血镁水平与血糖控制和胰岛素抵抗的关系。

Northern clinics of Istanbul Pub Date : 2025-04-25 eCollection Date: 2025-01-01 DOI:10.14744/nci.2024.75725
Osman Erinc, Soner Yesilyurt
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引用次数: 0

摘要

目的:镁在葡萄糖稳态中的作用、对血糖控制的影响及其因果关系一直是许多研究的主题。在这个方向上,在我们的研究中,我们旨在探讨血清镁(Mg)水平与血红蛋白A1c (HbA1c)和胰岛素抵抗的关系。方法:根据受试者的HbA1c水平将305例受试者分为3组:对照组121例,糖尿病前期组85例,糖尿病组99例。测定三组患者血清镁水平。研究了Mg与空腹血糖、空腹胰岛素和胰岛素抵抗稳态模型评估(HOMA-IR)的相关性。此外,患者的人口统计数据、血压、吸烟习惯和基本生化数据也被纳入分析。结果:各组患者血清镁水平差异有统计学意义(p)。结论:在本研究中,血清镁水平与HbA1c呈显著负相关。根据这一发现,评估高HbA1c患者的镁水平将是有用的。然而,由于研究镁、血糖控制和胰岛素敏感性之间关系的研究结果相互矛盾,需要更全面、更长期随访的前瞻性研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship between serum magnesium levels and glycemic control and insulin resistance.

Objective: The role of magnesium in glucose homeostasis, its effects on glycemic control and the causal relationship between them have been the subject of many studies. In this direction, in our study, we aimed to investigate the relationship between serum magnesium (Mg) levels and hemoglobin A1c (HbA1c) and insulin resistance.

Methods: Based on their HbA1c levels, 305 participants were split into 3 groups: 121 were in the control group, 85 were in the prediabetes group, and 99 were in the diabetes group. Serum magnesium levels were measured in these three groups. The correlation between Mg and fasting plasma glucose, fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) was also investigated. In addition, patients' demographic data, blood pressure, smoking habits and basic biochemical data were also included in the analysis.

Results: There was a significant statistical difference in terms of serum magnesium levels among all the groups (p<0.001). A strong negative correlation was found between serum magnesium levels and HbA1c (r=-0.316, p<0.001). There was also a weak negative relationship between Mg and serum fasting glucose, insulin, and HOMA-IR (r=-0.167 p=0.004, r=-0.167 p=0.003, and r=-0.198 p=0.001, respectively).

Conclusion: We observed a statistically significant negative correlation between serum magnesium levels and HbA1c in our study. According to this finding, it would be useful to assess magnesium levels in patients with high HbA1c levels. However, due to conflicting results among studies investigating the relationship between magnesium, glycemic control and insulin sensitivity with increasing interest, more comprehensive, prospective studies with longer follow-up periods are needed.

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