Northern clinics of Istanbul最新文献

{"title":"Rheumatic diseases detected in patients presenting with uveitis.","authors":"Esin Ozturk, Tuba Yuce Inel, Mahmut Kaya, Gercek Sen","doi":"10.14744/nci.2023.14564","DOIUrl":"10.14744/nci.2023.14564","url":null,"abstract":"<p><strong>Objective: </strong>Uveitis may occur in the course of systemic inflammatory rheumatic diseases (IRD), or it may be the first clinical manifestation of these diseases. The aim of this study was to determine the incidence of IRD in patients whose initial clinical manifestation was non-infectious uveitis.</p><p><strong>Methods: </strong>The study included adult patients diagnosed as having noninfectious uveitis in the department of ophthalmology and referred to rheumatology for further investigation of potential rheumatic diseases as underlying etiology of uveitis. The patients' demographic and clinical features, laboratory, and imaging findings were examined.</p><p><strong>Results: </strong>One hundred six patients who were diagnosed as having uveitis (42.4% anterior, 2.8% intermediate, 19.8% posterior, and 34.9% panuveitis) were included. Just over half (52.8%) of the patients were male and the mean age was 40.1±14.8 years. The mean age at the uveitis attack was 38.7±15 years. One-third (33%) of the patients were diagnosed as having rheumatologic disease (spondyloarthritis (SpA) n=10, Behcet disease (BD) n=17, vasculitides n=2, sarcoidosis n=2, undifferentiated connective tissue diseases n=3, rheumatoid arthritis n=1). SpA was diagnosed in 20% of patients presenting with anterior uveitis. BD was detected in 27% of patients referred with panuveitis and in 33.3% of patients whose first clinical finding was posterior segment involvement. Bilateral uveitis was detected in two-thirds of patients with posterior uveitis and tended to recur more frequently (p=0.014).</p><p><strong>Conclusion: </strong>Rheumatic diseases have been identified in approximately one-third of patients presenting with different types of uveitis. Investigations addressing systemic rheumatic diseases are of paramount importance in patients with uveitis because they may change diagnosis and treatment processes.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"406-413"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of quantitative evaluation of constipation in children with lower urinary tract dysfunction.","authors":"Tarik Emre Sener, Dogancan Dorucu, Sebahat Cam","doi":"10.14744/nci.2023.59827","DOIUrl":"10.14744/nci.2023.59827","url":null,"abstract":"<p><strong>Objective: </strong>There is a known association between lower urinary tract dysfunction (LUTD) and constipation. The objective of this study was to investigate any correlation between voiding and bowel symptoms in children with LUTD.</p><p><strong>Methods: </strong>Children presenting with LUTD to our pediatric urology unit were prospectively included. Demographic data were recorded. All patients filled out the \"Pediatric Lower Urinary Tract Symptom Score\" (P-LUTSS) and \"Constipation and Fecal Incontinence Symptom Severity\" (CFISS) questionnaires. Symptom score correlation and associations with clinical findings were evaluated.</p><p><strong>Results: </strong>76 patients were included. The mean P-LUTSS was 11±7.1; mean CFISS was 7.7±7.5. According to P-LUTSS risk groups, median CFISS score increased as the risk group was increased. There was direct correlation between P-LUTSS and CFISS for all patients. 6^th, 7^th, 8^th, 9^th, 10^th and 13^th questions of P-LUTSS were correlated with CFISS; the 1^st and 7^th questions of CFISS were correlated with P-LUTSS. Patients who responded not to have constipation on P-LUTSS had lower CFISS scores compared to those who had constipation. Patients who had a 0 score on CFISS had a mean P-LUTSS of 7.7±6.2, which put the majority of patients in low-risk group. Also, out of these 11 patients, 10 of them responded to have no constipation on P-LUTSS.</p><p><strong>Conclusion: </strong>A relationship between LUTD and bowel symptoms, as well as the positive correlation between P-LUTSS and CFISS was demonstrated in this study. Patients presenting with LUTD should undergo meticulous evaluation using special questionnaires for bowel symptoms. Only by then, a complete treatment approach can be provided.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"373-381"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of post-treatment radiological findings with relapses in idiopathic granulomatous mastitis patients.","authors":"Gunay Rona, Meral Arifoglu, Kenan Cetin, Muhammet Fikri Kundes","doi":"10.14744/nci.2023.32309","DOIUrl":"10.14744/nci.2023.32309","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to investigate the relationship between post-treatment radiological findings and recurrences in idiopathic granulomatous mastitis (IGM).</p><p><strong>Methods: </strong>Clinical data, ultrasound (US) and magnetic resonance imaging (MRI) examinations of 160 patients with IGM (mean age 34.6±7 years; range 20-56 years) who received only steroid or steroid+surgical treatment were evaluated retrospectively. Patients were grouped as radiological complete response (RCR) or radiological incomplete response (RIR).</p><p><strong>Results: </strong>Only in the steroid group, 79 (54.1%) patients were in the RCR group and 67 (45.9%) patients were in the RIR group. Recurrence occurred in 42 (26.3%) patients, 27 (16.9%) in the same breast and 15 (9.4%) in the contralateral breast. Most of the recurrences in the same breast had residual lesions up to recurrence (74.1%).</p><p><strong>Conclusion: </strong>Residual lesion after treatment is a risk factor for recurrence, and treatment can significantly reduce recurrences until the lesions disappear. The lesion size on MRI after treatment is not associated with recurrence.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"391-397"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors and outcomes related to new-onset acute kidney injury in septic medical intensive care unit patients.","authors":"Kamil Inci, Gulbin Aygencel, Nazlihan Boyaci Dundar, Ozant Helvaci, Melda Turkoglu","doi":"10.14744/nci.2024.30040","DOIUrl":"10.14744/nci.2024.30040","url":null,"abstract":"<p><strong>Objective: </strong>Sepsis-induced acute kidney injury (AKI) is a significant threat, contributing to worse outcomes in intensive care unit (ICU) patients. Thus, understanding the complex relationship between sepsis and renal dysfunction in ICU patients is crucial. We aimed to investigate the factors that may predispose to the development and the clinical consequences of new-onset AKI in septic medical ICU patients in this study.</p><p><strong>Methods: </strong>This retrospective cohort was conducted between December 2019 and April 2023 in the tertiary medical ICU of Gazi University Hospital, Ankara, Turkiye. Participants included septic medical ICU patients aged ≥18 without AKI on ICU admission. Data included demographics, comorbidities, disease severity and prognostic scoring, ICU admission, and ICU follow-up data. Statistical analyses, including logistic regression, were performed to identify independent risk factors for new-onset AKI development and ICU mortality.</p><p><strong>Results: </strong>Patients with new-onset AKI (36% incidence) had higher APACHE-II (21 [16-27] vs. 16 [12-18]) and SOFA (6 [3-9] vs. 3 [2-5]) scores and lower GCS (10 [6-15] vs. 14 [10-15]) on ICU admission (p<0.01 for all results). Independent risk factors for both new AKI development and ICU mortality included invasive mechanical ventilation (IMV) (OR (95% CI): 5.02 [1.59-15] for AKI and OR (95% CI): 13.2 [3-58.8] for ICU mortality, p<0.01), new-onset shock (OR (95% CI): 3.98 [1.42-11.1] for AKI, OR (95% CI): 14.5 [4.4-43.5] for mortality, p<0.01), and higher APACHE-II score (OR (95% CI): 1.08 [1.01-1.16]), for AKI, p=0.05 and (OR (95% CI): 1.04 [1.01-1.08], for mortality, p=0.01). AKI was more frequent in patients whose source of infection was the respiratory system (45% vs. 29%, p=0.01) and catheter-related bloodstream infection (CRBSI) (17% vs. 8%, p=0.03) than those who did not. New AKI development was associated with longer ICU stay (9 [5-18] vs. 5 [3-10] days, p<0.01) and was independently associated with ICU mortality (OR (95% CI): 28.6 [6.6-125], p<0.01).</p><p><strong>Conclusion: </strong>This study reveals new-onset AKI incidence of 36% in septic medical ICU patients. Additionally, it underlines the potential impact of infection sources on new AKI development. New-onset shock, IMV, and disease severity were independently associated with both new-onset AKI and ICU mortality in this population.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"414-421"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between the degree of visceral pleural invasion and survival in non-small cell lung cancer.","authors":"Seyma Ozden, Isil Gokdemir, Murat Kiyik","doi":"10.14744/nci.2023.25349","DOIUrl":"10.14744/nci.2023.25349","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the relationship between the degree of visceral pleural invasion (VPI) and survival in patients operated for non-small cell lung cancer (NSCLC).</p><p><strong>Methods: </strong>Between 2013 and 2015, 202 patients who were diagnosed with NSCLC in our center and followed up in our clinic were retrospectively evaluated. To examine the preoperative and postoperative prognostic factors of the patients, postoperative pathology results, demographic data and data on recurrence status were obtained from our hospital database and patient files.</p><p><strong>Results: </strong>VPI Survival analysis was performed by dividing 3 groups: PL0, PL1 and PL2. Mean survival (MS) was calculated as 39.528±1.469 (36.655-42.402; 95% CI) months for PL0, 35.136±3.115 (29.031-41.240; 95% CI) months for PL1, and 24.688±3.697 (17.441-31.934; 95% CI) for PL2 (p=0.020). When we consider PL0 and PL1 as a single group and compare it with PL2, the MS time of the PL0-PL1 group was 38.358±1.346 (35.721-40.995; 95% CI) months, while the MS time of the PL2 group was 24.688±3.697 (17.441-31.934; 95% CI) months (p=0.020).</p><p><strong>Conclusion: </strong>Although PL0, PL1 and PL2 were classified into a single group (all considered as T2), this study showed that the presence of PL2 was associated with a poor prognosis in terms of survival, independent of lymph node involvement, histopathological subtype of the tumor and tumor size.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"367-372"},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen titration with Oxygen Reserve Index in minimally invasive repair of pectus excavatum, a randomized controlled trial.","authors":"Agshin Mirzayev, Gul Cakmak, Ruslan Abdullayev, Tunc Lacin, Zuhal Aykac, Ayten Saracoglu","doi":"10.14744/nci.2023.45556","DOIUrl":"10.14744/nci.2023.45556","url":null,"abstract":"<p><strong>Objective: </strong>Perioperative hypoxemia is common during minimally invasive repair of pectus excavatum (MIRPE). Oxygen Reserve Index (ORI™) is a noninvasive method that shows blood oxygenation status. In addition, this method provides information about hypoxemia earlier than pulse oximetry. The primary aim of this study was to examine the value of ORI monitoring as an early predictor of hypoxemia during surgery. The secondary aim was to evaluate the value of ORI monitoring as a guide for oxygen titration to prevent hyperoxemia.</p><p><strong>Methods: </strong>This randomized controlled study enrolled 128 pediatric patients aged 8-18 years scheduled for elective MIRPE surgery. Patients were followed up with continuous peripheral oxygen saturation (SpO₂) measurement in the control group (Group C) and continuous ORI monitoring in the study group (Group O). After pneumothorax, a decrease of 1% in basal SpO₂ and 0.05 from basal ORI was considered clinically significant. Patient demographics, pre-induction, pre-first and second pneumothorax, and postoperative ORI, mean arterial pressure, temperature, perfusion index, end-tidal carbon dioxide values, length of hospital stay, anesthesia, and surgery durations were recorded.</p><p><strong>Results: </strong>Desaturation time was 59.46±15.57 seconds in Group O based on ORI, and 177.64±20.94 seconds in Group C according to SpO₂, and the difference was significant (p<0.001). Use of FiO₂>0.6 was lower in Group O, compared with Group C (p<0.05). Length of hospital stay was lower in Group O (p=0.002).</p><p><strong>Conclusion: </strong>ORI may detect hypoxemia earlier than SpO₂ monitoring during MIRPE surgery. ORI monitorization decreases exposure time to high oxygen concentrations and may increase patient safety during MIRPE surgery in pediatric patients.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"382-390"},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conducting risk assessments and case detection in online environments in the scope of fight with COVID-19.","authors":"Banu Cakir","doi":"10.14744/nci.2023.56659","DOIUrl":"10.14744/nci.2023.56659","url":null,"abstract":"","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"492-493"},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of conventional anorectal manometry and biofeedback therapy in adolescents with functional constipation.","authors":"Neslihan Gulcin, Ali Ihsan Anadolulu, Meltem Caglar, Huseyin Murat Mutus, Cigdem Ulukaya Durakbasa","doi":"10.14744/nci.2023.85126","DOIUrl":"10.14744/nci.2023.85126","url":null,"abstract":"<p><strong>Objective: </strong>The aim was to evaluate the outcomes of conventional anorectal manometry (ARMM) testing and biofeedback therapy in adolescents with functional constipation.</p><p><strong>Methods: </strong>A retrospective analysis of ARMM findings in patients aged 10-18 years with intractable constipation over a 4-year period was conducted.</p><p><strong>Results: </strong>Of the 41 patients (mean age, 13.5±2.44 years) included, 20 (48.7%) were male. Rectoanal inhibitory reflex (RAIR) was positive in all patients. Group 1 had 31 patients with dyssynergic defecation (DD) and Group 2 had 10 patients without DD. Anal canal resting pressure, squeeze test pressure, rectal defecation pressure, and first and urge sensation volumes were similar between the groups. Maximum tolerated volume and the relaxation percentage of RAIR were higher in Group 1 than in Group 2 (p<0.05). Among 31 patients referred for biofeedback therapy, 8 (25.6%) completed the program with complete resolution of their symptoms. The mean follow-up period for these patients was 21±14.7 months.</p><p><strong>Conclusion: </strong>DD is relatively common in patients with psychosocial adjustment disorders, and it can be diagnosed via ARMM. Despite the low rate of adherence to the therapy in the presented series, biofeedback therapy was highly effective in resolving the symptoms including soiling.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"466-470"},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Reply.","authors":"Suayip Birinci, Mustafa Mahir Ulgu, Sahin Aydin, Eray Ozcan","doi":"10.14744/nci.2024.18942","DOIUrl":"10.14744/nci.2024.18942","url":null,"abstract":"","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"493-494"},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of Marburg virus: A modeling study in endemic area.","authors":"Amnuay Kleebayoon, Viroj Wiwanitkit","doi":"10.14744/nci.2023.47048","DOIUrl":"10.14744/nci.2023.47048","url":null,"abstract":"<p><strong>Objective: </strong>An old disease called the Marburg virus infection has just recently started to appear in some African nations in recent years. The disease is currently being scrutinized for its potential to become a new global public health issue.</p><p><strong>Methods: </strong>The authors of this work employed a mathematical modeling technique to determine the final seroprevalence rate.</p><p><strong>Results: </strong>The seroprevalence rate can be estimated based on the results of the current investigation. This incidence may indicate that the endemic nation has an asymptomatic Marburg virus infection.</p><p><strong>Conclusion: </strong>This may also point to the significance of a possible asymptomatic Marburg virus sickness, which may be the cause of the disease's broad transmission. In light of the resurfacing Marburg virus disease concern, it is important to recognize this problem.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"485-487"},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}