Serum lipid profile in adolescents and adults with acne vulgaris receiving isotretinoin.

Pub Date : 2024-09-07 eCollection Date: 2024-01-01 DOI:10.22088/cjim.15.4.659

Kaveh Gharaei Nejad, Abbas Darjani, Narges Alizadeh, Seyede Tahoura Hakemzadeh, Afagh Hassanzadeh Rad, Ehsan Kazemnejad-Leili, Reyhaneh Ghadarjani, Hojat Eftekhari, Rana Rafiei, Setila Dalili

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Abstract

Background: Acne vulgaris is a chronic, inflammatory disease and one of the most common skin diseases. Isotretinoin is the best treatment for severe nodulocystic acne compared to other systemic medicine. Although serum lipids elevation is one of the side effects of this medicine; recent studies have shown controversial results. This study aimed to assess the serum lipid profile in adolescents and adults with acne vulgaris receiving isotretinoin.

Methods: This is a cross-sectional study on 65 adolescents and adults older than 16 years old (55 females and 10 males) with moderate to severe degrees of acne vulgaris under a fixed low dose of 20 mg/day Isotretinoin treatment for 120 days. We analyzed the data using the SPSS software Version 16 using paired sample t-test, Wilcoxon, and ANCOVA test.

Results: In this study, 65 records of patients with a mean age of 22.21±6.25 years were assessed. There was a significant elevation in Cholesterol and LDL levels, but in HDL and triglyceride levels no significant change occurred. A significant change in cholesterol levels was noticed in the adolescent age group, the female sex, and the normal weight group. Triglyceride had a significant change in the female sex and normal weight group and HDL significantly increased in male patients.

Conclusion: Although a low dose of isotretinoin can be used with minimal concern for changes in lipid profile in acne vulgaris patients, in the long-term follow-up and treatment, it seems that we have to administer it cautiously.

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接受异维A酸治疗的青少年和成人寻常型痤疮患者的血脂状况。

背景：寻常痤疮是一种慢性炎症性疾病，也是最常见的皮肤病之一。与其他系统性药物相比，异维A酸是治疗严重结节囊肿型痤疮的最佳药物。虽然血清脂质升高是这种药物的副作用之一，但最近的研究结果却存在争议。本研究旨在评估接受异维A酸治疗的青少年和成人寻常型痤疮患者的血清脂质状况：这是一项横断面研究，研究对象为 65 名 16 岁以上患有中度至重度寻常型痤疮的青少年和成人（55 名女性和 10 名男性），他们接受了为期 120 天、每天 20 毫克的固定低剂量异维A酸治疗。我们使用 SPSS 软件 16 版对数据进行了分析，使用了配对样本 t 检验、Wilcoxon 检验和方差分析检验：本研究共评估了 65 例患者的病历，患者平均年龄（22.21±6.25）岁。胆固醇和低密度脂蛋白水平明显升高，但高密度脂蛋白和甘油三酯水平无明显变化。青少年组、女性组和正常体重组的胆固醇水平有明显变化。女性和正常体重组的甘油三酯有明显变化，男性患者的高密度脂蛋白有明显增加：结论：虽然小剂量异维A酸可用于寻常型痤疮患者，对其血脂变化的影响很小，但在长期随访和治疗中，我们似乎必须谨慎用药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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