一个大型中低收入国家儿科肿瘤中心的儿童中枢神经系统癌症流行病学和临床结果:关于 5051 名儿童的报告。

IF 3.7 3区 医学 Q2 ONCOLOGY
Eslam Maher, Mohamed Kamal, Moatasem El-Ayadi, Amal Refaat, Abdelrahman Enayet, Mohamed El-Beltagy, Eman Eldebawy, Hala Taha, Madiha Awad, Mohamed S Zaghloul
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引用次数: 0

摘要

背景:中枢神经系统(CNS)肿瘤是儿童癌症相关死亡的主要原因。虽然大多数病例来自预后较差的中低收入国家(LMIC),但在这些地区开展的流行病学研究很少。方法:我们在埃及儿童肿瘤医院(CCHE)进行了一项为期15年的儿童中枢神经系统肿瘤登记队列研究。实施统一的治疗方案。使用Kaplan-Meier函数进行生存分析。病例使用ICCC-3分类进行额外注释。结果:共发现5051名≤18岁的儿童,占CCHE治疗的所有儿童癌症的20%。最常见的肿瘤部位为后颅窝(36.8%)和脑干(17.7%)。病理以星形细胞为主(n=1360;26.9%)和胚胎(n=1003;19.9%)。所有病例5年OS和EFS分别为64.6%和51.8%。更具体地说,鉴定出1421例低级别胶质瘤,5年OS = 91.1%。髓母细胞瘤(n=801)的5年生存率为66%。预后最差的是DIPG (n=633), 5年OS = 3.2%。结论:我们报道了大量来自LMIC的儿童中枢神经系统肿瘤。这项研究强调有必要了解儿童脑肿瘤的负担及其在资源有限的情况下的结果。影响:本研究报告了来自专业LMIC中心的5000多名中枢神经系统肿瘤儿童的流行病学和临床结果。尽管缺乏许多复杂和先进的设施,但LMIC可以通过经验和增加的努力来改善临床最终结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epidemiology and Clinical Outcomes of Childhood Central Nervous System Cancers in a Large Low/Middle-Income Country Pediatric Oncology Center: A Report on 5,051 Kids.

Background: Central nervous system (CNS) tumors are the leading cause of cancer-related deaths in children. Although most cases come from low- and middle-income countries (LMIC) where their prognosis is worse, few epidemiologic studies are conducted in these regions.

Methods: We conducted a registry-based cohort study for childhood CNS tumors at Children's Cancer Hospital, Egypt, over 15 years. Unified treatment protocols were implemented. Survival analyses were conducted using the Kaplan-Meier function. Cases were additionally annotated using the International Classification of Childhood Cancer-3 classification.

Results: In total, 5,051 children ≤18 years of age were identified, accounting for 20% of all childhood cancers treated at Children's Cancer Hospital, Egypt. The most common tumor sites were the posterior fossa (36.8%) and brainstem (17.7%). Pathologies were predominantly astrocytic (n = 1,360; 26.9%) and embryonal (n = 1,003; 19.9%) in origin. The 5-year overall survival (OS) and event-free survival for all cases were 64.6% and 51.8%, respectively. More specifically, 1,421 low-grade gliomas were identified, with a 5-year OS of 91.1%. Medulloblastoma (n = 801) recorded a 5-year OS of 66%. The entity with the worst prognosis was diffuse intrinsic pontine glioma (n = 633), with a 5-year OS of 3.2%.

Conclusions: We report on a large number of childhood CNS tumors from an LMIC. This study underscores the need to understand the burden of childhood brain tumors and its outcomes in resource-constrained settings.

Impact: This study reports on the epidemiology and clinical outcomes of 5,000+ children with CNS tumors from a specialized LMIC center. Despite the lack of many sophisticated and advanced facilities, LMICs can improve the clinical end-results with experience and augmented efforts.

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来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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