A comparison of neighborhood socioeconomic deprivation measures and the association with survival among Black and White women with endometrial cancer.

IF 3.7 3区 医学 Q2 ONCOLOGY
Anna Gottschlich, Jamaica R M Robinson, Julie J Ruterbusch, Kaitlin Burchett, Rebecca M Adams, Ariel Washington, Michele L Cote, Ann G Schwartz, Kristen S Purrington, Mike R Wilson
{"title":"A comparison of neighborhood socioeconomic deprivation measures and the association with survival among Black and White women with endometrial cancer.","authors":"Anna Gottschlich, Jamaica R M Robinson, Julie J Ruterbusch, Kaitlin Burchett, Rebecca M Adams, Ariel Washington, Michele L Cote, Ann G Schwartz, Kristen S Purrington, Mike R Wilson","doi":"10.1158/1055-9965.EPI-24-1833","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Black women with endometrial cancer (EC) have twice the mortality compared to White. Survival disparities remain after accounting for individual-level socioeconomic and cancer-related factors. We investigated associations between area-based deprivation and survival and explored whether area-based deprivation attenuates the association between race and survival, among a cohort of Black and White women.</p><p><strong>Methods: </strong>Data from ECs diagnosed between 2013-2022 were collected from a comprehensive cancer registry covering Metropolitan Detroit. Addresses at diagnosis were linked to Area Deprivation (ADI) and Social Vulnerability (SVI) indices. Adjusted Fine & Gray and Cox proportional hazard models were run investigating associations between area-based deprivation measures and survival; analyses were conducted estimating the proportion of the association between race and survival that was attenuated by area-based measures.</p><p><strong>Results: </strong>Higher deprivation was associated with poorer survival, adjusted for race, insurance status, and tumor characteristics. Compared to the least disadvantaged quartile, the quartile with the highest disadvantage using ADI and SVI had 1.18 (95% CI: 0.99, 1.43) and 1.40 (1.14, 1.71) times the hazard of EC-specific mortality, respectively. ADI and SVI attenuated 18% (3-38%) and 27% (10-48%) of associations between race and mortality overall, and 24% (95% CI: 3-61%) and 40% (95% CI: 16-78%) among those with high-grade histology.</p><p><strong>Conclusions: </strong>This study demonstrates a clear association between neighborhood-level disadvantage and survival among women with EC living in Metropolitan Detroit. Neighborhood disadvantage attenuates the relationship between race and survival, particularly among those with high-grade histology.</p><p><strong>Impact: </strong>These findings serve as motivation to understand how neighborhood impacts cancer outcomes.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Epidemiology Biomarkers & Prevention","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1158/1055-9965.EPI-24-1833","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Black women with endometrial cancer (EC) have twice the mortality compared to White. Survival disparities remain after accounting for individual-level socioeconomic and cancer-related factors. We investigated associations between area-based deprivation and survival and explored whether area-based deprivation attenuates the association between race and survival, among a cohort of Black and White women.

Methods: Data from ECs diagnosed between 2013-2022 were collected from a comprehensive cancer registry covering Metropolitan Detroit. Addresses at diagnosis were linked to Area Deprivation (ADI) and Social Vulnerability (SVI) indices. Adjusted Fine & Gray and Cox proportional hazard models were run investigating associations between area-based deprivation measures and survival; analyses were conducted estimating the proportion of the association between race and survival that was attenuated by area-based measures.

Results: Higher deprivation was associated with poorer survival, adjusted for race, insurance status, and tumor characteristics. Compared to the least disadvantaged quartile, the quartile with the highest disadvantage using ADI and SVI had 1.18 (95% CI: 0.99, 1.43) and 1.40 (1.14, 1.71) times the hazard of EC-specific mortality, respectively. ADI and SVI attenuated 18% (3-38%) and 27% (10-48%) of associations between race and mortality overall, and 24% (95% CI: 3-61%) and 40% (95% CI: 16-78%) among those with high-grade histology.

Conclusions: This study demonstrates a clear association between neighborhood-level disadvantage and survival among women with EC living in Metropolitan Detroit. Neighborhood disadvantage attenuates the relationship between race and survival, particularly among those with high-grade histology.

Impact: These findings serve as motivation to understand how neighborhood impacts cancer outcomes.

求助全文
约1分钟内获得全文 求助全文
来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信