Cancer Epidemiology Biomarkers & Prevention最新文献

{"title":"Biomarkers of Toxicant Exposure among Youth in Canada, England, and the United States Who Vape and/or Smoke Tobacco or Do Neither.","authors":"David Hammond, Jessica L Reid, Maciej L Goniewicz, Ann McNeill, Richard J O'Connor, Danielle Corsetti, Leonie S Brose, Bradley Schurr, Deborah Robson","doi":"10.1158/1055-9965.EPI-24-1338","DOIUrl":"10.1158/1055-9965.EPI-24-1338","url":null,"abstract":"<p><strong>Background: </strong>Few studies examine biomarkers of exposure to vaping and tobacco products among youth. We compared biomarkers for toxicants between youth who vape, smoke, \"dual-use\", or neither.</p><p><strong>Methods: </strong>Participants ages 16 to 19 years in Canada, England, and the United States completed surveys and self-collected urine samples between September 2019 and January 2022 (N = 364). Urine was tested for metabolites of tobacco-specific nitrosamine NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone) and six volatile organic compounds. Regression models examined differences in biomarker concentrations by past-week tobacco smoking and vaping, adjusting for creatinine, age, sex, country, and cannabis use.</p><p><strong>Results: </strong>Compared with no vaping/smoking, exclusive vaping was associated with similar exposure to acrolein and acrylonitrile but higher exposure to toluene (P = 0.04) and acrylamide (P = 0.034, only in sensitivity analysis using past 24-hour measure). Compared with dual use or exclusive smoking, exclusive vaping was associated with lower exposure to NNK, acrolein, acrylamide, and acrylonitrile (P ≤ 0.01) but higher toluene exposure than dual use (P = 0.012). Exposure was similar for dual-use and exclusive smoking. Benzene and xylene biomarkers were detected in <5% and not compared. Among those smoking, NNK exposure was higher in the United States (geometric mean = 25.4 pg/mg creatinine) versus Canada (16.1 pg/mg; P = 0.006) and England (14.1 pg/mg; P = 0.018).</p><p><strong>Conclusions: </strong>Youth exclusively vaping had similar exposure as no vaping/smoking except for two volatile organic compounds and lower exposure than smoking or dual use except toluene. Higher NNK levels among US youth who smoke likely reflect differences in tobacco blend.</p><p><strong>Impact: </strong>Findings are generally consistent with literature indicating lower toxicant exposure from vaping versus smoking but elevated exposure versus no use for some.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"815-824"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Inherited Genetic Variants with Multiple Primary Melanoma.","authors":"David C Gibbs, Brittany M Small, Isidora Autuori, Siok F Leong, Emily Ali, Jessica Kenney, Li Luo, Peter A Kanetsky, Klaus J Busam, Anne E Cust, Hoda Anton-Culver, Richard P Gallagher, Roberto Zanetti, Stefano Rosso, Lidia Sacchetto, Sharon N Edmiston, Kathleen Conway, David W Ollila, Colin B Begg, Marianne Berwick, Irene Orlow, Nancy E Thomas","doi":"10.1158/1055-9965.EPI-24-1442","DOIUrl":"10.1158/1055-9965.EPI-24-1442","url":null,"abstract":"<p><strong>Background: </strong>Recent genome-wide association studies (GWAS) have identified new susceptibility loci for melanoma, but their associations with multiple primary melanoma (MPM) are unclear.</p><p><strong>Methods: </strong>We investigated the associations of 69 SNPs in 39 GWAS-identified loci with odds of MPM relative to single primary melanoma in the international, population-based Genes, Environment, and Melanoma study. Per-minor-allele ORs and 95% confidence intervals (CI) for individuals with MPM \"cases\" (n = 1,205) relative to single primary melanoma \"controls\" (n = 2,458) were estimated using multivariable logistic regression, and polygenic risk scores (PRS) were calculated and weighted based on a 2020 GWAS meta-analysis (57 of the 68 independent GWAS SNPs available).</p><p><strong>Results: </strong>Thirteen SNPs in 11 gene regions (PARP1, CYP1B1/RMDN3, TERT, RAPGEF5, TYRP1, MTAP, CDKN2A/CDKN2B, KLF4, TYR, SOX6, and ASIP) were statistically significantly associated (P < 0.05) with MPM adjusting for age, sex, age-by-sex interaction, and study center. The highest versus lowest PRS quintile was associated with a 2.81-fold higher odds of MPM (95% CI, 2.10-3.78; P = 7.5 × 10-13); this association was attenuated but remained statistically significant after excluding SNPs individually associated with MPM (OR = 1.75, 95% CI, 1.32-2.31).</p><p><strong>Conclusions: </strong>Inherited genetic variants spanning 11 gene regions were independently associated with MPM. Nonsignificant SNPs were associated with MPM when aggregated into a PRS, indicating that their cumulative effect may influence MPM risk despite lacking individual statistical significance in our study population.</p><p><strong>Impact: </strong>Our findings provide additional evidence that these loci are associated with melanoma risk and estimate the magnitude of their genetic effect on subsequent (multiple) primary melanoma risk.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"805-814"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood Disinvestment Predicts Shorter Cancer Survival Time among Black Women Diagnosed with Invasive Breast Cancer.","authors":"Jesse J Plascak, Cathleen Y Xing, Stephen J Mooney, Andrew G Rundle, Mario Schootman, Bo Qin, Nur Zeinomar, Adana A M Llanos, Hari S Iyer, Karen S Pawlish, Christine B Ambrosone, Kitaw Demissie, Chi-Chen Hong, Elisa V Bandera","doi":"10.1158/1055-9965.EPI-24-1184","DOIUrl":"10.1158/1055-9965.EPI-24-1184","url":null,"abstract":"<p><strong>Background: </strong>Observed neighborhood disinvestment is a chronic social determinant that is understudied in relation to cancer outcomes. This study investigated associations between neighborhood disinvestment, stage at diagnosis, and breast cancer-specific survival (BCSS) time.</p><p><strong>Methods: </strong>Individual-level data included 844 women, diagnosed 2013 to 2019, from the Women's Circle of Health Follow-up Study, a population-based cohort of breast cancer survivors self-identifying as Black or African American. Neighborhood disinvestment was from a virtual audit of six indicators-garbage, graffiti, dumpsters, building conditions, yard conditions, and abandoned buildings-within 14,671 Google Street View streetscapes estimated at residential addresses using Universal Kriging. We fit accelerated failure time models of BCSS time as functions of neighborhood disinvestment by stage, adjusted for covariates (sociodemographic, lifestyle, and tumor- and treatment-related factors). Participants not experiencing an event at the end of follow-up (August 13, 2023) were right-censored.</p><p><strong>Results: </strong>With a median follow-up time of 89 months, there were 91 breast cancer-specific deaths. Disinvestment and stage statistically interacted (P < 0.01). For stage III and stage II diagnoses, BCSS time decreased by 27% (95% confidence interval, 1%, 48%) and 37% (95% confidence interval, 5%, 58%), respectively, with each SD increase in disinvestment after adjustment for covariates. There was little evidence of associations between disinvestment and survival time among stages I and IV.</p><p><strong>Conclusions: </strong>The tumor stage-dependent association between greater neighborhood disinvestment and shorter survival time could reflect chronic stress exposures suspected to adversely accumulate over time.</p><p><strong>Impact: </strong>Neighborhood disinvestment might be an important, independent marker of social disadvantage impacting breast cancer survival.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"684-690"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited Awareness of Alcohol-Related Cancer Risk Factors among Spanish-Preferring Adults in a National US Survey.","authors":"Yi Liao, Andy J King, Benjamin A Lyons, Kimberly A Kaphingst","doi":"10.1158/1055-9965.EPI-24-1354","DOIUrl":"10.1158/1055-9965.EPI-24-1354","url":null,"abstract":"<p><strong>Background: </strong>Alcohol is a modifiable risk factor for several types of cancer, though awareness of this link is often found to be low among the US population. The current study investigated beliefs about alcohol as a cancer risk factor among Spanish-preferring Americans, specifically for different types of alcoholic beverages (e.g., beer, liquor, and wine).</p><p><strong>Methods: </strong>We analyzed data from a national survey of US adults who prefer speaking Spanish, comparing their awareness of alcohol's link to cancer with the general population and Hispanic respondents in the Health Information National Trends Survey (HINTS) 5 Cycle 4 dataset.</p><p><strong>Results: </strong>Awareness among Spanish-speaking adults was lower (wine: 8.2%, beer: 18.3%, and liquor: 28.4%) than all HINTS respondents (wine: 20.3%, beer: 24.9%, and liquor: 31.2%) and specifically the Hispanic HINTS respondents (wine: 18.3%, beer: 22.4%, and liquor: 32.2%). Statistically significant differences were found for wine and beer compared with the general population and for wine compared with Hispanic respondents. Higher media literacy correlated with increased awareness, particularly for beer, whereas eHealth literacy showed an inverse relationship. Recent immigrants demonstrated greater awareness than long-term residents. Gender, insurance status, cancer history, and information-seeking behaviors predicted differential awareness.</p><p><strong>Conclusions: </strong>Awareness of the alcohol-cancer link among Spanish-preferring adults in the United States is below the national average, with factors such as media literacy, eHealth literacy, demographics, and length of US residency associated with this awareness.</p><p><strong>Impact: </strong>The study underscores the need for culturally adapted health communication strategies to improve knowledge of alcohol as a cancer risk factor among Spanish-preferring Americans.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"754-761"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NCI-Funded Cancer Epidemiology Survivor Cohorts: Overview, Progress, and Opportunities.","authors":"Lisa Gallicchio, Andrea N Burnett-Hartman, Kelly K Filipski, Nonniekaye Shelburne, Andrew N Freedman","doi":"10.1158/1055-9965.EPI-24-1750","DOIUrl":"10.1158/1055-9965.EPI-24-1750","url":null,"abstract":"<p><strong>Background: </strong>The goal of this article was to provide an overview of the current NCI-funded large cancer epidemiology survivor cohorts (CESC).</p><p><strong>Methods: </strong>Large CESCs were defined as observational cohort studies following at least 1,000 cancer survivors over time and collecting data on survivorship outcomes. CESCs with NCI grant funding on June 1, 2024 were identified in two ways: (i) by identifying grants funded under cancer epidemiology cohort-relevant Notice of Funding Opportunities and (ii) by applying the Research, Condition, and Disease Categorization-indexed concepts related to cohorts to the entire NCI grant portfolio in the NIH's proprietary Query, View, Reporting System and reviewing grants identified via this search for inclusion.</p><p><strong>Results: </strong>Thirty active grants supporting large CESCs were identified. Of the 30 CESCs, 36.7% are comprised of survivors of mixed cancer types; the remaining 63.3% are following survivors diagnosed with cancer of a single anatomic type or grouping (e.g., blood cancers). Special populations of focus include adult survivors of pediatric cancers, adolescent and young adult cancer survivors, pediatric cancer survivors, and stem cell transplant survivors. Notable gaps include cohorts following long-term cancer survivors, survivors of less common cancer types, and survivors from understudied populations.</p><p><strong>Conclusions: </strong>CESCs highlighted in this article represent a substantial investment in exploring the multifaceted factors that influence cancer outcomes. These cohorts encompass an increasing diversity of cancer types, treatments, and populations.</p><p><strong>Impact: </strong>CESCs provide valuable insights into clinical and molecular risk factors associated with cancer survivorship outcomes that inform guidelines and interventions.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"627-640"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Inflammation Biomarkers and the Risk of Esophageal Adenocarcinoma: A Nested Case-Control Study in the Department of Defense Serum Repository.","authors":"Omonefe O Omofuma, Jennifer A Rusiecki, Jessica L Petrick, Roni T Falk, William Wheeler, Ruth M Pfeiffer, M Constanza Camargo, Michael B Cook","doi":"10.1158/1055-9965.EPI-24-1544","DOIUrl":"10.1158/1055-9965.EPI-24-1544","url":null,"abstract":"<p><strong>Background: </strong>We previously identified associations of esophageal adenocarcinoma risk with four inflammation-related candidate biomarkers: TNF receptor 2 (TNFR2), IL17A, VEGFR3, and resistin.</p><p><strong>Methods: </strong>We aimed to replicate these candidates and discover novel associations with additional proteins. We conducted a nested case-control study of men with prediagnostic biospecimens stored at the US Department of Defense Serum Repository, including 203 incident esophageal adenocarcinoma cases. Controls were matched to cases in a ∼2:1 ratio by date of birth, race, service branch, and blood draw date. Multiplex immunoassays (Olink/Proseek panels) measured 254 proteins detected in ≥10% of all samples. Multivariable-adjusted conditional logistic regression models calculated associations between biomarker quantiles and esophageal adenocarcinoma. P values (<0.05) were used to indicate the statistical significance of candidates, and FDR was applied to the additional proteins. ORs from the current analysis and those from previous studies were combined for the candidate markers using fixed-effects meta-analysis.</p><p><strong>Results: </strong>Among the four candidates, the highest category of TNFR2 was associated with significantly increased esophageal adenocarcinoma risk (ORQ4 vs. Q1 = 1.87; 95% confidence interval: 1.02-3.42). In the meta-analysis, associations with esophageal adenocarcinoma were positive for TNFR2 (meta-analyzed ORhighest-vs.-lowest = 2.04; 1.12-2.95) and inverse for IL17A (meta-analyzed ORhighest-vs.-lowest = 0.53; 0.26-0.80). Of the additional 250 proteins, 45 were associated with esophageal adenocarcinoma risk and 6 (monocyte chemotactic protein 3, IL6, TNFR1, hepatocyte growth factor, TFF3, and FURIN) remained significant after FDR correction.</p><p><strong>Conclusions: </strong>We confirmed associations of TNFR2 and IL17A with esophageal adenocarcinoma risk. Additionally, our study expands the range of proteins associated with esophageal adenocarcinoma development.</p><p><strong>Impact: </strong>This is the largest assessment to discover novel associations of inflammation-related proteins with esophageal adenocarcinoma to date.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"649-657"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of Change in Emotional and Functional Well-Being Following Breast Cancer Diagnosis.","authors":"Yumeng Ren, Joanna Maselko, Xianming Tan, Andrew F Olshan, Angela M Stover, Antonia V Bennett, Marc A Emerson, Melissa A Troester","doi":"10.1158/1055-9965.EPI-24-0849","DOIUrl":"10.1158/1055-9965.EPI-24-0849","url":null,"abstract":"<p><strong>Background: </strong>Understanding the change in emotional well-being (EWB) and functional well-being (FWB) in breast cancer survivors can facilitate targeted support for unmet needs.</p><p><strong>Methods: </strong>Among 2,767 women with breast cancer in the Carolina Breast Cancer Study Phase 3, we assessed EWB and FWB with the Functional Assessment of Cancer Therapy - Breast instrument at 5 (baseline), 25, and 84 months after diagnosis. We identified well-being trajectories using latent class growth analysis, and relative frequency differences (RFD) with 95% confidence intervals (CI) were estimated for associations between trajectory group membership and demographic or clinical characteristics.</p><p><strong>Results: </strong>Five trajectory groups were identified for both EWB and FWB. Most participants (∼70%) were classified into \"good well-being\" (\"stable high\" or \"stable medium\"). A small percentage (∼10%) fell into \"very low baseline\" or \"early decrease\", and the rest were \"stable low\" (∼20%). Overall, younger vs. older age was associated with \"stable low\" EWB (25.4% vs. 19.3%; RFD 6.1%; 95% CI, 3.0%-9.2%). Black participants more frequently had \"stable low\" FWB (24.2% vs. 16.6%; RFD 7.6%; 95% CI, 4.6%-10.6%). Breast cancer recurrence was strongly associated with \"stable low\" EWB (28.7% vs. 21.3%; RFD 7.3%; 95% CI, 2.3%-12.3%) and FWB (28.7% vs. 19.2%; RFD 8.6%; 95% CI, 3.7%-13.5%). Being unmarried, lower income, having nonprivate insurance, advanced stage, mastectomy vs. breast conservation surgery, and chemotherapy were also predictors of poor well-being trajectories.</p><p><strong>Conclusions: </strong>Demographics and clinical features are associated with sustained poor well-being after breast cancer.</p><p><strong>Impact: </strong>Improvements in long-term well-being may warrant targeted support.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"676-683"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Tumor Mutation Burden in Cancer Patients with Underlying HIV Infection: Data from the Oncology Research Information Exchange Network (ORIEN).","authors":"Anna E Coghill, Nathan Van Bibber, Robert A Baiocchi, Susanne M Arnold, Gregory Riedlinger, Bryan P Schneider, Yonghong Zhang, Gita Suneja, Miguel Gomez Fontela, Daniel Abate-Daga, Jamie K Teer","doi":"10.1158/1055-9965.EPI-24-1321","DOIUrl":"10.1158/1055-9965.EPI-24-1321","url":null,"abstract":"<p><strong>Background: </strong>People living with HIV (PWH) have improved life expectancy because of effective human immunodeficiency virus (HIV) therapy but still experience immune impairment (e.g., altered CD4/CD8 T cells). We hypothesized that tumors diagnosed in PWH would have distinct molecular features.</p><p><strong>Methods: </strong>We utilized whole-exome sequencing of paired tumor and germline DNA and RNA from 229 patients with cancer enrolled into the Oncology Research Information Exchange Network to classify total tumor mutation burden (TMB), MHC class I neoantigen count, and MHC class II neoantigen count.</p><p><strong>Results: </strong>Specimens from 229 patients with cancer (110 PWH and 119 without HIV) were evaluated. Average TMB for tumors diagnosed in PWH was 249, compared with 172 for those without HIV. After adjustment for age, sex, race, smoking, and cancer site, the association between HIV and TMB remained statistically significant (OR = 1.72; 95% confidence interval (CI), 1.26-2.43). We further observed an association between HIV and higher putative class I neoantigen count (OR = 1.62; 95% CI, 1.10-2.41) but no association with putative class II neoantigens. When considering cancer sites separately in unadjusted analyses, average TMB was elevated in PWH for thyroid (P < 0.01) and bladder cancers (P = 0.03) and sarcoma (P = 0.04). Similarly, putative class I neoantigen count was elevated in PWH for head and neck (P < 0.01) and thyroid (P = 0.01) cancers, as well as sarcoma (P = 0.04).</p><p><strong>Conclusions: </strong>Our findings indicate that tumors diagnosed in PWH harbor a higher TMB and a higher number of putative class I neoantigens.</p><p><strong>Impact: </strong>A higher TMB in PWH may portend a more favorable response to certain cancer treatment modalities such as immune checkpoint inhibitors.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"774-779"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Etiologic Heterogeneity for Risk of Diffuse Large B-Cell Lymphoma Subtype Defined by the Cell of Origin.","authors":"Geffen Kleinstern, Dennis P Robinson, Lisa M Rimsza, Melissa C Larson, Rebecca L King, Grzegorz S Nowakowski, Carrie A Thompson, Stephen M Ansell, Matthew J Maurer, Andrew L Feldman, Susan L Slager, Anne J Novak, Thomas M Habermann, James R Cerhan","doi":"10.1158/1055-9965.EPI-24-1610","DOIUrl":"10.1158/1055-9965.EPI-24-1610","url":null,"abstract":"<p><strong>Background: </strong>Diffuse large B-cell lymphoma (DLBCL) is clinically heterogeneous, and gene expression profiling has identified at least two biologically distinct DLBCL subtypes defined by their cell of origin (COO): germinal center B cell (GCB) and activate B cell (ABC) or non-GCB. We evaluated a variety of putative DLBCL risk factors for etiologic heterogeneity by the COO in a clinic-based study of newly diagnosed DLBCL cases (N = 638) and frequency-matched controls (N = 2,253).</p><p><strong>Methods: </strong>The COO was determined on formalin-fixed, paraffin-embedded tumor tissue, with DLBCL classified as GCB (N = 283), non-GCB (N = 188), or undetermined/missing (N = 167; mainly because of lack of tissue). Multivariable logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI).</p><p><strong>Results: </strong>We identified heterogeneity by the COO for low socioeconomic status (SES), which was only associated with non-GCB DLBCL (OR = 1.88 for low vs. average SES; 95% CI, 1.08-3.27); alcohol use, which was only associated with GCB DLBCL (OR = 0.48 for former drinkers; 95% CI, 0.29-0.80 and OR = 0.47 for current drinkers; 95% CI, 0.32-0.71); and borderline heterogeneity for the regular use of regular/extra-strength aspirin, which was only associated with non-GCB DLBCL (OR = 0.36; 95% CI, 0.16-0.85). In contrast, there was no significant heterogeneity by the COO for family history, medical history, or other lifestyle factors.</p><p><strong>Conclusions: </strong>Although requiring confirmation, most risk factors for DLBCL did not show etiologic heterogeneity by the COO, with some notable exceptions including alcohol use, SES, and perhaps regular use of regular/extra-strength aspirin showing associations.</p><p><strong>Impact: </strong>Mechanistically, these findings suggest that most of the DLBCL risk factors evaluated here influence lymphomagenesis prior to differentiation into COO subtypes, with selected factors acting later.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"780-787"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between Anti-Gay Prejudice, Traditional Masculine Self-Concept, and Colorectal Cancer Screening-Related Outcomes among Black and White Men in the United States.","authors":"Tianen Chen, Rebekah Wicke, Andy J King, Drew Margolin, Rumi Chunara, Jeff Niederdeppe","doi":"10.1158/1055-9965.EPI-24-1590","DOIUrl":"10.1158/1055-9965.EPI-24-1590","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer screening can reduce colorectal cancer risk, yet many men are not up to date with screening guidelines. Although previous qualitative studies have suggested links among anti-gay prejudice, traditional masculine self-concept, racial identity, and colorectal cancer screening among men, scholars have yet to fully explore these associations using quantitative data. This study used a nationally representative sample of Black and White men in the United States to test these associations and examine the sociodemographic correlates.</p><p><strong>Methods: </strong>Using the National Opinion Research Center (NORC)/AmeriSpeak probability-based panel, we recruited a sample of Black and White men in the United States ages 45 to 74 years who had never been diagnosed with colorectal cancer (N = 909). Participants completed an online questionnaire measuring anti-gay prejudice, traditional masculine self-concept, sociodemographic variables, and screening-related outcomes (awareness of screening test options, screening intention, and adherence to screening recommendations).</p><p><strong>Results: </strong>Black participants reported higher levels of anti-gay prejudice and traditional masculine self-concept than White participants. Anti-gay prejudice was associated with lower awareness and lower screening intention. Black participants reported higher intention to follow screening recommendations but not higher odds of actual adherence than White participants.</p><p><strong>Conclusions: </strong>Men with anti-gay prejudice are less likely to be aware of colorectal cancer screening test options and less likely to intend to engage in colorectal cancer screening. The results have implications for the design and development of future interventions aimed at increasing colorectal cancer screening rates.</p><p><strong>Impact: </strong>Future studies could develop targeted interventions and observe subsequent changes or conduct longitudinal studies to further explore the role of anti-gay prejudice in colorectal cancer screening.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"714-721"},"PeriodicalIF":3.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}