Biochemia medica最新文献_第2页

The enzymatic analysis of alcohol (ethanol) in serum and plasma with the alcohol dehydrogenase reagent: focus on intra-analytical and post-analytical aspects. 用酒精脱氢酶试剂对血清和血浆中酒精的酶分析：重点是分析内和分析后方面。

IF 1.8

Biochemia medica Pub Date : 2025-10-15 Epub Date: 2025-08-15 DOI: 10.11613/BM.2025.030501

Cristiano Ialongo, Alan Wayne Jones

{"title":"The enzymatic analysis of alcohol (ethanol) in serum and plasma with the alcohol dehydrogenase reagent: focus on intra-analytical and post-analytical aspects.","authors":"Cristiano Ialongo, Alan Wayne Jones","doi":"10.11613/BM.2025.030501","DOIUrl":"10.11613/BM.2025.030501","url":null,"abstract":"The alcohol dehydrogenase (ADH) method is commonly used to measure serum alcohol concentration (SAC) and plasma alcohol concentration (PAC) for the rapid detection of ethanol intoxication in emergency medical departments. Alcohol dehydrogenase methods are sometimes used in forensic laboratories as a preliminary screening test prior to confirmation by gas chromatographic (GC) methods. This review identifies critical factors affecting results of ADH methods of analysis including clinical reliability and forensic defensibility. Key considerations include intra-analytical factors (method chemistry, calibration, analytical performance, interferences, calibrator stability, and sample matrix effects) and post-analytical factors (measurement units, reference ranges, performance specifications, uncertainty budget, medical decision levels, legal intoxication thresholds, ADH-GC agreement, and SAC/PAC to blood alcohol concentration (BAC) conversion). The yeast ADH method demonstrates high selectivity for ethanol with no assay-specific bias, and measurement error and uncertainty meet regulatory standards. However, ADH methods are prone to interferences, particularly from lactate dehydrogenase/lactic acid (LD/LA), leading to potential false positive results. Free hemoglobin (hemolysis) is another problem with ADH methods introducing a negative bias. When results provided by hospital laboratories are interpreted in a legal context, care is needed because ethanol concentrations in plasma/serum are about 15% higher than in whole blood (range 10-20%). Although less important in clinical practice, these differences are important to consider in a forensic context. The ADH method is not inherently a forensic assay, but these limitations can be mitigated by refining laboratory procedures and standardizing the assay methodology and quality control, thus strengthening forensic reliability and boosting confidence in the analytical results.","PeriodicalId":94370,"journal":{"name":"Biochemia medica","volume":"35 3","pages":"030501"},"PeriodicalIF":1.8,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refining quality control strategies in highly automated laboratories: experience in the integration of multistage statistical designs and risk management. 在高度自动化的实验室中改进质量控制策略：多阶段统计设计和风险管理的集成经验。

IF 1.8

Biochemia medica Pub Date : 2025-10-15 DOI: 10.11613/BM.2025.030704

María Costa-Pallaruelo, Álvaro García-Osuna, Marina Canyelles, Cecília Martínez-Bru, Nicoleta Nan, Rosa Ferrer-Perez, Francisco Blanco-Vaca, Leonor Guiñón

{"title":"Refining quality control strategies in highly automated laboratories: experience in the integration of multistage statistical designs and risk management.","authors":"María Costa-Pallaruelo, Álvaro García-Osuna, Marina Canyelles, Cecília Martínez-Bru, Nicoleta Nan, Rosa Ferrer-Perez, Francisco Blanco-Vaca, Leonor Guiñón","doi":"10.11613/BM.2025.030704","DOIUrl":"10.11613/BM.2025.030704","url":null,"abstract":"Introduction: The ISO 15189:2022 standard considers both the robustness of analytical methods and the risk of erroneous results in the quality control plan (QCP) design. Westgard et al.'s nomogram recommends quality control (QC) rules based on sample run size to ensure that the maximum expected number of unreliable patient results remains below one. This study aimed to implement a standardized, risk-based QC strategy across multiple analyzers without integrated on board QC, ensuring practical quality assurance.Material and methods: Thirty-two biochemistry parameters on Alinity c systems and three on Cobas Pro systems were included. The analytical performance of each parameter on each analyzer was assessed using sigma metric. Workload requirements were considered to determine the desired run size. Based on the \"sigma metric statistical QC run size nomogram\" proposed by Westgard et al., a multistage bracketed QCP was designed for each parameter. When multiple designs were available, the simplest QC rule was prioritized.Results: Seven QCPs were initially established for 35 parameters. In the absence of automation, practical adaptations based on sigma metrics were implemented. Additionally, to streamline management, the QCP covering the greatest number of parameters per analyzer was prioritized, which ultimately resulted in the adoption of only two general QCP. Only 4 individualized QCP were required to cover 10 parameters with lower sigma values.Conclusions: This approach demonstrates the feasibility of implementing a refined QC strategy for parameters with sigma ≥ 4 in a highly automated laboratory, ensuring consistent quality assurance and efficient resource allocation for higher-risk tests.","PeriodicalId":94370,"journal":{"name":"Biochemia medica","volume":"35 3","pages":"030704"},"PeriodicalIF":1.8,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between cholesterol efflux capacity and apolipoprotein A1: systematic review and meta-analysis. 胆固醇外排能力与载脂蛋白A1之间的关系：系统回顾和荟萃分析。

IF 1.8

Biochemia medica Pub Date : 2025-10-15 DOI: 10.11613/BM.2025.030506

Linas Černiauskas, Eglė Mazgelytė, Dovilė Karčiauskaitė

{"title":"The association between cholesterol efflux capacity and apolipoprotein A1: systematic review and meta-analysis.","authors":"Linas Černiauskas, Eglė Mazgelytė, Dovilė Karčiauskaitė","doi":"10.11613/BM.2025.030506","DOIUrl":"10.11613/BM.2025.030506","url":null,"abstract":"Introduction: High-density lipoprotein (HDL) particles are key participants in reverse cholesterol transport. Cholesterol efflux capacity (CEC) and apolipoprotein A1 (Apo A1) are HDL-related biomarkers often used to evaluate HDL particle functionality and quantity. This study aimed to assess the correlation between CEC and Apo A1 concentrations and explore whether methodological aspects influence the correlation results.Materials and methods: This meta-analysis was prospectively registered in the PROSPERO database (registration number CRD42024552535). Three databases, PubMed, Web of Science, and Cochrane Library, were screened for the studies published between January 2000 and May 2024. The correlation results were analyzed using a random-effects model, and sensitivity and subgroup analyses were performed.Results: A total of 19 studies with 4967 participants were included. This meta-analysis's results indicated a statistically significant positive moderate strength correlation between CEC and Apo A1 concentrations. A high level of study heterogeneity was observed among the included studies. Further exploration into this heterogeneity revealed that different cell culture lines and cholesterol acceptors used to evaluate CEC impact the overall result of the pooled correlation estimate. The methods used to evaluate Apo A1 did not significantly affect the correlation estimate between CEC and Apo A1 concentrations.Conclusions: The correlation between CEC and Apo A1 lacks strength and consistency for Apo A1 being used as a surrogate marker for HDL function in a clinical setting. Currently, there is a high need for the standardization of CEC measurement methodologies that impact the overall results and comparability of the studies that have already been conducted.","PeriodicalId":94370,"journal":{"name":"Biochemia medica","volume":"35 3","pages":"030506"},"PeriodicalIF":1.8,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preanalytical mystery: falsely elevated intact parathyroid hormone due to sampling from a grafted forearm. 分析前之谜：由于前臂移植取样，完整甲状旁腺激素错误升高。

IF 1.8

Biochemia medica Pub Date : 2025-10-15 DOI: 10.11613/BM.2025.031002

Yu-Wei Tseng, Chun-Chieh Yeh, Che-Yi Chou, Si-Yu Chen, Tze-Kiong Er

引用次数: 0

Application and insights on patient-based real-time quality control: detecting undetected errors in internal quality control through daily antibody positivity rate analysis. 基于患者的实时质量控制的应用与见解：通过每日抗体阳性率分析发现内部质量控制中未被发现的错误。

Biochemia medica Pub Date : 2025-06-15 Epub Date: 2025-04-15 DOI: 10.11613/BM.2025.020801

Chaochao Ma, Qi Zhang, Yingying Hu, Wenyi Ding, Liangyu Xia, Ling Qiu

{"title":"Application and insights on patient-based real-time quality control: detecting undetected errors in internal quality control through daily antibody positivity rate analysis.","authors":"Chaochao Ma, Qi Zhang, Yingying Hu, Wenyi Ding, Liangyu Xia, Ling Qiu","doi":"10.11613/BM.2025.020801","DOIUrl":"10.11613/BM.2025.020801","url":null,"abstract":"Introduction: Traditional internal quality control (IQC) has limitations in detecting systematic errors in clinical laboratories. Patient-Based Real-Time Quality Control (PBRTQC) has emerged as a complementary method, offering new approaches for quality monitoring. Among these, monitoring daily positivity rates provides meaningful insights into laboratory performance.Materials and methods: This study highlights a case in which PBRTQC was implemented to detect and address a reagent batch issue in thyroid peroxidase antibody (TPO-Ab) testing. Over one year (July 2023 to July 2024), daily positivity rates and their fluctuations were retrospectively analyzed and daily positivity rate alarm limits were established for monitoring.Results: A notable increase in the TPO-Ab positivity rate was identified starting in June 2024. For outpatients and inpatients, the positivity rates in June and July 2024 were 46.1% ± 7.8% (N = 9039) and 61.4% ± 12.0% (N = 8735), respectively. For the physical examination population, the positivity rates during the same months were 30.0% ± 11.7% (N = 4754) and 52.5% ± 18.1% (N = 5726), respectively. These rates were significantly higher than the pre-June 2024 average monthly positivity rates of 30.0% ± 2.9% (N = 9070 per month) for patients and 11.0% ± 2.4% (N = 4663 per month) for the physical examination population.Conclusions: PBRTQC, particularly monitoring daily positivity rates, is a valuable tool for early detection of systematic errors. Establishing PBRTQC systems can supplement traditional IQC to improve laboratory test quality.","PeriodicalId":94370,"journal":{"name":"Biochemia medica","volume":"35 2","pages":"020801"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of fasting duration on LDL cholesterol concentrations estimated by the Friedewald, Martin-Hopkins, and Sampson/NIH equations. 根据Friedewald、Martin-Hopkins和Sampson/NIH方程估算的空腹时间对LDL胆固醇浓度的影响。

Biochemia medica Pub Date : 2025-06-15 Epub Date: 2025-04-15 DOI: 10.11613/BM.2025.020704

Şerif Ercan, Ali Manav

{"title":"Impact of fasting duration on LDL cholesterol concentrations estimated by the Friedewald, Martin-Hopkins, and Sampson/NIH equations.","authors":"Şerif Ercan, Ali Manav","doi":"10.11613/BM.2025.020704","DOIUrl":"10.11613/BM.2025.020704","url":null,"abstract":"Introduction: A paradigm shift is occurring in lipid testing, as fasting is no longer required. We aimed to determine whether low-density lipoprotein cholesterol (LDL-C) concentrations calculated using three different equations, along with the components used in these calculations, vary with different fasting durations in routine clinical practice.Materials and methods: The concentrations of LDL-C were calculated using the Friedewald, Martin-Hopkins, and Sampson/NIH equations, along with the lipid components involved in these equations, depending on time since the last meal in a cohort of 77,300 outpatients at a community hospital. The study population was divided into groups according to fasting durations by 2-hour intervals. A general linear model was applied to identify differences between fasting and nonfasting groups.Results: Regardless of the calculation method, LDL-C concentrations varied with fasting duration for up to 8-10 hours. The greatest absolute mean differences in LDL-C concentrations between fasting and nonfasting states were - 0.32, - 0.30, and - 0.26 mmol/L when using the Friedewald, Sampson/NIH, and Martin-Hopkins equations, respectively. Among the equation components, triglyceride concentrations were the most sensitive to fasting duration, remaining elevated for 4-6 hours after the last meal, while total cholesterol and non-high-density lipoprotein cholesterol (HDL-C) concentrations decreased for up to 8-10 hours postprandially. However, HDL-C concentrations remained relatively stable.Conclusions: The variation in postprandial LDL-C concentrations was observed not to differ between the three calculation methods and reached negligible concentrations after at least 8 hours of fasting. If LDL-C concentrations measured in a nonfasting state are near clinical decision thresholds, subsequent lipid measurement should be performed in a fasting state.","PeriodicalId":94370,"journal":{"name":"Biochemia medica","volume":"35 2","pages":"020704"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An unusual case of neuroblastoma presenting with prolonged watery diarrhea in a pediatric patient. 一个不寻常的病例神经母细胞瘤表现为长期水样腹泻的儿科患者。

Biochemia medica Pub Date : 2025-06-15 DOI: 10.11613/BM.2025.020901

Claire Claeyssens, Peter Witters, Heidi Segers, Jan De Koster, Elena Levtchenko, Pieter Vermeersch

{"title":"An unusual case of neuroblastoma presenting with prolonged watery diarrhea in a pediatric patient.","authors":"Claire Claeyssens, Peter Witters, Heidi Segers, Jan De Koster, Elena Levtchenko, Pieter Vermeersch","doi":"10.11613/BM.2025.020901","DOIUrl":"10.11613/BM.2025.020901","url":null,"abstract":"Neuroblastomas represent a diverse group of neuroblastic tumors characterized by variability in their clinical progression and degree of differentiation. In rare cases, patients with neuroblastoma may present with paraneoplastic syndromes, such as watery diarrhea, hypokalemia, and achlorhydria (WDHA syndrome), linked to the secretion of vasoactive intestinal peptide (VIP). We report a case of a 14-month-old girl presented with a three-week history of watery diarrhea and signs of dehydration with no other symptoms. The patient's medical history was unremarkable, and no medication use was reported. Venous blood gas analysis revealed a normal anion gap metabolic acidosis with severe hypokalemia. The patient was referred to our hospital 48 hours post-admission due to persistent hypokalemic metabolic acidosis, unresponsive to intravenous fluid therapy. The primary causes of normal anion gap metabolic acidosis in young children are gastrointestinal bicarbonate loss due to diarrhea and renal bicarbonate loss. Semi-quantitative urine organic acid analysis, reported 48 hours after admission, revealed increased vanillylmandelic acid (VMA) (89 mmol/mol creatinine) and homovanillic acid (HVA) (21 mmol/mol creatinine), raising the suspicion of a neuroblastoma. Subsequent analysis of an acidified urine sample confirmed a more than threefold increase in VMA, HVA, normetanephrine, norepinephrine, and 3-methoxytyramine concentrations. In addition, VIP was markedly elevated (1994 ng/L) in a blood sample. The diagnosis of neuroblastoma was confirmed through imaging and histological examination. This case illustrates that chronic diarrhea with metabolic dysregulation (e.g. hypokalemia) can be the first and only symptom in patients with VIP-secreting neuroblastoma which can result in delayed diagnosis of neuroblastoma.","PeriodicalId":94370,"journal":{"name":"Biochemia medica","volume":"35 2","pages":"020901"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to Christelli et al.: Implementation of new Westgard Rules suggested by the Westgard Advisor software for five immunological parameters. What Six Sigma, quality control, the analytical Sigma-metric, and Westgard Advisor can and cannot do. 回复Christelli等人：实施Westgard Advisor软件建议的五个免疫学参数的新Westgard规则。六西格玛、质量控制、分析西格玛度量和韦斯特加顾问能做什么和不能做什么。

Biochemia medica Pub Date : 2025-06-15 DOI: 10.11613/BM.2025.020401

Sten Westgard, Hassan Bayat

引用次数: 0

Telomere length and oxidative stress in small cell lung cancer patients: changes through chemotherapy cycles compared to healthy controls. 小细胞肺癌患者端粒长度和氧化应激：通过化疗周期与健康对照的变化

Biochemia medica Pub Date : 2025-06-15 Epub Date: 2025-04-15 DOI: 10.11613/BM.2025.020705

Azra Guzonjić, Dragana Jovanović, Ivana Simić, Vesna Ćeriman Krstić, Natalija Samardzić, Barbara Ostanek, Janja Marc, Miron Sopić, Jelena Kotur Stevuljević

{"title":"Telomere length and oxidative stress in small cell lung cancer patients: changes through chemotherapy cycles compared to healthy controls.","authors":"Azra Guzonjić, Dragana Jovanović, Ivana Simić, Vesna Ćeriman Krstić, Natalija Samardzić, Barbara Ostanek, Janja Marc, Miron Sopić, Jelena Kotur Stevuljević","doi":"10.11613/BM.2025.020705","DOIUrl":"10.11613/BM.2025.020705","url":null,"abstract":"Introduction: Small cell lung cancer (SCLC) is an aggressive malignant disease with poor survival outcomes. The aim of this study was to investigate leukocyte telomere length (LTL) and redox status parameters during chemotherapy and evaluate their prognostic potential based on the hypothesis that shorter LTL and oxidative stress burden correlate with poorer survival.Materials and methods: This longitudinal study included 60 SCLC patients and 73 healthy controls. Leukocyte telomere length was measured by quantitative PCR (qPCR) method, while redox status parameters (MDA - malondialdehyde, IMA - ischemia-modified albumin, PON1 - paraoxonase 1, redox index) were determined by spectrophotometric methods before, after two and after four cycles of chemotherapy.Results: All measured parameters showed significant differences between patients and controls, except the oxy-score (P < 0.001). Significant differences in IMA, PON1 and redox index were observed between SCLC patient groups at different time points (P < 0.001). Significant differences in IMA and PON1 were observed between SCLC survival groups, with higher values found in survivors after two chemotherapy cycles (P < 0.001). Redox index was the highest in the pre-chemo group (P = 0.019). Among patients who died, PON1 activity differed significantly between those who died within 2 months and after 4 months (P = 0.028). Kaplan-Meier analysis showed that LTL and PON1 were significant predictors of survival, with values below the 25th percentile associated with a higher risk of death.Conclusions: Leukocyte telomere length and PON1 are potential prognostic biomarkers for SCLC survival, suggesting their potential use in non-invasive biomarker panels for improved patient stratification.","PeriodicalId":94370,"journal":{"name":"Biochemia medica","volume":"35 2","pages":"020705"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cumulative IgG reagent carryover detected in carryover evaluation of urinary total protein testing using AU5800 biochemistry analyzer. AU5800生化分析仪检测尿总蛋白携带评价中的累积IgG试剂携带。

Biochemia medica Pub Date : 2025-06-15 Epub Date: 2025-04-15 DOI: 10.11613/BM.2025.020702

Jialu Li, Guoxiang Bao

{"title":"Cumulative IgG reagent carryover detected in carryover evaluation of urinary total protein testing using AU5800 biochemistry analyzer.","authors":"Jialu Li, Guoxiang Bao","doi":"10.11613/BM.2025.020702","DOIUrl":"10.11613/BM.2025.020702","url":null,"abstract":"Introduction: Accurate measurement of urinary total protein (UTP) is crucial for diagnosing renal and systemic diseases. This study aims to comprehensively evaluate potential carryover scenarios in UTP testing using AU5800 biochemistry analyzer and to identify factors influencing assay accuracy.Materials and methods: High-concentration quality control materials and pure water was used to evaluate specific sample probe carryover. Additionally, 24-hour mixed urine samples from patients were used to evaluate specific carryover from the reagent probe, mixbars, and cuvettes. For cumulative sample carryover evaluation, pure water was used as reagent and mixed serum as sample for continuous testing. During the process, 24-hour urine samples were interspersed, and UTP concentrations were measured at 0, 10, 20, and 30 minutes. Cumulative reagent carryover was evaluated by testing pure water sequentially with eight reagents sharing the same analytical unit and inner cuvettes as UTP, with UTP concentrations of 24-hour urine samples recorded at 0, 10, 20, and 30 minutes.Results: Specific carryover from the sample probe, reagent probe, mixbars, and cuvettes was not detected during carryover evaluation of UTP testing. However, a significant cumulative reagent carryover of Immunoglobulin G (IgG) reagent was observed, while no cumulative sample carryover was identified.Conclusions: The full range of possible carryover scenarios in UTP testing was evaluated using AU5800 biochemistry analyzer. Our data provide valuable references for evaluating carryover in laboratories, ensuring the accuracy and reliability of laboratory results.","PeriodicalId":94370,"journal":{"name":"Biochemia medica","volume":"35 2","pages":"020702"},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0