Caspian Journal of Internal Medicine最新文献_第5页

Osteoporosis and obesity in the South East of Caspian Seashore and its relationship to osteoporosis prevalence in Iran. 里海东南部地区的骨质疏松症和肥胖症及其与伊朗骨质疏松症发病率的关系。

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Caspian Journal of Internal Medicine Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.629

Majid Malekzadeh Shafaroudi, Nourollah Rezaei, Behrooz Mohammadnejiad, Gholamali Usefi, Ali Malekzadeh Shafaroudi

{"title":"Osteoporosis and obesity in the South East of Caspian Seashore and its relationship to osteoporosis prevalence in Iran.","authors":"Majid Malekzadeh Shafaroudi, Nourollah Rezaei, Behrooz Mohammadnejiad, Gholamali Usefi, Ali Malekzadeh Shafaroudi","doi":"10.22088/cjim.15.4.629","DOIUrl":"10.22088/cjim.15.4.629","url":null,"abstract":"Background: Osteoporosis is the most common metabolic bone disease that begins with a decrease in bone mass and deterioration in the micro-architecture of the bone tissue, making the bones thinner and susceptible to fragility. A comprehensive estimation of the prevalence of osteoporosis in provinces of Iran seems to be necessary.Methods: This study was a descriptive-analytical study. The study population included 518 people aged 30-65 years including 297 males and 221 females to measure their bone density. The data collection method was through BMD measurement using Dual-Energy X-ray Absorptiometry (DXA) method. All obtained data stored in the SPSS-16 database and statistically analyzed. The data analyzed using analytical, statistical methods. The significance level of the test was considered to be P≤0.05.Results: In the present study, according to BMI status, 45.2% of the patients were obese, 38.2% were overweight. Despite the general belief that increasing in weight can be associated with an increase in bone mass, the present research revealed that nearly 35.9% of the research population, suffered obesity and osteoporosis at the same time. Metargression analysis of data from different studies have illustrated that changing in frequency of osteoporosis as an oriented change in prevalence of osteoporosis from west to east and south to north (P≤0.05).Conclusion: Iran society is under concern to more osteoporosis in the coming years at young and old ages which doubled with severe decline in growth rate of population from 3.7% to 0.63% in 2022. This can increase older people ratio over 30% in 2050.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"629-635"},"PeriodicalIF":0.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of robotic rehabilitation on fatigue experience, disability, and quality of life in patients with multiple sclerosis (MS): A systematic review and meta-analysis. 机器人康复对多发性硬化症（MS）患者疲劳体验、残疾和生活质量的影响：系统综述和荟萃分析。

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Caspian Journal of Internal Medicine Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.589

Abdorreza Naser Moghadasi, Mohsen Rastkar, Mehdi Mohammadifar, Aida Mohammadi, Mahsa Ghajarzadeh

{"title":"Effects of robotic rehabilitation on fatigue experience, disability, and quality of life in patients with multiple sclerosis (MS): A systematic review and meta-analysis.","authors":"Abdorreza Naser Moghadasi, Mohsen Rastkar, Mehdi Mohammadifar, Aida Mohammadi, Mahsa Ghajarzadeh","doi":"10.22088/cjim.15.4.589","DOIUrl":"10.22088/cjim.15.4.589","url":null,"abstract":"Background: Rehabilitation plays an important role in improving symptoms in patients with multiple sclerosis (MS). There are studies evaluating the effects of robotic rehabilitation in patients with MS, but the results varied between the studies. So, we designed this systematic review and meta-analysis to estimate pooled effects of robotic rehabilitation on fatigue, disability, and quality of life in subjects with MS.Methods: We systematically searched PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and also gray literature including references of the included studies, and also conference abstracts on October 1th 2022. Data regarding the total number of participants, first author, publication year, country of origin, mean age, EDSS, and results of fatigue and quality of life were recorded.Results: The first literature search revealed 6878 results, after deleting duplicates, 5019 studies remained. Two researchers, evaluated the titles and abstracts, and finally 77 full texts were assessed. For meta-analysis, we included 11 studies. The pooled Standardized Mean Difference (SMD) of Kurtzke Expanded Disability Status Scale (EDSS) (after-before) estimated as -0.56 (95%CI: -0.89,-0.23). The pooled SMD of Fatigue Severity Scale (FSS) estimated as -0.54(95%CI: -1.06, -0.01) (I2=66.7%, P=0.01). The pooled SMD of physical health subscale of multiple sclerosis quality of life (MSQOL-54) estimated as 0.36(95%CI:-0.23, 0.96) (I2=51.4%, P=0.1). The pooled SMD of mental health subscale of MSQOL54 estimated as 0.48 (95%CI: 0.07, 0.88) (I2=0%, P=0.6).Conclusions: The results of this systematic review and meta-analysis show that robotic rehabilitation has positive effects on fatigue, and disability in patients with MS.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"589-600"},"PeriodicalIF":0.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors affecting blood sugar changes in diabetic patients using a three-level model in analysis of longitudinal data. 在纵向数据分析中使用三水平模型分析影响糖尿病患者血糖变化的因素。

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Caspian Journal of Internal Medicine Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.615

Tahereh Rohani, Karimollah Hajian-Tilaki, Mahmoud Hajiahmadi, Behzad Heidari, Natali Rahimi Rahimabadi, Zahra Geraili

{"title":"Factors affecting blood sugar changes in diabetic patients using a three-level model in analysis of longitudinal data.","authors":"Tahereh Rohani, Karimollah Hajian-Tilaki, Mahmoud Hajiahmadi, Behzad Heidari, Natali Rahimi Rahimabadi, Zahra Geraili","doi":"10.22088/cjim.15.4.615","DOIUrl":"10.22088/cjim.15.4.615","url":null,"abstract":"Background: Diabetes, a currently threatening disease, has severe consequences for individuals' health conditions. The present study aimed to investigate the factors affecting the changes in the longitudinal outcome of blood sugar using a three-level analysis with the presence of missing data in diabetic patients.Methods: A total of 526 diabetic patients were followed longitudinally selected from the annual data collected from the rural population monitored by Tonekabon health centers in the North of Iran during 2018-2019 from the Iranian Integrated Health System (SIB) database. In analyzing this longitudinal data, the three-level model (level 1: observation (time), level 2: subject, level 3: health center) was carried out with multiple imputations of possible missing values in longitudinal data.Results: Results of fitting the three-level model indicated that every unit of change in the body mass index (BMI) significantly increased the fasting blood sugar by an average of 0.5 mg/dl (p=0.024). The impact of level 1 (observations) was insignificant in the three-level model. Still, the random effect of level 3 (healthcare centers) showed a highly significant measure for health centers (14.62, p<0.001).Conclusion: The BMI reduction, the healthcare centers' socioeconomic status, and the health services provided have potential effects in controlling diabetes.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"615-622"},"PeriodicalIF":0.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two metabolic enzymes, LDH and FASN, serum levels in Bladder cancer patients. 膀胱癌患者血清中 LDH 和 FASN 这两种代谢酶的水平。

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Caspian Journal of Internal Medicine Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.636

Mohammad Javad Fattahi, Fatemeh Sedaghat, Mohammad Reza Haghshenas, Ali Ariafar, Zahra Shiravani, Mahyar Malekzadeh, Shima Madani

{"title":"Two metabolic enzymes, LDH and FASN, serum levels in Bladder cancer patients.","authors":"Mohammad Javad Fattahi, Fatemeh Sedaghat, Mohammad Reza Haghshenas, Ali Ariafar, Zahra Shiravani, Mahyar Malekzadeh, Shima Madani","doi":"10.22088/cjim.15.4.636","DOIUrl":"10.22088/cjim.15.4.636","url":null,"abstract":"Background: Bladder cancer is one of the most common cancers in the world and is associated with high treatment costs and mortality. The role of different enzymes and molecules in this cancer has been the subject of extensive research in recent years. Among these, the role of metabolic enzymes such as FASN and LDH has been studied less than others. Therefore, the present study was designed to investigate the role of FASN and LDH in bladder cancer patients.Methods: One hundred cases diagnosed with bladder cancer and 50 sex-age- matched healthy individuals as control were examined. FASN and LDH serum levels in both patients and controls were determined by human-specific sandwich ELISA kits.Results: Serum levels of FASN and LDH elevated in bladder cancer patients in comparison to healthy individuals (P= 0.03, P= 0.01, respectively). We also found that than higher stages of bladder cancer (III-IV) had higher serum levels of LDH and FASN compared to early stages (I-II) (P= 0.007 and P= 0.006, respectively). Moreover, there was a statistically significant association between smoking history and serum FASN levels in bladder cancer patients (P=0.015). However, there were no remarkable associations between the serum levels of LDH and FASN with other clinicopathological features including sex, age, tumor grade, and tumor size.Conclusion: The data indicate that LDH and FASN may be good and useful biomarkers in the diagnosis and clinical management of bladder cancer. However, further studies are needed.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"636-643"},"PeriodicalIF":0.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic options, physiopathology, risk factors and genetic causes of permanent congenital hypothyroidism: A narrative review. 永久性先天性甲状腺功能减退症的诊断方案、生理病理、风险因素和遗传原因：叙述性综述。

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Caspian Journal of Internal Medicine Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.570

Zahra Rasoulizadeh, Mahtab Ordooei, Elahe Akbarian

{"title":"Diagnostic options, physiopathology, risk factors and genetic causes of permanent congenital hypothyroidism: A narrative review.","authors":"Zahra Rasoulizadeh, Mahtab Ordooei, Elahe Akbarian","doi":"10.22088/cjim.15.4.570","DOIUrl":"10.22088/cjim.15.4.570","url":null,"abstract":"Background: In Permanent congenital hypothyroidism (PCH) is a lifelong condition characterized by a deficiency in thyroid hormone, leading to various neurodevelopmental complications. Early clinical signs are often nonspecific and easily overlooked, but newborn screening programs have improved early detection.Methods: This narrative review aims to provide insights comparatively transient and permanent PCH and also the diagnosis, risk factors, underlying pathophysiology, and genetic causes associated with PCH. Relevant studies were identified through a comprehensive search using the term 'Permanent congenital hypothyroidism' (Mesh) across scientific databases of electronic databases such as PubMed, Scopus, and Web of Science.Results: Prompt initiation of thyroid hormone replacement therapy, particularly within the initial two weeks postpartum, crucially enhances neurocognitive development outcomes. Multiple predictive approaches, encompassing screening TSH levels, maternal thyroid history, and levothyroxine dosage per kilogram assessment, aid in identifying PCH. Recent studies have demonstrated a mounting prevalence of PCH, contributing significantly to the overall rise in CH incidence. Genetic factors, primarily DUOX2 and DUOXA2 mutations, alongside environmental influences such as post-term birth, low birth weight, and macrosomia, may induce PCH. Nonetheless, reliable markers for early PCH prediction upon diagnosis remain elusive, leading to delayed recognition post-ceasing levothyroxine treatment around age 3.Conclusions: Recent studies have observed an increased incidence of PCH, contributing substantially to the overall rise in cases of congenital hypothyroidism. Understanding the diagnostic options and genetic etiologies associated with PCH is crucial for the early identification and appropriate management.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"570-578"},"PeriodicalIF":0.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum tumor necrosis factor-alpha status in hospitalized patients with coronavirus disease-2019 (COVID-19). 冠状病毒病-2019（COVID-19）住院患者的血清肿瘤坏死因子-α状态。

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Caspian Journal of Internal Medicine Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.601

Mansour Babaei, Behzad Heidari, Mahmoud Sadeghi Haddad Zavareh, Zahra Ahmadnia, Hossein Ghorbani, Samaneh Rouhi

{"title":"Serum tumor necrosis factor-alpha status in hospitalized patients with coronavirus disease-2019 (COVID-19).","authors":"Mansour Babaei, Behzad Heidari, Mahmoud Sadeghi Haddad Zavareh, Zahra Ahmadnia, Hossein Ghorbani, Samaneh Rouhi","doi":"10.22088/cjim.15.4.601","DOIUrl":"10.22088/cjim.15.4.601","url":null,"abstract":"Background: Tumor necrosis factor alpha (TNF-α) produces an inflammatory process and plays a critical role against infection and in the control of viral infection. The present study was conducted to determine the status of serum TNF-α in hospitalized patients with coronavirus disease-2019 (COVID-19).Methods: In this cross-sectional study the serum TNF-α level, sex, and age, were determined in patients with COVID-19. The association between variables was determined using the student t-test, analysis of variance (ANOVA) test, multiple logistic regression analysis, and the statistical package for the Social Sciences (SPSS)-18 (p < 0.05).Results: A total of 91 (women 41.75%, and men 58.24%) patients with a mean serum TNF-α level of 9.9 picograms per milliliter (pg/mL) were considered. In all (100%) patients, the TNF-α serum level was more than the normal limit (P=0.95). 95.60% of patients suffered severe COVID-19, with a TNF-a serum level of 10.20 pg/mL (P=0.87). Mean TNF-α serum levels in women and men were 11.37 pg/mL and 8.8 pg/mL, respectively (P= 0.17). In the age group of > 70 years (11.30 pg/mL), serum TNF-α concentration was higher than the other age groups (p>0.05).Conclusion: A significant proportion of women and men patients with COVID-19 in the middle and old age had a high concentration of serum TNF-α which may indicate the severity of the disease. Serum TNF-α level is different in women and men of different ages, so it can contribute to treatment strategies.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"601-605"},"PeriodicalIF":0.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistochemical markers in predicting behavior of bladder urothelial carcinoma. 预测膀胱尿路上皮癌行为的免疫组化标记物。

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Caspian Journal of Internal Medicine Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.606

Simin Torabi Nezhad, Leila Malekmakan, Mina Mashayekh, Nazanin Karamifar, Taraneh Tadayon

{"title":"Immunohistochemical markers in predicting behavior of bladder urothelial carcinoma.","authors":"Simin Torabi Nezhad, Leila Malekmakan, Mina Mashayekh, Nazanin Karamifar, Taraneh Tadayon","doi":"10.22088/cjim.15.4.606","DOIUrl":"10.22088/cjim.15.4.606","url":null,"abstract":"Background: Bladder cancer is the 5th most prevalent cancer among Iranian men. Finding prognostic markers to predict behavior of this cancer can help us to choose the best treatment for patients from the first place. We aimed to evaluate the correlation of immunohistochemical markers with tumor stage, grade and prognosis of disease.Methods: In this study, we reassessed the specs of proven UC among Iranian patients. Sixty specimens were collected, contained of 30 low grade and 30 high grade urothelial carcinomas. All slides were assessed by immunohistochemistry study for p21, p27, Her-2/neu, E-cadherin, and CD10. Data were analyzed by SPSS 18.0 and a p-value < 0.05 was considered significant.Results: We evaluated 60 patients in this study with mean age of 66±11 years and majority of them are men. High expression of p27 showed significant correlation with LGUC (P=0.030). HGUC related with high expression of Her-2/neu, CD10 and aberrant expression of E-Cadherin (P<0.0001). Aberrant E-Cadherin and high expression of CD10 are associated with higher tumor stage (P=0.000). CD10 intensity was the only immunohistochemical markers to predict prognosis (P=0.010).Conclusion: In the present study, CD10 intensity is the only marker that directly predicts the prognosis. The higher intensity leads to poor prognosis (recurrence or metastasis). More studies must be done in this aspect to resolve the controversies and clarify the role of immunohistochemical markers in predicting BC behaviors.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"606-614"},"PeriodicalIF":0.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic importance of NUP98-rearrangements in acute myeloid leukemia: A systematic review and meta-analysis. 急性髓性白血病 NUP98 重排的预后重要性：系统回顾和荟萃分析。

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Caspian Journal of Internal Medicine Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.579

Maryam Sheikhi, Payam Siyadat, Mehrdad Rostami, Mohammad Hadi Sadeghian, Elnaz Zahiri, Mohammad Ghorbani, Hossein Ayatollahi, Amirali Ayatollahi, Reza Hemmatan Attarbashi, Zahra Khoshnegah

{"title":"Prognostic importance of NUP98-rearrangements in acute myeloid leukemia: A systematic review and meta-analysis.","authors":"Maryam Sheikhi, Payam Siyadat, Mehrdad Rostami, Mohammad Hadi Sadeghian, Elnaz Zahiri, Mohammad Ghorbani, Hossein Ayatollahi, Amirali Ayatollahi, Reza Hemmatan Attarbashi, Zahra Khoshnegah","doi":"10.22088/cjim.15.4.579","DOIUrl":"10.22088/cjim.15.4.579","url":null,"abstract":"Background: NUP98 gene fusions in acute myeloid leukemia (AML) have recently attracted much interest. Despite substantial research illuminating the roles of NUP98 fusions in the course of AML, their impacts on the outcome of patients with AML should be explored in more detail. As a result, this meta-analysis was designed to provide further light on the prognostic implications of NUP98 fusions in AML.Methods: We completed an extensive search in PubMed, Scopus, and Web of Science to identify papers evaluating the prognostic effects of NUP98 rearrangements in patients with AML until August 22, 2022. In total, 15 publications with 6142 participants fulfilled the requirements for the current meta-analysis. All the qualified studies were examined for information regarding HRs and 95% confidence interval (95%CI) for overall survival (OS) and event-free survival (EFS). In addition, we utilized Comprehensive Meta-analysis software version 2 (CMA2) for calculating pooled HRs and 95% CI.Section title: Our Results : analyses for NUP98-NSD1 indicated that this fusion could significantly impact the outcome of patients with AML (pooled HR: 2.84; 95% CI: 2.49-3.24, P=0.000). Additionally, we observed a strong correlation between NUP98-KDM5A rearrangement and poor prognosis in AML (pooled HR: 2.65; 95% CI: 2.5-2.81; P=0.000). A subgroup analysis also showed that the NUP98-NSD1 and FLT3-ITD together confer a poor prognostic effect (pooled HR: 2.60, 95% CI: 1.61-4.18; P=0.000).Conclusions: NUP98 fusions could significantly impact the outcome of patients with AML. The use of these fusions as prognostic indicators in AML seems rational.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"579-588"},"PeriodicalIF":0.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid function tests in overweight and obese children and adolescents with and without non-alcoholic fatty liver disease. 患有或未患有非酒精性脂肪肝的超重和肥胖儿童和青少年的甲状腺功能检测。

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Caspian Journal of Internal Medicine Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.4.623

Armineh Barzegar, Morteza Alijanpour, Mohammadreza Esmaeili Dooki, Soraya Khafri, Haj Ghorban Nooreddini, Mohammad Pournasrollah, Pouria Alijanpour

{"title":"Thyroid function tests in overweight and obese children and adolescents with and without non-alcoholic fatty liver disease.","authors":"Armineh Barzegar, Morteza Alijanpour, Mohammadreza Esmaeili Dooki, Soraya Khafri, Haj Ghorban Nooreddini, Mohammad Pournasrollah, Pouria Alijanpour","doi":"10.22088/cjim.15.4.623","DOIUrl":"10.22088/cjim.15.4.623","url":null,"abstract":"Background: Hypothyroidism can play an important role in the development of non-alcoholic fatty liver disease (NAFLD). This study compared the thyroid function tests in overweight and obese children and adolescents with and without NAFLD.Methods: This case-control study was conducted on 100 children and adolescents aged 4-18 years who referred to the endocrinology clinic of Amirkola Children's Hospital, Babol, Iran in 2021. 42 obese and overweight children with NAFLD were considered as case group and 56 persons without NAFLD as control group. They were selected after physical examination and body mass index (BMI) assessment. Then, TSH, T4, FBS, lipid profile, 25(OH) vit D3 (VD), AST and ALT levels were measured. Abdominal ultrasound was performed to survey fatty liver. T-test and Chi-score were used for analysis and p< 0.05 was considered significant.Results: The mean age in both group was 11.63±2.55 and 10.07±2.61 years, respectively (P=0.004). Hypothyroidism was not seen in the groups. Two groups in terms of mean TSH (P=0.92), T4 (P=0.87), FBS (P=0.33), cholesterol (P=0.44), LDL (P=0.35), VD (P=0.07) had no significant difference. However, difference was found between the two groups in terms of the mean level of AST (P=0.003), ALT (P=0.001), TG (P=0.02), HDL (P=0.01) and BMI (P0.001).Conclusion: This study showed that the mean level of thyroid hormones in both groups did not have significant difference and hypothyroidism was not seen. Other studies with larger sample size and longer periods of time are suggested.","PeriodicalId":9646,"journal":{"name":"Caspian Journal of Internal Medicine","volume":"15 4","pages":"623-628"},"PeriodicalIF":0.8,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare case of Pott's puffy tumor due to nasal foreign body. 伊朗外阴皮纤维肉瘤突起及文献综述：首例病例报告。

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Caspian Journal of Internal Medicine Pub Date : 2024-08-01 eCollection Date: 2024-01-01 DOI: 10.22088/cjim.15.3.553

Mohsen Mohammadi, Haniyeh Esfandiar, Nazanin Saeidizand, Ali Shaabani, Firooze Esmaeilzadeh

引用次数: 0