Yu-Wei Tseng, Chun-Chieh Yeh, Che-Yi Chou, Si-Yu Chen, Tze-Kiong Er
{"title":"Preanalytical mystery: falsely elevated intact parathyroid hormone due to sampling from a grafted forearm.","authors":"Yu-Wei Tseng, Chun-Chieh Yeh, Che-Yi Chou, Si-Yu Chen, Tze-Kiong Er","doi":"10.11613/BM.2025.031002","DOIUrl":null,"url":null,"abstract":"<p><p>Spurious elevations in intact parathyroid hormone (iPTH) can lead to unnecessary interventions. We describe a dialysis patient who developed unexpectedly high iPTH concentrations months after total parathyroidectomy with forearm autotransplantation (TPTX-AT). Blood samples had been collected from the grafted forearm, resulting in falsely elevated iPTH values. Once the sample was collected from the non-grafted arm, iPTH concentrations normalized. This case highlights the importance of sampling site awareness in laboratory diagnostics and demonstrates how implementing a simple laboratory information system (LIS)-based protocol can prevent misinterpretation.</p>","PeriodicalId":94370,"journal":{"name":"Biochemia medica","volume":"35 3","pages":"031002"},"PeriodicalIF":1.8000,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523601/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemia medica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11613/BM.2025.031002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Spurious elevations in intact parathyroid hormone (iPTH) can lead to unnecessary interventions. We describe a dialysis patient who developed unexpectedly high iPTH concentrations months after total parathyroidectomy with forearm autotransplantation (TPTX-AT). Blood samples had been collected from the grafted forearm, resulting in falsely elevated iPTH values. Once the sample was collected from the non-grafted arm, iPTH concentrations normalized. This case highlights the importance of sampling site awareness in laboratory diagnostics and demonstrates how implementing a simple laboratory information system (LIS)-based protocol can prevent misinterpretation.