Cancer Epidemiology Biomarkers & Prevention最新文献

{"title":"A comparison of neighborhood socioeconomic deprivation measures and the association with survival among Black and White women with endometrial cancer.","authors":"Anna Gottschlich, Jamaica R M Robinson, Julie J Ruterbusch, Kaitlin Burchett, Rebecca M Adams, Ariel Washington, Michele L Cote, Ann G Schwartz, Kristen S Purrington, Mike R Wilson","doi":"10.1158/1055-9965.EPI-24-1833","DOIUrl":"10.1158/1055-9965.EPI-24-1833","url":null,"abstract":"<p><strong>Background: </strong>Black women with endometrial cancer (EC) have twice the mortality compared to White. Survival disparities remain after accounting for individual-level socioeconomic and cancer-related factors. We investigated associations between area-based deprivation and survival and explored whether area-based deprivation attenuates the association between race and survival, among a cohort of Black and White women.</p><p><strong>Methods: </strong>Data from ECs diagnosed between 2013-2022 were collected from a comprehensive cancer registry covering Metropolitan Detroit. Addresses at diagnosis were linked to Area Deprivation (ADI) and Social Vulnerability (SVI) indices. Adjusted Fine & Gray and Cox proportional hazard models were run investigating associations between area-based deprivation measures and survival; analyses were conducted estimating the proportion of the association between race and survival that was attenuated by area-based measures.</p><p><strong>Results: </strong>Higher deprivation was associated with poorer survival, adjusted for race, insurance status, and tumor characteristics. Compared to the least disadvantaged quartile, the quartile with the highest disadvantage using ADI and SVI had 1.18 (95% CI: 0.99, 1.43) and 1.40 (1.14, 1.71) times the hazard of EC-specific mortality, respectively. ADI and SVI attenuated 18% (3-38%) and 27% (10-48%) of associations between race and mortality overall, and 24% (95% CI: 3-61%) and 40% (95% CI: 16-78%) among those with high-grade histology.</p><p><strong>Conclusions: </strong>This study demonstrates a clear association between neighborhood-level disadvantage and survival among women with EC living in Metropolitan Detroit. Neighborhood disadvantage attenuates the relationship between race and survival, particularly among those with high-grade histology.</p><p><strong>Impact: </strong>These findings serve as motivation to understand how neighborhood impacts cancer outcomes.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy Lifestyle Index and Breast Cancer Risk among Postmenopausal Women: The Multiethnic Cohort Study.","authors":"Bethany T Ogbenna, Xin He, Anna H Wu, Loïc Le Marchand, Lynne R Wilkens, James Butler, Typhanye Dyer, Iona Cheng, Cher M Dallal","doi":"10.1158/1055-9965.EPI-24-1181","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1181","url":null,"abstract":"<p><strong>Background: </strong>Consistent evidence supports a reduction in breast cancer risk with a high healthy lifestyle index (HLI) score; however, this relationship has not been well studied in multiethnic populations.</p><p><strong>Methods: </strong>Within the Multiethnic Cohort study, we followed 65,561 African American, Japanese American, Latina, Native Hawaiian, and White postmenopausal women for incident invasive breast cancer (n=4,555, mean 19.2 years). The HLI summed seven components with higher scores assigned to healthier behaviors: diet quality, physical activity, sedentary behavior, smoking status, alcohol consumption, body mass index and sleep duration. Multivariable Cox proportional hazards models estimated adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for associations between the HLI score (continuous, tertiles (T)) and breast cancer risk overall and stratified by race and ethnicity and hormone receptor status. Multiplicative interaction by race and ethnicity (P-int) and heterogeneity of effect by hormone receptor status (P-het) assessed by the Wald test.</p><p><strong>Results: </strong>Higher HLI scores were associated with reduced postmenopausal breast cancer risk (aHRcont:0.95 [95% CI:0.94-0.97], P<0.0001; aHRT2vsT1:0.92 [95% CI:0.85-0.99], aHRT3vsT1: 0.81 [95% CI:0.75-0.87], P-trend<0.01) with similar risk reductions observed across racial and ethnic groups (P-trend≤0.05; P-int=0.96). Similar findings were observed with hormone receptor-positive breast cancer (overall: P-trend<0.01; P-int=0.90); no significant associations were observed with hormone receptor-negative breast cancer (P-trend >0.05; P-int=0.64; P-het=0.79).</p><p><strong>Conclusions: </strong>Higher HLI scores are associated with breast cancer risk reductions overall, by race and ethnicity and hormone receptor status.</p><p><strong>Impact: </strong>Engaging in healthy lifestyle behaviors may reduce breast cancer risk among a multiethnic population of postmenopausal women.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racialized Economic Segregation, Treatment and Outcomes in Women with Triple-Negative Breast Cancer.","authors":"Stanton Davis, Min Lian, Graham A Colditz, Kia L Davis, James Struthers, Ying Liu","doi":"10.1158/1055-9965.EPI-24-1398","DOIUrl":"10.1158/1055-9965.EPI-24-1398","url":null,"abstract":"<p><strong>Background: </strong>We previously demonstrated differences in treatment and mortality between non-Hispanic Black (NHB) and non-Hispanic White (NHW) women with triple-negative breast cancer (TNBC). The impact of residential segregation on TNBC treatment and outcomes remains unknown.</p><p><strong>Methods: </strong>We identified NHB and NHW women with TNBC diagnosed from 2010-2015 and followed through 2016, using the Surveillance, Epidemiology, and End Results dataset. County-level racialized economic segregation was measured using the Index of Concentration at the Extremes. Multilevel Cox regression and multilevel logistic regression accounting for county-level clustering were used to calculate hazard ratios (HRs) and odds ratios (ORs).</p><p><strong>Results: </strong>Of 25217 patients, 25.6% were NHB. Compared with patients in counties with the highest concentration of high-income NHW residents (most privileged), patients in counties with the highest concentration of low-income NHB residents (most deprived) had significantly higher risks of breast cancer-specific mortality (HR=1.14, 95% CI 1.01-1.30; Ptrend=0.12), overall mortality (HR=1.15, 95% CI 1.02-1.29; Ptrend=0.06), and late-stage diagnosis (OR=1.15, 95% CI 1.01-1.32; Ptrend=0.03). Overall, 28.2%, 24.5%, and 18.3% of excess risks of breast cancer mortality, overall mortality, and late-stage diagnosis in NHB (vs NHW) patients were explained by residential segregation. There was no significant association between residential segregation and treatment.</p><p><strong>Conclusions: </strong>Living in the most deprived vs privileged neighborhoods was associated with lower likelihoods of early detection and survival of TNBC, contributing to TNBC outcome disparities between NHBs and NHWs.</p><p><strong>Impact: </strong>This highlights the importance of breast cancer screening for neighborhoods with predominantly low-income NHB residents and elucidating the pathways linking segregation to TNBC prognosis.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clonal Hematopoiesis of Indeterminate Potential as a Predictor of Colorectal Cancer Risk: Insights from the UK Biobank Cohort.","authors":"Yongfeng Liu, Zhihui Xi, Jianlong Zhou, Fa Ling, Yucheng Zhang, Huajie Xie, Jiabin Zheng, Baijin Xia, Huolun Feng, Yong Li","doi":"10.1158/1055-9965.EPI-24-1342","DOIUrl":"10.1158/1055-9965.EPI-24-1342","url":null,"abstract":"<p><strong>Background: </strong>Clonal hematopoiesis of indeterminate potential (CHIP) has been shown to be associated with the occurrence of solid tumors, but its relationship with colorectal cancer still needs to be studied.</p><p><strong>Methods: </strong>We conducted a prospective matched case-control study using data from the UK Biobank, including 5,310 incident colorectal cancer cases and 26,550 controls matched for age, sex, and body mass index.</p><p><strong>Results: </strong>Analysis of the UK Biobank data revealed that the presence of CHIP was associated with an increased risk of colorectal cancer. The odds ratio (OR) for colorectal cancer in the presence of CHIP was 1.20 (P = 0.006). This association remained significant even after excluding participants with a family history of bowel cancer (multivariate OR, 1.19; P = 0.007). Subgroup analyses demonstrated that CHIP independently increased the risk of colorectal cancer in females (multivariate OR, 1.25; P = 0.018) and in individuals older than 60 years (multivariate OR, 1.17; P = 0.046). Gene-specific analyses revealed that mutations in TET2 and ATM were particularly significant in relation to colorectal cancer risk, with an OR of 1.62 (P = 0.002) for TET2 and 2.98 (P < 0.001) for ATM.</p><p><strong>Conclusions: </strong>Our findings indicate that CHIP is associated with an increased risk of colorectal cancer, particularly in individuals more than 60 years of age or in females.</p><p><strong>Impact: </strong>Screening for CHIP in the population may improve the early detection and diagnosis rates of colorectal cancer.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"405-411"},"PeriodicalIF":3.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Clinical Covariates on Serum miRNA Expression among Women without Ovarian Cancer.","authors":"Laura Wollborn, James W Webber, Stephanie Alimena, Sudhanshu Mishra, Chad B Sussman, Cameron E Comrie, Daniel G Packard, Marta Williams, Trinity Russell, Wojciech Fendler, Dipanjan Chowdhury, Kevin M Elias","doi":"10.1158/1055-9965.EPI-23-1355","DOIUrl":"10.1158/1055-9965.EPI-23-1355","url":null,"abstract":"<p><strong>Background: </strong>Serum miRNAs are potential biomarkers for ovarian cancer; however, many factors may influence miRNA expression. To understand potential confounders in miRNA analysis, we examined how sociodemographic factors and comorbidities, including known ovarian cancer risk factors, influence serum miRNA levels in women without ovarian cancer.</p><p><strong>Methods: </strong>Data from 1,576 women from the Mass General Brigham Biobank collected between 2012 and 2019, excluding subjects previously or subsequently diagnosed with ovarian cancer, were examined. Using a focused panel of 179 miRNA probes optimized for serum profiling, miRNA expression was measured by flow cytometry using the Abcam FirePlex assay and correlated with subjects' electronic medical records.</p><p><strong>Results: </strong>The study population broadly reflected the New England population. The median age of subjects was 49 years, 34% were current or prior smokers, 33% were obese (body mass index > 30 kg/m2), 49% were postmenopausal, and 11% had undergone prior bilateral oophorectomy. Significant differences in miRNA expression were observed among ovarian risk factors such as age, obesity, menopause, BRCA1 or BRCA2 germline mutations, or existence of breast cancer in family history. Additionally, miRNA expression was significantly altered by prior bilateral oophorectomy, hypertension, and hypercholesterolemia. Other variables, such as smoking; parity; age at menarche; hormonal replacement therapy; oral contraception; breast, endometrial, or colon cancer; and diabetes, were not associated with significant changes in the panel when corrected for multiple testing.</p><p><strong>Conclusions: </strong>Serum miRNA expression patterns are significantly affected by patient demographics, exposure history, and medical comorbidities.</p><p><strong>Impact: </strong>Understanding confounders in serum miRNA expression is important for refining clinical assays for cancer screening.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"385-393"},"PeriodicalIF":3.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Health Conditions among LGBTQ+ Cancer Survivors: Letter.","authors":"Di Zhao, Jie Liu","doi":"10.1158/1055-9965.EPI-24-1737","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1737","url":null,"abstract":"","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":"34 3","pages":"448"},"PeriodicalIF":3.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red Meat, Poultry, and Fish Consumption and the Risk of Liver Cancer: A Prospective Cohort Study of 0.5 Million Chinese Adults.","authors":"Chun-Rui Wang, Dong Cai, Kun He, Jie-Jun Hu, Xin Dai, Qian Zhu, Guo-Chao Zhong","doi":"10.1158/1055-9965.EPI-24-1158","DOIUrl":"10.1158/1055-9965.EPI-24-1158","url":null,"abstract":"<p><strong>Background: </strong>Epidemiological evidence on meat consumption and liver cancer risk is limited and inconclusive; moreover, no prospective study has been conducted to investigate this association in China. Hence, we performed this study to examine the association of red meat, poultry, and fish consumption with the risk of liver cancer in a Chinese population.</p><p><strong>Methods: </strong>A total of 510,048 Chinese adults of ages 30 to 79 years were included and were followed up through December 31, 2016. Red meat, poultry, and fish consumption was evaluated using an interviewer-administered laptop-based questionnaire. HRs and 95% confidence intervals (CI) for liver cancer incidence were calculated using Cox regression.</p><p><strong>Results: </strong>Over a mean follow-up of 9.94 years, 1,906 liver cancer cases were observed. Each 50 g/day increase in red meat (HR 0.72; 95% CI, 0.49-1.05), poultry (HR 0.93; 95% CI, 0.83-1.03), and fish (HR 0.95; 95% CI, 0.85-1.05) consumption was not associated with the risk of liver cancer in the whole study population; however, subgroup analysis revealed an inverse association with poultry consumption in rural residents but not in urban residents (Pinteraction = 0.046). The initial associations did not change materially in a series of sensitivity analyses.</p><p><strong>Conclusions: </strong>Red meat and fish consumption is not associated with the risk of liver cancer in this Chinese population. The inverse association with poultry consumption in Chinese rural residents should be interpreted with caution.</p><p><strong>Impact: </strong>This is the first prospective study examining the association between meat consumption and the risk of liver cancer in the Chinese population.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"412-419"},"PeriodicalIF":3.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-FDX1 Autoantibody as a Potential Biomarker for Non-Small Cell Lung Cancer Detection.","authors":"Jing Li, Xiaobin Cao, Lulu Zhang, Aichen Liu, Siyu Liu, Fengqi Chen, Yutong Li, Hanke Ma, Wenke Sun, Songyun Ouyang, Liping Dai, Jingjing Liu","doi":"10.1158/1055-9965.EPI-24-1096","DOIUrl":"10.1158/1055-9965.EPI-24-1096","url":null,"abstract":"<p><strong>Background: </strong>Autoantibodies can be readily identified prior to biopsy and may serve as valuable biomarkers for cancer detection. Ferredoxin 1 (FDX1) is a key regulator in the process of cuproptosis and affects the prognosis of lung cancer. In this study, we investigated whether the anti-FDX1 autoantibody could serve as a novel biomarker for the detection of non-small cell lung cancer (NSCLC).</p><p><strong>Methods: </strong>A total of 1,155 plasma samples were divided into the verification and validation groups. The expression levels of the anti-FDX1 autoantibody in 414 patients with NSCLC, 327 patients with benign pulmonary nodules (BPN), and 414 normal controls (NC) were detected using ELISA. Western blotting and immunofluorescence analyses were performed to confirm the ELISA results.</p><p><strong>Results: </strong>Plasma anti-FDX1 autoantibody levels were significantly higher in patients with NSCLC than in patients with BPN and NCs in the verification and validation groups. The ELISA results were confirmed by Western blotting and immunofluorescence. The anti-FDX1 autoantibody distinguished NSCLC from NC and BPN with an AUC (95% confidence interval) of 0.806 (0.772-0.839) and 0.627 (0.584-0.670), respectively.</p><p><strong>Conclusions: </strong>Our study demonstrated the potential benefits of the anti-FDX1 autoantibody as a novel biomarker for NSCLC detection.</p><p><strong>Impact: </strong>These findings suggested that the anti-FDX1 autoantibody may facilitate the detection of NSCLC.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"439-447"},"PeriodicalIF":3.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential DNA Methylation in the Benign and Cancerous Prostate Tissue of African American and European American Men.","authors":"Meytal Chernoff, Kathryn Demanelis, Marc Gillard, Dayana Delgado, Kevin J Gleason, Meritxell Oliva, Lin Chen, Anthony Williams, Russel Z Szmulewitz, Donald J Vander Griend, Brandon L Pierce","doi":"10.1158/1055-9965.EPI-24-0288","DOIUrl":"10.1158/1055-9965.EPI-24-0288","url":null,"abstract":"<p><strong>Background: </strong>African American (AA) men are at increased risk of prostate cancer compared with European American (EA) men. Biological mechanisms, including epigenetics, likely contribute to this disparity, but prior studies have been limited by sample size, candidate gene approaches, or lack of epigenome-wide DNA methylation (DNAm) data.</p><p><strong>Methods: </strong>To improve our understanding of these mechanisms, we compared DNAm features distinguishing tumor and paired histologically benign tissue from 76 AA and 75 EA patients with prostate cancer. We generated genome-wide array-based DNAm data and conducted differential methylation analyses comparing tumor and benign tissues in each ancestry group. We then examined the predictive ability of our identified sites and differential methylation by ancestry group.</p><p><strong>Results: </strong>We identified 90,747 and 98,929 differentially methylated CpGs in AA and EA, respectively, with 76,400 common to both groups. We identified 6,267 genes with differentially methylated promoters common to both ancestries and 639 and 1,301 genes unique to AA and EA respectively, as well as differentially methylated pathways. Only 10 CpGs were needed to distinguish tumor from benign based on a receiver operating characteristic curve (AUC > 0.9), with differentially methylated CpGs in one ancestry accurately predicting tumor versus benign in the other group. We also identified ancestry-associated CpGs (89 in tumor, 423 in benign).</p><p><strong>Conclusions: </strong>Methylation features distinguishing tumor and benign were similar for EA and AA men; however, subtle differences were identified.</p><p><strong>Impact: </strong>Differences in tumor and ancestry-associated CpGs may reveal differential tumor growth strategies, an important area for future disparities research.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"428-438"},"PeriodicalIF":3.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and Clinical Outcomes of Childhood Central Nervous System Cancers in a Large Low/Middle-Income Country Pediatric Oncology Center: A Report on 5,051 Kids.","authors":"Eslam Maher, Mohamed Kamal, Moatasem El-Ayadi, Amal Refaat, Abdelrahman Enayet, Mohamed El-Beltagy, Eman Eldebawy, Hala Taha, Madiha Awad, Mohamed S Zaghloul","doi":"10.1158/1055-9965.EPI-24-1188","DOIUrl":"10.1158/1055-9965.EPI-24-1188","url":null,"abstract":"<p><strong>Background: </strong>Central nervous system (CNS) tumors are the leading cause of cancer-related deaths in children. Although most cases come from low- and middle-income countries (LMIC) where their prognosis is worse, few epidemiologic studies are conducted in these regions.</p><p><strong>Methods: </strong>We conducted a registry-based cohort study for childhood CNS tumors at Children's Cancer Hospital, Egypt, over 15 years. Unified treatment protocols were implemented. Survival analyses were conducted using the Kaplan-Meier function. Cases were additionally annotated using the International Classification of Childhood Cancer-3 classification.</p><p><strong>Results: </strong>In total, 5,051 children ≤18 years of age were identified, accounting for 20% of all childhood cancers treated at Children's Cancer Hospital, Egypt. The most common tumor sites were the posterior fossa (36.8%) and brainstem (17.7%). Pathologies were predominantly astrocytic (n = 1,360; 26.9%) and embryonal (n = 1,003; 19.9%) in origin. The 5-year overall survival (OS) and event-free survival for all cases were 64.6% and 51.8%, respectively. More specifically, 1,421 low-grade gliomas were identified, with a 5-year OS of 91.1%. Medulloblastoma (n = 801) recorded a 5-year OS of 66%. The entity with the worst prognosis was diffuse intrinsic pontine glioma (n = 633), with a 5-year OS of 3.2%.</p><p><strong>Conclusions: </strong>We report on a large number of childhood CNS tumors from an LMIC. This study underscores the need to understand the burden of childhood brain tumors and its outcomes in resource-constrained settings.</p><p><strong>Impact: </strong>This study reports on the epidemiology and clinical outcomes of 5,000+ children with CNS tumors from a specialized LMIC center. Despite the lack of many sophisticated and advanced facilities, LMICs can improve the clinical end-results with experience and augmented efforts.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"420-427"},"PeriodicalIF":3.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}