Romanian journal of ophthalmology最新文献

{"title":"Ibandronic Acid Induced Orbital Inflammation and Concurrent Anterior Uveitis - A Rare Presentation.","authors":"Jayasri Periyandavan, Amudha Purushothaman, Vijhayapriya Thanasekaran, Ezhilvathani T Namaskaram","doi":"10.22336/rjo.2025.42","DOIUrl":"10.22336/rjo.2025.42","url":null,"abstract":"<p><strong>Aim: </strong>To report the first case of orbital inflammation with concurrent anterior uveitis induced by oral Ibandronate, a bisphosphonate used for osteoporosis and other bone disorders.</p><p><strong>Material and methods: </strong>A 55-year-old female, with a history of diabetes and hypertension, developed bilateral eye pain, redness, and photophobia two days after taking oral Ibandronate for a thoracic spine fracture. Examination revealed reduced visual acuity, anterior uveitis at presentation, and bilateral proptosis two days later. The imaging revealed diffuse bilateral orbital inflammation.</p><p><strong>Results: </strong>After discontinuing the drug, the patient was treated with intravenous methylprednisolone, leading to significant improvement in ocular symptoms.</p><p><strong>Discussion: </strong>Bisphosphonates, including Ibandronate, can cause ocular adverse effects such as uveitis and orbital inflammation. The pathophysiology is linked to immune modulation via gamma T-cell activation. Most cases respond to discontinuation of drug and steroid administration. The risk-benefit ratio of steroid administration has to be weighed, as it can worsen osteoporosis. Early detection and timely discontinuation of the drug can avoid sight-threatening complications.</p><p><strong>Conclusion: </strong>This case underscores the importance of early recognition and prompt management of ocular complications, particularly as the use of bisphosphonates continues to increase.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 2","pages":"267-270"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phacocele Induced by Traumatic Blunt Injury in a 53-Year-Old Woman: A Case Report.","authors":"Bleidele Sandra, Veitners Alberts, Zemitis Arturs, Vasilcenko Irina, Bagante Ieva, Laganovska Guna","doi":"10.22336/rjo.2025.40","DOIUrl":"10.22336/rjo.2025.40","url":null,"abstract":"<p><strong>Purpose: </strong>To report a 53-year-old woman with a traumatic phacocele after blunt eye trauma.</p><p><strong>Methods: </strong>In this case, a comprehensive ophthalmological examination, computed tomography (CT), eye ultrasonography, optical coherence tomography (OCT), as well as eye and orofacial surgeries, were performed. The surgery was divided into three different stages: a revision of the wound, maxillofacial surgery, and a 25G pars plana vitrectomy with retropupillary Artisan IOL implantation.</p><p><strong>Results: </strong>During the latest examination, occurring one and a half months after the incident, the patient presented with a best-corrected visual acuity (BCVA) of 20/70 in the left eye.</p><p><strong>Discussion: </strong>Phacocele is a rare consequence of blunt ocular trauma, most commonly observed in elderly patients after a fall, with the lens dislocated in the superonasal quadrant. Prompt surgical management is essential, although long-term visual results may be affected by postoperative complications.</p><p><strong>Conclusion: </strong>Phacocele, defined as the displacement of the crystalline lens into the subconjunctival space, is a rare complication that may arise from blunt eye trauma. Due to its infrequency, there is limited literature and documented cases available. As demonstrated in this case, the patient exhibited significant improvement in best-corrected visual acuity (BCVA) following surgical interventions in the eye.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 2","pages":"254-258"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective Evaluation of Ocular Surface Adverse Effects in Patients Receiving Topical Antiglaucoma Treatment.","authors":"Cristina-Mihaela Anghel-Timaru, Daniela Adriana Iliescu, Leon Zăgrean","doi":"10.22336/rjo.2025.31","DOIUrl":"10.22336/rjo.2025.31","url":null,"abstract":"<p><p>Topical treatments remain the primary therapeutic strategy for glaucoma, with the primary objective of reducing intraocular pressure (IOP), the only modifiable risk factor for the disease. While these medications are effective in lowering IOP, they are also associated with a variety of potential adverse effects. This study aims to compare the effects of various topical antiglaucoma medications on the ocular surface in patients with open-angle glaucoma or intraocular hypertension. Patients were classified based on their treatment type and assessed using the Schirmer test, tear break-up time (TBUT), and fluorescein staining. The monitoring period spanned from February 2019 to September 2024. Preliminary results suggested that the daily number of drops administered may have a more significant impact on outcomes than the presence or absence of preservatives in the eye drops.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 2","pages":"190-199"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standard and accelerated crosslinking protocols in keratoconus - differences and evolution at one year.","authors":"Maria-Silvia Dina, Mihaela-Monica Constantin, Maria-Cristina Marinescu, Cătălina-Gabriela Corbu, Cătălina-Ioana Tătaru, Călin-Petru Tătaru","doi":"10.22336/rjo.2025.29","DOIUrl":"10.22336/rjo.2025.29","url":null,"abstract":"<p><strong>Objectives: </strong>Keratoconus (KC) is a bilateral, progressive corneal ectasia that involves corneal thinning and a decrease in visual acuity. Stopping the progression of keratoconus can be achieved through various photooxidative crosslinking (CXL) methods. The objective of this study was to compare two protocols of epi-off corneal crosslinking-the standard and the accelerated protocol-in terms of efficacy after a one-year follow-up.</p><p><strong>Methods: </strong>41 eyes with progressive keratoconus were treated with corneal crosslinking, either using the accelerated (Acc-CXL) or standard protocol (Std-CXL). The following parameters were monitored: refraction, corneal diopter power on topographic maps (Kmax and Kmin), corneal thickness (CCT), resistance factor (CRF), hysteresis, and the depth of the demarcation line. All measurements were repeated 12 months after the intervention.</p><p><strong>Results: </strong>The progression of keratoconus was halted in 20 eyes using the accelerated method and in 21 eyes using the standard procedure. Both methods resulted in a statistically significant regression of the spherical equivalent, Kmax, and an increase in CCT and CRF, without substantial differences in efficacy. The demarcation line was highlighted on average at a depth of 278.9 ± 31.71 micrometres for the Acc-CXL group and 280.42 ± 47.85 micrometres for the Std-CXL group. It was correlated with the initial topographical values.</p><p><strong>Discussion: </strong>The evaluation of patients revealed no progression of keratoconus following the procedure. Approximately 40% of the cases in the accelerated protocol group and 38.09% of the cases in the standard protocol group have maintained the parameters at a constant level. In comparison, approximately 60% of the cases have shown improvements. An Australian registry revealed that both CXL protocols are safe and effective; however, the standard procedure leads to improved visual acuity, a more significant flattening of the steepest meridian, and a higher chance of an effect greater than one diopter power.</p><p><strong>Conclusions: </strong>Corneal crosslinking (CXL) was effective in halting the progression of keratoconus using both methods. Accelerated CXL is faster and more comfortable for patients, with similar efficiency to standard CXL.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 2","pages":"175-183"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the pandemic on the intravitreal injection treatment for patients with age-related macular degeneration, regardless of lockdown periods.","authors":"Mahmut Oğuz Ulusoy, Cansu Erseven, Büşra Erel, Sadık Görkem Çevik, İrfan Perente","doi":"10.22336/rjo.2025.27","DOIUrl":"10.22336/rjo.2025.27","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of the pandemic on the intravitreal injection treatment routine for patients with neovascular age-related macular degeneration, regardless of lockdown periods.</p><p><strong>Methods: </strong>We evaluated the data of intravitreal injections between March 2020 and June 1, 2021, which was the last day of official restrictions. We divided into two groups: a regular treatment group and a group that was interrupted for at least 3 months without excuse. The initial visual acuity at the beginning of the pandemic, the last visual acuity, the visual acuity after interruption, the central macular thickness, and the interruption time were recorded.</p><p><strong>Results: </strong>A total of 156 patients' data were evaluated. There are forty-eight patients in the regular treatment group, 77 in the interruption group, and 31 in the discontinued group. The visual loss was significantly higher in the interruption group (respectively, -0.11 ± 0.19 vs. 0.03 ± 0.16, p<0.001). Central macular thickness changes were higher in the interruption group (respectively, 31.8 ± 5.7µm vs. 13.5 ± 4.6, p<0.001). The mean interruption time was 6.71 ± 2.45 months.</p><p><strong>Discussion: </strong>Half of the patients in our study interrupted their treatment during the pandemic, and this interruption had a negative impact on their visual acuity and central macular thickness. In addition to COVID-19's own high mortality and morbidity, it also had adverse effects on patients who required regular follow-up and treatment.</p><p><strong>Conclusion: </strong>Since interruptions in treatment negatively impact the prognosis of AMD, effective protocols that do not require frequent visits are necessary.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 2","pages":"164-168"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Cataract Surgery Influence Iris-Based Biometric Authentication?","authors":"Sonali Vinay Kumar, Vinay Kumar, Natasha Vinay Kumar, Alok Sati, Sanjay Kumar Mishra","doi":"10.22336/rjo.2025.30","DOIUrl":"10.22336/rjo.2025.30","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the impact of cataract surgery on the reliability and accuracy of iris recognition systems used for biometric identification.</p><p><strong>Methods: </strong>We carried out a prospective observational study on patients undergoing cataract surgery via phacoemulsification. The study comprised 100 participants who underwent cataract surgery. We recorded preoperative iris scans using a standard biometric device (iris camera) and rescanned the same patients after surgery. Matching scores before and after surgery were analyzed to detect discrepancies. We examined the Hamming distance to evaluate changes in the iris pattern.</p><p><strong>Results: </strong>The mean age of the study population was 64 ± 6.2 years (range, 52-74 years). The study population comprised 62 males and 38 females. Out of the total cases, 72 involved the right eye and 28 involved the left eye. The majority of patients presented within the current study presented with visual acuity between 6/18 and 3/60. We performed phacoemulsification and implanted foldable intraocular lenses in all cases. The study found no notable changes in iris pattern matching accuracy following uncomplicated cataract surgery. Postoperative images were matched with preoperative images in 95 patients, demonstrating that the surgery did not affect biometric reliability. The mean Hamming distance before and after surgery remained within the acceptable threshold for authentication, with 99% of cases successfully matched.</p><p><strong>Discussion: </strong>The study supports the robustness of iris-based biometric systems under routine ophthalmic surgical conditions. This system's resilience to variations caused by cataract surgery demonstrates its robustness in practical sessions.</p><p><strong>Conclusion: </strong>Cataract surgery, when performed without complications, does not impair the accuracy of iris-based biometric identification. These findings underscore the feasibility of using iris recognition systems in healthcare and security, even among patients undergoing ocular procedures.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 2","pages":"184-189"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital Metastasis from Hidradenocarcinoma.","authors":"Mary Stephen, Kumaradarshini Maruthachalam, Nirupama Kasturi, Jayasri Periyandavan","doi":"10.22336/rjo.2025.46","DOIUrl":"10.22336/rjo.2025.46","url":null,"abstract":"<p><p>Hidradenocarcinoma is a rare form of malignant adnexal tumor. This malignant tumor has been reported to metastasize to regional lymph nodes, and distant metastasis into structures like the orbit and extraocular muscle is uncommon. Orbital metastasis comprises about 10% of all orbital neoplasms. Common systemic malignancies contributing to orbital metastasis are breast cancer, prostate cancer, and skin malignancy, melanoma. We report the case of a middle-aged man with left axillary hidradenocarcinoma with an orbital metastatic lesion infiltrating the inferior rectus muscle with optic nerve involvement. This case report describes a rare presentation of orbital metastasis from an adnexal tumour.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 2","pages":"287-290"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Usual Suspects: Unilateral Optic Disc Edema as a Rare Initial Sign of Vogt-Koyanagi-Harada Syndrome.","authors":"Vipin Rana, Vikas Sharma, Kanwaljeet Singh, Amit Nandan Tripathi, Ranjit Goenka, Ashish Markan","doi":"10.22336/rjo.2025.44","DOIUrl":"10.22336/rjo.2025.44","url":null,"abstract":"<p><strong>Objective: </strong>To report a case of unilateral optic disc edema as a rare initial presentation of Vogt-Koyanagi-Harada (VKH) syndrome and emphasize the importance of early diagnosis using advanced imaging and cerebrospinal fluid analysis.</p><p><strong>Case presentation: </strong>We present the case of a 23-year-old male who initially presented with unilateral optic disc edema, retro-orbital pain, and headache, progressing to bilateral involvement with serous retinal detachments. Advanced imaging, including fundus fluorescein angiography (FFA), Indocyanine green angiography (ICG), and Enhanced depth imaging-Optical coherence tomography (EDI-OCT), revealed hallmark findings of VKH, such as choroidal granulomas and increased choroidal thickness. Cerebrospinal fluid analysis confirmed pleocytosis and melanin-laden macrophages, which helped to establish the diagnosis. The patient was treated with high-dose intravenous corticosteroids and azathioprine, with significant improvement.</p><p><strong>Discussion: </strong>VKH progresses through prodromal, acute uveitic, chronic, and recurrent phases. Although typically presenting with panuveitis, isolated optic disc edema as an initial sign is rare. Early diagnosis requires multimodal imaging and cerebrospinal fluid analysis to differentiate VKH from other inflammatory and infectious aetiologies.</p><p><strong>Conclusion: </strong>This case highlights the importance of considering VKH in patients presenting with disc edema, whether unilateral or bilateral, particularly when accompanied by vitreous cells. Advanced ocular imaging and thorough systemic evaluation are critical for early diagnosis. Prompt treatment can prevent progression to chronic disease and irreversible vision loss.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 2","pages":"275-279"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfonamide Allergy and Alternative Treatments in Ocular Toxoplasmosis.","authors":"Francisco Calleja Casado, Antonio Duch Samper","doi":"10.22336/rjo.2025.25","DOIUrl":"10.22336/rjo.2025.25","url":null,"abstract":"<p><strong>Purpose: </strong>To summarize current knowledge on the clinical features, diagnosis, and treatment of ocular toxoplasmosis, with emphasis on alternatives for sulfonamide-allergic patients.</p><p><strong>Materials and methods: </strong>A comprehensive PubMed search (1908-2021) was conducted using terms like <i>Toxoplasma gondii</i>, ocular toxoplasmosis, posterior uveitis, and retinochoroiditis. Priority was given to studies published after 2000, particularly those from 2010 onwards. Google Scholar, as well as English and Spanish sources, were also utilized.</p><p><strong>Results: </strong>Ocular toxoplasmosis is the most common infectious form of posterior uveitis worldwide, typically presenting as necrotizing retinochoroiditis with associated vitreomacular adhesion and vitritis. Diagnosis is mainly clinical, supported by serology (IgG/IgM) and PCR of intraocular fluids when needed. Standard treatment includes systemic antiparasitic agents (e.g., pyrimethamine with sulfadiazine or trimethoprim-sulfamethoxazole) plus corticosteroids. In patients with sulfonamide allergies, alternatives such as pyrimethamine with clindamycin or azithromycin, or intravitreal clindamycin with dexamethasone, are effective. Recent studies show comparable outcomes with these regimens. Prompt treatment of active disease helps reduce retinal damage.</p><p><strong>Discussion: </strong>Recent evidence supports the efficacy and safety of non-sulfonamide regimens and intravitreal therapies in managing ocular toxoplasmosis. These options are particularly valuable for patients with contraindications to standard treatments. Advances in imaging and molecular diagnostics have also enhanced early recognition and tailored management of the disease, contributing to improved visual outcomes.</p><p><strong>Conclusion: </strong>Advances in diagnostic tools (PCR, intraocular antibody detection) and alternative therapies have improved outcomes in ocular toxoplasmosis, including in patients who are intolerant to sulfonamides. Clindamycin-based or intravitreal approaches offer effective, safe options. Further research is needed to refine treatment protocols, prevent recurrences, and clarify disease pathogenesis.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 2","pages":"147-157"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Choroidal Thickness in Type 2 Diabetes Using Spectral-Domain Optical Coherence Tomography.","authors":"Shivapriya Manivannan, Avadhesh Oli","doi":"10.22336/rjo.2025.28","DOIUrl":"10.22336/rjo.2025.28","url":null,"abstract":"<p><strong>Background and objectives: </strong>Microvascular changes induced by diabetes mellitus (DM) are the primary cause of diabetic retinopathy (DR) and choroidopathy. There is a lack of evidence linking diabetic retinopathy (DR) to changes in choroidal thickness (CT), so we designed this study to investigate this relationship. The choroidal thickness of DM patients, with or without DR, was compared to that of controls (subjects without diabetes) using spectral domain optical coherence tomography (SD-OCT).</p><p><strong>Materials and methods: </strong>We recruited 132 participants for a prospective observational study. Choroidal thickness at five points: subfoveal and at 500 and 1000 µm, both temporally and nasally to the fovea, was measured. OCT measurements, insulin use, lipid profiles, age, gender, fundus examination, and glycaemic control were recorded. The inferential and descriptive statistics were applied.</p><p><strong>Results: </strong>When compared to DM patients without DR, CT showed a trend toward lower values; however, only CT at 1000 μm temporal to the fovea (300.25 ± 65.37 μm in control group 1, 304.82 ± 76.71 μm in group 2, and 271.84 ± 65.07 μm in DR group 3) reached statistical significance (p = 0.05). Each diabetic subgroup did not differ in sub-foveal choroidal thickness (SFCT) (p = 0.586). Patients without DME (289.53 ± 63.86 μm) and those with DME (289.83 ± 100.99 μm) had comparable SFCTs (p = 0.992).</p><p><strong>Discussion: </strong>When comparing diabetic patients with and without diabetic retinopathy to healthy controls, there are differences in CT (increased, decreased, or no change). The atrophy and dropout of the choriocapillaris in eyes with diabetic retinopathy may be the cause of the decrease in CT in DR patients that our study revealed.</p><p><strong>Conclusion: </strong>DR patients showed a statistically significant decrease in CT at the 1000 μm temporal to fovea choroidal subregion compared to DM patients without DR. These results suggest that diabetes induces pathological changes in the choroid, resulting in retinopathy.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 2","pages":"169-174"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}