Caspian Journal of Internal Medicine最新文献_第5页

Accuracy of bone height and thickness measurements in cone beam computed tomography using different voxel sizes in maxilla and mandible. 上颌和下颌骨不同体素大小的锥束ct测量骨高和骨厚的准确性。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-21 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.136

Ehsan Moudi, Melika Mollaei, Sina Haghanifar, Atefeh Gholampour, Ali Bijani

{"title":"Accuracy of bone height and thickness measurements in cone beam computed tomography using different voxel sizes in maxilla and mandible.","authors":"Ehsan Moudi, Melika Mollaei, Sina Haghanifar, Atefeh Gholampour, Ali Bijani","doi":"10.22088/cjim.17.1.136","DOIUrl":"10.22088/cjim.17.1.136","url":null,"abstract":"Background: Cone Beam Computed Tomography (CBCT) is used to evaluate the hard tissue of the maxillofacial area, and the dose received by the patient depends on the resolution of the images. This study investigated the effect of CBCT resolution (voxel size) on its linear measurement accuracy.Methods: This in vitro study was conducted on 19 human mandibles and 11 dry maxillae. On each jaw, four anterior and four posterior regions were examined. Markers were placed in the designated areas using gutta-percha. The jaws were scanned at three voxel sizes (100, 150, 200 µm). The bone height and thickness were measured in the prepared images and compared with the sizes obtained. Paired t-test, t-test, one-way ANOVA, and Tukey's post-hoc tests were used for statistical analysis.Results: Buccal and lingual bone height measurements showed significant differences across voxel sizes (p < 0.05), with higher resolution (100 µm) yielding greater accuracy. No significant difference was found in bone thickness measurements between resolutions (p = 0.20). Height measurements were significantly less accurate in anterior than posterior regions (p < 0.05). No significant difference was observed between maxilla and mandible except for buccal height at medium and standard resolutions. All CBCT measurements underestimated actual dimensions. Thickness measurements were more accurate than height measurements.Conclusion: Using high resolution in CBCT machines is recommended to reduce linear measurement error when there is a short distance to the critical anatomical structures.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"136-142"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating ejection dynamic parameters for assessing severe aortic stenosis. 评估射血动力学参数评估严重主动脉瓣狭窄。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-21 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.106

Mohammad Reza Aghajankhah, Mansour Abooee, Hassan Moladoust, Mohammad Assadian Rad

{"title":"Evaluating ejection dynamic parameters for assessing severe aortic stenosis.","authors":"Mohammad Reza Aghajankhah, Mansour Abooee, Hassan Moladoust, Mohammad Assadian Rad","doi":"10.22088/cjim.17.1.106","DOIUrl":"10.22088/cjim.17.1.106","url":null,"abstract":"Background: Accurate diagnosis of aortic stenosis (AS) severity is crucial for effective treatment. This study aimed to define cutoff values for aortic ejection dynamic parameters, including ejection time (ET), acceleration time (AT), and the AT/ET ratio in patients with severe AS.Methods: In both severe AS and control groups, the aortic valve area (AVA) was estimated using the continuity equation, and the trans-aortic mean pressure gradient (MPG) was measured using continuous-wave Doppler echocardiography. Blood flow time-velocity integral in the left ventricular outflow tract (LVOT TVI) was measured with pulsed-wave Doppler ultrasound, placing the sample volume 1 cm below the aortic valve. Severe AS was defined as AVA ≤1 cm2 and MPG ≥ 40 mmHg. Clinical data were recorded, and 2D and Doppler echocardiography, including ejection dynamic parameters were analyzed.Results: AT with a cutoff of 73 ms demonstrated perfect accuracy in diagnosing severe AS, with both sensitivity and specificity of 100%. ET with a cutoff of 278 ms showed 90% sensitivity and 100% specificity for identifying severe AS. Additionally, the AT/ET ratio exhibited a positive relationship with MPG (r = 0.55, P = 0.001) and a negative relationship with AVA (r = -0.52, P = 0.003). The AT/ET ratio, using a cutoff value of 0.278, yielded a sensitivity of 96% and a specificity of 100% for diagnosing severe AS.Conclusion: Aortic Doppler ejection dynamic parameters can serve as complementary assessment indices, diagnosing severe AS with acceptable accuracy.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"106-112"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acromegalic features and hypoglycemia: Doege-Potter syndrome. 肢端肥大症特征和低血糖：多吉-波特综合征。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-21 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.205

José Paz-Ibarra, Hilder Herrera Silvestre, Gianella Andrea Lúcar Siu, Gianfranco Del Carpio Reymer, Wildor Cubas Llalle, Marcio Concepción-Zavaleta, Luis Concepción-Urteaga, Juan Eduardo Quiroz-Aldave, Joseph Arzapalo Benavides, José Somocurcio Peralta

{"title":"Acromegalic features and hypoglycemia: Doege-Potter syndrome.","authors":"José Paz-Ibarra, Hilder Herrera Silvestre, Gianella Andrea Lúcar Siu, Gianfranco Del Carpio Reymer, Wildor Cubas Llalle, Marcio Concepción-Zavaleta, Luis Concepción-Urteaga, Juan Eduardo Quiroz-Aldave, Joseph Arzapalo Benavides, José Somocurcio Peralta","doi":"10.22088/cjim.17.1.205","DOIUrl":"10.22088/cjim.17.1.205","url":null,"abstract":"Background: Doege-Potter syndrome (DPS) is a condition characterized by severe, symptomatic, and sustained hypoglycemia, refractory to medical treatment, due to non-insular tumor cells.Case presentation: We describe the case of a 73-year-old male with acromegalic features and two months of hypoglycemic episodes, in whom a giant mass was identified in the right hemithorax via radiography. Surgical resection of the tumor resolved hypoglycemia and improved the acromegalic traits.Solitary fibrous tumors (SFTs) are rare neoplasms that predominantly affect individuals aged 50 to 60 years. Doege-Potter syndrome is a cause of hypoglycemia, present in 2-4% of SFT cases. Its manifestations arise from abnormal synthesis and secretion of insulin-like growth factor (IGF)-2 by the SFT. In rare instances, patients with DPS may exhibit signs of acromegaly, attributed to the stimulation of the IGF-1 receptor by IGF-2. The initial diagnostic approach to DPS includes imaging and hormonal studies, while the definitive diagnosis is made through histopathology.Conclusions: We emphasize the importance of considering DPS in patients with thoracic tumors and persistent hypoglycemia, especially when accompanied by acromegalic features.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"205-210"},"PeriodicalIF":1.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monocytes in HIV associated atherosclerosis: A review of pathogenesis and clinical implications. 单核细胞在HIV相关动脉粥样硬化中的作用：发病机制和临床意义的综述。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-11 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.1

Peyman Eini, Pooya Eini, Sara Pourhemmati, Fateme Yousefimoghaddam, Amirreza Taherkhani, Reyhane Yahya

{"title":"Monocytes in HIV associated atherosclerosis: A review of pathogenesis and clinical implications.","authors":"Peyman Eini, Pooya Eini, Sara Pourhemmati, Fateme Yousefimoghaddam, Amirreza Taherkhani, Reyhane Yahya","doi":"10.22088/cjim.17.1.1","DOIUrl":"10.22088/cjim.17.1.1","url":null,"abstract":"Atherosclerosis, a chronic inflammatory disease of arterial walls, remains a leading cause of global mortality, with ischemic heart disease (IHD) and stroke as primary contributors. In people living with HIV (PLWH), this risk is amplified due to persistent immune activation and conventional cardiovascular risk factors such as hypertension and dyslipidemia. HIV-specific mechanisms, including viral proteins, gut microbial translocation, and chronic inflammation, drive monocyte dysfunction, foam cell formation, and vascular damage, contributing to accelerated atherogenesis. Antiretroviral therapy (ART) has significantly improved the life expectancy of PLWH, transforming HIV into a chronic condition. However, ART does not fully normalize immune activation, particularly monocyte-driven inflammation, which remains central to atherosclerosis progression. Protease inhibitor (PI)-based ART regimens are associated with metabolic disturbances, exacerbating dyslipidemia and insulin resistance, further increasing cardiovascular disease (CVD) risk. Imaging techniques, such as carotid intima-media thickness (CIMT) and coronary artery calcium (CAC) scoring, reveal subclinical atherosclerosis in this population. Adjunctive therapies like statins and anti-inflammatory agents, including interleukin (IL)-1β antagonists, show promise in mitigating inflammation and CVD risk. Targeted strategies addressing monocyte activation, chronic inflammation, and gut microbial translocation are critical. Comprehensive care for PLWH requires integrating ART optimization with lifestyle interventions, lipid-lowering therapies, and novel treatments targeting immune dysfunction. Future research should refine biomarkers for early atherosclerosis detection, tailor CVD risk assessments, and explore therapeutic innovations to reduce cardiovascular morbidity and mortality in PLWH.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"1-13"},"PeriodicalIF":1.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy and mechanism of action of cardiac rehabilitation after revascularization for multi-vessel coronary artery disease. 多支冠状动脉病变血运重建后心脏康复的临床疗效及作用机制。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-11 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.52

Shengwei Ding, Chenfeng Ji, Zilong Liu, Hui Zhang, Chunming Tian, Chen Wang

{"title":"Clinical efficacy and mechanism of action of cardiac rehabilitation after revascularization for multi-vessel coronary artery disease.","authors":"Shengwei Ding, Chenfeng Ji, Zilong Liu, Hui Zhang, Chunming Tian, Chen Wang","doi":"10.22088/cjim.17.1.52","DOIUrl":"10.22088/cjim.17.1.52","url":null,"abstract":"Background: Analyzing the clinical efficacy and mechanism of action of cardiac rehabilitation after revascularization for coronary multibranch lesions.Methods: 150 patients with multiple coronary artery lesions were selected for the study from July 2022 to March 2023, and were randomly divided into observation group (75 cases, complete revascularization + cardiac rehabilitation intervention) and control group (75 cases, complete revascularization). The level of patients' 6 min walking experiment, quality of life, cardiac function indexes, and laboratory indexes were analyzed.Results: The level of 6-min walking test was significantly higher in the observation group than in the control group (p<0.05); the quality of life of patients in the observation group was significantly higher than that of the control group (p<0.05); the levels of left ventricular end-systolic internal diameter (LVESD), left ventricular end-diastolic internal diameter (LVEDD), left ventricular pressure (LVP), and interventricular septal thickness (LVS) in patients in the observation group were significantly lower than that of the control group; and the level of LV ejection fraction (LVEFA) levels were significantly higher than those of the control group (P=0.00); serum homocysteine (Hcy) and blood uric acid (SUA) levels of patients in the observation group were significantly lower than those of the control group (P=0.00).Conclusion: Complete revascularization + cardiac rehabilitation intervention can effectively improve patients' 6-min walking test level, improve patients' cardiac function indexes, improve patients' quality of life, improve patients' laboratory index levels, and play a significant role in improving patients' prognosis, which is worthy of widespread promotion.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"52-58"},"PeriodicalIF":1.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of potassium-competitive acid blockers in eradicating Helicobacter pylori and treating gastro-esophageal reflux disease: A systematic review and meta-analysis. 钾竞争酸阻滞剂在根除幽门螺杆菌和治疗胃食管反流病中的有效性和安全性：一项系统综述和荟萃分析

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-11 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.14

Ni Nyoman Gita Kharisma Dewi, Ni Luh Putu Yunia Dewi, Putu Itta Sandi Lesmana Dewi, Kadek Mercu Narapati Pamungkas, Dwijo Anargha Sindhughosa, I Ketut Mariadi

{"title":"Efficacy and safety of potassium-competitive acid blockers in eradicating Helicobacter pylori and treating gastro-esophageal reflux disease: A systematic review and meta-analysis.","authors":"Ni Nyoman Gita Kharisma Dewi, Ni Luh Putu Yunia Dewi, Putu Itta Sandi Lesmana Dewi, Kadek Mercu Narapati Pamungkas, Dwijo Anargha Sindhughosa, I Ketut Mariadi","doi":"10.22088/cjim.17.1.14","DOIUrl":"10.22088/cjim.17.1.14","url":null,"abstract":"Background: This systematic review aimed to assess the efficacy and safety of PCAB versus PPI in eradicating H. pylori and GERD.Methods: The studies were searched through databases of PubMed, ScienceDirect, Wiley Online Library, and CENTRAL. A random-effects meta-analysis was performed to evaluate the efficacy and safety of PCAB in eradicating H. pylori and treating GERD, using odds ratios (OR) and 95% confidence intervals (95%CI) as the effect measures.Results: PCAB therapy demonstrated superior efficacy and safety compared to PPI-based therapy in eradicating H. pylori (efficacy OR 1.40 [95% CI 1.12-1.76]; safety OR 0.71 [0.52-0.95]) and treating GERD (efficacy OR 1.62 [1.01-2.61]; safety OR 0.90 [0.71-1.14]). Vonoprazan therapy, but not tegoprazan, particularly showed superiority, with ORs of 1.66 [1.24-2.23] for H. pylori eradication (safety OR 0.71 [0.52-0.95]) and 1.80 [1.00-3.25] for GERD (safety OR 1.03 [0.83-1.27]). For H. pylori eradication, vonoprazan triple therapy showed greater efficacy overall (OR 1.94 [1.19-3.17]) and compared to lansoprazole (OR 2.84 [1.97-4.11]) and rabeprazole (OR 2.63 [1.05-6.58]), though not compared to esomeprazole (OR 1.62 [0.69-3.81]). In GERD treatment, both short-term (8 weeks) and long-term (24 weeks) vonoprazan therapies were similarly effective (OR 2.55 [1.71-3.80] and OR 2.17 [1.00-4.72], respectively) and showed particular efficacy in patients with severe (grade C/D) reflux esophagitis (OR 3.51 [1.65-7.46]).Conclusions: Vonoprazan had a superior efficacy than PPI in eradicating H. pylori and treating GERD, but not for tegoprazan. PCAB demonstrated a favorable safety profile.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"14-36"},"PeriodicalIF":1.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Azithromycin on serum FeNO, IgE, and eosinophil levels in bronchiectasis patients. 阿奇霉素对支气管扩张患者血清FeNO、IgE和嗜酸性粒细胞水平的影响。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-11 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.59

Niloofar Keikhaei, Seyedeh Hatameh Asadinejad Tahergourabi, Seyed Ali Javad-Mousavi, Vahan Moradians

{"title":"Azithromycin on serum FeNO, IgE, and eosinophil levels in bronchiectasis patients.","authors":"Niloofar Keikhaei, Seyedeh Hatameh Asadinejad Tahergourabi, Seyed Ali Javad-Mousavi, Vahan Moradians","doi":"10.22088/cjim.17.1.59","DOIUrl":"10.22088/cjim.17.1.59","url":null,"abstract":"Background: Azithromycin, a macrolide antibiotic with notable anti-inflammatory properties, is widely used in the treatment of bronchiectasis. This study aimed to assess changes in serum fractional exhaled nitric oxide (FeNO), immunoglobulin E (IgE), and eosinophils levels before and after azithromycin treatment in bronchiectasis patients.Methods: A retrospective cohort study was conducted at Rasul Akram Hospital involving bronchiectasis patients. Participants were evaluated in two phases: before receiving azithromycin (500 mg on every other day) and three months following oral azithromycin treatment. Demographic data, medical history, and baseline FeNO, IgE, and eosinophil levels were collected during the initial visit. These biomarkers were measured again at the follow-up visit.Results: The study included 50 participants, with a mean (±SD) age of 40.78 (±5.45) years; 48% were females, and 52% were males. FeNO levels showed a significant decrease from 47.64±16.20 ppb at baseline to 18.6 ±5.99 ppb post-treatment (p<0.001). IgE levels also declined significantly from 747.90±166.87 IU/mL initially to 280.40±115.93 IU/mL (p<0.001). Additionally, eosinophil counts decreased from an initial mean of 687.00±199.18 cells/µL to 236.30±203.17 cells/µL at post-treatment (p<0.001). Patients with mild and moderate bronchiectasis exhibited significant reductions in inflammatory markers (p<0.001), those with more severe bronchiectasis did not show a comparable level of improvement. Gender and smoking status had no significant impact on treatment outcomes.Conclusion: Azithromycin administration significantly improved IgE, FeNO, and eosinophil serum levels, underscoring its therapeutic potential in modifying bronchiectasis-related inflammation.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"59-66"},"PeriodicalIF":1.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiotensin-converting enzyme gene insertion/deletion polymorphism and its impact on response to azithromycin and doxycycline treatment in acne vulgaris patients. 寻常痤疮患者血管紧张素转换酶基因插入/缺失多态性及其对阿奇霉素和多西环素治疗反应的影响

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-11 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.74

Alireza Tavakolizadeh, Hamideh Mohammadzadeh, Ali Mohammad Mokhtari, Younes Karami, Milad Khorasani, Zahra Saadatian, Zahra Rajabzadeh, Mohammad Amin Momeni-Moghaddam

{"title":"Angiotensin-converting enzyme gene insertion/deletion polymorphism and its impact on response to azithromycin and doxycycline treatment in acne vulgaris patients.","authors":"Alireza Tavakolizadeh, Hamideh Mohammadzadeh, Ali Mohammad Mokhtari, Younes Karami, Milad Khorasani, Zahra Saadatian, Zahra Rajabzadeh, Mohammad Amin Momeni-Moghaddam","doi":"10.22088/cjim.17.1.74","DOIUrl":"10.22088/cjim.17.1.74","url":null,"abstract":"Background: Acne vulgaris (AV) is a common inflammatory skin disorder. Systemic treatments like azithromycin and doxycycline are frequently used. The Angiotensin-Converting Enzyme (ACE) has been implicated in inflammation and skin diseases. This study investigated the association between ACE I/D polymorphism and therapeutic response to azithromycin versus doxycycline in moderate AV.Methods: This clinical trial enrolled 54 moderate AV patients divided equally into two groups: one received 100 mg/day doxycycline, the other 250 mg/day azithromycin for 3 months. DNA was extracted via salting-out method, and ACE I/D polymorphism was analyzed by PCR and electrophoresis. Treatment efficacy was assessed using Michelson's acne score and standardized photography. Post-treatment, genotype-phenotype correlations were evaluated.Results: The doxycycline group showed significantly higher recovery rates (59.3%) compared to azithromycin (18.5%) (p<0.001). However, no statistically significant association was observed between improvement percentages and genotypes in either the doxycycline ((P = 0.567) or azithromycin (P = 0.533) groups.Conclusion: Doxycycline was significantly more effective than azithromycin for moderate AV. However, no significant association was found between ACE I/D polymorphism and treatment response for either antibiotic. These findings guide therapeutic selection while suggesting that ACE genotyping may not predict treatment response in moderate AV.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"74-81"},"PeriodicalIF":1.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of norepinephrine and phenylephrine on maternal hemodynamic changes after spinal anesthesia in cesarean section: A randomized clinical trial. 去甲肾上腺素和苯肾上腺素对剖宫产脊髓麻醉后产妇血流动力学变化的影响：一项随机临床试验。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-11 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.67

Nadia Banihashem, Milad Minagar, Hoda Shirafkan, Farhad Norollahi

{"title":"Effect of norepinephrine and phenylephrine on maternal hemodynamic changes after spinal anesthesia in cesarean section: A randomized clinical trial.","authors":"Nadia Banihashem, Milad Minagar, Hoda Shirafkan, Farhad Norollahi","doi":"10.22088/cjim.17.1.67","DOIUrl":"10.22088/cjim.17.1.67","url":null,"abstract":"Background: Hypotension after spinal anesthesia is a serious complication during cesarean sections, potentially reducing maternal cardiac output and placental blood flow, affecting both mother and baby. This study aimed to compare the effects of norepinephrine and phenylephrine on maternal hemodynamic changes following spinal anesthesia in elective cesarean surgeries.Methods: In this clinical trial study, 52 pregnant mothers' candidates for elective cesarean surgery were divided into two groups. After spinal anesthesia, the norepinephrine group received a 10-microgram bolus of norepinephrine, while the phenylephrine group received 100 micrograms of phenylephrine. The primary outcomes included blood pressure, heart rate, and measurement time. These were recorded three times before the start of spinal anesthesia, immediately after, and every 3 minutes until discharge, and then twice at 3-minute intervals after childbirth.Results: Mean arterial pressure in norepinephrine group was always higher than phenylephrine. Their difference was significant at the ninth minute (p<0.001) and the twelfth minute (P=0.009). Diastolic pressure in the two studied groups was significant at the ninth minute (p<0.001). 2 patients in norepinephrine group (7.6%) and 6 (23%)patients in phenylephrine group needed vasopressor. 3.8% of patients in norepinephrine group and 34% of patients in phenylephrine group had bradycardia (P=0.020).Conclusion: This study shows that norepinephrine is as effective as phenylephrine in preventing blood pressure drop in patients undergoing cesarean section, but it does not cause bradycardia.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"67-73"},"PeriodicalIF":1.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency of prognostically important acute myeloid leukemia mutations in the Iranian population: A systematic review and meta-analysis. 伊朗人群中预后重要的急性髓系白血病突变的频率：一项系统回顾和荟萃分析。

IF 1.2

Caspian Journal of Internal Medicine Pub Date : 2026-01-11 eCollection Date: 2026-01-01 DOI: 10.22088/cjim.17.1.37

Mohammad Navid Khaksari, Mohammadreza Meghdadi, Mehrdad Rostami, Zahra Khoshnegah, Samaneh Boroumand-Noughabi, Ali Bazi, Alireza Khiabani, Mohammad Reza Keramati

{"title":"Frequency of prognostically important acute myeloid leukemia mutations in the Iranian population: A systematic review and meta-analysis.","authors":"Mohammad Navid Khaksari, Mohammadreza Meghdadi, Mehrdad Rostami, Zahra Khoshnegah, Samaneh Boroumand-Noughabi, Ali Bazi, Alireza Khiabani, Mohammad Reza Keramati","doi":"10.22088/cjim.17.1.37","DOIUrl":"10.22088/cjim.17.1.37","url":null,"abstract":"Background: The geographic diversity of molecular genetic abnormalities in AML can help understand the genetic and environmental factors involved in the development of leukemia. In addition, high-risk groups can be recognized by identifying common mutations in AML patients, and appropriate treatment based on the type of mutation can be adopted. This systematic study and meta-analysis analyzed the common mutations in AML patients in Iran.Methods: In this systematic study, common mutations in Iranian AML patients were comprehensively examined across four databases: PubMed, Scopus, Web of Science, and Magiran, from 1980 to 2024, following the PRISMA guidelines. Meta-Analysis Version 2 (CMA2 was used for data analysis, and I²-test values greater than 50% were considered to indicate high heterogeneity among the studies.Results: By reviewing 40 articles, it was found that the prevalence of FLT3-ITD mutation was 21.9% (CI: 19.19 - 24.1) in 34 studies (3,152 AML cases), FLT3-TKD mutation 6.6% (CI: 4.7 - 9.3) in 19 studies, NPM1 mutation 19% (CI: 15.9-22.6) in 18 studies DNMT3A mutation 13.9% (CI: 11.1 - 17.2) in 5 studies, CEBPA mutation was 18.5% (CI: 10.3 - 31) in 5 studies, and WT-1 mutation prevalence was 8.2% (CI: 5.6-11.8) in 4 studies. Other mutations investigated in the studies included NRAS, IDH1, IDH2, TET2, c-kit, ASXL1, and RUNX1.Conclusions: Studies have shown that the FLT3-ITD mutation is the most prevalent mutation among Iranian AML patients. Following this, the most common mutations identified were NPM1, CEBPA, DNMT3A, and WT1, in that order.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"17 1","pages":"37-51"},"PeriodicalIF":1.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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