Romanian journal of ophthalmology最新文献

{"title":"A neural network model for predicting the effectiveness of treatment in patients with neovascular glaucoma associated with diabetes mellitus.","authors":"Olga Volodymyrivna Guzun, Oleg Serhiyovich Zadorozhnyy, Volodymyr Viktorovych Vychuzhanin, Natalia Ivanivna Khramenko, Liudmyla Mykolayivna Velichko, Andrii Rostyslavovich Korol, Valeriu Nicon Cușnir, Lilia Gheorghe Dumbrăveanu, Vitalie Valeriu Cușnir","doi":"10.22336/rjo.2024.53","DOIUrl":"10.22336/rjo.2024.53","url":null,"abstract":"<p><strong>Introduction: </strong>The study hypothesizes that neural networks can be an effective tool for predicting treatment outcomes in patients with diabetic neovascular glaucoma (NVG), considering not only baseline intraocular pressure (IOP) values but also inflammation and intraocular microcirculation indicators.</p><p><strong>Objective: </strong>To investigate the diagnostic significance of inflammation and intraocular blood circulation indicators in a neural network model predicting the effectiveness of transscleral cyclophotocoagulation (TSC CPC) treatment in patients with NVG of diabetic origin.</p><p><strong>Methods: </strong>This retrospective cohort study included 127 patients (127 eyes; aged Me 65.0 years) with painful diabetic NVG and 20 healthy individuals (aged Me 61.5 years) as an immunological control. All patients underwent TSC CPC with a diode laser. Treatment success was defined as achieving an IOP level of ≤ 21 mmHg and maintaining or improving best-corrected visual acuity (BCVA) after 12 months of observation. Preoperative systemic immune-inflammation index (SII = platelets × [neutrophils/lymphocytes]) and systemic inflammation response index (SIRI = neutrophils × [monocytes/lymphocytes]) were calculated. We assessed the values of volumetric pulse blood filling, determined by the rheographic coefficient (RQ, 0/00), using the rheoophthalmography (ROG) method. Multiple regression analysis was used to conclude the significance of treatment efficacy based on initial clinical and laboratory indicators, followed by constructing a prediction model in the neural network.</p><p><strong>Results: </strong>The development of the neural network model identified the most significant \"input\" parameters: SIRI (100%), RQ (85.7%), and SII (80.7%), which significantly influenced treatment success. The sensitivity of the neural network model was 100%, specificity was 30%, and the percentage of correctly predicted events during testing on the control group was 92.9%.</p><p><strong>Conclusions: </strong>Neural network-based prediction of transscleral cyclophotocoagulation effectiveness for patients with diabetic neovascular glaucoma allows for a sufficiently accurate forecast of treatment success with a probability of 92.9%. We believe the in-time correction of systemic inflammation and intraocular blood circulation can significantly reduce intraocular pressure, preserve visual acuity, and improve the quality of life in patients with diabetic NVG after TSC CPC. Further research is required to support these findings.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 3","pages":"294-300"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capsular vascularization: role of suprachoroidal triamcinolone and histopathology.","authors":"Avadhesh Oli, Simran Dhami, Lakshmi Nair, Deepti Mutreja, Bhavaraj Veerabhadhra Rao","doi":"10.22336/rjo.2024.58","DOIUrl":"10.22336/rjo.2024.58","url":null,"abstract":"<p><strong>Introduction: </strong>Neovascularization of the lens is a rare entity linked to lens-induced inflammation due to many causes like trauma. We describe a case managed using suprachoroidal triamcinolone, an anti-VEGF injection, in conjunction with cataract surgery and IOL implantation.</p><p><strong>Patient and clinical findings: </strong>A male patient, 27, presented with a severe reduction in vision in his right eye (RE) accompanied by redness for one month. He also had a distant history of blunt trauma to the RE approximately eight years before. His vision in the RE was reduced to hand motion and 20/20 in the left eye. Examining the anterior segment in RE revealed lenticular neovascularization, irregular anterior capsular thickening, iris sphincter tear at the 12 o'clock position, and fine KPs, with iris pigment clumps on the anterior capsule.</p><p><strong>Diagnosis treatment and results: </strong>To reduce vascularization and inflammation, the patient was treated with intravitreal Anti-VEGF and suprachoroidal triamcinolone by an innovative technique, along with cataract surgery, following which visual acuity improved to 20/20.</p><p><strong>Conclusions and significance: </strong>In this exceptional case report, suprachoroidal TA has been used for the first time to treat ocular inflammation and vascularization in traumatic cataract with capsular neovascularization and lens-induced uveitis.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 3","pages":"321-324"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Optical Coherence Tomographic follow-up of a 10-year-old girl with unilateral retinal parasitism.","authors":"Omer Karti, Turhan Mammadov, Songul Bayram Delibas, Ali Osman Saatci","doi":"10.22336/rjo.2024.59","DOIUrl":"10.22336/rjo.2024.59","url":null,"abstract":"<p><strong>Objective: </strong>Retinal parasitism by worms is a rare clinical occurrence and may cause diagnostic and therapeutic challenges. We present a girl with unilateral involvement who was first diagnosed at the age of 10. Change in parasite appearance inside the lesion was recorded by optical coherence tomography (OCT) 14 years apart.</p><p><strong>Methods: </strong>Case report.</p><p><strong>Results: </strong>A 10-year-old girl was referred to our clinic with a presumptive diagnosis of a unilateral posterior pole mass. She had been examined at another institution for the left exotropia and decreased vision, without any accompanying systemic symptoms. Upon our examination, a subretinal lesion, of two disc diameters in size, was detected two disc diameters above the left optic disc, and a spiral-shaped, non-motile roundworm could be spotted inside the lesion. Adjacent chorioretinal atrophy and marked fibrosis surrounded the lesion, without any active inflammation. OCT sections through the lesion delineated the hyperreflective appearance of the spiraling roundworm. Fourteen years later, the worm inside the lesion had lost its spiraling form, and the remnants appeared as a coalesced whitish material inside the lesion on the OCT.</p><p><strong>Discussion: </strong>Although rare, retinal parasitism by worms presents significant diagnostic challenges due to its atypical presentation and the potential for misdiagnosis. In this case, the initial presentation of a subretinal lesion containing a spiral-shaped roundworm was notable for its lack of associated systemic symptoms and the absence of active inflammation, often seen in more common ocular infections. The long-term follow-up, using OCT, provided valuable insights into the infection's natural course, showing the gradual degeneration and transformation of the parasite into a coalesced whitish material, over 14 years. This case underlines the importance of longitudinal imaging in understanding the progression of such unusual retinal conditions and the need for awareness of parasitic infections as a differential diagnosis in similar clinical scenarios.</p><p><strong>Conclusions: </strong>The present case demonstrates the natural evolution of the inactive subretinal worm by OCT and color fundus images.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 3","pages":"325-329"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical Density and Polarized Light Microscopy to confirm calcification of Intra-ocular Lens.","authors":"Avadhesh Oli, Simran Dhami","doi":"10.22336/rjo.2024.60","DOIUrl":"10.22336/rjo.2024.60","url":null,"abstract":"<p><strong>Introduction: </strong>Intra-ocular lens (IOL) calcification is a rare yet serious complication, presenting as clouding within the optics of IOL and necessitating IOL exchange.</p><p><strong>Patient and clinical findings: </strong>In this case, a 77-year-old male experienced gradual vision loss in his left eye (LE) over four years post-cataract surgery a decade before. His best corrected visual acuity (BCVA) was 3/60 in the LE, with the anterior segment displaying a clear cornea but an opacified IOL within the capsular bag. Ultrasound biomicroscopy (UBM) revealed hyperechoic reflections from the IOL in the LE. ImageJ software used on UBM images indicated a significant difference in optical density (OD) compared to the right eye (RE).</p><p><strong>Results: </strong>The patient was diagnosed with IOL calcification in LE, and underwent anterior vitrectomy and IOL exchange with sulcus-placed IOL with optic capture in the capsular bag, resulting in an improved visual acuity of 6/18. Microscopic examination of explanted IOL revealed whitish calcium carbonate crystal deposits on the IOL, which were visible under polarized light.</p><p><strong>Conclusions and significance: </strong>The innovative use of polarized light and ImageJ software can be used in resource-constraint settings to confirm the diagnosis in such cases. Based on ImageJ on the UBM image, OD can pick up even subtle changes in the optical clarity of the IOL optic preoperatively.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 3","pages":"330-334"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing Limbal Dermoids in Patients with Goldenhar Syndrome: A Case Series.","authors":"Anchal Tripathi, Shalini Mohan, Lav Pathak","doi":"10.22336/rjo.2024.55","DOIUrl":"10.22336/rjo.2024.55","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical characteristics, associated systemic features, and management outcomes of patients with limbal dermoids diagnosed with Goldenhar syndrome.</p><p><strong>Methods: </strong>This case series included patients from the eye outpatient department, diagnosed with Goldenhar syndrome based on systemic evaluation. Demographic data, ophthalmological assessments, and systemic evaluations were recorded. Various surgical interventions were employed based on the extent of limbal dermoids, and postoperative follow-up spanned one year.</p><p><strong>Results: </strong>Seven patients (nine eyes) were included, with a mean age of 7.71±4.15 years. Limbal dermoids were bilateral in two patients and unilateral in five. Grade 1 and grade 2 limbal dermoids were observed. The mean BCVA was 0.50±0.11 (logMAR), and astigmatism was present in six patients. Systemic features of Goldenhar syndrome included vertebral anomalies, ear abnormalities, facial anomalies, and lower limb deformity. Surgical interventions varied, with simple excision, lamellar keratoplasty, and amniotic membrane transplantation utilized. Postoperatively, corneal scar formation occurred in all simple excision cases.</p><p><strong>Conclusion: </strong>This case series underscores the rarity of limbal dermoids in the context of Goldenhar syndrome and the importance of early surgical intervention in managing these cases. By sharing our experiences and outcomes, we hope to contribute to the broader understanding of this condition and its optimal treatment.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 3","pages":"306-311"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Brief Review on Adult-Onset Coats' Disease.","authors":"Mary Stephen, Shreyas Temkar, Jayasri Periyandavan, Kalyan Basa","doi":"10.22336/rjo.2024.40","DOIUrl":"10.22336/rjo.2024.40","url":null,"abstract":"<p><p>Adult-onset Coats disease is an uncommon and vision-threatening disease characterized by the development of abnormal blood vessels in the retina. Coats' disease commonly affects children in the first decade of life, but very rarely manifests in adults after the third decade of life, or who characteristically present with unilateral vision loss. Despite being a sight-threatening disease, the etiology remains inconclusive and various genetic and vascular abnormalities are implicated. Diagnosis relies on ophthalmologic examination, fundus photography, fluorescein angiography, and optical coherence tomography. Treatment modalities include laser photocoagulation, intravitreal injections of anti-vascular endothelial growth factor agents, and, in advanced cases, surgical interventions are needed and the treatment is aimed at avoiding complications like retinal detachment and neovascular glaucoma, which were comparatively rare in adult-onset Coats' disease. Despite therapeutic advancements, the prognosis varies, with some patients experiencing significant visual impairment. This review outlines the clinical features, diagnosis, management, and prognosis of adult-onset Coats' disease, underscoring the importance of early detection and intervention in optimizing visual outcomes.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 3","pages":"212-218"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unusual cause of hemolacria: retained contact lens in upper fornix.","authors":"Obaidur Rehman, Shreya Keshari, Sima Das","doi":"10.22336/rjo.2024.57","DOIUrl":"10.22336/rjo.2024.57","url":null,"abstract":"<p><p>A 64-year-old male was referred for complaints of blood in tears and bloody discharge of unknown cause in the left eye. The patient was a chronic bandage contact lens (BCL) user. He had no history of recent trauma. A blood-stained BCL was present on the cornea in the left eye, which was removed. The ocular surface was dry with vascularization of the cornea. Double eversion of the upper eyelid with a Desmarre's retractor revealed a pyogenic granuloma with large papillae on the forniceal conjunctiva and a folded BCL hidden in the fornix. The folded BCL was carefully removed from the \"upper fornix trap\" and topical steroid eyedrops were prescribed.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 3","pages":"318-320"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations between dyslipidemia and retinal parameters measured with Angio-OCT in type II diabetics without diabetic retinopathy.","authors":"Geanina Totolici, Carmen Tiutiuca, Sanda Jurja, Dana Tutunaru","doi":"10.22336/rjo.2024.50","DOIUrl":"10.22336/rjo.2024.50","url":null,"abstract":"<p><strong>Aim: </strong>To analyze the relationship between lipoproteins such as total cholesterol, LDL-c, TG, and retinal parameters in patients with DM type II without signs of DR.</p><p><strong>Method: </strong>A case-control study, consisting of 2 groups. A group of 64 patients with type II diabetes without signs of DR and a control group of 24 healthy subjects. Patients with DM type I, those who showed signs of DR, and those who had associated other eye diseases were excluded.</p><p><strong>Results: </strong>The patients of the two studied groups had a similar average age: 65 years in the DM type II group and 64 years in the control group. In the group with DM, the average CRT was 241.31 µm, a significantly lower value compared to the control group, 252.51. The average value of DVFC was 19.19%, in patients with DM and 24.29% in the control group. An indirect correlation with moderate intensity was established between total cholesterol and CRT, (rs=-0.442, p≤0.001), thus it tended to decrease as total cholesterol increased. With increasing total cholesterol level, DVFC had a mild tendency to decrease (rs=-0.381, p≤0.001). An indirect correlation, but weak in intensity, existed between the LDL/HDL ratio and the DVFC S value (rs=-0.240, p=0.001).</p><p><strong>Discussions: </strong>Central retinal thickness and central vascular density of the superficial capillary plexus were significantly lower in patients with type II diabetes, compared to control subjects. Total cholesterol had higher values in the DM group and an indirect correlation was established with CRT and DVFC, these having a moderate tendency to decrease as the total cholesterol values increased. An indirect and moderate relationship in intensity was also present between LDL and retinal parameters studied. These results were similar to those of other studies conducted, such as that of Chen et al. or Bernaous et al., who showed an association between various lipid classes and the frequency of DR. However, other studies, such as Ausdiab, found that this association did not hold.</p><p><strong>Conclusions: </strong>Type II diabetes patients tend to have elevated serum lipid levels compared to normal subjects, but the impact of dyslipidemia on the onset and progression of DR is incompletely elucidated.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 3","pages":"274-282"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Floppy iris. How is floppy iris syndrome managed? What do urologists and ophthalmologists say?","authors":"Bogdan Bumbuluț, Dan Mircea Stănilă","doi":"10.22336/rjo.2024.54","DOIUrl":"10.22336/rjo.2024.54","url":null,"abstract":"<p><strong>Introduction: </strong>This study focuses on the effect of chronic treatment on the eye, regarding the so-called Intraoperative Floppy Iris Syndrome (IFIS) or Floppy Iris Syndrome, which can occur during cataract surgery.</p><p><strong>Aim: </strong>The study aimed to establish the influence of tamsulosin, used in benign prostatic hyperplasia (BPH) treatment on the iris, during cataract surgery, considering the increased incidence of both conditions in older age.</p><p><strong>Methods: </strong>This study included one hundred male patients, operated on for cataracts at the Ofta Total Clinic and Dr. Stănilă Medical Centre, in Sibiu, out of 601 patients operated on for cataracts between February and October 2022. Of the 100 patients, 24 used medication for BPH. 5 patients used prostamol, a phytotherapeutic preparation, which is an extract from Serenoarepens, and the remaining 19 used tamsulosin, which is an alpha-blocker, most commonly used in the treatment of BPH, considered the first-line treatment option.</p><p><strong>Results: </strong>In 15 patients, we intraoperatively managed, a medium mydriasis through pharmacological dilation, including intracameral administration of phenocaine and mechanical dilation or stripping. In 4 patients it was necessary to apply iris dilators. Due to the small pupil in 2 patients, we caught the iris in the phacoemulsification probe, and a small, incomplete iris coloboma was formed. Sometimes, there was a turnover of Descemet in 4 patients. The pupil remained semi-dilated and slightly areflective in the patients to whom we applied iris hooks. The patients' visual acuity was satisfactory, between 0.9 and 0.6.</p><p><strong>Discussions: </strong>The topic gives rise to many discussions. It seems that stopping the administration of tamsulosin for a short time does not help the occurrence of IFIS, because the iris lesions seem irreversible. Patients at risk of developing cataracts should be evaluated and possibly referred to an ophthalmologist to determine surgery before starting treatment for BPH and to competently assess the administration of this medication.</p><p><strong>Conclusions: </strong>Collaboration between urologists and ophthalmologists is required for patients prone to the appearance of cataracts since both conditions are frequently encountered in elderly patients.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 3","pages":"301-305"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 79th Annual Meeting of the European Board of Ophthalmology, alongside the UEMS Meeting.","authors":"Cornel Ştefan, Marian Burcea, Alina Gheorghe","doi":"10.22336/rjo.2024.39","DOIUrl":"https://doi.org/10.22336/rjo.2024.39","url":null,"abstract":"","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"68 3","pages":"211"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}