补充姜黄素后骨髓瘤患者的脂联素水平:一项随机临床试验研究。

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL
Caspian Journal of Internal Medicine Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI:10.22088/cjim.16.2.320
Damai Santosa, Damar Mashkun Rizqi, Eko Adhi Pangarsa, Budi Setiawan, Suyono Suyono, Mika Lumban Tobing, Suhartono Suhartono, Soeharyo Hadisaputro, Ignatius Riwanto, Aru Wisaksono Sudoyo, Catharina Suharti
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引用次数: 0

摘要

背景:多发性骨髓瘤(MM)以循环脂联素水平降低为特征,与糖尿病、肥胖、心血管疾病、癌症和血浆异常等多种疾病相关。姜黄素已被证明能抑制脂肪生成并提高血清脂联素水平。值得注意的是,研究骨髓瘤患者中脂联素水平与姜黄素补充之间关系的研究有限。本研究旨在评价姜黄素补充剂对提高骨髓瘤患者脂联素水平的疗效。方法:将骨髓瘤患者随机分为美法兰+强的松+姜黄素(MPC)组(n=17)和美法兰+强的松(MP)组(n=16)。MPC组给予美法兰4 mg/m2 +强的松40 mg/m2,连用7 d (MP),姜黄素8 g/ d连用28 d。MP组给予MP和安慰剂。每28天随访一次,共4个治疗周期。治疗前后评估血红蛋白、白蛋白、白细胞(WBC)、血小板、尿素、肌酐、钙、蛋白M和脂联素。采用Mann Whitney检验或独立t检验进行分析。结果:共24例受试者完成治疗。4个治疗周期后,MPC组血清脂联素水平高于MP组[(平均,12227.1±5748.3)vs(11365.4±9175.5),P = 0.78]。结论:MP方案中每日添加8000 mg姜黄素,连续28天可提高骨髓瘤患者4个治疗周期后血清脂联素水平。这项研究发现,骨髓瘤患者可能受益于服用姜黄素补充剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adiponectin levels in myeloma patients after curcumin supplementation: A randomized clinical pilot study.

Background: Multiple myeloma (MM) is characterized by reduced circulating adiponectin levels, a condition associated with various diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer, and plasma dyscrasias. Curcumin has been shown to inhibit adipogenesis and elevate serum adiponectin levels. Notably, limited studies investigating the relationship between adiponectin levels and curcumin supplementation in myeloma patients. This study is to evaluate the efficacy curcumin supplements on increasing the levels of adiponectin in myeloma patients.

Methods: Patients with myeloma were randomly to melphalan, prednisone, curcumin (MPC) (n=17) and melphalan with prednisone (MP) (n=16) groups. The MPC group was treated by melphalan 4 mg/m2 and prednisone 40 mg/m2 for 7 days (MP), and curcumin 8 grams daily for 28 days. The MP group received MP and placebo. Subjects were followed-up every 28 days and a total of four treatment cycles. Hemoglobin, albumin, white blood cell (WBC), platelets, urea, creatinine, calcium, protein M, and adiponectin evaluated before and after treatment. Mann Whitney test or the Independent T-test were used to analysis.

Results: Total subject (24 subjects) completed the treatment. Serum adiponectin levels after four treatment cycles in the MPC group were higher than in the MP group [(mean, 12227.1±5748.3) vs (11365.4±9175.5), P = 0.78].

Conclusion: Supplementing MP regimen with 8000 mg curcumin daily for 28 days increases the serum adiponectin level after four treatment cycles in myeloma patients. This research found that myeloma patients may benefit by taking curcumin supplementation.

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来源期刊
Caspian Journal of Internal Medicine
Caspian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
1.90
自引率
7.10%
发文量
90
审稿时长
20 weeks
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