Caspian Journal of Internal Medicine最新文献_第3页

Ten-year surveillance and epidemiological patterns of measles and rubella: A study in the Babol County. 麻疹和风疹的十年监测和流行病学模式：在巴博尔县的一项研究。

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Caspian Journal of Internal Medicine Pub Date : 2025-06-22 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.424

Amirhossein Alizadeh-Nodehi, Hossein-Ali Nikbakht, Mohammad-Ali Jahani, Seyedeh-Niko Hashemi, Sharareh Asadi

{"title":"Ten-year surveillance and epidemiological patterns of measles and rubella: A study in the Babol County.","authors":"Amirhossein Alizadeh-Nodehi, Hossein-Ali Nikbakht, Mohammad-Ali Jahani, Seyedeh-Niko Hashemi, Sharareh Asadi","doi":"10.22088/cjim.16.3.424","DOIUrl":"10.22088/cjim.16.3.424","url":null,"abstract":"Background: The trend of measles and rubella has changed over the last two decades, with the increase in vaccination coverage and the establishment of the surveillance system. This study aimed to demonstrate the current status of the surveillance system and the epidemiological trend of measles and rubella.Methods: This cross-sectional study retrospectively investigated the status of the surveillance system and the epidemiological patterns of measles and rubella in Babol Mazandaran, during 2014-2023. The study included 348 patients diagnosed with rubella and measles (suspected and definite). Their information was obtained and analyzed from the health department's information registration system.Results: Out of 348 suspected cases (272 suspected cases of rubella and 76 suspected cases of measles), 2 cases were identified as rubella and 1 case as confirmed measles. 108 (31.03%) cases of suspected cases were in the age group below one year and 153(43.97%) cases were in the age group of 1 to 6 years. The age-specific incidence has decreased with increasing age (p <0.001), and the incidence of suspected cases has increased from 2014 to 2023 (p <0.001). The proportion of appropriate laboratory sample collection before and after COVID-19 was 100%. However, the source of infection remained unknown for all confirmed cases.Conclusion: The quality of data, timeliness, and sensitivity of the health surveillance system in the region under study are acceptable. However, continuous training for healthcare providers and upgrading the equipment and facilities at the regional level are needed to maintain and improve this situation.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"424-436"},"PeriodicalIF":1.0,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular involvement in Sweet's syndrome: A practical review. 心血管与斯威特综合征的关系：一个实用的回顾。

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Caspian Journal of Internal Medicine Pub Date : 2025-06-15 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.393

Margarida Cabral, Luís Graça Santos, Catarina Ruivo, João Morais

引用次数: 0

Incidence and prognostic significance of atrial fibrillation in patients with tako-tsubo syndrome-systematic review and meta-analysis. tako-tsubo综合征患者心房颤动的发生率及预后意义——系统回顾与荟萃分析

IF 1

Caspian Journal of Internal Medicine Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.405

Andrzej Osiecki, Krzysztof Sarwiński, Jakub Gąsior, Wacław Kochman, Dariusz Michałkiewicz, Agnieszka Pawlak

{"title":"Incidence and prognostic significance of atrial fibrillation in patients with tako-tsubo syndrome-systematic review and meta-analysis.","authors":"Andrzej Osiecki, Krzysztof Sarwiński, Jakub Gąsior, Wacław Kochman, Dariusz Michałkiewicz, Agnieszka Pawlak","doi":"10.22088/cjim.16.3.405","DOIUrl":"10.22088/cjim.16.3.405","url":null,"abstract":"Background: Tako-tsubo syndrome (TTs) is relatively young cardiovascular entity, being initially described in the 1991 by dr Hikaru Sato. Most patients with TTs are admitted to the hospital with the suspicion of acute coronary syndrome or present signs and symptoms typical for acute heart failure. Atrial arrhythmias are thought to complicate almost 10% of all TTs cases. The most prevalent among them is atrial fibrillation (AF). Our aim in this study was to systematically evaluate results of observational studies to assess the incidence and prognostic relevance of supraventricular tachyarrhythmias in TTs patients.Methods: We performed systematic search of the Cochrane Central Register of Controlled Trials, PubMed, and EMBASE databases for research evaluating the incidence and prognostic relevance of atrial fibrillation(AF)/atrial flutter(AFl)/atrial tachycardia(AT) in patients hospitalized due to TTs. Odd ratio (OR) with a 95% confidence interval (CI) was estimated using a random effect model.Results: 10 studies comprising 4183 patients were included. The incidence of atrial arrhythmias ranged between 7% to 33%. In our research, supraventricular tachyarrhythmias were associated with significant increased risk for all-cause death (OR 2.99; 95% CI: 2.36- 3.80; p < 0.05), intra-hospital mortality (OR 2.46; 95% CI: 1.30 - 4.63; p < 0.05) and long-term mortality (OR 3.01 95% CI: 2.33- 3.90; p < 0.05).Conclusions: Our meta-analysis suggests that atrial arrhythmias are associated with an elevated risk for short and long-term adverse outcomes in patients with TTs.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"405-416"},"PeriodicalIF":1.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Fampridine on cognition in patients with multiple sclerosis (MS): a systematic review and meta-analysis. 福普定对多发性硬化症（MS）患者认知功能的影响：一项系统综述和荟萃分析。

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Caspian Journal of Internal Medicine Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.384

Abdorreza Naser Moghadasi, Narges Ebrahimi, Sara Bagherieh, Aida Mohammadi, Mohammad Ali Sahraian, Mahsa Ghajarzadeh

{"title":"Effect of Fampridine on cognition in patients with multiple sclerosis (MS): a systematic review and meta-analysis.","authors":"Abdorreza Naser Moghadasi, Narges Ebrahimi, Sara Bagherieh, Aida Mohammadi, Mohammad Ali Sahraian, Mahsa Ghajarzadeh","doi":"10.22088/cjim.16.3.384","DOIUrl":"10.22088/cjim.16.3.384","url":null,"abstract":"Background: Cognitive impairment (CI) is a disabling complication in patients with multiple sclerosis (MS). Fampridine is used to improve walking abilities in subjects with MS while it is also used for improving cognition, although the results are heterogeneous. Therefore, we aimed to conduct a systematic review and meta-analysis to investigate the effect of fampridine on cognition in patients with MS.Methods: We performed a comprehensive search in PubMed, EMBASE, Scopus, Web of Science, google scholar, and also gray including references of the references and conference abstracts on January 1th 2020. We extracted data regarding the number of participants, first author, publication year, and country of origin, age, disease duration, Expanded Disability Status Scale (EDSS), duration of follow up, type of cognition test, and scores before and after the treatment.Results: We identified 4972 studies in the preliminary search. After deduplication, 2607 articles remained. Two researchers screened the title and the abstracts, removing 2590 studies. Finally, 15 studies remained for meta-analysis. The included studies were published between 2013 and 2021, and the most frequent country of origin was Denmark. The mean age of participants of the studies ranged between 39 and 53 years and the mean EDSS ranged between 4 and 5.8, respectively. The SMD (standardized mean difference) of Symbol Digit Modalities Test (SDMT) (after-before treatment) was 0.45(95%CI: 0.06-0.84) (I2=75.3%, p<0.001). The SMD of Paced Auditory Serial Addition Test (PASAT) (after-before treatment) was 0.25 (95%CI: 0.13-0.37) (I2=84.3%, p<0.001).Conclusions: Fampridine has a significant role in decreasing cognitive impairments is MS patients.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"384-392"},"PeriodicalIF":1.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of sumac seed (Rhus coriaria L.) capsules prepared from an aqueous extract in diabetic patients: A double-blind clinical trial study. 漆树籽（Rhus coriaria L.）水提取物胶囊对糖尿病患者的有效性：一项双盲临床试验研究。

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Caspian Journal of Internal Medicine Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.3.417

Hossein Asgarirad, Soleiman Mahjoub, Mohsen Yadollahi, Siamak Navaee, Shervin Amirkhanloo, AliSina Shohreh

{"title":"Effectiveness of sumac seed (Rhus coriaria L.) capsules prepared from an aqueous extract in diabetic patients: A double-blind clinical trial study.","authors":"Hossein Asgarirad, Soleiman Mahjoub, Mohsen Yadollahi, Siamak Navaee, Shervin Amirkhanloo, AliSina Shohreh","doi":"10.22088/cjim.16.3.417","DOIUrl":"10.22088/cjim.16.3.417","url":null,"abstract":"Background: Type 2 diabetes or non-insulin-dependent diabetes is one of the most common types of diabetes. The existing treatments for type 2 diabetes have not been able to completely cure this disease in affected cases. Sumac showed antioxidants, reducing blood sugar and serum cholesterol levels. In this study, according to the positive effects of sumac in diabetic diseases, it was tried that sumac capsules were prepared from the aqueous extract of this plant, and its effect on the factors of diabetes in patients was evaluated.Methods: This double-blind randomized controlled clinical trial was conducted on sixty type 2diabetic volunteers. The volunteers were divided into two groups, control, and sumac supplement groups. Baseline venous blood samples were collected after overnight fasting before intervention and a second sampling was done in the 12th week. Hb1AC, FBS, TG, TC, LDL-C, and HDL-C were measured via commercial kits.Results: FBS, HDL-C, and HbA1C measured in the sumac supplement group were significantly different (p<0.01) compared to the control group and baseline of the study. Moreover, there is no significant difference in levels of the sumac supplement group (CHOL, LDL-C, and TG) compared to the control group and baseline of the study (p>0.05).Conclusion: Our data confirmed the anti-diabetic effect of sumac in patients. Because of sumac safety, it seems that sumac capsules can be used for the treatment of diabetic patients along with routine chemical drugs.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 3","pages":"417-423"},"PeriodicalIF":1.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary alveolar proteinosis: A case report and literature review. 肺泡蛋白沉积症1例报告并文献复习。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2025-04-01 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.362

Yasaman Sajadi, Simin Mouodi, Ehsan Chogan, Mahmood Monadi

{"title":"Pulmonary alveolar proteinosis: A case report and literature review.","authors":"Yasaman Sajadi, Simin Mouodi, Ehsan Chogan, Mahmood Monadi","doi":"10.22088/cjim.16.2.362","DOIUrl":"10.22088/cjim.16.2.362","url":null,"abstract":"Background: Pulmonary alveolar proteinosis (PAP) is a rare disease caused by the accumulation of surfactant in the lung's alveoli, as a result of malfunction in the cleaning function of alveolar macrophages. The major symptoms include cough and dyspnea. Computed tomography scan usually reveals crazy-paving pattern. Lung biopsy confirms the diagnosis by showing accumulations of periodic acid-schiff-positive lipoproteinaceous materials.Case presentation: In this report, we present a middle-age man with progressive dyspnea on exertion, and frequent cough with no noteworthy medical history. The results of initial examinations and laboratory tests were non-diagnostic, so imaging studies were requested for the patient. After imaging and suspecting PAP as a differential diagnosis due to results of high resolution computed tomography, a transbronchial biopsy was performed to confirm the diagnosis. Then, according to the histopathology reports, the diagnosis of PAP was made. During the biopsy procedure, the patient developed pneumothorax, and accurate treatment approaches were considered for this complication.Conclusions: In patients with chronic progressive dyspnea and cough, appropriate and timely imaging and other paraclinic investigations must be considered by the physicians.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"362-368"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medication errors in prescription of chemotherapy regimens: A prospective observational study among cancer patients at Iranian referral hospital. 化疗方案处方中的用药错误：伊朗转诊医院癌症患者的前瞻性观察研究

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Caspian Journal of Internal Medicine Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.355

Sahar Karimi, Mehrnaz Vaez, Amir Aria, Mehran Sharifi, Azadeh Moghaddas

{"title":"Medication errors in prescription of chemotherapy regimens: A prospective observational study among cancer patients at Iranian referral hospital.","authors":"Sahar Karimi, Mehrnaz Vaez, Amir Aria, Mehran Sharifi, Azadeh Moghaddas","doi":"10.22088/cjim.16.2.355","DOIUrl":"10.22088/cjim.16.2.355","url":null,"abstract":"Background: Medication errors are a significant cause of adverse events in cancer patients. The study aimed to investigate unintentional medication errors during chemotherapy regimen prescription.Methods: During the six months' follow-ups, 201 adult patients admitted to outpatients' chemotherapy ward of Omid Hospital, Isfahan, Iran were examined. An information checklist by the aim of data gathering including patients' demographic information, laboratory data, medications history, chemotherapy drug doses and protocol of administration, pre-medications drugs, and supportive treatment was prepared. The data was compared by standard guidelines and data were presented in percent and frequency.Results: Among the enrolled patients, 327 errors were identified. Sixty-five percent of patients were females and the mean age of patients was 49.2±2.8 years old. Gastrointestinal and breast cancers were among the most frequently reported cancers. The highest frequency of errors (67.27%) was attributed to the prescription of pre-medication drug administration primarily in the management of chemotherapy-induced nausea and vomiting. Medication errors in selection and volume of infused serums (20.18%) and in adjusting the dosage of chemotherapy regimens (10.39%) were the most observed errors.Conclusion: This study highlighted the important areas to improve cancer management at the medical center. By addressing these challenges and implementing necessary changes, the center can enhance the quality of care provided to cancer patients, ensure adherence to international standards, and improve patient outcomes.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"355-361"},"PeriodicalIF":0.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adiponectin levels in myeloma patients after curcumin supplementation: A randomized clinical pilot study. 补充姜黄素后骨髓瘤患者的脂联素水平：一项随机临床试验研究。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.320

Damai Santosa, Damar Mashkun Rizqi, Eko Adhi Pangarsa, Budi Setiawan, Suyono Suyono, Mika Lumban Tobing, Suhartono Suhartono, Soeharyo Hadisaputro, Ignatius Riwanto, Aru Wisaksono Sudoyo, Catharina Suharti

{"title":"Adiponectin levels in myeloma patients after curcumin supplementation: A randomized clinical pilot study.","authors":"Damai Santosa, Damar Mashkun Rizqi, Eko Adhi Pangarsa, Budi Setiawan, Suyono Suyono, Mika Lumban Tobing, Suhartono Suhartono, Soeharyo Hadisaputro, Ignatius Riwanto, Aru Wisaksono Sudoyo, Catharina Suharti","doi":"10.22088/cjim.16.2.320","DOIUrl":"10.22088/cjim.16.2.320","url":null,"abstract":"Background: Multiple myeloma (MM) is characterized by reduced circulating adiponectin levels, a condition associated with various diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer, and plasma dyscrasias. Curcumin has been shown to inhibit adipogenesis and elevate serum adiponectin levels. Notably, limited studies investigating the relationship between adiponectin levels and curcumin supplementation in myeloma patients. This study is to evaluate the efficacy curcumin supplements on increasing the levels of adiponectin in myeloma patients.Methods: Patients with myeloma were randomly to melphalan, prednisone, curcumin (MPC) (n=17) and melphalan with prednisone (MP) (n=16) groups. The MPC group was treated by melphalan 4 mg/m2 and prednisone 40 mg/m2 for 7 days (MP), and curcumin 8 grams daily for 28 days. The MP group received MP and placebo. Subjects were followed-up every 28 days and a total of four treatment cycles. Hemoglobin, albumin, white blood cell (WBC), platelets, urea, creatinine, calcium, protein M, and adiponectin evaluated before and after treatment. Mann Whitney test or the Independent T-test were used to analysis.Results: Total subject (24 subjects) completed the treatment. Serum adiponectin levels after four treatment cycles in the MPC group were higher than in the MP group [(mean, 12227.1±5748.3) vs (11365.4±9175.5), P = 0.78].Conclusion: Supplementing MP regimen with 8000 mg curcumin daily for 28 days increases the serum adiponectin level after four treatment cycles in myeloma patients. This research found that myeloma patients may benefit by taking curcumin supplementation.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"320-327"},"PeriodicalIF":0.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astonish yourself while worrying about another: Patients' reactions of HTLV-1-associated myelopathy/tropical spastic paraparesis diagnosis. 震惊自己的同时担心别人：htlv -1相关脊髓病/热带痉挛性截瘫诊断的患者反应

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Caspian Journal of Internal Medicine Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.305

Malihe Davoudi, Reza Boostani, Zahra Sadat Manzari

{"title":"Astonish yourself while worrying about another: Patients' reactions of HTLV-1-associated myelopathy/tropical spastic paraparesis diagnosis.","authors":"Malihe Davoudi, Reza Boostani, Zahra Sadat Manzari","doi":"10.22088/cjim.16.2.305","DOIUrl":"10.22088/cjim.16.2.305","url":null,"abstract":"Background: This study aimed to explore the patients' reactions when HAM/TSP was diagnosed. This qualitative content analysis study was conducted on HAM/TSP patients referred to an HTLV-1 clinic in Mashhad, Iran.Methods: We selected a purposive sample of 16 HAM/TSP patients meeting the inclusion criteria to participate in semi-structured interviews to explore their reactions and emotions when they first learned about their diagnosis. A qualitative content analysis was utilized with MAXQDA 2020 software.Results: Four categories and 14 subcategories were extracted, summarized in the main concept \"Astonish yourself while worrying about another.\" The categories included threatened mental health, fear of falling into the path of ambiguity and darkness, fears and conflicts of deciding to expose the disease, and the double stress of threatening the health of others.\"Conclusion: HAM/TSP is an incurable and progressive disease with several physical complications. Its first diagnosis can also cause severe psychological damage to patients and profoundly affect the patient's social and family relationships. Therefore, it seems that education and health policies should integrate multidisciplinary teams to minimize the effects of HAM/TSP on the patients' quality of life.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"305-313"},"PeriodicalIF":0.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Right ventricular echocardiographic function in patients with breast cancer undergoing anthracycline-based chemotherapy: A prospective study. 接受蒽环类药物化疗的乳腺癌患者的右心室超声心动图功能：一项前瞻性研究。

IF 0.8

Caspian Journal of Internal Medicine Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.22088/cjim.16.2.347

Kamran Mohammadi, Mohammad Gertasi, Mortaza Raeisi, Haleh Bodagh, Razieh Parizad, Asma Yosefzadeh

{"title":"Right ventricular echocardiographic function in patients with breast cancer undergoing anthracycline-based chemotherapy: A prospective study.","authors":"Kamran Mohammadi, Mohammad Gertasi, Mortaza Raeisi, Haleh Bodagh, Razieh Parizad, Asma Yosefzadeh","doi":"10.22088/cjim.16.2.347","DOIUrl":"10.22088/cjim.16.2.347","url":null,"abstract":"Background: Chemotherapy regimens with anthracyclines, widely used in treating breast cancer and lymphoma, are associated with significant cardiac toxicity. While previous studies have primarily focused on left ventricular (LV) function, limited research exists on right ventricular (RV) function. This study aimed to evaluate RV echocardiographic function in breast cancer patients undergoing anthracycline-based chemotherapy.Methods: A cohort of 72 breast cancer patients receiving anthracycline treatment at Ghazi Tabatabai and Madani Hospitals from April to March 2022 participated in this study. Echocardiography was performed before treatment initiation, 15 days after the second chemotherapy session, and 15 days after the final session. Cardiotoxicity levels were calculated using SPSS V22 software with inferential statistical methods, including repeated measures analysis and the Friedman test.Results: RV-free wall strain remained stable 15 days after the second treatment session compared to baseline but showed a statistically significant decrease 15 days after the final session (P = 0.044). The prevalence of abnormal RV-free wall strain increased significantly during the final assessment (P = 0.037). Tumor regression grade (TRG) also demonstrated significant changes over time (P = 0.003). Right ventricular systolic pressure (RVSP) increased significantly throughout the study (P = 0.035), while no significant changes were observed in other parameters such as LVEF, E/E', LAVI, or TAPSE.Conclusion: Anthracycline-based chemotherapy leads to a decline in RV-free wall strain over time, highlighting the importance of monitoring RV function alongside LV function during treatment. Advanced echocardiographic techniques, including strain imaging, may help detect subclinical RV dysfunction earlier.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"16 2","pages":"347-354"},"PeriodicalIF":0.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0