Cancer Epidemiology Biomarkers & Prevention最新文献

{"title":"Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study.","authors":"Saleh Alduhayh, Ruhina Shirin Laskar, Xia Jiang, Zhaozhong Zhu, Emma E Vincent, Andrei-Emil Constantinescu, Daniel D Buchanan, Robert C Grant, Amanda I Phipps, Hermann Brenner, Wen-Yi Huang, Sun-Seog Kweon, Li Li, Rachel Pearlman, Sergi Castellví-Bel, Stephen B Gruber, Christopher I Li, Andrew Pellatt, Elizabeth A Platz, Bethany Van Guelpen, Wei Zheng, Andrew T Chan, Jane C Figueiredo, Shuji Ogino, Cornelia M Ulrich, Marc J Gunter, Philip Haycock, Gianluca Severi, Neil Murphy, Niki Dimou","doi":"10.1158/1055-9965.EPI-24-0970","DOIUrl":"10.1158/1055-9965.EPI-24-0970","url":null,"abstract":"<p><strong>Background: </strong>The tumor immunosurveillance theory supports that allergic conditions could decrease cancer risk. However, observational evidence yielded inconsistent results for the association between allergic diseases and colorectal cancer risk. We used Mendelian randomization (MR) to examine potential causal associations of allergies with the risk of overall and early-onset colorectal cancer.</p><p><strong>Methods: </strong>Genome-wide association study summary statistical data were used to identify genetic variants associated with allergic diseases (Nvariants = 65) and individual allergic conditions (asthma, hay fever/allergic rhinitis, and eczema). Using two-sample MR, we examined these variants in relation to incident overall (Ncases = 52,775 cases) and early-onset colorectal cancer (Ncases = 6,176). The mediating role of white blood cells was examined using multivariable MR.</p><p><strong>Results: </strong>In inverse-variance-weighted models, genetic liability to allergic diseases was inversely associated with overall {OR per log (odds) = 0.90 [95% confidence interval (CI), 0.85-0.96]; P < 0.01} and early-onset colorectal cancer [OR = 0.83 (95% CI, 0.73-0.95); P = 0.01]. Similar inverse associations were found for hay fever/allergic rhinitis or eczema, whereas no evidence of association was found between liability to asthma-related phenotypes and colorectal cancer risk. Multivariable MR adjustment for eosinophils weakened the inverse associations for liability to allergic diseases for overall [OR = 0.96 (95% CI, 0.89-1.03); P = 0.26] and early-onset colorectal cancer [OR = 0.86 (95% CI, 0.73-1.01); P = 0.06].</p><p><strong>Conclusions: </strong>Our study supports a potential causal association between liability to allergic diseases, specifically hay fever/allergic rhinitis or eczema, and colorectal cancer, possibly at least in part mediated via eosinophil counts.</p><p><strong>Impact: </strong>Our results provide evidence that allergic responses may also have a role in immunosurveillance against colorectal cancer.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"722-736"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Metabolic Syndrome a Risk Factor for Skin Cancer? A UK Biobank Observational and Two-Sample Mendelian Randomization Study.","authors":"Emily A M Black, Claudia Allemani, Tom Dudding","doi":"10.1158/1055-9965.EPI-24-1388","DOIUrl":"10.1158/1055-9965.EPI-24-1388","url":null,"abstract":"<p><strong>Background: </strong>Skin cancers are the third most common cancer worldwide, with incidence increasing. Metabolic syndrome (MetS) is a cluster of metabolic abnormalities strongly associated with the development of cardiovascular disease. More than one in five individuals have MetS, and it is linked with at least 14 different cancers. This study aimed to investigate whether MetS is a risk factor for skin cancer.</p><p><strong>Methods: </strong>A prospective cohort study was conducted in the UK Biobank. The association between MetS and skin cancer was investigated using multivariable Poisson regression. To investigate causality, a two-sample Mendelian randomization (MR) study was conducted using summary-level genome-wide association study data from the UK Biobank (MetS) and FinnGen (skin cancer).</p><p><strong>Results: </strong>A total of 467,919 participants were included; 26.7% had MetS. Follow-up was for up to 10.8 years. MetS showed a moderately sized protective effect on basal-cell carcinoma, whereas the effect for squamous cell carcinoma and malignant melanoma crossed the null. Overall, MR found there was some weak evidence for increased odds of skin cancer in those with MetS [OR = 1.07 (95% confidence interval: 1.01, 1.14)].</p><p><strong>Conclusions: </strong>The observational study identifies a moderately sized protective effect of MetS on basal-cell carcinoma with MR evidence suggesting a weak causal effect in the opposite direction.</p><p><strong>Impact: </strong>This study has found little-to-no effect of MetS on skin cancer despite links between MetS and at least 14 other cancers.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"641-648"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes.","authors":"Lindsay J Collin, Kara L Cushing-Haugen, Kathryn L Terry, Ellen L Goode, Anna H Wu, Holly R Harris, Naoko Sasamoto, Daniel W Cramer, Francesmary Modugno, Esther Elishaev, Zhuxuan Fu, Kirsten B Moysich, Peter A Fasching, Celeste Leigh Pearce, Usha Menon, Aleksandra Gentry-Maharaj, Simon A Gayther, Nicolas Wentzensen, Marc T Goodman, Joshy George, Aline Talhouk, Michael S Anglesio, Susan J Ramus, David D L Bowtell, Shelley S Tworoger, Joellen M Schildkraut, Penelope M Webb, Jennifer A Doherty","doi":"10.1158/1055-9965.EPI-24-1143","DOIUrl":"10.1158/1055-9965.EPI-24-1143","url":null,"abstract":"<p><strong>Background: </strong>Ovarian high-grade serous carcinomas (HGSC) comprise four distinct molecular subtypes based on mRNA expression patterns, with differential survival. Understanding risk factor associations is important to elucidate the etiology of HGSC. We investigated associations between different epidemiologic risk factors and HGSC molecular subtypes.</p><p><strong>Methods: </strong>We pooled data from 11 case-control studies with epidemiologic and tumor gene expression data from custom NanoString CodeSets developed through a collaboration within the Ovarian Tumor Tissue Analysis consortium. The PrOTYPE-validated NanoString-based 55-gene classifier was used to assign HGSC gene expression subtypes. We examined associations between epidemiologic factors and HGSC subtypes in 2,070 cases and 16,633 controls using multivariable-adjusted polytomous regression models.</p><p><strong>Results: </strong>Among the 2,070 HGSC cases, 556 (27%) were classified as C1.MES, 340 (16%) as C5.PRO, 538 (26%) as C2.IMM, and 636 (31%) as C4.DIF. The key factors, including oral contraceptive use, parity, breastfeeding, and family history of ovarian cancer, were similarly associated with all subtypes. Heterogeneity was observed for several factors. Former smoking [OR = 1.25; 95% confidence interval (CI) = 1.03, 1.51] and genital powder use (OR = 1.42; 95% CI = 1.08, 1.86) were uniquely associated with C2.IMM. History of endometriosis was associated with C5.PRO (OR = 1.46; 95% CI = 0.98, 2.16) and C4.DIF (OR = 1.27; 95% CI = 0.94, 1.71) only. Family history of breast cancer (OR = 1.44; 95% CI = 1.16, 1.78) and current smoking (OR = 1.40; 95% CI = 1.11, 1.76) were associated with C4.DIF only.</p><p><strong>Conclusions: </strong>This study observed heterogeneous associations of epidemiologic and modifiable factors with HGSC molecular subtypes.</p><p><strong>Impact: </strong>The different patterns of associations may provide key information about the etiology of the four subtypes.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"762-773"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited Awareness of Alcohol-Related Cancer Risk Factors among Spanish-Preferring Adults in a National US Survey.","authors":"Yi Liao, Andy J King, Benjamin A Lyons, Kimberly A Kaphingst","doi":"10.1158/1055-9965.EPI-24-1354","DOIUrl":"10.1158/1055-9965.EPI-24-1354","url":null,"abstract":"<p><strong>Background: </strong>Alcohol is a modifiable risk factor for several types of cancer, though awareness of this link is often found to be low among the US population. The current study investigated beliefs about alcohol as a cancer risk factor among Spanish-preferring Americans, specifically for different types of alcoholic beverages (e.g., beer, liquor, and wine).</p><p><strong>Methods: </strong>We analyzed data from a national survey of US adults who prefer speaking Spanish, comparing their awareness of alcohol's link to cancer with the general population and Hispanic respondents in the Health Information National Trends Survey (HINTS) 5 Cycle 4 dataset.</p><p><strong>Results: </strong>Awareness among Spanish-speaking adults was lower (wine: 8.2%, beer: 18.3%, and liquor: 28.4%) than all HINTS respondents (wine: 20.3%, beer: 24.9%, and liquor: 31.2%) and specifically the Hispanic HINTS respondents (wine: 18.3%, beer: 22.4%, and liquor: 32.2%). Statistically significant differences were found for wine and beer compared with the general population and for wine compared with Hispanic respondents. Higher media literacy correlated with increased awareness, particularly for beer, whereas eHealth literacy showed an inverse relationship. Recent immigrants demonstrated greater awareness than long-term residents. Gender, insurance status, cancer history, and information-seeking behaviors predicted differential awareness.</p><p><strong>Conclusions: </strong>Awareness of the alcohol-cancer link among Spanish-preferring adults in the United States is below the national average, with factors such as media literacy, eHealth literacy, demographics, and length of US residency associated with this awareness.</p><p><strong>Impact: </strong>The study underscores the need for culturally adapted health communication strategies to improve knowledge of alcohol as a cancer risk factor among Spanish-preferring Americans.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"754-761"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NCI-Funded Cancer Epidemiology Survivor Cohorts: Overview, Progress, and Opportunities.","authors":"Lisa Gallicchio, Andrea N Burnett-Hartman, Kelly K Filipski, Nonniekaye Shelburne, Andrew N Freedman","doi":"10.1158/1055-9965.EPI-24-1750","DOIUrl":"10.1158/1055-9965.EPI-24-1750","url":null,"abstract":"<p><strong>Background: </strong>The goal of this article was to provide an overview of the current NCI-funded large cancer epidemiology survivor cohorts (CESC).</p><p><strong>Methods: </strong>Large CESCs were defined as observational cohort studies following at least 1,000 cancer survivors over time and collecting data on survivorship outcomes. CESCs with NCI grant funding on June 1, 2024 were identified in two ways: (i) by identifying grants funded under cancer epidemiology cohort-relevant Notice of Funding Opportunities and (ii) by applying the Research, Condition, and Disease Categorization-indexed concepts related to cohorts to the entire NCI grant portfolio in the NIH's proprietary Query, View, Reporting System and reviewing grants identified via this search for inclusion.</p><p><strong>Results: </strong>Thirty active grants supporting large CESCs were identified. Of the 30 CESCs, 36.7% are comprised of survivors of mixed cancer types; the remaining 63.3% are following survivors diagnosed with cancer of a single anatomic type or grouping (e.g., blood cancers). Special populations of focus include adult survivors of pediatric cancers, adolescent and young adult cancer survivors, pediatric cancer survivors, and stem cell transplant survivors. Notable gaps include cohorts following long-term cancer survivors, survivors of less common cancer types, and survivors from understudied populations.</p><p><strong>Conclusions: </strong>CESCs highlighted in this article represent a substantial investment in exploring the multifaceted factors that influence cancer outcomes. These cohorts encompass an increasing diversity of cancer types, treatments, and populations.</p><p><strong>Impact: </strong>CESCs provide valuable insights into clinical and molecular risk factors associated with cancer survivorship outcomes that inform guidelines and interventions.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"627-640"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Inherited Genetic Variants with Multiple Primary Melanoma.","authors":"David C Gibbs, Brittany M Small, Isidora Autuori, Siok F Leong, Emily Ali, Jessica Kenney, Li Luo, Peter A Kanetsky, Klaus J Busam, Anne E Cust, Hoda Anton-Culver, Richard P Gallagher, Roberto Zanetti, Stefano Rosso, Lidia Sacchetto, Sharon N Edmiston, Kathleen Conway, David W Ollila, Colin B Begg, Marianne Berwick, Irene Orlow, Nancy E Thomas","doi":"10.1158/1055-9965.EPI-24-1442","DOIUrl":"10.1158/1055-9965.EPI-24-1442","url":null,"abstract":"<p><strong>Background: </strong>Recent genome-wide association studies (GWAS) have identified new susceptibility loci for melanoma, but their associations with multiple primary melanoma (MPM) are unclear.</p><p><strong>Methods: </strong>We investigated the associations of 69 SNPs in 39 GWAS-identified loci with odds of MPM relative to single primary melanoma in the international, population-based Genes, Environment, and Melanoma study. Per-minor-allele ORs and 95% confidence intervals (CI) for individuals with MPM \"cases\" (n = 1,205) relative to single primary melanoma \"controls\" (n = 2,458) were estimated using multivariable logistic regression, and polygenic risk scores (PRS) were calculated and weighted based on a 2020 GWAS meta-analysis (57 of the 68 independent GWAS SNPs available).</p><p><strong>Results: </strong>Thirteen SNPs in 11 gene regions (PARP1, CYP1B1/RMDN3, TERT, RAPGEF5, TYRP1, MTAP, CDKN2A/CDKN2B, KLF4, TYR, SOX6, and ASIP) were statistically significantly associated (P < 0.05) with MPM adjusting for age, sex, age-by-sex interaction, and study center. The highest versus lowest PRS quintile was associated with a 2.81-fold higher odds of MPM (95% CI, 2.10-3.78; P = 7.5 × 10-13); this association was attenuated but remained statistically significant after excluding SNPs individually associated with MPM (OR = 1.75, 95% CI, 1.32-2.31).</p><p><strong>Conclusions: </strong>Inherited genetic variants spanning 11 gene regions were independently associated with MPM. Nonsignificant SNPs were associated with MPM when aggregated into a PRS, indicating that their cumulative effect may influence MPM risk despite lacking individual statistical significance in our study population.</p><p><strong>Impact: </strong>Our findings provide additional evidence that these loci are associated with melanoma risk and estimate the magnitude of their genetic effect on subsequent (multiple) primary melanoma risk.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"805-814"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood Disinvestment Predicts Shorter Cancer Survival Time among Black Women Diagnosed with Invasive Breast Cancer.","authors":"Jesse J Plascak, Cathleen Y Xing, Stephen J Mooney, Andrew G Rundle, Mario Schootman, Bo Qin, Nur Zeinomar, Adana A M Llanos, Hari S Iyer, Karen S Pawlish, Christine B Ambrosone, Kitaw Demissie, Chi-Chen Hong, Elisa V Bandera","doi":"10.1158/1055-9965.EPI-24-1184","DOIUrl":"10.1158/1055-9965.EPI-24-1184","url":null,"abstract":"<p><strong>Background: </strong>Observed neighborhood disinvestment is a chronic social determinant that is understudied in relation to cancer outcomes. This study investigated associations between neighborhood disinvestment, stage at diagnosis, and breast cancer-specific survival (BCSS) time.</p><p><strong>Methods: </strong>Individual-level data included 844 women, diagnosed 2013 to 2019, from the Women's Circle of Health Follow-up Study, a population-based cohort of breast cancer survivors self-identifying as Black or African American. Neighborhood disinvestment was from a virtual audit of six indicators-garbage, graffiti, dumpsters, building conditions, yard conditions, and abandoned buildings-within 14,671 Google Street View streetscapes estimated at residential addresses using Universal Kriging. We fit accelerated failure time models of BCSS time as functions of neighborhood disinvestment by stage, adjusted for covariates (sociodemographic, lifestyle, and tumor- and treatment-related factors). Participants not experiencing an event at the end of follow-up (August 13, 2023) were right-censored.</p><p><strong>Results: </strong>With a median follow-up time of 89 months, there were 91 breast cancer-specific deaths. Disinvestment and stage statistically interacted (P < 0.01). For stage III and stage II diagnoses, BCSS time decreased by 27% (95% confidence interval, 1%, 48%) and 37% (95% confidence interval, 5%, 58%), respectively, with each SD increase in disinvestment after adjustment for covariates. There was little evidence of associations between disinvestment and survival time among stages I and IV.</p><p><strong>Conclusions: </strong>The tumor stage-dependent association between greater neighborhood disinvestment and shorter survival time could reflect chronic stress exposures suspected to adversely accumulate over time.</p><p><strong>Impact: </strong>Neighborhood disinvestment might be an important, independent marker of social disadvantage impacting breast cancer survival.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"684-690"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Inflammation Biomarkers and the Risk of Esophageal Adenocarcinoma: A Nested Case-Control Study in the Department of Defense Serum Repository.","authors":"Omonefe O Omofuma, Jennifer A Rusiecki, Jessica L Petrick, Roni T Falk, William Wheeler, Ruth M Pfeiffer, M Constanza Camargo, Michael B Cook","doi":"10.1158/1055-9965.EPI-24-1544","DOIUrl":"10.1158/1055-9965.EPI-24-1544","url":null,"abstract":"<p><strong>Background: </strong>We previously identified associations of esophageal adenocarcinoma risk with four inflammation-related candidate biomarkers: TNF receptor 2 (TNFR2), IL17A, VEGFR3, and resistin.</p><p><strong>Methods: </strong>We aimed to replicate these candidates and discover novel associations with additional proteins. We conducted a nested case-control study of men with prediagnostic biospecimens stored at the US Department of Defense Serum Repository, including 203 incident esophageal adenocarcinoma cases. Controls were matched to cases in a ∼2:1 ratio by date of birth, race, service branch, and blood draw date. Multiplex immunoassays (Olink/Proseek panels) measured 254 proteins detected in ≥10% of all samples. Multivariable-adjusted conditional logistic regression models calculated associations between biomarker quantiles and esophageal adenocarcinoma. P values (<0.05) were used to indicate the statistical significance of candidates, and FDR was applied to the additional proteins. ORs from the current analysis and those from previous studies were combined for the candidate markers using fixed-effects meta-analysis.</p><p><strong>Results: </strong>Among the four candidates, the highest category of TNFR2 was associated with significantly increased esophageal adenocarcinoma risk (ORQ4 vs. Q1 = 1.87; 95% confidence interval: 1.02-3.42). In the meta-analysis, associations with esophageal adenocarcinoma were positive for TNFR2 (meta-analyzed ORhighest-vs.-lowest = 2.04; 1.12-2.95) and inverse for IL17A (meta-analyzed ORhighest-vs.-lowest = 0.53; 0.26-0.80). Of the additional 250 proteins, 45 were associated with esophageal adenocarcinoma risk and 6 (monocyte chemotactic protein 3, IL6, TNFR1, hepatocyte growth factor, TFF3, and FURIN) remained significant after FDR correction.</p><p><strong>Conclusions: </strong>We confirmed associations of TNFR2 and IL17A with esophageal adenocarcinoma risk. Additionally, our study expands the range of proteins associated with esophageal adenocarcinoma development.</p><p><strong>Impact: </strong>This is the largest assessment to discover novel associations of inflammation-related proteins with esophageal adenocarcinoma to date.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"649-657"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of Change in Emotional and Functional Well-Being Following Breast Cancer Diagnosis.","authors":"Yumeng Ren, Joanna Maselko, Xianming Tan, Andrew F Olshan, Angela M Stover, Antonia V Bennett, Marc A Emerson, Melissa A Troester","doi":"10.1158/1055-9965.EPI-24-0849","DOIUrl":"10.1158/1055-9965.EPI-24-0849","url":null,"abstract":"<p><strong>Background: </strong>Understanding the change in emotional well-being (EWB) and functional well-being (FWB) in breast cancer survivors can facilitate targeted support for unmet needs.</p><p><strong>Methods: </strong>Among 2,767 women with breast cancer in the Carolina Breast Cancer Study Phase 3, we assessed EWB and FWB with the Functional Assessment of Cancer Therapy - Breast instrument at 5 (baseline), 25, and 84 months after diagnosis. We identified well-being trajectories using latent class growth analysis, and relative frequency differences (RFD) with 95% confidence intervals (CI) were estimated for associations between trajectory group membership and demographic or clinical characteristics.</p><p><strong>Results: </strong>Five trajectory groups were identified for both EWB and FWB. Most participants (∼70%) were classified into \"good well-being\" (\"stable high\" or \"stable medium\"). A small percentage (∼10%) fell into \"very low baseline\" or \"early decrease\", and the rest were \"stable low\" (∼20%). Overall, younger vs. older age was associated with \"stable low\" EWB (25.4% vs. 19.3%; RFD 6.1%; 95% CI, 3.0%-9.2%). Black participants more frequently had \"stable low\" FWB (24.2% vs. 16.6%; RFD 7.6%; 95% CI, 4.6%-10.6%). Breast cancer recurrence was strongly associated with \"stable low\" EWB (28.7% vs. 21.3%; RFD 7.3%; 95% CI, 2.3%-12.3%) and FWB (28.7% vs. 19.2%; RFD 8.6%; 95% CI, 3.7%-13.5%). Being unmarried, lower income, having nonprivate insurance, advanced stage, mastectomy vs. breast conservation surgery, and chemotherapy were also predictors of poor well-being trajectories.</p><p><strong>Conclusions: </strong>Demographics and clinical features are associated with sustained poor well-being after breast cancer.</p><p><strong>Impact: </strong>Improvements in long-term well-being may warrant targeted support.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"676-683"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12911322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between Anti-Gay Prejudice, Traditional Masculine Self-Concept, and Colorectal Cancer Screening-Related Outcomes among Black and White Men in the United States.","authors":"Tianen Chen, Rebekah Wicke, Andy J King, Drew Margolin, Rumi Chunara, Jeff Niederdeppe","doi":"10.1158/1055-9965.EPI-24-1590","DOIUrl":"10.1158/1055-9965.EPI-24-1590","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer screening can reduce colorectal cancer risk, yet many men are not up to date with screening guidelines. Although previous qualitative studies have suggested links among anti-gay prejudice, traditional masculine self-concept, racial identity, and colorectal cancer screening among men, scholars have yet to fully explore these associations using quantitative data. This study used a nationally representative sample of Black and White men in the United States to test these associations and examine the sociodemographic correlates.</p><p><strong>Methods: </strong>Using the National Opinion Research Center (NORC)/AmeriSpeak probability-based panel, we recruited a sample of Black and White men in the United States ages 45 to 74 years who had never been diagnosed with colorectal cancer (N = 909). Participants completed an online questionnaire measuring anti-gay prejudice, traditional masculine self-concept, sociodemographic variables, and screening-related outcomes (awareness of screening test options, screening intention, and adherence to screening recommendations).</p><p><strong>Results: </strong>Black participants reported higher levels of anti-gay prejudice and traditional masculine self-concept than White participants. Anti-gay prejudice was associated with lower awareness and lower screening intention. Black participants reported higher intention to follow screening recommendations but not higher odds of actual adherence than White participants.</p><p><strong>Conclusions: </strong>Men with anti-gay prejudice are less likely to be aware of colorectal cancer screening test options and less likely to intend to engage in colorectal cancer screening. The results have implications for the design and development of future interventions aimed at increasing colorectal cancer screening rates.</p><p><strong>Impact: </strong>Future studies could develop targeted interventions and observe subsequent changes or conduct longitudinal studies to further explore the role of anti-gay prejudice in colorectal cancer screening.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"714-721"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}