Clonal Hematopoiesis of Indeterminate Potential as a Predictor of Colorectal Cancer Risk: Insights from the UK Biobank Cohort.

IF 3.7 3区医学 Q2 ONCOLOGY

Cancer Epidemiology Biomarkers & Prevention Pub Date : 2025-03-03 DOI:10.1158/1055-9965.EPI-24-1342

Yongfeng Liu, Zhihui Xi, Jianlong Zhou, Fa Ling, Yucheng Zhang, Huajie Xie, Jiabin Zheng, Baijin Xia, Huolun Feng, Yong Li

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引用次数: 0

Abstract

Background: Clonal hematopoiesis of indeterminate potential (CHIP) has been shown to be associated with the occurrence of solid tumors, but its relationship with colorectal cancer still needs to be studied.

Methods: We conducted a prospective matched case-control study using data from the UK Biobank, including 5,310 incident colorectal cancer cases and 26,550 controls matched for age, sex, and body mass index.

Results: Analysis of the UK Biobank data revealed that the presence of CHIP was associated with an increased risk of colorectal cancer. The odds ratio (OR) for colorectal cancer in the presence of CHIP was 1.20 (P = 0.006). This association remained significant even after excluding participants with a family history of bowel cancer (multivariate OR, 1.19; P = 0.007). Subgroup analyses demonstrated that CHIP independently increased the risk of colorectal cancer in females (multivariate OR, 1.25; P = 0.018) and in individuals older than 60 years (multivariate OR, 1.17; P = 0.046). Gene-specific analyses revealed that mutations in TET2 and ATM were particularly significant in relation to colorectal cancer risk, with an OR of 1.62 (P = 0.002) for TET2 and 2.98 (P < 0.001) for ATM.

Conclusions: Our findings indicate that CHIP is associated with an increased risk of colorectal cancer, particularly in individuals more than 60 years of age or in females.

Impact: Screening for CHIP in the population may improve the early detection and diagnosis rates of colorectal cancer.

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克隆造血作为结直肠癌风险的不确定预测因子：来自英国生物银行队列的见解。

背景：克隆造血不确定电位（CHIP）已被证实与实体瘤的发生有关，但其与结直肠癌的关系仍有待研究。方法：我们使用来自UK Biobank的数据进行了一项前瞻性匹配病例对照研究，包括5310例结直肠癌（CRC）病例和26550例年龄、性别和体重指数（BMI）匹配的对照组。结果：对英国生物银行数据的分析显示，CHIP的存在与CRC风险增加有关。CHIP存在时CRC的优势比（OR）为1.20 （P = 0.006）。即使在排除有肠癌家族史的参与者后，这种关联仍然显著（多变量OR， 1.19, P = 0.007）。亚组分析显示，CHIP单独增加了女性（多变量OR， 1.25, P = 0.018）和60岁以上个体(多变量OR， 1.17；P = 0.046)。基因特异性分析显示，TET2和ATM突变与结直肠癌风险的关系尤为显著，TET2的OR为1.62 (P = 0.002)， ATM的OR为2.98 （P < 0.001）。结论：我们的研究结果表明CHIP与结直肠癌的风险增加有关，特别是在60岁以上的个体或女性中。影响：在人群中进行CHIP筛查可以提高CRC的早期发现和诊断率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.