Northern clinics of Istanbul最新文献

{"title":"Vaccine spending and economic recovery: OECD panel data analysis.","authors":"Engin Aydın, Mustafa Ozyesil, Havane Tembelo","doi":"10.14744/nci.2026.36418","DOIUrl":"https://doi.org/10.14744/nci.2026.36418","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates whether public spending on vaccination programmes contributes to macroeconomic normalization following severe health shocks in high-income Organisation for Economic Co-operation and Development (OECD) economies.</p><p><strong>Methods: </strong>An unbalanced OECD panel dataset was analysed using a fixed-effects specification that incorporates structural controls including inflation, unemployment, trade openness, and general health expenditure.</p><p><strong>Results: </strong>The empirical results indicate that vaccine expenditure does not exert a statistically significant independent effect on economic recovery, although the coefficients display a positive but economically modest direction. Conversely, several macroeconomic fundamentals demonstrate stronger and more consistent associations with recovery dynamics.</p><p><strong>Conclusion: </strong>Vaccination functions as a necessary but insufficient component of recovery strategies, with its economic influence mediated through system-level efficiency rather than direct fiscal input. Integrated policy frameworks that combine public health interventions with structural economic measures are required.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"72-86"},"PeriodicalIF":0.9,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular and clinical findings in Osteogenesis Imperfecta: A cohort study from a single tertiary center.","authors":"Emre Ozer, Esra Kilic, Husnu Mutlu Turan, Mustafa Altan, Vehap Topcu, Banu Turhan, Abdurrahman Bitkay, Pinar Kocaay, Mehmet Boyraz, Fatih Gurbuz","doi":"10.14744/nci.2026.25588","DOIUrl":"https://doi.org/10.14744/nci.2026.25588","url":null,"abstract":"<p><strong>Objective: </strong>Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous skeletal fragility disorder. Although COL1A1/COL1A2 variants account for most cases, non-COL1A genes and overlapping monogenic bone fragility conditions complicate diagnosis and genotype-phenotype interpretation in routine practice. We aimed to describe the clinical spectrum and molecular findings of patients evaluated for suspected or confirmed OI at a tertiary referral center, and to assess phenotype patterns across genotype-informed groups.</p><p><strong>Methods: </strong>We conducted a single-center retrospective cohort study at Ankara City Hospital. Pediatric and adult patients evaluated for suspected/confirmed OI were included. Clinical, radiologic, and treatment data were extracted from medical records. All patients underwent targeted next-generation sequencing panel testing, and variants were interpreted according to ACMG criteria. Findings were summarized descriptively and analyzed across COL1A1/COL1A2, non-COL1A OI-associated genes, and non-OI bone-related genes.</p><p><strong>Results: </strong>Forty-two individuals were included (age range at genetic evaluation: 0.1-47 years). The most common referral indication was recurrent long-bone fractures (81.0%), while 31.0% presented with or additional vertebral compression fractures and/or osteoporosis. Variants in OI-associated genes were identified in 30/42 patients (71.4%); 23/42 (54.7%) had molecularly confirmatory pathogenic/likely pathogenic variants in established OI-associated genes. Among genetically confirmed OI cases, 17/23 (73.9%) involved COL1A1/COL1A2. In the non-COL1A subgroup, biallelic pathogenic/likely pathogenic variants were found in CRTAP, P3H1, and FKBP10 (n=5), and one patient had a heterozygous WNT1 variant. Seven patients (16.7%) had negative panel results. At last follow-up, 83.3% were independently ambulatory.</p><p><strong>Conclusion: </strong>In this tertiary-center cohort, integrating phenotype with molecular testing improved diagnostic stratification in suspected OI and highlighted the predominance of COL1A-related disease. However, the continued clinical relevance of VUS and panel-negative results underscores the need for broader second-tier genetic testing and periodic reanalysis in cases where clinical suspicion persists.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"105-112"},"PeriodicalIF":0.9,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and management practices in polymyalgia rheumatica among Turkish rheumatologists: An online cross-sectional survey.","authors":"Sevilay Batibay, Gozde Sen","doi":"10.14744/nci.2026.24119","DOIUrl":"https://doi.org/10.14744/nci.2026.24119","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate real-world diagnostic and therapeutic approaches to polymyalgia rheumatica (PMR) among Turkish rheumatologists and compare them with international guideline recommendations.</p><p><strong>Methods: </strong>A cross-sectional online survey was conducted among rheumatologists practicing in Turkiye between September and October 2025. A self-administered 29-item questionnaire was distributed through professional communication networks. The survey was developed with reference to the 2012 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria and international management guidelines. It assessed self-reported diagnostic approaches, screening practices for giant cell arteritis (GCA), treatment strategies, and follow-up and monitoring practices. Data were recorded and analyzed in a de-identified manner using descriptive statistics.</p><p><strong>Results: </strong>A total of 101 rheumatologists participated in the survey. Diagnostic approaches varied substantially: use of the 2012 EULAR/ACR criteria was reported by 65 (64.4%), referral to the 2010 British Society for Rheumatology/British Health Professionals in Rheumatology (BSR/BHPR) guideline by 10 (9.9%), and primary reliance on clinical judgment by 76 (75.2%). Elevated erythrocyte sedimentation rate and/or C-reactive protein (ESR/CRP) were considered necessary for diagnosis by 92 (91.1%). Use of imaging modalities, including ultrasonography (US), magnetic resonance imaging (MRI), and positron emission tomography (PET), was highly heterogeneous, and routine screening for giant cell arteritis (GCA) was reported by 25 (24.8%). Glucocorticoid (GC) monotherapy was the preferred first-line treatment among 76 participants (75.2%), with most clinicians selecting guideline-recommended starting doses (12.5-25 mg/day) and initiating tapering between weeks 4 and 8. Disease-modifying antirheumatic drugs (DMARDs) were most commonly introduced at first relapse (55, 54.5%). Although osteoporosis risk assessment was reported by 86 (85.1%), the use of dual-energy X-ray absorptiometry (DXA), the Fracture Risk Assessment Tool (FRAX), and referral for exercise programs remained inconsistent.</p><p><strong>Conclusion: </strong>Although initial GC therapy was generally consistent with guideline recommendations, considerable heterogeneity was observed in diagnostic approaches, imaging use, screening for GCA, and long-term monitoring practices, indicating persistent gaps between guidelines and real-world clinical practice.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"36-44"},"PeriodicalIF":0.9,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between physical activity, daily step count, and posture in office workers and examination of DIERS pedoscan static plantar load distribution parameters: A cross sectional study.","authors":"Gulsemin Erturk Celik, Abdurrahman Iskender, Serife Coskun Sagirkaya, Alper Doganci","doi":"10.14744/nci.2026.31855","DOIUrl":"https://doi.org/10.14744/nci.2026.31855","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine the relationship between physical activity level daily step count, and posture in office workers, and to investigate the associations of these variables with static plantar load distribution percentages across foot subregions.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among office workers. Posture was evaluated using the New York Posture Rating Scale (NYPRS) by a single rater. Self-reported physical activity level was assessed using the International Physical Activity Questionnaire - Short Form (IPAQ-SF). Daily step counts were derived from pedometer records as the 7 day average and were collected via screenshots, application logs, or manual logs. Plantar static load distribution was measured using the DIERS pedoscan under barefoot conditions with a 20 second, 3 trial protocol. Normality was assessed using the Shapiro-Wilk test in conjunction with skewness and kurtosis values, and interpretation was guided by the ranges recommended by Tabachnick and Fidell.</p><p><strong>Results: </strong>A total of 39 office workers participated, with a mean age of 39.21±7.99 years and a mean body mass index (BMI) of 25.68±3.39 kg/m². Posture scores (NYPRS) were generally high, with the majority of participants classified in the \"good\" to \"very good\" category. There was a significant positive correlation between daily step count and NYPRS score (r=0.360, p=0.024). A significant positive association was also found between IPAQ and NYPRS (r=0.364, p=0.023). IPAQ and daily step count were moderately and significantly correlated (r=0.549, p<0.001). No statistically significant relationships were detected between static plantar load distribution percentages across foot subregions measured using the DIERS pedoscan system and NYPRS, IPAQ, daily step count, or BMI (all p>0.05).</p><p><strong>Conclusion: </strong>In this sample, both daily step count and physical activity level assessed by IPAQ were positively associated with NYPRS posture scores. In contrast, DIERS pedoscan static regional load distribution parameters were not related to posture or activity indicators. These findings suggest that interventions aimed at increasing physical activity in office workers may be linked to posture, whereas static load distribution measurements may be limited in explaining these relationships.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"28-35"},"PeriodicalIF":0.9,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and early outcomes of single-stage hybrid revascularization for femoroiliac occlusive disease in patients with advanced peripheral arterial disease.","authors":"Mustafa Aldag, Nicoline Jochmann-Schiek","doi":"10.14744/nci.2026.39111","DOIUrl":"https://doi.org/10.14744/nci.2026.39111","url":null,"abstract":"<p><strong>Objective: </strong>To assess the feasibility and early outcomes of single-stage hybrid revascularization consisting of common femoral endarterectomy with pericardial patch angioplasty and endovascular recanalization of the ipsilateral iliac arteries in patients with combined femoroiliac occlusive disease.</p><p><strong>Methods: </strong>Between January 2022 and October 2025, consecutive patients with multilevel iliofemoral peripheral artery disease (PAD) who underwent simultaneous single-stage hybrid revascularization at our institution were retrospectively analyzed. The hybrid strategy comprised common femoral endarterectomy with bovine pericardial patch angioplasty and intraoperative angiography-guided endovascular recanalization of the ipsilateral iliac arteries using balloon angioplasty with or without stent implantation; wire-guided iliac embolectomy was performed when indicated. Preoperative assessment included computed tomography angiography (1-mm slice thickness) and color-coded duplex ultrasonography. Patients were followed for at least three months with clinical assessment and duplex ultrasound. The primary endpoint was primary technical success of the planned hybrid procedure. Secondary endpoints included postoperative complications, length of hospital stay, three-month iliac stent patency, mortality, and amputation-free survival.</p><p><strong>Results: </strong>Twenty-eight patients were available for analysis. The median age was 73 (IQR: 14.5) years, and 64.3% were male. Most patients presented with advanced disease (Fontaine III-IV, 85.8%), and 60.7% had rest pain. Primary technical success was achieved in 85.7%. Bailout femorofemoral crossover bypass was required in 10.7%, and staged endovascular completion was planned in one patient. Iliac stenting was performed in 67.9%; wire-guided iliac embolectomy achieved thrombus extraction in 78.6% of attempted cases. The median length of stay was 10.5 (IQR:7) 13.4 days. Wound-healing disorders occurred in 7.1%. At three months, iliac stent patency was 100% and mortality was 0%. Amputation-free survival was 82.1%, with minor and major amputations in 10.7% and 7.1%, respectively.</p><p><strong>Conclusion: </strong>Single-stage hybrid revascularization for femoroiliac occlusive disease in patients with advanced PAD was feasible and was associated with favorable early outcomes. Larger prospective studies with longer follow-up are needed to confirm durability and comparative effectiveness.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic effect of famotidine in breast adenocarcinoma cells line.","authors":"Mert Kaskal, Oguzcan Kinikoglu, George Zelhof, Emine Kubra Bilir","doi":"10.14744/nci.2026.55899","DOIUrl":"https://doi.org/10.14744/nci.2026.55899","url":null,"abstract":"<p><strong>Objective: </strong>Breast cancer remains a leading cause of cancer-related mortality among women worldwide. Famotidine, a histamine H₂-receptor antagonist commonly prescribed for gastric conditions, has demonstrated potential anticancer effects through mechanisms unrelated to acid suppression. The study aims to evaluate the cytotoxic of famotidine on breast adenocarcinoma (MCF)-7 cell line through in vitro assays.</p><p><strong>Methods: </strong>MCF-7 cells were treated with varying concentrations of famotidine (0.364-20 mg/mL) for 24 hours. Cell viability and cytotoxicity were assessed using the MTT assay and Live/Dead fluorescence staining. Morphological changes were evaluated under phase-contrast and fluorescence microscopy. The statistical comparisons were performed using ANOVA statistical analysis.</p><p><strong>Results: </strong>Famotidine treatment resulted in a dose-dependent reduction in cell viability. Higher concentrations (≥5 mg/mL) led to substantial cytotoxicity, with viability falling below 20%. Live/Dead assays confirmed these results, showing increased red (dead cell) fluorescence at higher doses. Morphological analysis revealed change in cell morphology which is consistent with non-specific cytotoxic injury.</p><p><strong>Conclusion: </strong>Famotidine exhibits physiologically cytotoxic effects in MCF-7 breast cancer cells in vitro.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"58-63"},"PeriodicalIF":0.9,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multidimensional tool in disaster medicine: Development of the disaster anxiety scale.","authors":"Fatih Cemal Tekin, Yasemin Durduran, Yusuf Cokunlu","doi":"10.14744/nci.2025.29560","DOIUrl":"https://doi.org/10.14744/nci.2025.29560","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop a multidimensional scale to assess disaster-related anxiety, addressing the limitations of generic and disaster-specific anxiety instruments. The new tool, the Multidimensional Disaster Anxiety Scale (MDAS), was designed to enable a comprehensive and practical evaluation of anxiety across all disaster types, with the potential to improve identification of vulnerable groups and inform psychosocial interventions.</p><p><strong>Methods: </strong>The methodological study followed a systematic process: item pool development, pilot testing, data collection, and assessment of reliability and validity. The initial item pool was generated through literature review and expert consultations, resulting in a draft with 30 items. These were reviewed for content validity by multidisciplinary experts, and items with low Content Validity Ratio (CVR) or deemed irrelevant were excluded. The sample, determined as 600 individuals, was selected using the cluster sampling method. After performing the Exploratory Factor Analysis (EFA), the sample was equally divided into two groups in order to collect data for the Confirmatory Factor Analysis (CFA). Statistical analyses included item-total correlations, Cronbach's alpha, split-half reliability, EFA, CFA, composite reliability (CR), and average variance extracted (AVE).</p><p><strong>Results: </strong>After validity and reliability analyses, the MDAS was finalized with 18 items across two subdimensions: Cognitive (Ideational) and Reactive. EFA revealed two factors, accounting for 57.1% of the total variance, with all factor loadings above 0.50. Cronbach's alpha demonstrated high internal consistency for the total scale (0.917), as well as the Cognitive (0.909) and Reactive (0.899) subscales. CFA confirmed the two-factor model with good fit indices (CFI=0.99, TLI=0.99, RMSEA=0.071, SRMR=0.071). CR and AVE values exceeded recommended thresholds for construct reliability and validity. The scale uses a 5-point Likert response format; scores range from 18 to 90, with higher scores indicating greater disaster anxiety.</p><p><strong>Conclusion: </strong>The MDAS is a valid, reliable, and sensitive instrument for the multidimensional assessment of disaster-related anxiety in the general population. Its generic structure allows application across various disaster contexts, supporting its utility in disaster preparedness, response, and recovery phases. The scale facilitates identification of individuals at risk, evaluation of intervention effectiveness, and clinical follow-up after disasters. Future research should further assess its psychometric properties, diagnostic performance, and establish cut-off values for clinical use.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"87-97"},"PeriodicalIF":0.9,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic submucosal dissection in gastrointestinal lesions: Clinical outcomes from a single center.","authors":"Huseyin Aykut, Emin Pala, Suleyman Sayar, Oguzhan Ozturk, Resul Kahraman, Kamil Ozdil","doi":"10.14744/nci.2025.37108","DOIUrl":"https://doi.org/10.14744/nci.2025.37108","url":null,"abstract":"<p><strong>Objective: </strong>Endoscopic Submucosal Dissection (ESD) is increasingly utilized for en bloc resection of superficial gastrointestinal neoplasms, providing accurate histopathological evaluation and potential curative treatment. Despite its widespread use in Eastern Asia, clinical data from Turkiye remain limited. In this study, we aimed to retrospectively analyze clinical parameters such as technical success, complication rates, histopathological findings and local recurrence rates observed during follow-up in ESD procedures performed at our center.</p><p><strong>Methods: </strong>We retrospectively analyzed 147 patients who underwent ESD or hybrid ESD at a tertiary center between January 2020 and January 2025. Demographic characteristics, lesion features, procedural outcomes, complications, and follow-up results were evaluated.</p><p><strong>Results: </strong>En bloc resection was achieved in 99.3% of cases, with R0 resection in 93.9%. Invasive adenocarcinoma was detected in 7 patients; 3 patients with invasive adenocarcinoma and 1 patient with incomplete resection were referred for surgery. Intra-procedural complications (mainly bleeding) occurred in 3.4%, while post-procedural complications (post-ESD coagulation syndrome or microperforation) occurred in 4.7%. All complications were managed conservatively, and none required surgery. Median hospital stay was 1 day. Recurrence was rare and successfully managed either endoscopically or surgically.</p><p><strong>Conclusion: </strong>ESD is a safe and effective treatment for superficial gastrointestinal neoplasms in appropriately selected patients when performed by an experienced team. High technical success and low complication rates can be achieved in experienced centers. Future prospective, multicenter studies are warranted to establish standardized ESD practice in Turkiye.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"19-27"},"PeriodicalIF":0.9,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic symptoms in hydatid cyst; common or rare?","authors":"Ozge Atik, Ali Can, Mehmet Gokturk Kaban, Yusuf Kayar","doi":"10.14744/nci.2026.34437","DOIUrl":"https://doi.org/10.14744/nci.2026.34437","url":null,"abstract":"<p><strong>Objective: </strong>Hydatid cyst infections may follow a different course, ranging from asymptomatic to life-threatening conditions. The rupture of a hydatid cyst can lead to a variety of allergic reactionsfromurticaria to anaphylactic shock. This study aimed to investigate the frequency and diversity of allergic symptoms in patients with hydatid cysts and to explore their relationship between clinical and laboratory findings.</p><p><strong>Methods: </strong>This study included 106 patients diagnosed with hydatid cysts of the liverbetween January 2017 and February 2024.The demographic characteristics such as age, gender, clinical symptoms and laboratory results were recorded. The characteristics of patients with allergic symptoms were analyzedin addition to cyst rupture.</p><p><strong>Results: </strong>The median age of patients was 33 and 77% were male. Allergic symptoms were present in one out of every ten patients. Allergic symptoms were pruritus in 5 patients, acute urticaria in 2 patients, and anaphylaxis in 3 patients. Only 22% (n=23) of the patients had eosinophilia. The characteristics of ruptured and non-ruptured patients were compared and it was observed that hemoglobin level was lower and γ-glutamyl transferase (GGT) level was higher in ruptured patients (p=0.032, p=0.015 respectively).</p><p><strong>Conclusion: </strong>Although allergic symptoms are not very common in hydatid cysts, life-threatening events such as anaphylaxis may still occur. This risk should always be considered, especially in cysts at risk of rupture.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"64-71"},"PeriodicalIF":0.9,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approach to the treatment of precocious puberty in small-for-gestational-age girls with normal growth catch-up.","authors":"Pinar Atla, Heves Kirmizibekmez, Gulcan Seymen, Fatma Dursun","doi":"10.14744/nci.2025.25478","DOIUrl":"https://doi.org/10.14744/nci.2025.25478","url":null,"abstract":"<p><strong>Objective: </strong>Clinical observations show that the development of puberty occurs earlier, and the course is accelerated in children born small for gestational age (SGA) compared to peers born average for gestational age (AGA). The aim of this study was to investigate the response to GnRH analogue (GnRAa) treatment in SGA and AGA girls with central precocious puberty (CPP).</p><p><strong>Methods: </strong>This study included 16 SGA and 137 AGA girls who were receiving GnRHa treatment due to onset of central puberty before the age of eight. SGA group included girls who exhibited normal growth and did not receive growth hormone GH treatment. The response to treatment parameters were compared at the 12^th month and at the end of the treatment.</p><p><strong>Results: </strong>The mean age at the onset of puberty, anthropometric data, bone age, difference between bone age and decimal age were not different between SGA and AGA groups, as well as baseline luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol, stimulated LH and LH/FSH ratio. Height SDS, BMI SDS, and predicted adult height at presentation, at 12^th month and at the end of the treatment were not different in SGA girls. A significant difference was detected only in BMI parameter which increased in 12^th month in AGA girls.</p><p><strong>Conclusion: </strong>The findings of our study indicate that SGA girls with precocious puberty who have achieved growth catch-up and lack additional risk factors require a similar approach to AGA girls when initiating and modifying treatment during the follow-up period.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"45-50"},"PeriodicalIF":0.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}