Cancer Epidemiology Biomarkers & Prevention最新文献

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Asymptomatic Incidence of Monoclonal Gammopathy of Undetermined Significance and Preclinical Duration to Myeloma Diagnosis: A Modeling Study. 意义未定的单克隆丙种球蛋白病的无症状发病率和骨髓瘤诊断的临床前持续时间:模型研究。
IF 3.7 3区 医学
Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-06 DOI: 10.1158/1055-9965.EPI-24-0490
Mengmeng Ji, Yi-Hsuan Shih, John H Huber, Mei Wang, Eric J Feuer, Ruth Etzioni, Shi-Yi Wang, Su-Hsin Chang
{"title":"Asymptomatic Incidence of Monoclonal Gammopathy of Undetermined Significance and Preclinical Duration to Myeloma Diagnosis: A Modeling Study.","authors":"Mengmeng Ji, Yi-Hsuan Shih, John H Huber, Mei Wang, Eric J Feuer, Ruth Etzioni, Shi-Yi Wang, Su-Hsin Chang","doi":"10.1158/1055-9965.EPI-24-0490","DOIUrl":"10.1158/1055-9965.EPI-24-0490","url":null,"abstract":"<p><p>Background Monoclonal gammopathy of undetermined significance (MGUS) is the premalignant condition of multiple myeloma (MM). Given a lack of population-based screening for MGUS and its asymptomatic nature, the epidemiology of MGUS remains unknown. This study estimated age- and race/ethnicity-specific MGUS incidence and preclinical duration from MGUS to MM in the United States. Methods A previously published modeling approach was used to calculate national MGUS incidence using estimates of MGUS prevalence, MM incidence, MM-specific and all-cause mortality, and population age distribution from the National Health and Nutrition Examination Survey, 1999-2004, and Surveillance, Epidemiology, and End Results, 2000-2021. The estimated MGUS prevalence was divided by MGUS incidence to obtain preclinical duration of MM. Results MGUS incidence for non-Hispanic white (NHW) populations was 52, 86, 142, and 181 and for non-Hispanic black (NHB) population was 110, 212, 392, and 570 per 100,000 person-years at ages 50, 60, 70, and 80, respectively. The average preclinical duration was 20.5 (95% confidence interval, CI: 16.5, 26.1) years for the NHW population and 14.2 (95% CI: 11.5, 17.6) years for the NHB population. The cumulative risk of developing MGUS in age 50-85 was 2.8% (95% CI: 1.7%, 4.2%) for the NHW population and 6.1% (95% CI: 3.8%, 10.0%) for the NHB population. Conclusion NHB populations had a higher MGUS incidence rate at all ages and a shorter preclinical duration of MM compared to their NHW counterparts. Impact This study provides insights into the epidemiology of MGUS and enhances our understanding of the natural history of MM.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lifecourse growth and development determinants of mammographic density in Black women. 黑人妇女乳房 X 线照相密度的生命周期生长和发育决定因素。
IF 3.7 3区 医学
Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-02 DOI: 10.1158/1055-9965.EPI-24-0494
Zahna Bigham, Etienne X Holder, Angie Mae Rodday, Janis Breeze, Kerrie P Nelson, Julie R Palmer, Karen M Freund, Kimberly A Bertrand
{"title":"Lifecourse growth and development determinants of mammographic density in Black women.","authors":"Zahna Bigham, Etienne X Holder, Angie Mae Rodday, Janis Breeze, Kerrie P Nelson, Julie R Palmer, Karen M Freund, Kimberly A Bertrand","doi":"10.1158/1055-9965.EPI-24-0494","DOIUrl":"10.1158/1055-9965.EPI-24-0494","url":null,"abstract":"<p><strong>Background: </strong>High mammographic density is one of the strongest breast cancer risk factors; however, determinants of high mammographic density are understudied in Black women. We assessed growth and development factors across the lifecourse in relation to mammographic density.</p><p><strong>Methods: </strong>Within the Black Women's Health Study (BWHS), we used Cumulus software to assess percent mammographic density from digital screening mammograms for 5,905 women ages 40-74. We fit linear regression models to quantify the association of lifecourse characteristics including birth weight, childhood somatotype, age at menarche, body mass index (BMI) at age 18, height, BMI at mammography, and adulthood waist-to-hip ratio with density overall and by age. We also performed a path analysis to assess the total and mediating effects of the growth and development factors on density.</p><p><strong>Results: </strong>BMI at age 18, height, BMI at mammography, and waist-to-hip ratio were significantly and inversely associated with density. On path analysis, total effects of childhood somatotype (standardized  = -0.05, p <0.001), BMI at age 18 (standardized  = -0.13, p <0.001), BMI at mammography (standardized  = -0.22, p <0.001), and waist-to-hip ratio (standardized  = -0.04, p <0.001) were associated with density.</p><p><strong>Conclusions: </strong>Several factors across the lifecourse - greater childhood somatotype, BMI at age 18, height, BMI at mammography, and waist-to-hip ratio - were associated with lower mammographic density in this cohort of Black women.</p><p><strong>Impact: </strong>Body size closer to the time of mammography may be more meaningful in determining mammographic density, though early life adiposity also influences mammographic density.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colposcopy Referral and CIN3+ Risk of Human Papillomavirus Genotyping Strategies in Cervical Cancer Screening. 阴道镜检查转诊与宫颈癌筛查中人类乳头瘤病毒基因分型策略的 CIN3+ 风险。
IF 3.7 3区 医学
Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-01 DOI: 10.1158/1055-9965.EPI-24-0046
Kelsi R Kroon, Johannes A Bogaards, Daniëlle A M Heideman, Chris J L M Meijer, Johannes Berkhof
{"title":"Colposcopy Referral and CIN3+ Risk of Human Papillomavirus Genotyping Strategies in Cervical Cancer Screening.","authors":"Kelsi R Kroon, Johannes A Bogaards, Daniëlle A M Heideman, Chris J L M Meijer, Johannes Berkhof","doi":"10.1158/1055-9965.EPI-24-0046","DOIUrl":"10.1158/1055-9965.EPI-24-0046","url":null,"abstract":"<p><strong>Background: </strong>High-risk human papillomavirus (hrHPV)-based cervical cancer screening in the Netherlands led to a substantial increase in number of colposcopy referrals and low-grade lesions detected. Genotyping strategies may be employed to lower the screening-related burden.</p><p><strong>Methods: </strong>We evaluated 14 triage strategies with genotyping (HPV16/18 or HPV16/18/31/33/45/52/58) for hrHPV-positive borderlineormilddyskaryosis (BMD)ornormal cytology,usingdata from a population-based hrHPV-based screening trial with 5-year interval (POBASCAM). We considered colposcopy referral at baseline, after 6-month repeat cytology and after 5-year hrHPV testing. Performance was evaluated by one-round positive and negative predictive value (PPVandNPV) for CIN3+ and by two-roundcolposcopy referral rate. To identify efficient strategies, they were ordered by the one-round colposcopy referral rate. Adjacent strategies were compared by the marginal PPV for detecting one additional CIN3+ (mPPV).</p><p><strong>Results: </strong>The most conservative strategy (repeat cytology after BMD and HPV16/18/31/33/45/52/58-positive normal cytology, next round otherwise) yielded an mPPV of 28%, NPV of 98.2%, and two-round colposcopy referral rate of 47.2%. Adding direct referral after BMD or genotype-positive BMD yielded an mPPV ≤ 8.2%, NPV ≥ 98.5% and an increase in colposcopy referral rate of 1.9% to 6.5%. Adding direct referral after HPV16/18-positive normal cytology yielded an mPPV ≤ 3.5%, NPV ≥ 99.5% and an increase in colposcopy referral rate of 13.9%.</p><p><strong>Conclusions: </strong>Direct colposcopy referral of women with BMD or normal cytology is unlikely to be efficient, but genotype-guided direct referral after BMD may be considered because the increase in colposcopies is limited.</p><p><strong>Impact: </strong>hrHPV screening programs can become very efficient when immediate colposcopy referral is limited to women at highest CIN3+ risk. See related In the Spotlight, p. 979.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"1037-1045"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140304964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
History of Infertility and Risk of Colorectal Cancer. 不孕不育史与罹患结直肠癌的风险。
IF 3.7 3区 医学
Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-01 DOI: 10.1158/1055-9965.EPI-24-0313
Leslie V Farland, Kimberly E Lind, Denise J Roe, Nazmus Saquib, Howard D Strickler, Lihong Qi, Cynthia A Thomson, Holly R Harris
{"title":"History of Infertility and Risk of Colorectal Cancer.","authors":"Leslie V Farland, Kimberly E Lind, Denise J Roe, Nazmus Saquib, Howard D Strickler, Lihong Qi, Cynthia A Thomson, Holly R Harris","doi":"10.1158/1055-9965.EPI-24-0313","DOIUrl":"10.1158/1055-9965.EPI-24-0313","url":null,"abstract":"<p><strong>Background: </strong>There has been limited prior research on the association between infertility and risk of colorectal cancer.</p><p><strong>Methods: </strong>Data from postmenopausal women in the Women's Health Initiative were used to estimate the association between self-reported infertility (12 months of trying to get pregnant without achieving a pregnancy) and the risk of colorectal cancer using Cox proportional hazard models.</p><p><strong>Results: </strong>No association was observed between infertility and risk of postmenopausal colorectal cancer [RR, 0.97; 95% confidence interval (CI), 0.87-1.08], invasive colorectal cancer (RR, 0.99; 95% CI, 0.88-1.10), or colorectal cancer mortality (RR, 0.89; 95% CI, 0.71-1.12).</p><p><strong>Conclusions: </strong>Infertility was not found to be associated with colorectal cancer risk among postmenopausal women. Risk did not vary by specific infertility diagnoses.</p><p><strong>Impact: </strong>Infertility may not be associated with colorectal cancer risk.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"1129-1131"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding Benign Breast Disease and Subsequent Breast Cancer in Hispanic White Females: A Step Closer to Evidence-Based Management. 了解西班牙裔白人女性的良性乳腺疾病及其后的乳腺癌;向循证管理迈进了一步。
IF 3.7 3区 医学
Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-01 DOI: 10.1158/1055-9965.EPI-24-0204
Kush R Lohani, Andrea M Nibbe, Robert A Vierkant, Laura M Pacheco-Spann, Lisa R Seymour, Celine M Vachon, Mark E Sherman, Stacey J Winham, Amy C Degnim, Deirdre A Hill
{"title":"Understanding Benign Breast Disease and Subsequent Breast Cancer in Hispanic White Females: A Step Closer to Evidence-Based Management.","authors":"Kush R Lohani, Andrea M Nibbe, Robert A Vierkant, Laura M Pacheco-Spann, Lisa R Seymour, Celine M Vachon, Mark E Sherman, Stacey J Winham, Amy C Degnim, Deirdre A Hill","doi":"10.1158/1055-9965.EPI-24-0204","DOIUrl":"10.1158/1055-9965.EPI-24-0204","url":null,"abstract":"<p><strong>Introduction: </strong>Although Hispanic White (HW) females have a lower incidence of breast cancer than non-Hispanic White (NHW) females, breast cancer risk is unclear for HW females after benign breast disease (BBD).</p><p><strong>Methods: </strong>We compared BBD characteristics and subsequent breast cancer risk among HW and NHW females in New Mexico using a population-based collection of benign breast biopsies (1996-2007). BBD was categorized as nonproliferative disease (NPD), proliferative disease without atypia (PDWA), or atypical hyperplasia (AH). Breast cancer risk was assessed as absolute risk (AR) using cumulative incidence and RR by comparing the number of breast cancer events in BBDs to non-BBD.</p><p><strong>Results: </strong>This study included 3,684 HW and 6,587 NHW females with BBD. HW females had similar proportions of NPD (58.6% vs. 54.3%), PDWA (21.4% vs. 23.5%), and AH (3.6% vs. 3.3%) as NHW females. Breast cancer risk among all females with BBD was higher than population-based expected rates (RR, 1.87) and was similar for HW and NHW subgroups (RR = 1.99 vs. 1.84). As expected, breast cancer risk increased with increasing BBD severity, both overall [RR, 1.81 (NPD), 1.85 (PDWA), and 3.10 (AH)] and in the HW and NHW subgroups. Adjusted AR of breast cancer at 5 years also increased with the severity of BBD (HW vs. NHW; NPD: 1.4% vs. 2.1%; PDWA: 1.5% vs. 2.7%; AH: 6% vs. 4.8%).</p><p><strong>Conclusions: </strong>We found similar breast cancer RRs and ARs in HW and NHW. Risk counseling should ensure that HW females receive breast cancer clinical management warranted by their similar absolute risks.</p><p><strong>Impact: </strong>The present population-based provides evidence for the clinical management of HW females with BBD for the prevention of breast cancer.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"1107-1113"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Risk of Second Malignant Neoplasm after Childhood Cancer Treatment: A Systematic Review. 儿童癌症治疗后二次恶性肿瘤的遗传风险:系统综述。
IF 3.7 3区 医学
Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-01 DOI: 10.1158/1055-9965.EPI-24-0010
Claire Ducos, Naïla Aba, Filippo Rosselli, Brice Fresneau, Baraah Al Ahmad Nachar, Monia Zidane, Florent de Vathaire, Simone Benhamou, Nadia Haddy
{"title":"Genetic Risk of Second Malignant Neoplasm after Childhood Cancer Treatment: A Systematic Review.","authors":"Claire Ducos, Naïla Aba, Filippo Rosselli, Brice Fresneau, Baraah Al Ahmad Nachar, Monia Zidane, Florent de Vathaire, Simone Benhamou, Nadia Haddy","doi":"10.1158/1055-9965.EPI-24-0010","DOIUrl":"10.1158/1055-9965.EPI-24-0010","url":null,"abstract":"<p><p>Second malignant neoplasm (SMN) is one of the most severe long-term risks for childhood cancer survivors (CCS), significantly impacting long-term patient survival. While radiotherapy and chemotherapy are known risk factors, the observed inter-individual variability suggests a genetic component contributing to the risk of SMN. This article aims to conduct a systematic review of genetic factors implicated in the SMN risk among CCS. Searches were performed in PubMed, Scopus, and Web of Sciences. Eighteen studies were included (eleven candidate gene studies, three genome-wide association studies, and four whole exome/genome sequencing studies). The included studies were based on different types of first cancers, investigated any or specific types of SMN, and focused mainly on genes involved in drug metabolism and DNA repair pathways. These differences in study design and methods used to characterize genetic variants limit the scope of the results and highlight the need for further extensive and standardized investigations. However, this review provides a valuable compilation of SMN risk-associated variants and genes, facilitating efficient replication and advancing our understanding of the genetic basis for this major risk for CCS.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"999-1011"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-Specific Cancer Mortality in the US During the COVID-19 Pandemic, March to December 2020. 2020 年 3 月至 12 月 COVID-19 大流行期间美国特定年龄段癌症死亡率。
IF 3.7 3区 医学
Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-01 DOI: 10.1158/1055-9965.EPI-24-0121
Meredith S Shiels, Anika T Haque, Neal D Freedman, Hae-Rin Kim, Amy Berrington de González, Paul S Albert
{"title":"Age-Specific Cancer Mortality in the US During the COVID-19 Pandemic, March to December 2020.","authors":"Meredith S Shiels, Anika T Haque, Neal D Freedman, Hae-Rin Kim, Amy Berrington de González, Paul S Albert","doi":"10.1158/1055-9965.EPI-24-0121","DOIUrl":"10.1158/1055-9965.EPI-24-0121","url":null,"abstract":"<p><strong>Background: </strong>It is important to understand the impact of the COVID-19 pandemic on cancer death rates in 2020 in the US. We estimated whether there were larger-than-expected changes in cancer mortality rates from March to December 2020 after accounting for temporal and seasonal patterns using data from January 2011 to February 2020 by cancer type and age.</p><p><strong>Methods: </strong>We obtained death counts and underlying causes of death by cancer type, month/year (2011-2020), and age group from the National Center for Health Statistics and population estimates from the US Census Bureau. Poisson regression was used to test for significant changes in cancer death rates from March to December 2020 compared with prior years.</p><p><strong>Results: </strong>After accounting for temporal trends and seasonal patterns, total cancer death rates were significantly lower than expected during March to December 2020 among 55- to 64-year-olds and ≥75-year-olds, but not in other age groups. Cancer death rates were 2% lower than expected from March to June among 55- to 64-year-olds and 2% to 3% lower from March to July and December among ≥75-year-olds. Among ≥75-year-olds, colorectal cancer death rates were lower from March to June [rate ratios (RR) = 0.94-0.96; P < 0.05]; however, lung cancer death rates were 5% lower across each month (all RRs = 0.95; P < 0.05).</p><p><strong>Conclusions: </strong>In the US, cancer death rates based on the underlying cause of death were broadly similar to expected rates from March to December 2020. However, cancer death rates were lower than expected among 55- to 64-year-olds and ≥75-year-olds, likely due to COVID-19 as a competing cause of death.</p><p><strong>Impact: </strong>Cancer mortality rates from 2020 should be interpreted with caution.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"1023-1027"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141282996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimating the Effects of Cancer Screening in Clinical Practice Settings: The Role of Selective Uptake and Suboptimal Adherence along the Cancer Screening Continuum. 估算临床实践中癌症筛查的效果:癌症筛查过程中选择性接受和次优坚持的作用。
IF 3.7 3区 医学
Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-01 DOI: 10.1158/1055-9965.EPI-23-1491
Jennifer L Lund, M Patricia Rivera, I-Hsuan Su, Jason M Long, Xiaomeng Chen, Joyce Pak, Michael G Hudgens, Til Stürmer, Daniel S Reuland, Louise M Henderson
{"title":"Estimating the Effects of Cancer Screening in Clinical Practice Settings: The Role of Selective Uptake and Suboptimal Adherence along the Cancer Screening Continuum.","authors":"Jennifer L Lund, M Patricia Rivera, I-Hsuan Su, Jason M Long, Xiaomeng Chen, Joyce Pak, Michael G Hudgens, Til Stürmer, Daniel S Reuland, Louise M Henderson","doi":"10.1158/1055-9965.EPI-23-1491","DOIUrl":"10.1158/1055-9965.EPI-23-1491","url":null,"abstract":"<p><p>Randomized controlled trials (RCT) are the gold standard in determining efficacy of cancer screening tests. Yet, systematic differences between RCT and the general populations eligible for screening raise concerns about the generalizability and relevance of RCT findings to guide the development and dissemination of cancer screening programs. Observational studies from clinical practice settings have documented selective uptake in screening-i.e., variation across subgroups regarding who is screened and not screened-as well as suboptimal adherence to screening recommendations, including follow-up of positive findings with subsequent imaging studies and diagnostic invasive procedures. When the effectiveness of a screening intervention varies across subgroups, and there is selective uptake and suboptimal adherence to screening in clinical practice relative to that in the RCT, the effects of screening reported in RCTs are not expected to generalize to clinical practice settings. Understanding the impacts of selective uptake and suboptimal adherence on estimates of the effectiveness of cancer screening in clinical practice will generate evidence that can be used to inform future screening recommendations and enhance shared decision-making tools.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"984-988"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promise and Perils of Primary HPV Testing. 初级人类乳头瘤病毒检测的希望与危险。
IF 3.7 3区 医学
Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-01 DOI: 10.1158/1055-9965.EPI-24-0716
Jennifer C Spencer, Cosette M Wheeler
{"title":"Promise and Perils of Primary HPV Testing.","authors":"Jennifer C Spencer, Cosette M Wheeler","doi":"10.1158/1055-9965.EPI-24-0716","DOIUrl":"10.1158/1055-9965.EPI-24-0716","url":null,"abstract":"<p><p>Cervical cancer screening has reduced morbidity and mortality in many countries, but efforts to optimize screening modalities and schedules are ongoing. Using data from a randomized trial conducted in British Columbia, Canada, in conjunction with a provincial screening registry, Gottschlich and colleagues demonstrated that the estimated risk for precancerous disease (cervical intraepithelial neoplasia grades 2 or worse) at 8 years following a negative human papillomavirus (HPV) test was similar to the current standard of care (Pap testing after 3 years). The study supports extending screening intervals for those with a negative HPV test beyond currently recommended 5-year intervals. In an ideal world, the resources saved through less frequent routine cervical screening could be redirected to increasing screening uptake and follow-up of abnormalities to improve equity in cervical cancer prevention. However, implementation of extending screening intervals remains less than straightforward in settings with fragmented healthcare systems that lack information systems to support patient call/recall, such as the United States. To achieve the full promise of primary HPV testing, stakeholders at every level must commit to identifying and addressing the diverse spectrum of barriers that undergird existing inequities in care access, appropriately resource implementation strategies, and improve health information systems. See related article by Gottschlich et al., p. 904.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":"33 8","pages":"982-983"},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11292190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Joint Associations of Diet and Device-Measured Physical Activity with Mortality and Incident CVD and Cancer: A Prospective Analysis of the UK Biobank Study. 饮食和设备测量的体育锻炼与死亡率及心血管疾病和癌症发病率的联合关系:英国生物库研究的前瞻性分析。
IF 3.7 3区 医学
Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-01 DOI: 10.1158/1055-9965.EPI-23-1185
Elif Inan-Eroglu, Matthew Ahmadi, Raaj Kishore Biswas, Ding Ding, Leandro F M Rezende, I-Min Lee, Edward L Giovannucci, Emmanuel Stamatakis
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