORC/silver dressings versus dECM were also inconsistent.Conclusions: Collagen-based dressings are safe and effective for improving DFU healing when compared with standard wound care. However, current evidence is insufficient and heterogeneous to establish superiority over other advanced biologic therapies. Further head-to-head randomized trials are warranted.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 2","pages":"278-301"},"PeriodicalIF":1.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can dobutamine stress echocardiography predict improvement of left ventricular dyssynchrony after coronary artery bypass grafting? 多巴酚丁胺应激超声心动图能否预测冠状动脉旁路移植术后左室非同步化的改善？

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-21 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.158

Rezvanieh Salehi, Zahra Jabbary, Fariba Abaszadeh, Maryam Chenaghlou

{"title":"Can dobutamine stress echocardiography predict improvement of left ventricular dyssynchrony after coronary artery bypass grafting?","authors":"Rezvanieh Salehi, Zahra Jabbary, Fariba Abaszadeh, Maryam Chenaghlou","doi":"10.22088/cjim.17.1.158","DOIUrl":"10.22088/cjim.17.1.158","url":null,"abstract":"Background: For patients with advanced, diffuse Coronary artery disease (CAD), surgical myocardial revascularization via coronary artery bypass grafting (CABG) continues to represent the gold standard therapeutic approach. Given the paucity of studies demonstrating CABG benefits in patients with significant left intraventricular dyssynchrony (LVD), we conducted this study to evaluate how viable myocardial tissue volume, quantified by dobutamine stress echocardiography (DSE), predicts postoperative LVD improvement.Methods: This investigation employed a cross-sectional analytical design to assess 30 CABG candidates with moderate-severe ischemic cardiomyopathy. Myocardial viability evaluation utilized dobutamine stress echocardiography, complemented by tissue Doppler Imaging for synchronized assessment of regional LV contractility.Results: Demographic analysis revealed a study population aged 61.5±7.9 years (range: 47 to 85 years), comprising 73.3% males. Left ventricular ejection fraction (LVEF) measurements improved from 32.2±4.6% at baseline to 39.6±5.2 % following surgical revascularization (p<0.001). Postoperative resolution of left ventricular dyssynchrony occurred in 9 patients (30.0 %), whereas 19 patients (63.3 %) showed no improvement (p<0.001). Two patients (6.6 %) died due to progressive heart failure and inadequate revascularization.Conclusion: Our current study demonstrates significant postoperative improvements in LVEF, LVEDD, and left ventricular dyssynchrony. However, given that approximately two-thirds of cases showed only minimal improvement in dyssynchrony, it would be reasonable to consider cardiac resynchronization therapy (CRT) for these patients.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"158-162"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of dietary phytochemical index with sleep quality in older adults of Amirkola city. 阿米尔科拉市老年人膳食植物化学指数与睡眠质量的关系

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-21 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.181

Masooumeh Rabipour, Angela Hamidia, Reza Ghadimi, Seyed Reza Hosseini, Ali Bijani, Parvin Sajadi

{"title":"Association of dietary phytochemical index with sleep quality in older adults of Amirkola city.","authors":"Masooumeh Rabipour, Angela Hamidia, Reza Ghadimi, Seyed Reza Hosseini, Ali Bijani, Parvin Sajadi","doi":"10.22088/cjim.17.1.181","DOIUrl":"10.22088/cjim.17.1.181","url":null,"abstract":"Background: Diet can play a significant role in sleep regulation, particularly in older adults. This study aimed to investigate the association between the Dietary Phytochemical Index (DPI) and sleep quality among the elderly in Amirkola City.Methods: This case-control study was part of the second phase of the Amirkola Cohort Study on aging. A total of 800 elderly individuals aged ≥60 years (400 with good sleep quality and 400 with poor sleep quality, matched for age and sex) were randomly selected. Inclusion criteria comprised having complete demographic data in the cohort profile, no known history of malignancy (including gastric and intestinal cancers), absence of psychiatric or cognitive disorders (such as psychiatric hospitalization), and no drug addiction. Data were collected using the Pittsburgh Sleep Quality Index (PSQI) and a semi-quantitative food frequency questionnaire (SQ-FFQ), which were then analyzed statistically.Results: Total energy intake and the number of chronic diseases significantly impacted sleep quality (OR=1.002, 95% CI: 1.001-1.003, P = 0.004 and OR=1.257, 95% CI:1.170-1.352, p < 0.001, respectively). Furthermore, Poorer sleep quality was significantly associated with a higher number of chronic diseases in both gender, male and female (OR=1.244, 95% CI: 1.097-1.411, P = 0.001 and OR=1.225, 95% CI: 1.106-1.357, P < 0.001). However, Dietary Phytochemical Index (DPI) and Energy intake from plant sources did not show a significant effect on sleep quality.Conclusion: Dietary modifications and management of chronic diseases could be effective in improving sleep quality among the elderly. However, further research is recommended.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"181-190"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the effect of pirfenidone on lung CT scans in patients with severe COVID-19 Hospitalized at Shahid Sadoughi Hospital, Yazd, Iran. 研究吡非尼酮对伊朗亚兹德Shahid Sadoughi医院重症COVID-19患者肺部CT扫描的影响。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-21 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.163

Sakineh Khatoon Gholamrezaei, Mohammad Samet, Amir Pasha Amelshahbaz, Nasim Namiranian, Fatemeh Al-Sadat Aghaei Meybodi

{"title":"Investigating the effect of pirfenidone on lung CT scans in patients with severe COVID-19 Hospitalized at Shahid Sadoughi Hospital, Yazd, Iran.","authors":"Sakineh Khatoon Gholamrezaei, Mohammad Samet, Amir Pasha Amelshahbaz, Nasim Namiranian, Fatemeh Al-Sadat Aghaei Meybodi","doi":"10.22088/cjim.17.1.163","DOIUrl":"10.22088/cjim.17.1.163","url":null,"abstract":"Background: This study aimed to evaluate the effect of pirfenidone on lung CT scan lesions in patients with severe COVID-19.Methods: In this cross-sectional study, data were extracted from the electronic medical records of patients with severe COVID-19 who received one of the following treatments: pirfenidone alone (n= 40), prednisolone alone (n= 55), pirfenidone combined with methylprednisolone (n= 18), or supportive care only (n= 32). Chest CT images taken at baseline and two months post-treatment were assessed by a trained radiologist. p< 0.05 was considered statistically significant.Results: The distribution of initial CT scan findings, Comparison of CT scan findings at admission and two months post-discharge, as well as the extent of pulmonary fibrosis and ground-glass opacity (GGO) grades across the groups, showed no statistically significant differences. However, significant differences were observed in CT scan findings and GGO grades between the four study groups at two months post-discharge. Moreover, in both the pirfenidone (p= 0.00) and supportive care (p= 0.01) groups, the extent of pulmonary fibrosis between admission and two months post-discharge showed statistically significant changes.Conclusion: In summary, although antifibrotic agents such as pirfenidone may not lead to significant improvement in lung CT scan findings in patients with severe COVID-19, they may help slow the progression of pulmonary fibrosis following the acute phase of the disease.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"163-172"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional status impact on engraftment time in hematopoietic stem cell transplants (HSCT) in Semarang, Indonesia: A cross-sectional study. 在三宝垄，印度尼西亚，营养状况对造血干细胞移植（HSCT）移植时间的影响：一项横断面研究。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-21 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.152

Damai Santosa, Daniel Rizky, Kevin Tandarto, Ika Kartiyani, Vina Yunarvika, Desta Nur Ewika Ardini, Budi Setiawan, Eko Adhi Pangarsa, Catharina Suharti

{"title":"Nutritional status impact on engraftment time in hematopoietic stem cell transplants (HSCT) in Semarang, Indonesia: A cross-sectional study.","authors":"Damai Santosa, Daniel Rizky, Kevin Tandarto, Ika Kartiyani, Vina Yunarvika, Desta Nur Ewika Ardini, Budi Setiawan, Eko Adhi Pangarsa, Catharina Suharti","doi":"10.22088/cjim.17.1.152","DOIUrl":"10.22088/cjim.17.1.152","url":null,"abstract":"Background: Nutritional support is a critical consideration in the care of individuals undergoing hematopoietic stem cell transplantation (HSCT), given the metabolic alterations induced by intensive treatments. This study aimed to explore the correlation between nutritional status and the time to engraftment in HSCT patients at Dr. Kariadi General Hospital, Semarang, Indonesia.Methods: This study included adult patients with malignant diseases who underwent autologous or allogeneic HSCT at Dr. Kariadi General Hospital between 2013 and 2023. Nutritional status was evaluated using body mass index (BMI), energy intake, and the type and duration of nutritional support. Neutrophil and platelet engraftment were defined as the time to sustained absolute neutrophil count (ANC) ≥500 cells/mm³ and platelet count ≥20 × 10⁹/L, respectively, and correlations between numerical variables were analyzed using Pearson's test.Results: A total of 45 HSCT patients were involved in this study. There was a significant negative correlation between nutritional intake and neutrophil engraftment (r = -0.776, p <0.001) and platelet engraftment (r= -0.72, P = 0.00), indicating that as the engraftment time increased, nutritional intake decreased. Furthermore, a positive but weak correlation (r = 0.24, P = 0.10) was found between BMI and time to engraftment.Conclusion: The study highlights that nutritional status significantly influences engraftment time in HSCT patients, supporting the importance of comprehensive nutritional support to improve outcomes and shorten engraftment.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"152-157"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0