Northern clinics of Istanbul最新文献

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Dodder (Cuscuta sp.) extract prevents cognitive deficits in a rat model of hepatic encephalopathy.
Northern clinics of Istanbul Pub Date : 2024-11-14 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.95776
Omercan Albayrak, Bilge Nur Hatipoglu, Dilek Ozbeyli, Ali Sen, Turkan Koyuncuoglu, Ozge Cevik, Feriha Ercan, Fatma Kanpalta, Ahmet Dogan, Seren Ede Pazarbasi, Goksel Sener
{"title":"Dodder (<i>Cuscuta</i> sp.) extract prevents cognitive deficits in a rat model of hepatic encephalopathy.","authors":"Omercan Albayrak, Bilge Nur Hatipoglu, Dilek Ozbeyli, Ali Sen, Turkan Koyuncuoglu, Ozge Cevik, Feriha Ercan, Fatma Kanpalta, Ahmet Dogan, Seren Ede Pazarbasi, Goksel Sener","doi":"10.14744/nci.2023.95776","DOIUrl":"10.14744/nci.2023.95776","url":null,"abstract":"<p><strong>Objective: </strong>In our study, the protective effect of dodder plant extract against encephalopathy induced by cholestatic liver disease model was investigated.</p><p><strong>Methods: </strong>Spraque Dawley rats were used in the study. For the cholestatic liver disease model, the bile duct ligation (BDL) was applied. The groups were determined as control, Cuscuta sp. (CUS), BDL and BDL + CUS. Double ligation was performed in the bile duct in the BDL groups. For the applications, saline (SF) was administered to the control and BDL groups for 28 days while 250 mg/kg of Cuscuta sp. extract was given by oral gavage to the CUS and BDL + CUS groups. At the end of the experiment, cognitive evaluations were made by applying new object recognition and Morris water maze tests. After these tests, blood-brain barrier (BBB) measurements were made in half of the groups. In the other half of the groups, brain tissue samples were taken by decapitation and transforming growth factor-beta (TGF-β), 8-hydroxydeoxyguanosine (8-OHdG) and sodium-potassium adenosine triphosphatase (Na<sup>+</sup>/K<sup>+</sup>-ATPase) measurements were made in the tissues. Histological examinations of the tissues were also performed.</p><p><strong>Results: </strong>Cognitive performance was low, and BBB permeability was found to be increased in the group with bile duct ligation. In addition, TGF-β and 8-OHdG levels were increased in tissues, while Na<sup>+</sup>/K<sup>+</sup>-ATPase enzyme activity was suppressed. Treatment with Cuscuta sp. increased cognitive performance and decreased BBB permeability. Other biochemical parameters examined were significantly (p<0.05-0.001) reversed and supported by histological findings.</p><p><strong>Conclusion: </strong>Our findings in the study suggest that dodder plant may be beneficial for the protection of cognitive performance and brain tissue in encephalopathy caused by cholestasis.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 6","pages":"512-519"},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative physical activity limitations and balance changes on patients who have been operated for breast cancer.
Northern clinics of Istanbul Pub Date : 2024-11-14 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.44538
Onur Zambak, Fikret Ezberci, Duygu Kurtulus, Huseyin Kerem Tolan, Hakan Cakit
{"title":"Postoperative physical activity limitations and balance changes on patients who have been operated for breast cancer.","authors":"Onur Zambak, Fikret Ezberci, Duygu Kurtulus, Huseyin Kerem Tolan, Hakan Cakit","doi":"10.14744/nci.2023.44538","DOIUrl":"10.14744/nci.2023.44538","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study is to assess the postoperative physical activity limitations and balance changes in patients who have been operated on for breast cancer. Some physical activity limitations and balance disorders can be expected after breast cancer surgery.</p><p><strong>Methods: </strong>From 2008 to 2016, 112 patients who underwent breast cancer surgery were included in this study. The patients who have some neurological, physical, pulmonary or cardiac diseases were not included. Patients were invited to the hospital. Lack of balance and physical activity limitations were evaluated with a questionnaire including 17 questions.</p><p><strong>Results: </strong>On the postoperative frequency distribution of physical activities criteria out of 112 patients %33.1 (n=37) people got 4 points and over while %66.9 (n=75) people got less than 4 points. After the operation, since more than 75 people got less than 4 points, it is accepted as inadequate in terms of physical activity. Looking at balance changes, in patients with breast-conserving surgery (BCS)were approximately 5.94-0.82 where as average modified radical mastectomy (MRM)was 5.94-0.41. According to criteria on postoperated patients' balance changes, the value of f was 3.162, contrary to this, as the value of p was found 0.078. Differences between operation and balance changes were not significant.</p><p><strong>Conclusion: </strong>The patients who have had breast cancer surgery, physical activities were limited and life quality was down after the operation. On the other hand, there was no significant difference on balance changes depending on the operations.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 6","pages":"541-546"},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The evaluation of cyclin D1 expression in prostate carcinoma cases.
Northern clinics of Istanbul Pub Date : 2024-11-13 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.79735
Asude Aksoy, Selcen Vicdanli, Gokhan Artas
{"title":"The evaluation of cyclin D1 expression in prostate carcinoma cases.","authors":"Asude Aksoy, Selcen Vicdanli, Gokhan Artas","doi":"10.14744/nci.2023.79735","DOIUrl":"10.14744/nci.2023.79735","url":null,"abstract":"<p><strong>Objective: </strong>Cyclin D1 (CDDN1) is an important protein for mitotic cell cycle advancement through the G1 phase and contributes to the control of the cyclin-dependent kinases CDK4 and CDK6. We evaluated the relationship between CDDN1 expression and clinicopathological features in prostate cancer (PCa) cases and whether CDDN1 could be used as a prognostic biomarker for PCa cases in this study.</p><p><strong>Methods: </strong>This study comprised ninety cases; seventy-five had PCa and fifteen had benign prostatic hypertrophy (BPH) diagnoses (as the control group). The pathological specimens were stained immunohistochemically and categorized as a 'low' (L) or a 'high' (H) group for CDDN1 expression. The cases' clinicopathological features and survival rates were evaluated statistically, within a 95% confidence interval, p<0.05, retrospectively.</p><p><strong>Results: </strong>The median follow-up time was 75 (17-96) months, and the median overall survival (OS) was 87 months (CI 95%: 74.74-99.25). While the OS was 66 months (CI 95%: 49.61-82.38) in the H-CDDN1 group, the OS of the L-CDDN1 group was not yet reached. The OS of the L-CDDN1 group was longer in statistical significance (p=0.011). A Cox regression analysis revealed that the levels of CDDN1 expression, the values of lactate dehydrogenase, and post-treatment prostate specific antigen were found to be prognostic factors for OS in PCa cases (p<0.05).</p><p><strong>Conclusion: </strong>Our results suggest the overexpression of CDDN1 is a potentially useful but poor prognostic biomarker for PCa cases.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 6","pages":"534-540"},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of corporate experiences during the accreditation process in the field of health - A qualitative study.
Northern clinics of Istanbul Pub Date : 2024-11-13 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.28482
Tuncay Palteki, Nedim Havle, Demet Gokmen Kavak, Ayse Sibel Oksuz, Aykut Ilker Arslan, Ezgi Salar, Esengul Purkuloglu, Gamze Ozcan, Nesrin Aydemir, Ozlem Palancioglu, Yeliz Soy Kibriz
{"title":"Evaluation of corporate experiences during the accreditation process in the field of health - A qualitative study.","authors":"Tuncay Palteki, Nedim Havle, Demet Gokmen Kavak, Ayse Sibel Oksuz, Aykut Ilker Arslan, Ezgi Salar, Esengul Purkuloglu, Gamze Ozcan, Nesrin Aydemir, Ozlem Palancioglu, Yeliz Soy Kibriz","doi":"10.14744/nci.2023.28482","DOIUrl":"10.14744/nci.2023.28482","url":null,"abstract":"<p><strong>Objective: </strong>In our study, we attempted to determine the accreditation process experience of hospital senior managers accredited by the Turkish Health Care Quality and Accreditation Institute (TUSKA). Along with the institutions' accomplishments through the accreditation program, the major challenges they faced during the accreditation process were revealed.</p><p><strong>Methods: </strong>One of the qualitative research designs used was interpretive phenomenological analysis, which was carried out through semi-structured interviews with hospital senior managers.</p><p><strong>Results: </strong>In the study conducted with eight participants, 55 sub-themes emerged under 12 main themes. The participants expressed their opinions on a wide range of topics, from the achievements related to the accreditation process to the difficulties they encountered, from their strengths to the dissemination of accreditation throughout the country.</p><p><strong>Conclusion: </strong>It has been understood that the national hospital accreditations carried out in our country provide important gains to the institutions in management and clinical activities, while the expectations on incentives and other similar issues have not yet been met.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 6","pages":"501-511"},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-menopausal status in primary antiphospholipid syndrome is associated with low HDL-C levels.
Northern clinics of Istanbul Pub Date : 2024-11-11 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2023.71363
Jozélio Freire de Carvalho
{"title":"Post-menopausal status in primary antiphospholipid syndrome is associated with low HDL-C levels.","authors":"Jozélio Freire de Carvalho","doi":"10.14744/nci.2023.71363","DOIUrl":"10.14744/nci.2023.71363","url":null,"abstract":"","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 6","pages":"600-601"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of bladder capacity in pediatric patients with nocturnal enuresis using voiding diary and uroflowmetry: A retrospective study. 使用排尿日记和尿流流量计评估夜间遗尿症儿童患者的膀胱容量:回顾性研究。
Northern clinics of Istanbul Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2024.89990
Sevim Yener, Zekeriya Ilce
{"title":"Evaluation of bladder capacity in pediatric patients with nocturnal enuresis using voiding diary and uroflowmetry: A retrospective study.","authors":"Sevim Yener, Zekeriya Ilce","doi":"10.14744/nci.2024.89990","DOIUrl":"10.14744/nci.2024.89990","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective study was conducted in a tertiary hospital in Turkiye, it was aimed to evaluate the results of kidney and bladder ultrasonography, uroflowmetric study and volume frequency chart in children diagnosed with bedwetting at night.</p><p><strong>Methods: </strong>This study focused on patients aged 5-17 years who were treated for nocturnal enuresis in the single-center pediatric urology clinic of a tertiary hospital between 2017-2021. Patients' comorbidities, surgical history, urinary ultrasonography findings, uroflowmetry examination results, and two-day voiding diary were requested.</p><p><strong>Results: </strong>The number of pediatric patients diagnosed with enuresis nocturna was 956. Abnormal ultrasonography findings were observed in 13.9% of patients. Almost half of the patients had a positive family history, and 13.4% had a history of previous surgical procedures. While the voiding diary indicated that 54.2% of patients had bladder volumes equivalent to the expected bladder capacity, uroflowmetry examination revealed low bladder capacity in 65% of patients.</p><p><strong>Conclusion: </strong>This study underscores the significance of comprehensive evaluations, including detailed ultrasonography and voiding diary measurements, in pediatric patients with monosymptomatic enuresis nocturna. Our study suggests that bladder volume measured through a two-day weekend voiding diary may provide more effective information for estimating optimal bladder capacity compared to measurements obtained through uroflowmetry.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"471-475"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the teratogenic effects of pregabalin usage during pregnancy: A multicenter case-control study. 评估孕期使用普瑞巴林的致畸影响:一项多中心病例对照研究。
Northern clinics of Istanbul Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2024.57702
Mert Kaskal, Busra Kuru, Ilknur Erkoseoglu, Huseyin Yilmaz, Baris Karadas, M Zafer Goren
{"title":"Evaluation of the teratogenic effects of pregabalin usage during pregnancy: A multicenter case-control study.","authors":"Mert Kaskal, Busra Kuru, Ilknur Erkoseoglu, Huseyin Yilmaz, Baris Karadas, M Zafer Goren","doi":"10.14744/nci.2024.57702","DOIUrl":"10.14744/nci.2024.57702","url":null,"abstract":"<p><strong>Objective: </strong>Information regarding pregabalin use is limited. We aimed to assess the outcome of the patients who have taken pregabalin at a certain time during their pregnancies.</p><p><strong>Methods: </strong>31 patients used pregabalin treatment during pregnancy and 93 control patients were included in the study who applied to hospital between the years 2013-2022. In this multicenter case-controlled study, the outcome of the pregnancies and the health condition of the newborn in the pregabalin and control groups were evaluated.</p><p><strong>Results: </strong>Preterm delivery rates (5/27 (18.5%) vs. 5/87 (5.7%); OR 0.26, 95% CI 0.07-1.01, p=0.04) and lower birth weight (6/27 (22.2%) vs. 5/81 (6.6%); OR 4.34, 95% CI 1.20-15.65, p=0.016) were found higher in the pregabalin group compared to the control group. However, significant difference was not found between the birth dates of babies in pregabalin and control groups with the log-rank test (p=0.30). Spontaneous abortion rates were not significantly different (2/31 (6.4%) vs. 4/93 (4.3%); OR 1.52, 95% CI 0.26-8.72, p=0.63). Although major malformation rates in pregabalin were higher than those in controls (3/27 (11%) vs. 4/88 (4.5%); OR 0.38, 95% CI 0.07-1.82, p=0.21) the outcomes were statistically insignificant.</p><p><strong>Conclusion: </strong>Preterm delivery rates and lower birth weight were higher in pregabalin group. Also, it should not be ignored that chronic diseases of the pregnant women in pregabalin group may affect the outcomes poorly.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"460-465"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-life neovascular AMD treatment considering reimbursement in Turkiye: One-year comparison of switching to intravitreal ranibizumab or aflibercept after treatment failure with three loading intravitreal bevacizumab injections. 考虑到土耳其的报销问题,真实的新生血管性黄斑变性治疗:治疗失败后改用玻璃体内注射雷尼珠单抗或阿弗利贝赛普治疗一年的比较。
Northern clinics of Istanbul Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2024.75688
Mehmet Orkun Sevik, Nimet Zeynep Tiras, Aslan Aykut, Didem Dizdar Yigit, Ozlem Sahin
{"title":"Real-life neovascular AMD treatment considering reimbursement in Turkiye: One-year comparison of switching to intravitreal ranibizumab or aflibercept after treatment failure with three loading intravitreal bevacizumab injections.","authors":"Mehmet Orkun Sevik, Nimet Zeynep Tiras, Aslan Aykut, Didem Dizdar Yigit, Ozlem Sahin","doi":"10.14744/nci.2024.75688","DOIUrl":"10.14744/nci.2024.75688","url":null,"abstract":"<p><strong>Objective: </strong>To compare one-year anatomical and functional results of switching to an on-label intravitreal anti-vascular endothelial growth factor (anti-VEGF) agent (intravitreal ranibizumab [IVR] or aflibercept [IVA]) after treatment failure with three loading doses of off-label intravitreal bevacizumab (IVB), which is mandatory in the treatment of neovascular age-related macular degeneration (nAMD) to get reimbursement from Social Security Institution in Turkiye.</p><p><strong>Methods: </strong>This comparative, real-life, retrospective cohort study included treatment-naïve nAMD patients treated starting with three loading doses of IVB, switched to three loading doses of IVR and IVA due to treatment failure after IVB loading, and followed up one year with a treat-and-extend (T&E) protocol with 2-week extension/shortening intervals. The primary outcomes were changes in best-corrected visual acuity (BCVA; logMAR) and central macular thickness (CMT, µm) one year after the switch, and the secondary outcomes were maximum treatment intervals, number of injections, and disease activity rates.</p><p><strong>Results: </strong>The mean age (72.9±8.2 and 72.2±6.7, p=0.677) and gender (60.0% and 47.4% females, p=0.398) were similar among the IVR (35 eyes/patients) and IVA (38 eyes/patients) groups. The median BCVA and CMT were significantly improved during the study period (p<0.001) with no significant intergroup differences. The ratio of 4-, 6-, 8-, 10-, and 12-week maximum treatment intervals were 28.6%, 17.1%, 14.3%, 8.6%, and 31.4% in the IVR, and 13.2%, 15.8%, 21.1%, 15.8%, and 34.2% in the IVA group (p=0.492). The median (IQR) number of injections in the IVA group (8 [7-9]) was significantly lower than the IVR group (9 [8-12]) during the one-year T&E period (p=0.026). The disease activity rates were 34.3% and 26.4% one month (p=0.610) and 37.1% and 21.1% one year (p=0.195) after the switch in IVR and IVA groups.</p><p><strong>Conclusion: </strong>This real-life comparison study indicates that, after the treatment failure with three loading doses of IVB, switching to either on-label anti-VEGF agent can be regarded as comparable considering functional and anatomical results. However, although maximum treatment intervals were not significantly different, fewer injections were required with aflibercept during the one-year T&E follow-up period.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"451-459"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental investigation of the effect of thymoquinone on the viability of random patterned skin flaps. 胸腺醌对随机图案皮瓣存活率影响的实验研究。
Northern clinics of Istanbul Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2024.51482
Gulsum Cebi, Tugba Feryal Yildiz, Eda Merve Kurtulus, Yagmur Aydin, Merdan Serin
{"title":"Experimental investigation of the effect of thymoquinone on the viability of random patterned skin flaps.","authors":"Gulsum Cebi, Tugba Feryal Yildiz, Eda Merve Kurtulus, Yagmur Aydin, Merdan Serin","doi":"10.14744/nci.2024.51482","DOIUrl":"10.14744/nci.2024.51482","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study is to demonstrate the potential effects of thymoquinone, a well-known antioxidant agent, on random flap viability and thus to improve the clinical use of these flaps.</p><p><strong>Methods: </strong>In this study, 24 Sprague Dawley female albino rats weighing between 200-250 grams were used. Three groups consisting of randomly selected 8 rats were formed, as study, sham and control groups. Modified McFarlane flap model sized 3x9 cm. was used. In control group, only local wound care was carried out for ten days after flap elevation. In sham group, daily intraperitoneal dimethyl sulfoxide (DMSO) solution was injected in the post-operative 10-day period. In the study group thymoquinone and DMSO solution were injected intraperitoneally together. 10 days later, the study was terminated and flaps were photographed for necrotic area measurements, tissue and blood samples were taken out for biochemical and histopathological studies. In biochemical studies, tissue and serum total antioxidant capacity (TAC) and thiobarbituric acid reactive substrates (TBARS) levels were measured. Histopathological studies included inflammatory cell infiltration, collagen, fibroblast formation and angiogenesis.</p><p><strong>Results: </strong>There was significant decrease in the necrotic areas of flaps in the study group. Serum and tissue antioxidant levels were significantly high and TBARS levels were significantly low. Histopathological examination showed no significant difference in inflammatory cell infiltration, fibroblast formation or angiogenesis between the groups. However, collagen density in the study group was found to be more than the other groups and the structure was better formed.</p><p><strong>Conclusion: </strong>Thymoquinone increases the flap viability due to its antioxidant properties and it has a positive contribution to wound healing, although it has no significant anti-inflammatory or anjiogenetic activity. In the future, we think that it can be clinically useful for preventing distal flap necrosis in patients with high risk.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"440-450"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determining the effectiveness of a virtual service /patient-based education program on patient care and clinical decision-making in nursing: A quasi-experimental study. 确定虚拟服务/以病人为基础的教育计划对病人护理和护理临床决策的有效性:准实验研究。
Northern clinics of Istanbul Pub Date : 2024-10-02 eCollection Date: 2024-01-01 DOI: 10.14744/nci.2024.78095
Taner Onay, Mehmet Ali Gulpinar, Merve Saracoglu, Esra Akdeniz
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