Cancer Epidemiology Biomarkers & Prevention最新文献

{"title":"Plasma Insulin-Like Growth Factor Binding Protein-7 is Positively Associated with Age, Obesity, Mortality, and Cancer in Postmenopausal Women.","authors":"Melissa C Orenduff, Carl F Pieper, Emma H Allott, Michael F Coleman, Su Yon Jung, Mara Z Vitolins, Jenifer I Fenton, Chu Chen, Candyce H Kroenke, Fred K Tabung, Ana Barac, Electra D Paskett, Michael N Pollak, Jennifer Hays-Grudo, Shine Chang, Stephen D Hursting","doi":"10.1158/1055-9965.EPI-24-1644","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1644","url":null,"abstract":"<p><strong>Background: </strong>Predictors of premature death and cancer development are needed to more precisely identify individuals who may warrant preventive intervention. Circulating IGF binding protein-7 (IGFBP7) and, to lesser extent, the IGFBP7/IGF-1 ratio are emerging biomarkers of renal and cardiovascular morbidity. However, their relationships with aging, obesity, mortality and cancer risk remain unclear.</p><p><strong>Methods: </strong>This hypothesis-generating study investigated plasma IGFBP7, IGF-1, and their ratio as predictors of all-cause mortality, any cancer (excluding nonmelanoma skin cancer), obesity-related cancer (composite of 13 cancer types), and breast cancer incidence in a large longitudinal cohort of postmenopausal women. We assessed relationships of each biomarker with age, body mass index (BMI), and each outcome (bivariately and controlling for age, BMI, race, physical activity, education, income, marital status, alcohol intake, smoking, diabetes, and hormone therapy) in 793 Women's Health Initiative-Observational Study participants (mean 19.4 year follow-up).</p><p><strong>Results: </strong>In adjusted analyses, IGFBP7 increased with age and obesity, and was positively associated with risks of all-cause mortality [hazard ratio (HR)=2.42 (95% CI: 1.37-4.26), p=0.002], any cancer [HR=2.04 (1.05-3.94), p=0.035], and obesity-related cancer [HR=1.58 (0.99-2.51), p=0.053]. Also in adjusted analyses, the IGFBP7/IGF-1 ratio increased with age and was positively associated with all-cause mortality [HR=1.51 (1.14-1.99), p=0.004] and any cancer incidence [HR=5.44 (1.13-26.1), p=0.034].</p><p><strong>Conclusions: </strong>Plasma IGFBP7 and the IGFBP7/IGF1 ratio are positively associated with age, obesity (IGFBP7 only), mortality, and cancer in postmenopausal women.</p><p><strong>Impact: </strong>Plasma IGFBP7 may represent an age- and obesity-sensitive biomarker of increased risk of developing cancer and/or dying prematurely.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genital, oral, and anal type-specific human papillomavirus concordance within individuals and between partners.","authors":"Alissa Moore, Mariam El-Zein, Ann N Burchell, Pierre-Paul Tellier, François Coutlée, Eduardo L Franco","doi":"10.1158/1055-9965.EPI-24-1843","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1843","url":null,"abstract":"<p><strong>Background: </strong>Studying human papillomavirus (HPV) genotype concordance between male and female partners and between multiple anatomical sites can help our understanding of HPV epidemiology.</p><p><strong>Methods: </strong>Heterosexual couples aged 18+ formed within the past 6 months attended visits at 0, 2, 4, 6, 9, and 12 months. They answered questionnaires and provided genital, oral, and anal samples for HPV genotyping. We calculated observed/expected (O/E) concordance (with 95% confidence intervals [CI]) between anatomical sites of HPV genotype-specific infections, across all visits and cumulatively (i.e., ever-positivity). We used mixed-effects logistic regression with random intercepts at the person-level to estimate odds ratios (OR) for concordance and to assess predictors of genital HPV detection and partner concordance.</p><p><strong>Results: </strong>Within-individual O/E genital/anal concordance was 23.37 (CI: 15.55-38.05) for females and 14.79 (CI: 9.20-43.45) for males, whereas genital/genital O/E concordance between partners was 14.99 (CI: 12.47-18.41). Genital/genital concordance for ever-positivity within couples was substantial: O/E: 10.06 (CI: 8.55-12.12), OR: 70.75 (CI: 43.70-114.56) for females and 67.34 (CI: 41.96-108.06) for males. Significant predictors of genital ever-positivity were one's partner's ever-positivity, OR: 66.2 (CI: 40.96-107.08) in females and 61.53 (CI: 38.19-99.14) in males, and age above the median in females and males, OR: 1.66 (CI: 1.06-2.59) in females and 1.95 (CI: 1.30-2.91) in males. Concordance doubled (OR: 1.96, CI: 1.12-3.46) with occasions of intimacy above the median.</p><p><strong>Conclusions: </strong>We observed substantial genital/anal concordance within individuals (particularly females) and genital/genital concordance between partners. Certain sociodemographic and behavioral factors influenced concordance.</p><p><strong>Impact: </strong>Findings shed light on HPV natural history and transmissibility.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Skin Cancer Risk Reduction Interventions for Young Adults: Findings from a Hybrid Type-II Effectiveness-Implementation Trial.","authors":"Carolyn J Heckman, Elizabeth A Handorf, Anna Mitarotondo, Olga Khavjou, Sharon L Manne, Amy L Yaroch, Karen Glanz","doi":"10.1158/1055-9965.EPI-24-1636","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1636","url":null,"abstract":"<p><strong>Background: </strong>Engagement in sun protection behaviors is low among young adults (YA, ages 18-25 years). Efficacious sun safety interventions for this at-risk population and information on intervention engagement and costs are needed. The purpose was to conduct secondary analyses examining intervention implementation strategies and outcomes (e.g., engagement), intervention moderators, and costs of three digital interventions to increase sun protection behaviors previously evaluated for effectiveness in a randomized controlled trial (RCT).</p><p><strong>Methods: </strong>The RCT compared three conditions: a Basic efficacious intervention, an Enhanced version of the intervention, and an educational e-Pamphlet. Sun protection measures, intervention engagement and implementation, putative moderators, and intervention costs were assessed through one year.</p><p><strong>Results: </strong>Engagement (4.6 of 12 modules completed) was similar for Basic and Enhanced. Engagement was significantly associated with sun protection. Men and individuals with lower tanning ability completed more modules than women and those with higher tanning ability. Enhanced was more effective than Basic for men (but not women) through one year. After initial development, both active interventions were similar in cost per person at larger sample sizes.</p><p><strong>Conclusions: </strong>Despite attempts at enhancement, engagement in Basic and Enhanced was similar. Although all interventions were costly to create, they were less costly to maintain and could be scaled up for dissemination. Based on both engagement and effects on sun protection, the Enhanced intervention would be recommended for men, women, or both.</p><p><strong>Impact: </strong>This digital intervention offers the potential to reduce skin cancer risk in a large population of US YAs.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers of Nicotine and Tobacco Carcinogen Exposure in Socioeconomically Disadvantaged Black Adults Receiving a Brief Smoking Reduction Intervention.","authors":"Emma Brett, Jessica Slear, Maciej L Goniewicz, Andrea King","doi":"10.1158/1055-9965.EPI-24-1789","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1789","url":null,"abstract":"<p><strong>Background: </strong>Retrospective reporting of cigarette use can impact the accuracy of outcomes in tobacco treatment trials. The inclusion of objective measures of smoking, like biomarkers of nicotine and tobacco exposure, is recommended. Most trials examining biomarkers after a behavioral intervention have included predominantly White adults enrolled in cessation, versus reduction, trials. The current study examined biomarkers of nicotine and tobacco exposure within a harm reduction trial in Black adults who smoke (AWS).</p><p><strong>Methods: </strong>Non-treatment-seeking socioeconomically disadvantaged Black AWS (N=65) were randomized to a treatment-as-usual control or enhanced care (EC) single-session intervention aimed to reduce their smoking. Biospecimens were collected at baseline and 1-month post-treatment to measure objective markers of nicotine and smoke exposure, including expired carbon monoxide, urinary metabolites of nicotine (cotinine and trans-3'-hydroxycotinine), and urinary tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL).</p><p><strong>Results: </strong>Those in the EC condition self-reported a significant reduction in smoking at follow-up (p <.01), but there were no concomitant decreases across biomarkers (all ps >.05). Exploratory analyses in participants who reported at least 50% smoking reductions or reduced daily cigarette intake by at least three cigarettes at follow-up compared to baseline revealed nonsignificant changes across all biomarkers (all ps >.05).</p><p><strong>Conclusions: </strong>Self-reported smoking reductions were not biochemically verified across measures. It is possible that compensatory behaviors when reducing smoking (e.g., deeper inhalations) or underreporting of smoking contributed to this discrepancy.</p><p><strong>Impact: </strong>Partial smoking reduction does not appear to reduce biomarkers of carcinogen exposure and may not be an effective strategy to narrow tobacco-related health disparities in Black AWS.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of neighborhood socioeconomic deprivation measures and the association with survival among Black and White women with endometrial cancer.","authors":"Anna Gottschlich, Jamaica R M Robinson, Julie J Ruterbusch, Kaitlin Burchett, Rebecca M Adams, Ariel Washington, Michele L Cote, Ann G Schwartz, Kristen S Purrington, Mike R Wilson","doi":"10.1158/1055-9965.EPI-24-1833","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1833","url":null,"abstract":"<p><strong>Background: </strong>Black women with endometrial cancer (EC) have twice the mortality compared to White. Survival disparities remain after accounting for individual-level socioeconomic and cancer-related factors. We investigated associations between area-based deprivation and survival and explored whether area-based deprivation attenuates the association between race and survival, among a cohort of Black and White women.</p><p><strong>Methods: </strong>Data from ECs diagnosed between 2013-2022 were collected from a comprehensive cancer registry covering Metropolitan Detroit. Addresses at diagnosis were linked to Area Deprivation (ADI) and Social Vulnerability (SVI) indices. Adjusted Fine & Gray and Cox proportional hazard models were run investigating associations between area-based deprivation measures and survival; analyses were conducted estimating the proportion of the association between race and survival that was attenuated by area-based measures.</p><p><strong>Results: </strong>Higher deprivation was associated with poorer survival, adjusted for race, insurance status, and tumor characteristics. Compared to the least disadvantaged quartile, the quartile with the highest disadvantage using ADI and SVI had 1.18 (95% CI: 0.99, 1.43) and 1.40 (1.14, 1.71) times the hazard of EC-specific mortality, respectively. ADI and SVI attenuated 18% (3-38%) and 27% (10-48%) of associations between race and mortality overall, and 24% (95% CI: 3-61%) and 40% (95% CI: 16-78%) among those with high-grade histology.</p><p><strong>Conclusions: </strong>This study demonstrates a clear association between neighborhood-level disadvantage and survival among women with EC living in Metropolitan Detroit. Neighborhood disadvantage attenuates the relationship between race and survival, particularly among those with high-grade histology.</p><p><strong>Impact: </strong>These findings serve as motivation to understand how neighborhood impacts cancer outcomes.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy Lifestyle Index and Breast Cancer Risk among Postmenopausal Women: The Multiethnic Cohort Study.","authors":"Bethany T Ogbenna, Xin He, Anna H Wu, Loïc Le Marchand, Lynne R Wilkens, James Butler, Typhanye Dyer, Iona Cheng, Cher M Dallal","doi":"10.1158/1055-9965.EPI-24-1181","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1181","url":null,"abstract":"<p><strong>Background: </strong>Consistent evidence supports a reduction in breast cancer risk with a high healthy lifestyle index (HLI) score; however, this relationship has not been well studied in multiethnic populations.</p><p><strong>Methods: </strong>Within the Multiethnic Cohort study, we followed 65,561 African American, Japanese American, Latina, Native Hawaiian, and White postmenopausal women for incident invasive breast cancer (n=4,555, mean 19.2 years). The HLI summed seven components with higher scores assigned to healthier behaviors: diet quality, physical activity, sedentary behavior, smoking status, alcohol consumption, body mass index and sleep duration. Multivariable Cox proportional hazards models estimated adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for associations between the HLI score (continuous, tertiles (T)) and breast cancer risk overall and stratified by race and ethnicity and hormone receptor status. Multiplicative interaction by race and ethnicity (P-int) and heterogeneity of effect by hormone receptor status (P-het) assessed by the Wald test.</p><p><strong>Results: </strong>Higher HLI scores were associated with reduced postmenopausal breast cancer risk (aHRcont:0.95 [95% CI:0.94-0.97], P<0.0001; aHRT2vsT1:0.92 [95% CI:0.85-0.99], aHRT3vsT1: 0.81 [95% CI:0.75-0.87], P-trend<0.01) with similar risk reductions observed across racial and ethnic groups (P-trend≤0.05; P-int=0.96). Similar findings were observed with hormone receptor-positive breast cancer (overall: P-trend<0.01; P-int=0.90); no significant associations were observed with hormone receptor-negative breast cancer (P-trend >0.05; P-int=0.64; P-het=0.79).</p><p><strong>Conclusions: </strong>Higher HLI scores are associated with breast cancer risk reductions overall, by race and ethnicity and hormone receptor status.</p><p><strong>Impact: </strong>Engaging in healthy lifestyle behaviors may reduce breast cancer risk among a multiethnic population of postmenopausal women.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racialized Economic Segregation, Treatment and Outcomes in Women with Triple-Negative Breast Cancer.","authors":"Stanton Davis, Min Lian, Graham A Colditz, Kia L Davis, James Struthers, Ying Liu","doi":"10.1158/1055-9965.EPI-24-1398","DOIUrl":"10.1158/1055-9965.EPI-24-1398","url":null,"abstract":"<p><strong>Background: </strong>We previously demonstrated differences in treatment and mortality between non-Hispanic Black (NHB) and non-Hispanic White (NHW) women with triple-negative breast cancer (TNBC). The impact of residential segregation on TNBC treatment and outcomes remains unknown.</p><p><strong>Methods: </strong>We identified NHB and NHW women with TNBC diagnosed from 2010-2015 and followed through 2016, using the Surveillance, Epidemiology, and End Results dataset. County-level racialized economic segregation was measured using the Index of Concentration at the Extremes. Multilevel Cox regression and multilevel logistic regression accounting for county-level clustering were used to calculate hazard ratios (HRs) and odds ratios (ORs).</p><p><strong>Results: </strong>Of 25217 patients, 25.6% were NHB. Compared with patients in counties with the highest concentration of high-income NHW residents (most privileged), patients in counties with the highest concentration of low-income NHB residents (most deprived) had significantly higher risks of breast cancer-specific mortality (HR=1.14, 95% CI 1.01-1.30; Ptrend=0.12), overall mortality (HR=1.15, 95% CI 1.02-1.29; Ptrend=0.06), and late-stage diagnosis (OR=1.15, 95% CI 1.01-1.32; Ptrend=0.03). Overall, 28.2%, 24.5%, and 18.3% of excess risks of breast cancer mortality, overall mortality, and late-stage diagnosis in NHB (vs NHW) patients were explained by residential segregation. There was no significant association between residential segregation and treatment.</p><p><strong>Conclusions: </strong>Living in the most deprived vs privileged neighborhoods was associated with lower likelihoods of early detection and survival of TNBC, contributing to TNBC outcome disparities between NHBs and NHWs.</p><p><strong>Impact: </strong>This highlights the importance of breast cancer screening for neighborhoods with predominantly low-income NHB residents and elucidating the pathways linking segregation to TNBC prognosis.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is metabolic syndrome a risk factor for skin cancer? A UKBiobank Observational and two Sample Mendelian randomization Study.","authors":"Emily A M Black, Claudia Allemani, Tom Dudding","doi":"10.1158/1055-9965.EPI-24-1388","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1388","url":null,"abstract":"<p><strong>Background: </strong>Skin cancers (SCs) are the third most common cancer worldwide, with incidence increasing. Metabolic syndrome (MetS) is a cluster of metabolic abnormalities strongly associated with the development of cardiovascular disease. More than 1 in 5 individuals have MetS and it is linked with at least 14 different cancers. This study aimed to investigate whether MetS is a risk factor for SC.</p><p><strong>Methods: </strong>A prospective cohort study was conducted in UK Biobank. The association between MetS and SC was investigated using multivariable Poisson regression. To investigate causality, a two sample Mendelian randomization (MR) study was conducted using summary level Genome-wide association study data from UK Biobank (MetS) and FinnGen (SC).</p><p><strong>Results: </strong>467,919 participants were included, 26.7% had MetS. Follow-up was for up to 10.8 years. MetS showed a moderately sized protective effect on BCC while the effect for SCC and MM crossed the null. Overall, MR found there was some weak evidence for increase odds of SC in those with MetS (1.07 (OR = 1.07 (95% CI: 1.01, 1.14)). Conclusions= The observational study identifies a moderately sized protective effect of MetS on BCC with MR evidence suggesting a weak causal effect is in the opposite direction.</p><p><strong>Impact: </strong>This study has found little to no effect of MetS on SC, despite links between MetS and at least 14 other cancers.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Inflammation Biomarkers and the Risk of Esophageal Adenocarcinoma: A Nested Case-control Study in the Department of Defense Serum Repository.","authors":"Omonefe O Omofuma, Jennifer A Rusiecki, Jessica L Petrick, Roni T Falk, William Wheeler, Ruth M Pfeiffer, M Constanza Camargo, Michael B Cook","doi":"10.1158/1055-9965.EPI-24-1544","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1544","url":null,"abstract":"<p><strong>Background: </strong>We previously identified associations of esophageal adenocarcinoma (EA) risk with four inflammation-related candidate biomarkers: TNFR2, IL17A, VEGFR3 and resistin.</p><p><strong>Methods: </strong>We aimed to replicate these candidates and discover novel associations with additional proteins. We conducted a nested case-control study of men with prediagnostic biospecimens stored at the US Department of Defense Serum Repository, including 203 incident EA cases. Controls were matched to cases in an ~2:1 ratio by date of birth, race, service branch, and blood draw date. Multiplex immunoassays (Olink/Proseek panels) measured 254 proteins detected in ≥10% of all samples. Multivariable-adjusted conditional logistic regression models calculated associations between biomarker quantiles and EA. P-values (<0.05) were used to indicate the statistical significance of candidates, and false discovery rate (FDR) was applied to the additional proteins. Odds ratios (ORs) from the current analysis and from previous studies were combined for the candidate markers using fixed effects meta-analysis.</p><p><strong>Results: </strong>Among the four candidates, the highest category of TNFR2 was associated with significantly increased EA risk (ORQ4vsQ1=1.87, 95% confidence interval: 1.02-3.42). In the meta-analysis, associations with EA were positive for TNFR2 (meta-analyzed ORhighest-vs-lowest=2.04, 1.12-2.95) and inverse for IL17A (meta-analyzed ORhighest-vs-lowest=0.53, 0.26-0.80). Of the additional 250 proteins, 45 were associated with EA risk and 6 (MCP3, IL6, TNFR1, HGF, TFF3 and FURIN) remained significant after FDR correction.</p><p><strong>Conclusions: </strong>We confirmed associations of TNFR2 and IL17A with EA risk. Additionally, our study expands the range of proteins associated with EA development.</p><p><strong>Impact: </strong>This is the largest assessment of inflammation-related proteins with EA to date.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The causal relationship between telomere length and cancer risk: A two-sample Mendelian randomization.","authors":"Su Hyun Lee, Dae Sub Song, Un Chong Kim, Sun Ha Jee, Kyoungho Lee","doi":"10.1158/1055-9965.EPI-24-1168","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1168","url":null,"abstract":"<p><strong>Background: </strong>Telomere length shortens with age and is associated with an increased risk of numerous chronic diseases. However, the causal direction between telomere length and cancer risk remains uncertain. This study aimed to assess the causal impact of telomere length on cancer risk using Mendelian randomization(MR) analysis.</p><p><strong>Methods: </strong>Genome-wide association studies(GWAS) from Singapore and China data, the Korean Cancer Prevention Study(KCPS)-II, the Korean Genome Epidemiologic Study(KoGES), and the Biobank of Japan(BBJ) were utilized. A two-sample MR study was performed using summary-level GWAS data from individuals of East Asian ancestry. Single nucleotide polymorphism(SNPs) associated with telomere length were used as instrumental variables.</p><p><strong>Results: </strong>Longer telomere length per 1SD increase due to germline genetic variants was associated with a higher risk of site-specific cancer. In the KCPS-II and KOGES, the strongest association was observed with thyroid cancer[OR 2.49(95%CI, 1.79-3.47), 2.27(1.49-3.46)], followed by lung cancer [OR 2.19(95%CI, 1.60-3.08) and 1.45(1.12-1.87)]. Similar results were observed in BBJ, with OR 2.92(95%CI, 1.75-4.88) for thyroid cancer and 2.04(1.41-2.94) for lung cancer. In histological subgroup analysis of KCPS-II, a significant relationship was found with lung adenocarcinoma [(OR 2.26(95%CI, 1.55-3.31)] but not with lung squamous cell carcinoma(1.21, 0.47-3.06). After removing outlier SNPs in the radial MR analysis, significant associations were identified for both lung adenocarcinoma [(OR 1.88(95%CI, 1.25-2.82)] and lung squamous cell carcinoma (2.29,1.05-4.98).</p><p><strong>Conclusion: </strong>Our findings suggest that longer telomere length increases the risk of various cancers in East Asian populations.</p><p><strong>Impact: </strong>Genetically determined longer telomere length may contribute to a risk of certain cancers.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}