{"title":"Red Meat, Poultry, and Fish Consumption and the Risk of Liver Cancer: A Prospective Cohort Study of 0.5 Million Chinese Adults.","authors":"Chun-Rui Wang, Dong Cai, Kun He, Jie-Jun Hu, Xin Dai, Qian Zhu, Guo-Chao Zhong","doi":"10.1158/1055-9965.EPI-24-1158","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Epidemiological evidence on meat consumption and liver cancer risk is limited and inconclusive; moreover, no prospective study has been conducted to investigate this association in China. Hence, we performed this study to examine the association of red meat, poultry, and fish consumption with the risk of liver cancer in a Chinese population.</p><p><strong>Methods: </strong>A total of 510,048 Chinese adults of ages 30 to 79 years were included and were followed up through December 31, 2016. Red meat, poultry, and fish consumption was evaluated using an interviewer-administered laptop-based questionnaire. HRs and 95% confidence intervals (CI) for liver cancer incidence were calculated using Cox regression.</p><p><strong>Results: </strong>Over a mean follow-up of 9.94 years, 1,906 liver cancer cases were observed. Each 50 g/day increase in red meat (HR 0.72; 95% CI, 0.49-1.05), poultry (HR 0.93; 95% CI, 0.83-1.03), and fish (HR 0.95; 95% CI, 0.85-1.05) consumption was not associated with the risk of liver cancer in the whole study population; however, subgroup analysis revealed an inverse association with poultry consumption in rural residents but not in urban residents (Pinteraction = 0.046). The initial associations did not change materially in a series of sensitivity analyses.</p><p><strong>Conclusions: </strong>Red meat and fish consumption is not associated with the risk of liver cancer in this Chinese population. The inverse association with poultry consumption in Chinese rural residents should be interpreted with caution.</p><p><strong>Impact: </strong>This is the first prospective study examining the association between meat consumption and the risk of liver cancer in the Chinese population.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"412-419"},"PeriodicalIF":3.7000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Epidemiology Biomarkers & Prevention","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1158/1055-9965.EPI-24-1158","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Epidemiological evidence on meat consumption and liver cancer risk is limited and inconclusive; moreover, no prospective study has been conducted to investigate this association in China. Hence, we performed this study to examine the association of red meat, poultry, and fish consumption with the risk of liver cancer in a Chinese population.
Methods: A total of 510,048 Chinese adults of ages 30 to 79 years were included and were followed up through December 31, 2016. Red meat, poultry, and fish consumption was evaluated using an interviewer-administered laptop-based questionnaire. HRs and 95% confidence intervals (CI) for liver cancer incidence were calculated using Cox regression.
Results: Over a mean follow-up of 9.94 years, 1,906 liver cancer cases were observed. Each 50 g/day increase in red meat (HR 0.72; 95% CI, 0.49-1.05), poultry (HR 0.93; 95% CI, 0.83-1.03), and fish (HR 0.95; 95% CI, 0.85-1.05) consumption was not associated with the risk of liver cancer in the whole study population; however, subgroup analysis revealed an inverse association with poultry consumption in rural residents but not in urban residents (Pinteraction = 0.046). The initial associations did not change materially in a series of sensitivity analyses.
Conclusions: Red meat and fish consumption is not associated with the risk of liver cancer in this Chinese population. The inverse association with poultry consumption in Chinese rural residents should be interpreted with caution.
Impact: This is the first prospective study examining the association between meat consumption and the risk of liver cancer in the Chinese population.
背景:关于肉类消费和肝癌风险的流行病学证据有限且不确定;此外,尚无前瞻性研究对中国的这种关联进行调查。因此,我们进行了这项研究,以检查中国人群中红肉、家禽和鱼类消费与肝癌风险的关系。方法:共纳入510048名年龄在30-79岁的中国成年人,随访至2016年12月31日。红肉、家禽和鱼类的消费情况使用访谈者管理的基于笔记本电脑的问卷进行评估。采用Cox回归计算肝癌发病率的风险比(hr)和95%可信区间(CIs)。结果:在平均9.94年的随访中,观察到1906例肝癌病例。红肉(HR 0.72, 95% CI 0.49-1.05)、家禽(HR 0.93, 95% CI 0.83-1.03)和鱼(HR 0.95;(95% CI 0.85-1.05)在整个研究人群中,摄入与肝癌风险无关;然而,亚组分析显示农村居民与家禽消费呈负相关,而城市居民则没有(p交互作用=0.046)。在一系列的敏感性分析中,最初的关联并没有发生实质性的变化。结论:在中国人群中,食用红肉和鱼与患肝癌的风险无关。在中国农村居民中,应谨慎解释与家禽消费的负相关关系。影响:这是第一个在中国人群中研究肉类消费与肝癌风险之间关系的前瞻性研究。
期刊介绍:
Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.