Northern clinics of Istanbul最新文献

{"title":"Predictive values of news and Mts in patients presenting with dyspnea: A comparative cohort study.","authors":"Kurtulus Aciksari","doi":"10.14744/nci.2025.37233","DOIUrl":"10.14744/nci.2025.37233","url":null,"abstract":"<p><strong>Objective: </strong>Dyspnea is a frequent yet potentially life-threatening complaint in emergency departments. This study aimed to compare the predictive accuracy of the National Early Warning Score and the Manchester Triage System for key clinical outcomes among dyspneic ED patients.</p><p><strong>Methods: </strong>We retrospectively analyzed 726 adult dyspneic patients presenting to a tertiary ED. Demographics, initial vital signs, MTS triage category, and calculated NEWS values were recorded at admission. Outcomes included hospital ward admission, intensive care unit admission, in-hospital mortality, 48-hour reattendance, and length of stay. Statistical analyses comprised chi-square, Kruskal-Wallis, and logistic regression models.</p><p><strong>Results: </strong>The mean age was 61.1 years, and 52.9% were female. Of the patients, 13.8% were admitted to wards, 3.2% to ICUs, and 2.3% died; 4.1% reattended within 48 hours. NEWS risk stratification strongly aligned with MTS categories (p<0.001). Higher NEWS scores were associated with older age, higher respiratory and pulse rates, lower blood pressure, and reduced oxygen saturation. NEWS independently predicted hospital admission (OR=4.47, p<0.001) and ICU admission (OR=1.94, p=0.001), whereas MTS predicted ICU admission (inverse association, OR=0.34, p<0.001) and mortality (OR=0.30, p<0.001).</p><p><strong>Conclusion: </strong>NEWS more accurately predicted hospital and ICU admission, while MTS was more strongly associated with mortality in dyspneic ED patients. These complementary roles suggest that combining both tools-or developing a dyspnea-specific hybrid model-may enhance risk stratification and improve outcomes.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"131-138"},"PeriodicalIF":0.9,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repurposing antiviral drugs targeting RNA viruses: A focus on the fusion protein of human metapneumovirus.","authors":"Merve Aras, Ozlem Tonguc Yayintas","doi":"10.14744/nci.2026.85353","DOIUrl":"10.14744/nci.2026.85353","url":null,"abstract":"<p><strong>Objective: </strong>Human metapneumovirus (HMPV) is a clinically important respiratory pathogen causing severe lower respiratory tract infections, particularly in infants, elderly individuals, and immunocompromised patients. Despite its substantial disease burden and global circulation, no HMPV-specific antiviral therapy has been approved to date. This unmet clinical need underscores the importance of identifying rapidly translatable therapeutic strategies. The present study aimed to identify potential inhibitors of the HMPV fusion (F) protein through a structure-based drug repurposing approach, leveraging the advantages of existing safety and pharmacokinetic profiles of approved antivirals.</p><p><strong>Methods: </strong>Thirteen antiviral agents predicted to interact with the HMPV F protein were selected from the DrugBank database. Comprehensive in silico molecular docking analyses were conducted to evaluate ligand-protein interactions, with Ribavirin used as a reference compound and positive control. Binding affinity values were quantitatively compared, using the Ribavirin binding energy (-6.2 kcal/mol) as a benchmark for relative performance.</p><p><strong>Results: </strong>The docking analyses revealed that multiple approved antiviral agents-namely Ledipasvir, Velpatasvir, Paritaprevir, Elbasvir, Pibrentasvir, Glecaprevir, Voxilaprevir, Ombitasvir, Grazoprevir, Dasabuvir, and Sofosbuvir-exhibited significantly higher binding affinities to the HMPV F protein than Ribavirin. These findings highlight the unexpected and mechanistically relevant interaction potential of hepatitis C virus-targeting antivirals with the HMPV fusion machinery, suggesting a novel avenue for therapeutic intervention.</p><p><strong>Conclusion: </strong>This study provides compelling in silico evidence that drug repurposing of clinically approved antiviral agents may accelerate the development of effective HMPV-specific therapies. By targeting the highly conserved and functionally critical HMPV F protein, the identified candidate compounds offer strong translational potential and justify prioritization for experimental validation and preclinical investigation. Collectively, these results contribute to filling a critical therapeutic gap and support drug repurposing as a viable and time-efficient strategy to address emerging and neglected viral respiratory infections.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"221-229"},"PeriodicalIF":0.9,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of cytoreductive nephrectomy on survival in patients with metastatic renal cell carcinoma receiving tyrosine kinase inhibitors.","authors":"Irem Bilgetekin, Erdem Ozturk, Cengiz Karacin, Fatma Bugdayci Basal, Zeynep Akdagcik, Berna Oksuzoglu","doi":"10.14744/nci.2026.49035","DOIUrl":"10.14744/nci.2026.49035","url":null,"abstract":"<p><strong>Objective: </strong>The role of cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (RCC) is controversial. The aim of this study was to compare survival outcomes between nephrectomy and non-nephrectomy groups in patients with de novo metastatic renal cell carcinoma receiving tyrosine kinase inhibitors (TKI).</p><p><strong>Methods: </strong>This retrospective study included 99 patients with de novo metastatic renal cell carcinoma, stratified according to receipt of cytoreductive nephrectomy. Baseline clinicopathological variables, including International Metastatic RCC Database Consortium (IMDC) risk category, Eastern Cooperative Oncology Group (ECOG) performance status, sarcomatoid features, Fuhrman grade, and TKI regimen, were collected. Overall survival was evaluated using Kaplan-Meier analysis.</p><p><strong>Results: </strong>Among 99 patients, IMDC risk categories were favorable in 21 (21.2%), intermediate in 52 (52.5%), and poor in 26 (26.3%). CN was performed in 67 patients (67.7%). Pazopanib and sunitinib were used in 50 (50.5%) and 49 (49.5%) patients, respectively. In comparison with the nephrectomy cohort, a greater percentage of patients in the non-nephrectomy cohort were classified as poor risk (37.5% vs. 20.8%, p=0.010). Overall survival differed significantly across IMDC risk groups (p=0.001). In the favorable-risk subgroup, median overall survival was longer with nephrectomy than without surgery (42 vs. 12 months, p=0.042). There was no significant difference in survival between pazopanib and sunitinib treatment (14 vs. 16 months, p=0.251).</p><p><strong>Conclusion: </strong>CN was associated with improved overall survival in the favorable-risk subgroup, whereas no significant survival difference was observed in intermediate- or poor-risk groups.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"179-184"},"PeriodicalIF":0.9,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical auditory dysfunction in a genetic rat model of childhood absence epilepsy.","authors":"Fatma Nur Komur, Yavuz Gundogdu, Mahmut Furkan Beyaz, Ayca Ciprut","doi":"10.14744/nci.2026.34466","DOIUrl":"10.14744/nci.2026.34466","url":null,"abstract":"<p><strong>Objective: </strong>Childhood absence epilepsy (CAE) is defined by cognitive, behavioral, and neurophysiological abnormalities, but its impact on auditory function remains underexplored. Using Genetic Absence Epilepsy Rats from Strasbourg (GAERS), this study aimed to examine both peripheral and central auditory pathways function to better understand the auditory consequences of CAE.</p><p><strong>Methods: </strong>The experimental and control groups consisted of six-month-old male GAERS (n=6) and Wistar (n=6) rats. Auditory functions were assessed using distortion product otoacoustic emissions (DPOAE) and auditory brainstem responses (ABR). DPOAE amplitudes and ABR wave thresholds, latencies, and amplitudes were analyzed for group comparison.</p><p><strong>Results: </strong>DPOAE amplitudes were significantly reduced across all tested frequencies in epileptic rats compared to controls. In addition, ABR thresholds were slightly elevated compared to controls, but remained within clinically normal limits. Prolonged latencies were obtained in all waves except Wave I, indicating subcortical auditory pathway involvement in the epileptic group. A distinct ABR amplitude pattern emerged in epilepsy, characterized by increased Wave I-II amplitudes, a marked reduction at Wave III, and subsequent increases at Waves IV-V.</p><p><strong>Conclusion: </strong>The results showed both peripheral and central auditory nervous system dysfunction in GAERS rats, providing translational insight into CAE. Subclinical abnormalities in auditory neuronal processing may contribute to speech-in-noise difficulties, language impairments, and learning problems in affected children. Early detection and follow-up are valuable for the clinical management of auditory involvement in pediatric epilepsy.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"154-161"},"PeriodicalIF":0.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of arthroplasty surgery experience on successful outcomes in primary total hip arthroplasty surgery.","authors":"Alper Dunki, Murat Birinci, Hakan Batuhan Kaya, Mesut Akkaya, Omer Polat","doi":"10.14744/nci.2025.77854","DOIUrl":"10.14744/nci.2025.77854","url":null,"abstract":"<p><strong>Objective: </strong>Total hip arthroplasty (THA) is one of the orthopaedic surgeries performed today that yields satisfactory results. The surgeon volume has an important effect on the success of THA and we predict that surgeon-related variables can be brought to the most optimal level with experience.</p><p><strong>Methods: </strong>Patients who underwent primary THA surgery between 2015 and 2024 and had at least 1 year of follow-up were included in the study. High volume (HV) in surgeons who performed at least 20 primary THA operations in at least 3 consecutive years. Surgeons with 5 years or more of experience in orthopedics and traumatology were defined as low volume (LV). Acetabular inclination angle, limb length discrepancy, femoral stem malalignment, and hip rotation center conformity according to the Ranawat triangle method were determined from postoperative radiographs.</p><p><strong>Results: </strong>In the study investigating the relationship between primary THA and surgeon volume, a significant relationship was found between surgical time, hospital stay, dislocation, blood loss, leg length discrepancy and hip rotation center according to Ranawat triangle as surgeon experience increased. No significant relationship was found between the groups in terms of revision surgery, acetabular inclination angle, femoral stem malalignment and periprosthetic infection.</p><p><strong>Conclusion: </strong>As in every field, there is a linear relationship between increasing experience in a surgery or disease group and successful results in orthopedics and traumatology. Complication rates may decrease with the increase in HV surgeons in every field. For this reason; increasing the experience of surgeons in a certain field in orthopedics and traumatology will help them follow new developments in this field.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"194-201"},"PeriodicalIF":0.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine spending and economic recovery: OECD panel data analysis.","authors":"Engin Aydın, Mustafa Ozyesil, Havane Tembelo","doi":"10.14744/nci.2026.36418","DOIUrl":"10.14744/nci.2026.36418","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates whether public spending on vaccination programmes contributes to macroeconomic normalization following severe health shocks in high-income Organisation for Economic Co-operation and Development (OECD) economies.</p><p><strong>Methods: </strong>An unbalanced OECD panel dataset was analysed using a fixed-effects specification that incorporates structural controls including inflation, unemployment, trade openness, and general health expenditure.</p><p><strong>Results: </strong>The empirical results indicate that vaccine expenditure does not exert a statistically significant independent effect on economic recovery, although the coefficients display a positive but economically modest direction. Conversely, several macroeconomic fundamentals demonstrate stronger and more consistent associations with recovery dynamics.</p><p><strong>Conclusion: </strong>Vaccination functions as a necessary but insufficient component of recovery strategies, with its economic influence mediated through system-level efficiency rather than direct fiscal input. Integrated policy frameworks that combine public health interventions with structural economic measures are required.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"72-86"},"PeriodicalIF":0.9,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular and clinical findings in Osteogenesis Imperfecta: A cohort study from a single tertiary center.","authors":"Emre Ozer, Esra Kilic, Husnu Mutlu Turan, Mustafa Altan, Vehap Topcu, Banu Turhan, Abdurrahman Bitkay, Pinar Kocaay, Mehmet Boyraz, Fatih Gurbuz","doi":"10.14744/nci.2026.25588","DOIUrl":"10.14744/nci.2026.25588","url":null,"abstract":"<p><strong>Objective: </strong>Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous skeletal fragility disorder. Although COL1A1/COL1A2 variants account for most cases, non-COL1A genes and overlapping monogenic bone fragility conditions complicate diagnosis and genotype-phenotype interpretation in routine practice. We aimed to describe the clinical spectrum and molecular findings of patients evaluated for suspected or confirmed OI at a tertiary referral center, and to assess phenotype patterns across genotype-informed groups.</p><p><strong>Methods: </strong>We conducted a single-center retrospective cohort study at Ankara City Hospital. Pediatric and adult patients evaluated for suspected/confirmed OI were included. Clinical, radiologic, and treatment data were extracted from medical records. All patients underwent targeted next-generation sequencing panel testing, and variants were interpreted according to ACMG criteria. Findings were summarized descriptively and analyzed across COL1A1/COL1A2, non-COL1A OI-associated genes, and non-OI bone-related genes.</p><p><strong>Results: </strong>Forty-two individuals were included (age range at genetic evaluation: 0.1-47 years). The most common referral indication was recurrent long-bone fractures (81.0%), while 31.0% presented with or additional vertebral compression fractures and/or osteoporosis. Variants in OI-associated genes were identified in 30/42 patients (71.4%); 23/42 (54.7%) had molecularly confirmatory pathogenic/likely pathogenic variants in established OI-associated genes. Among genetically confirmed OI cases, 17/23 (73.9%) involved COL1A1/COL1A2. In the non-COL1A subgroup, biallelic pathogenic/likely pathogenic variants were found in CRTAP, P3H1, and FKBP10 (n=5), and one patient had a heterozygous WNT1 variant. Seven patients (16.7%) had negative panel results. At last follow-up, 83.3% were independently ambulatory.</p><p><strong>Conclusion: </strong>In this tertiary-center cohort, integrating phenotype with molecular testing improved diagnostic stratification in suspected OI and highlighted the predominance of COL1A-related disease. However, the continued clinical relevance of VUS and panel-negative results underscores the need for broader second-tier genetic testing and periodic reanalysis in cases where clinical suspicion persists.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"105-112"},"PeriodicalIF":0.9,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and management practices in polymyalgia rheumatica among Turkish rheumatologists: An online cross-sectional survey.","authors":"Sevilay Batibay, Gozde Sen","doi":"10.14744/nci.2026.24119","DOIUrl":"10.14744/nci.2026.24119","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate real-world diagnostic and therapeutic approaches to polymyalgia rheumatica (PMR) among Turkish rheumatologists and compare them with international guideline recommendations.</p><p><strong>Methods: </strong>A cross-sectional online survey was conducted among rheumatologists practicing in Turkiye between September and October 2025. A self-administered 29-item questionnaire was distributed through professional communication networks. The survey was developed with reference to the 2012 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria and international management guidelines. It assessed self-reported diagnostic approaches, screening practices for giant cell arteritis (GCA), treatment strategies, and follow-up and monitoring practices. Data were recorded and analyzed in a de-identified manner using descriptive statistics.</p><p><strong>Results: </strong>A total of 101 rheumatologists participated in the survey. Diagnostic approaches varied substantially: use of the 2012 EULAR/ACR criteria was reported by 65 (64.4%), referral to the 2010 British Society for Rheumatology/British Health Professionals in Rheumatology (BSR/BHPR) guideline by 10 (9.9%), and primary reliance on clinical judgment by 76 (75.2%). Elevated erythrocyte sedimentation rate and/or C-reactive protein (ESR/CRP) were considered necessary for diagnosis by 92 (91.1%). Use of imaging modalities, including ultrasonography (US), magnetic resonance imaging (MRI), and positron emission tomography (PET), was highly heterogeneous, and routine screening for giant cell arteritis (GCA) was reported by 25 (24.8%). Glucocorticoid (GC) monotherapy was the preferred first-line treatment among 76 participants (75.2%), with most clinicians selecting guideline-recommended starting doses (12.5-25 mg/day) and initiating tapering between weeks 4 and 8. Disease-modifying antirheumatic drugs (DMARDs) were most commonly introduced at first relapse (55, 54.5%). Although osteoporosis risk assessment was reported by 86 (85.1%), the use of dual-energy X-ray absorptiometry (DXA), the Fracture Risk Assessment Tool (FRAX), and referral for exercise programs remained inconsistent.</p><p><strong>Conclusion: </strong>Although initial GC therapy was generally consistent with guideline recommendations, considerable heterogeneity was observed in diagnostic approaches, imaging use, screening for GCA, and long-term monitoring practices, indicating persistent gaps between guidelines and real-world clinical practice.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"36-44"},"PeriodicalIF":0.9,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between physical activity, daily step count, and posture in office workers and examination of DIERS pedoscan static plantar load distribution parameters: A cross sectional study.","authors":"Gulsemin Erturk Celik, Abdurrahman Iskender, Serife Coskun Sagirkaya, Alper Doganci","doi":"10.14744/nci.2026.31855","DOIUrl":"10.14744/nci.2026.31855","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine the relationship between physical activity level daily step count, and posture in office workers, and to investigate the associations of these variables with static plantar load distribution percentages across foot subregions.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among office workers. Posture was evaluated using the New York Posture Rating Scale (NYPRS) by a single rater. Self-reported physical activity level was assessed using the International Physical Activity Questionnaire - Short Form (IPAQ-SF). Daily step counts were derived from pedometer records as the 7 day average and were collected via screenshots, application logs, or manual logs. Plantar static load distribution was measured using the DIERS pedoscan under barefoot conditions with a 20 second, 3 trial protocol. Normality was assessed using the Shapiro-Wilk test in conjunction with skewness and kurtosis values, and interpretation was guided by the ranges recommended by Tabachnick and Fidell.</p><p><strong>Results: </strong>A total of 39 office workers participated, with a mean age of 39.21±7.99 years and a mean body mass index (BMI) of 25.68±3.39 kg/m². Posture scores (NYPRS) were generally high, with the majority of participants classified in the \"good\" to \"very good\" category. There was a significant positive correlation between daily step count and NYPRS score (r=0.360, p=0.024). A significant positive association was also found between IPAQ and NYPRS (r=0.364, p=0.023). IPAQ and daily step count were moderately and significantly correlated (r=0.549, p<0.001). No statistically significant relationships were detected between static plantar load distribution percentages across foot subregions measured using the DIERS pedoscan system and NYPRS, IPAQ, daily step count, or BMI (all p>0.05).</p><p><strong>Conclusion: </strong>In this sample, both daily step count and physical activity level assessed by IPAQ were positively associated with NYPRS posture scores. In contrast, DIERS pedoscan static regional load distribution parameters were not related to posture or activity indicators. These findings suggest that interventions aimed at increasing physical activity in office workers may be linked to posture, whereas static load distribution measurements may be limited in explaining these relationships.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"28-35"},"PeriodicalIF":0.9,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and early outcomes of single-stage hybrid revascularization for femoroiliac occlusive disease in patients with advanced peripheral arterial disease.","authors":"Mustafa Aldag, Nicoline Jochmann-Schiek","doi":"10.14744/nci.2026.39111","DOIUrl":"10.14744/nci.2026.39111","url":null,"abstract":"<p><strong>Objective: </strong>To assess the feasibility and early outcomes of single-stage hybrid revascularization consisting of common femoral endarterectomy with pericardial patch angioplasty and endovascular recanalization of the ipsilateral iliac arteries in patients with combined femoroiliac occlusive disease.</p><p><strong>Methods: </strong>Between January 2022 and October 2025, consecutive patients with multilevel iliofemoral peripheral artery disease (PAD) who underwent simultaneous single-stage hybrid revascularization at our institution were retrospectively analyzed. The hybrid strategy comprised common femoral endarterectomy with bovine pericardial patch angioplasty and intraoperative angiography-guided endovascular recanalization of the ipsilateral iliac arteries using balloon angioplasty with or without stent implantation; wire-guided iliac embolectomy was performed when indicated. Preoperative assessment included computed tomography angiography (1-mm slice thickness) and color-coded duplex ultrasonography. Patients were followed for at least three months with clinical assessment and duplex ultrasound. The primary endpoint was primary technical success of the planned hybrid procedure. Secondary endpoints included postoperative complications, length of hospital stay, three-month iliac stent patency, mortality, and amputation-free survival.</p><p><strong>Results: </strong>Twenty-eight patients were available for analysis. The median age was 73 (IQR: 14.5) years, and 64.3% were male. Most patients presented with advanced disease (Fontaine III-IV, 85.8%), and 60.7% had rest pain. Primary technical success was achieved in 85.7%. Bailout femorofemoral crossover bypass was required in 10.7%, and staged endovascular completion was planned in one patient. Iliac stenting was performed in 67.9%; wire-guided iliac embolectomy achieved thrombus extraction in 78.6% of attempted cases. The median length of stay was 10.5 (IQR:7) 13.4 days. Wound-healing disorders occurred in 7.1%. At three months, iliac stent patency was 100% and mortality was 0%. Amputation-free survival was 82.1%, with minor and major amputations in 10.7% and 7.1%, respectively.</p><p><strong>Conclusion: </strong>Single-stage hybrid revascularization for femoroiliac occlusive disease in patients with advanced PAD was feasible and was associated with favorable early outcomes. Larger prospective studies with longer follow-up are needed to confirm durability and comparative effectiveness.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}