Northern clinics of Istanbul最新文献

{"title":"Baseline macular structural and vascular changes as predictive markers of visual improvement in central retinal vein occlusion.","authors":"Ulviye Kivrak, Guzide Akcay","doi":"10.14744/nci.2025.26932","DOIUrl":"https://doi.org/10.14744/nci.2025.26932","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the changes in posterior segment parameters that affect visual prognosis in patients with central retinal vein occlusion (CRVO).</p><p><strong>Methods: </strong>This retrospective study included 58 eyes of 58 CRVO patients. Best-corrected visual acuity (BCVA), intraocular pressure, central macular thickness (CMT), hyperreflective foci (HRF), ellipsoid zone (EZ) loss, disorganization of retinal inner layers (DRIL), intraretinal cystic changes, posterior vitreous detachment (PVD), and macular superficial and deep vascular density (VD), as well as superficial and deep foveal avascular zone (FAZ) areas, were assessed at baseline and 3 months follow-up after treatment. The treatments (intravitreal injections and laser) received were recorded.</p><p><strong>Results: </strong>The mean age was 63.02±9.91 years, 37 (63.8%) were female, and 39 (67.3%) were classified as having non-ischemic CRVO. The mean baseline BCVA was 0.64±0.85 logMAR; at 3 months, it improved to 0.39±0.65 logMAR (p<0.001). The mean baseline CMT was 478.9±82.6 µm, and at 3 months, it reduced to 288.56±72.39 µm (p<0.001). At baseline, HRF in 31% of eyes, EZ disruption in 44.8% of eyes, DRIL in 17.2% of eyes, intraretinal cysts in 55.2% of eyes, and PVD in 43.1% of eyes. A significant decrease in BCVA was observed in patients with EZ loss (p<0.001), while the presence of intraretinal cysts had significant impact on CMT (p=0.007). Furthermore, a statistically significant negative correlation was observed between foveal and superior VD in both the superficial and deep capillary plexus (SCP, DCP) and changes in BCVA (logMAR). In contrast, a positive correlation was found between superficial FAZ area and BCVA (logMAR). Additionally, a statistically significant positive correlation was noted between foveal VD in both the SCP and DCP and changes in CMT.</p><p><strong>Conclusion: </strong>The study emphasizes the importance of structural and vascular changes in predicting functional outcomes and suggests the utility of optical coherence tomography (OCT) and OCT angiography in early visual prognosis and treatment planning.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 2","pages":"222-230"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of single-dose platelet-rich plasma and hyaluronic acid therapies in knee osteoarthritis: A 12-week follow-up study.","authors":"Caglar Karabas, Ezgi Akyildiz Tezcan","doi":"10.14744/nci.2024.89587","DOIUrl":"https://doi.org/10.14744/nci.2024.89587","url":null,"abstract":"<p><strong>Objective: </strong>Osteoarthritis (OA) is a prevalent and disabling joint condition that affects millions worldwide, particularly in the knee joint, and it presents limited therapeutic options. Platelet-rich plasma (PRP) and hyaluronic acid (HA) have emerged as promising intra-articular treatments. This study aimed to compare the effects of single-dose PRP and HA on pain, functionality, and stiffness in patients with knee OA over a 12-week follow-up period.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 64 patients who underwent single-dose intra-articular HA or PRP treatment for knee OA between December 2021 and June 2022. Pain and functional outcomes were assessed using the Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores. Patient satisfaction was evaluated using a Likert scale. Appropriate statistical analyses were performed to compare treatment outcomes and p<0.05 was considered statistically significant.</p><p><strong>Results: </strong>Both PRP and HA treatments led to significant improvements in pain, functionality, and stiffness over the 12-week follow-up period. VAS pain scores decreased significantly in both groups, but a greater reduction was observed in the HA group. Additionally, the HA group exhibited superior improvement in the WOMAC physical function score at the 4-week mark (p=0.047).</p><p><strong>Conclusion: </strong>This study is another novel contribution to the growing literature on treatment of PRP and HA treatments for knee OA, where we highlighted the potential benefits of single-dose HA in alleviating pain and enhancing physical function.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 2","pages":"204-210"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stair-climbing test as a physical performance tool in chronic heart failure: Association with left ventricular ejection fraction and pulmonary functions.","authors":"Busra Alkan, Sevgi Ozalevli","doi":"10.14744/nci.2023.66743","DOIUrl":"https://doi.org/10.14744/nci.2023.66743","url":null,"abstract":"<p><strong>Objective: </strong>The cardiopulmonary exercise test (CPET), which is used as the gold standard in the evaluation of exercise capacity in patients with chronic heart failure (CHF), is not always possible to perform in clinics and field tests are preferred. The aim of this study was to determine the effectiveness of the symptom-limited stair climbing test (SLSCT) in patients with CHF.</p><p><strong>Methods: </strong>Thirty-one patients (mean age: 65.52±7.57 years) with New York Heart Association (NYHA) Classification stage II-III CHF were included. Exercise capacity was assessed by SLSCT, 6-minute walk test (6MWT), and CPET. Predicted peak oxygen consumption (VO_2peak), heart rate (HR), blood pressure (BP), and left ventricular ejection fraction (LVEF), pulmonary functions were measured.</p><p><strong>Results: </strong>The predicted VO_2peak calculated from SLCT was significantly higher than that of 6MWT and CPET (p<0.05). On analyzing the HR changes, SLSCT increased HR by more than 6MWT and less than CPET (p<0.05). There were significant correlations between the predicted VO_2peak values by SLSCT and LVEF, BMI (Body Mass Index), FEV1 (Forced Expiratory Volume in One Second), and FVC (Forced Vital Capacity), predicted VO_2peak of CPET (r=0.36-0.55, p≤0.05).</p><p><strong>Conclusion: </strong>SLSCT was found to be effective and easy to use in assessing exercise capacity in CHF patients. Compared with 6MWT, SLSCT gives better results in determining the clinical status and hemodynamic responses of the patients. SLSCT can be an alternative method for assessing exercise capacity in the absence of CPET.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 2","pages":"196-203"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological and molecular analysis in dermis and epidermis of patients with systemic and localized scleroderma.","authors":"Betul Sozeri, Seyma Turkmen, Basak Yildiz Atikan, Huseyin Aktug","doi":"10.14744/nci.2024.45389","DOIUrl":"https://doi.org/10.14744/nci.2024.45389","url":null,"abstract":"<p><strong>Objective: </strong>Scleroderma has a wide range of clinical manifestations due to vasculopathy, autoimmunity, altered endothelium function, and abnormal fibrosis, which are accused in the pathogenesis of the disease. The aim of this study is to shed light on the pathogenesis of the disease in childhood via dermal immunohistochemical analysis of the cases.</p><p><strong>Methods: </strong>A single-blind clinical trial is conducted with evaluation of the tissue samples obtained from patients. The samples are stained with PAS, hematoxylin and eosin, E-Cadherin, Connective tissue growth factor (CTGF), Tunnel, and staining for Transforming growth factor beta 1 (TGF-β1) and evaluated by light microscopy. In addition, both TGF-β1 level and mRNA expression analyses in plasma and tissue samples from patients are performed. A total of 15 patients (systemic, n=8 or localized; n=7) were enrolled in the study.</p><p><strong>Results: </strong>The mean age of onset of the disease was 9.2±1.2 years, and the mean age of diagnosis was 15.3±3.2 years. Antinuclear antibody (ANA) titer was between 1/160-1/640 in all patients with systemic sclerosis. There was no ANA positivity in patients with localized scleroderma. A total of 22 tissue samples (15 diseased tissues, 7 healthy tissues) were examined. Histopathological examination has shown that two clinically different subgroups have different characteristics at the tissue level.</p><p><strong>Conclusion: </strong>TGF-β1 levels, which play a fundamental role in the pathogenesis of the disease, are found in both plasma and skin have been shown high. This elevation was found particularly in patients with systemic scleroderma to be more pronounced. Also, in patients with localized scleroderma, skin fibroblasts have been shown to limit the pathologic response.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 2","pages":"189-195"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional distribution of intratesticular varicoceles accompanying extratesticular varicocele cases.","authors":"Yusuf Aksu","doi":"10.14744/nci.2023.54614","DOIUrl":"https://doi.org/10.14744/nci.2023.54614","url":null,"abstract":"<p><strong>Objective: </strong>Only few cases of intratesticular varicocele (ITV) have been reported in the literature, mostly as single cases or a case series. In this study, we aimed to describe the topographic distribution of ITVs in the testicular parenchyma and the correlation between ITV accompanying extratesticular varicocele (ETV) and age.</p><p><strong>Methods: </strong>Approximately 10,537 patients with scrotal pain and swelling who visited our hospital between August 2014 and May 2020 and underwent scrotal colour Doppler ultrasonography were included in this study. Of these patients, 2285 had ETV, and the remaining patients (n=8252) had other testicular pathologies such as acute-chronic torsion, testicular mass, orchitis, significant testicular atrophy, or isolated extratesticular varicocele, and were thus excluded from the study. Among the 2285 patients, only 20 had ITV.</p><p><strong>Results: </strong>Of the 20 patients with ITV, 2 had isolated ITV, and the remaining had ITV accompanying ETV, of whom only one had a right ETV. One patient had left testicular atrophy accompanying an isolated ITV. Among the ITV cases, subcapsular ITV was the most common (n=13), followed by central ITV (n=4) and subcapsular and hilar ITV (n=3). The patients' ages ranged from 18 to 30 years.</p><p><strong>Conclusion: </strong>ITV is a rare clinical entity that occurs only in young men, with most cases accompanying ETV. ITV is generally peripherally located in the testicular parenchyma. In this study, no correlations were found between ITV, ETV, and age. As in this study, testicular atrophy is rarely observed in patients with ITV. No studies have presented ITV cases with spermiogram analysis results. Thus, the effect of ITV on male reproductive fertility is still unknown, and further study on this topic is needed.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 2","pages":"173-178"},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the correlations between nutrition literacy of mothers and offspring physical growth and development, dietary diversity and quality, and vitamin levels.","authors":"Sakina Mammadova, Ozlem Tezol, Gulhan Temel","doi":"10.14744/nci.2023.32067","DOIUrl":"https://doi.org/10.14744/nci.2023.32067","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between nutrition literacy (NL) of mothers and physical growth and development, dietary diversity and quality, and vitamin levels of their children aged 24-59 months.</p><p><strong>Methods: </strong>A cross-sectional survey-based study was conducted at well-child outpatient clinic. Eighty-eight mother-child pairs included. Mother's Evaluation Instrument of Nutrition Literacy for Adults (EINLA) scores and child anthropometric z-scores, age when reaching six gross motor milestones, dietary diversity and the Mediterranean Diet Quality Index scores, and serum vitamin A, B1, B2, B12, C, D, and E levels were measured. Two independent groups comparison statistics and Spearman rank correlations were performed.</p><p><strong>Results: </strong>Thirty-four mothers (38.6%) had borderline and 54 mothers (61.4%) had adequate NL level. The percentages of wasted and acutely malnourished children were higher in the borderline NL group (17.6% vs. 1.9%, p=0.005 and 14.7% vs. 1.9%, p=0.030, respectively). There was no significant correlation between maternal EINLA score and child motor skill acquisition, dietary diversity, or serum vitamin status (p>0.05). There was a correlation between maternal EINLA score and child dietary quality score (r=0.218, p=0.041).</p><p><strong>Conclusion: </strong>Increasing NL of mothers may be a step toward improving the dietary quality of children and reducing the burden of child undernutrition.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 2","pages":"179-188"},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on leadership, organizational culture and digital transformation in dentistry.","authors":"Orhan Comlek","doi":"10.14744/nci.2025.48897","DOIUrl":"https://doi.org/10.14744/nci.2025.48897","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the impact of leadership support, organizational culture and digital transformation on employee satisfaction, employee motivation, patient satisfaction, organizational learning capacity and innovative performance in the dental sector. Employee and patient satisfaction is critical to improve service quality and ensure a sustainable healthcare system. Leadership support promotes job satisfaction and motivation, while organizational culture supports collaboration and communication. Digital transformation increases operational efficiency, streamlines workflows and improves patient satisfaction. The study aims to provide theoretical and practical insights into health management and organizational development in dental clinics.</p><p><strong>Methods: </strong>A quantitative research design was used involving 300 participants from dental clinics in Istanbul. Data were collected through questionnaires and analyzed using SPSS software. Statistical methods including factor, correlation and regression analyses were applied to test the hypotheses. The study examined the relationships between leadership, organizational culture, digital transformation and their effects on the dependent variables.</p><p><strong>Results: </strong>The results show that leadership support significantly increases employee satisfaction, motivation, patient satisfaction, innovative performance, and organizational learning capacity. In addition, organizational culture and digital transformation showed positive but statistically insignificant effects on these variables. While digital transformation increased operational efficiency, it did not significantly affect employee motivation or patient satisfaction. The findings emphasize the importance of leadership in driving innovation and improving service quality in dental clinics.</p><p><strong>Conclusion: </strong>Leadership significantly promotes employee and patient satisfaction, employee motivation, organizational learning and innovative performance. Organizational culture contributes positively to the dependent variables, but its effects are less pronounced. Digital transformation positively affects patient satisfaction. The study underlines the need for effective leadership strategies and the integration of digital technologies to improve dental service outcomes. These findings provide valuable guidance for developing management strategies in dentistry. Future research should investigate the long-term effects of digital transformation and innovative technologies on satisfaction, motivation and organizational performance.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 2","pages":"153-161"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of survey/questionnaire-based drug utilization studies in Turkiye.","authors":"Onur Gultekin, Nazim Haspolat, Bahar Cicek, Dieudonné Havyarimana, Ahmet Akici, Volkan Aydin","doi":"10.14744/nci.2024.60252","DOIUrl":"10.14744/nci.2024.60252","url":null,"abstract":"<p><strong>Objective: </strong>Drug utilization studies (DUS), providing insights into various aspects of pharmacoepidemiology from prescribing to medication use, can be conducted through real-world data from health records and survey-based data. In this study, we aimed to describe survey/questionnaire-based DUS conducted in Turkiye.</p><p><strong>Methods: </strong>We searched online databases for the most frequently used keywords in DUS from January 1993 till May 2023 and identified 180 survey-based DUS conducted in Turkiye. We described DUS by their populations, sociodemographic characteristics, timeframe, setting and provinces, data collection method, medication categories, and article-specific variables were evaluated.</p><p><strong>Results: </strong>We identified that 68.3% of the DUS were in English and 91.7% were indexed in Web of Science (median 1 [interquartile range: 1-2] citation). We found that 21.7% of the articles (n=39) had pharmacology affiliation. Adults are the target population in 37.8% of the studies and age and gender were not reported in 27.2% and 16.7%, respectively. The response rate was not stated in 55.0%. We determined that 48.3% of the studies were focused on a single medication/medication group. The mean time from data collection to publication was 2.5±1.9 years, and the highest number of articles (10.6%) were published in 2021.</p><p><strong>Conclusion: </strong>Our systematic review shows that the majority of DUS were listed in well-known international indices, suggesting that our local studies invoke global interest and hold a valuable position in health research. Nevertheless, lack of reporting of methodological characteristics in substantial part of the studies can be considered an important room for improvement of DUS.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 6","pages":"525-533"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can HALP (Hemoglobin, albumin, lymphocyte, and platelet) score distinguish malignant and benign causes of extrahepatic cholestasis in patients with extrahepatic bile duct obstruction?","authors":"Ibrahimhalil Dusunceli, Zeynep Gok Sargin, Umut Celik, Fatih Sargin","doi":"10.14744/nci.2024.23169","DOIUrl":"10.14744/nci.2024.23169","url":null,"abstract":"<p><strong>Objective: </strong>Cholestatic diseases are common and classified as benign or malignant based on their etiology. HALP is a unique nutritional immune marker that combines indicators of nutritional status, including hemoglobin and albumin, with immune function markers like lymphocyte and platelet counts. We investigated the HALP score's ability to differentiate between benign and malignant causes in extrahepatic cholestasis patients.</p><p><strong>Methods: </strong>This research was designed as cross-sectional and retrospective. Between 1 January 2020-1 January 2022, patients diagnosed with extrahepatic cholestasis were included. The diagnoses were confirmed using non-invasive imaging methods, ERCP (endoscopic retrograde cholangiopancreatography), and tissue biopsy results. Based on the type of extrahepatic biliary obstruction, either benign or malignant, the patients were divided into two groups. The HALP score was calculated by multiplying the patient's albumin (g/L), hemoglobin (g/L), and lymphocyte count (/L) and dividing by the platelet count (/L).</p><p><strong>Results: </strong>In 121 of 216 patients, extrahepatic cholestasis was caused by benign factors, mostly choledocholithiasis, while malignant causes, predominantly pancreatic head cancer, were responsible for extrahepatic cholestasis in 95 patients. The malignant cholestasis group had significantly higher bilirubin levels (p<0.001), lower hemoglobin levels (p=0.005), lower albumin levels (p<0.001), higher lymphocyte counts (p<0.001), and higher platelet levels (p=0.001) compared to the benign cholestasis group. There was no considerable difference in the HALP score between the two groups, as indicated by a p-value of 0.741.</p><p><strong>Conclusion: </strong>The HALP score could not distinguish between benign and malignant causes of extrahepatic cholestasis.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 6","pages":"555-559"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do we know about dynapenia?","authors":"Ridvan Sivritepe, Ozge Kiran Siyer, Serhat Mert Tiril, Sema Ucak Basat","doi":"10.14744/nci.2024.48642","DOIUrl":"10.14744/nci.2024.48642","url":null,"abstract":"<p><p>Dynapenia is a condition characterized by decreased muscle strength and function in older adults that is not due to a specific underlying disease or medical condition. Dynapenia is common among older adults and has significant health effects, including functional impairment, disability, increased risk of falls, hospitalization, and death. Oxidative stress, mitochondrial dysfunction and chronic inflammation are involved in the etiopathophysiology of dynapenia. Diagnosis of dynapenia is based on the evaluation of muscle strength and function using methods such as hand grip strength, timed up and go test and short physical performance battery. Management of dynapenia involves a multifaceted approach that includes exercise, nutrition, pharmacological interventions, management of underlying medical conditions, and fall prevention strategies. With appropriate interventions, older adults with dynapenia can improve muscle strength and function, reduce the risk of falls and disability, and maintain their independence and quality of life.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 6","pages":"593-599"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}