Greater adherence to lifestyle recommendations after cancer diagnosis is associated with lower mortality in the UK Biobank.

IF 3.7 3区医学 Q2 ONCOLOGY

Cancer Epidemiology Biomarkers & Prevention Pub Date : 2025-02-28 DOI:10.1158/1055-9965.EPI-24-1783

Stephanie Byrne, Elina Hypponen, Beben Benyamin, Terry Boyle

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引用次数: 0

Abstract

Background: Research supporting the current recommendation to adhere to a healthy lifestyle following cancer diagnosis is limited. We investigated whether a healthy lifestyle after diagnosis is associated with a lower risk of mortality among those diagnosed with any malignant cancer, and breast, colorectal and prostate cancers.

Methods: In 2006-2010, UK Biobank participants (aged 37-73 years) were assessed. Analyses were restricted to those with a malignant cancer diagnosis prior to baseline (n=20,805, including 5,845 breast, 1,943 colorectal and 2,715 prostate cancer cases). Participants were followed for all-cause and cancer-specific death up to November 2022. A lifestyle index was determined based on lifestyle recommendations for cancer prevention. Cox regression was used to examine associations with all-cause and cancer-specific mortality among those with any cancer, and separately for breast, colorectal and prostate cancers, adjusting for relevant confounders.

Results: There were 4,328 deaths and 3,354 cancer-specific deaths in the 258,985 person-years of follow up. A higher lifestyle index, representing greater adherence to recommendations, was associated with a lower risk of all-cause mortality (any cancer - highest vs lowest lifestyle index tertile: HR[95%CI]=0.77[0.71,0.83]; breast: 0.75[0.64,0.88]; colorectal: 0.68[0.52,0.89]; prostate: 0.73[0.59,0.89]), and cancer-specific mortality in all populations examined (any cancer: 0.82[0.75,0.89]; breast: 0.88[0.71,1.09]; colorectal: 0.58[0.36,0.94]; prostate: 0.70[0.53,0.93]), although evidence was weaker for cancer-specific mortality among colorectal and breast cancer survivors.

Conclusions: Our findings provide evidence to support the recommendation to follow a healthy lifestyle after cancer diagnosis to prolong life.

Impact: Clinical guidelines and public health programs promoting a healthy lifestyle to cancer survivors may prolong life.

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.