Northern clinics of Istanbul最新文献

{"title":"Evaluation of corporate experiences during the accreditation process in the field of health - A qualitative study.","authors":"Tuncay Palteki, Nedim Havle, Demet Gokmen Kavak, Ayse Sibel Oksuz, Aykut Ilker Arslan, Ezgi Salar, Esengul Purkuloglu, Gamze Ozcan, Nesrin Aydemir, Ozlem Palancioglu, Yeliz Soy Kibriz","doi":"10.14744/nci.2023.28482","DOIUrl":"10.14744/nci.2023.28482","url":null,"abstract":"<p><strong>Objective: </strong>In our study, we attempted to determine the accreditation process experience of hospital senior managers accredited by the Turkish Health Care Quality and Accreditation Institute (TUSKA). Along with the institutions' accomplishments through the accreditation program, the major challenges they faced during the accreditation process were revealed.</p><p><strong>Methods: </strong>One of the qualitative research designs used was interpretive phenomenological analysis, which was carried out through semi-structured interviews with hospital senior managers.</p><p><strong>Results: </strong>In the study conducted with eight participants, 55 sub-themes emerged under 12 main themes. The participants expressed their opinions on a wide range of topics, from the achievements related to the accreditation process to the difficulties they encountered, from their strengths to the dissemination of accreditation throughout the country.</p><p><strong>Conclusion: </strong>It has been understood that the national hospital accreditations carried out in our country provide important gains to the institutions in management and clinical activities, while the expectations on incentives and other similar issues have not yet been met.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 6","pages":"501-511"},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-menopausal status in primary antiphospholipid syndrome is associated with low HDL-C levels.","authors":"Jozélio Freire de Carvalho","doi":"10.14744/nci.2023.71363","DOIUrl":"10.14744/nci.2023.71363","url":null,"abstract":"","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 6","pages":"600-601"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142804166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of bladder capacity in pediatric patients with nocturnal enuresis using voiding diary and uroflowmetry: A retrospective study.","authors":"Sevim Yener, Zekeriya Ilce","doi":"10.14744/nci.2024.89990","DOIUrl":"10.14744/nci.2024.89990","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective study was conducted in a tertiary hospital in Turkiye, it was aimed to evaluate the results of kidney and bladder ultrasonography, uroflowmetric study and volume frequency chart in children diagnosed with bedwetting at night.</p><p><strong>Methods: </strong>This study focused on patients aged 5-17 years who were treated for nocturnal enuresis in the single-center pediatric urology clinic of a tertiary hospital between 2017-2021. Patients' comorbidities, surgical history, urinary ultrasonography findings, uroflowmetry examination results, and two-day voiding diary were requested.</p><p><strong>Results: </strong>The number of pediatric patients diagnosed with enuresis nocturna was 956. Abnormal ultrasonography findings were observed in 13.9% of patients. Almost half of the patients had a positive family history, and 13.4% had a history of previous surgical procedures. While the voiding diary indicated that 54.2% of patients had bladder volumes equivalent to the expected bladder capacity, uroflowmetry examination revealed low bladder capacity in 65% of patients.</p><p><strong>Conclusion: </strong>This study underscores the significance of comprehensive evaluations, including detailed ultrasonography and voiding diary measurements, in pediatric patients with monosymptomatic enuresis nocturna. Our study suggests that bladder volume measured through a two-day weekend voiding diary may provide more effective information for estimating optimal bladder capacity compared to measurements obtained through uroflowmetry.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"471-475"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the teratogenic effects of pregabalin usage during pregnancy: A multicenter case-control study.","authors":"Mert Kaskal, Busra Kuru, Ilknur Erkoseoglu, Huseyin Yilmaz, Baris Karadas, M Zafer Goren","doi":"10.14744/nci.2024.57702","DOIUrl":"10.14744/nci.2024.57702","url":null,"abstract":"<p><strong>Objective: </strong>Information regarding pregabalin use is limited. We aimed to assess the outcome of the patients who have taken pregabalin at a certain time during their pregnancies.</p><p><strong>Methods: </strong>31 patients used pregabalin treatment during pregnancy and 93 control patients were included in the study who applied to hospital between the years 2013-2022. In this multicenter case-controlled study, the outcome of the pregnancies and the health condition of the newborn in the pregabalin and control groups were evaluated.</p><p><strong>Results: </strong>Preterm delivery rates (5/27 (18.5%) vs. 5/87 (5.7%); OR 0.26, 95% CI 0.07-1.01, p=0.04) and lower birth weight (6/27 (22.2%) vs. 5/81 (6.6%); OR 4.34, 95% CI 1.20-15.65, p=0.016) were found higher in the pregabalin group compared to the control group. However, significant difference was not found between the birth dates of babies in pregabalin and control groups with the log-rank test (p=0.30). Spontaneous abortion rates were not significantly different (2/31 (6.4%) vs. 4/93 (4.3%); OR 1.52, 95% CI 0.26-8.72, p=0.63). Although major malformation rates in pregabalin were higher than those in controls (3/27 (11%) vs. 4/88 (4.5%); OR 0.38, 95% CI 0.07-1.82, p=0.21) the outcomes were statistically insignificant.</p><p><strong>Conclusion: </strong>Preterm delivery rates and lower birth weight were higher in pregabalin group. Also, it should not be ignored that chronic diseases of the pregnant women in pregabalin group may affect the outcomes poorly.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"460-465"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-life neovascular AMD treatment considering reimbursement in Turkiye: One-year comparison of switching to intravitreal ranibizumab or aflibercept after treatment failure with three loading intravitreal bevacizumab injections.","authors":"Mehmet Orkun Sevik, Nimet Zeynep Tiras, Aslan Aykut, Didem Dizdar Yigit, Ozlem Sahin","doi":"10.14744/nci.2024.75688","DOIUrl":"10.14744/nci.2024.75688","url":null,"abstract":"<p><strong>Objective: </strong>To compare one-year anatomical and functional results of switching to an on-label intravitreal anti-vascular endothelial growth factor (anti-VEGF) agent (intravitreal ranibizumab [IVR] or aflibercept [IVA]) after treatment failure with three loading doses of off-label intravitreal bevacizumab (IVB), which is mandatory in the treatment of neovascular age-related macular degeneration (nAMD) to get reimbursement from Social Security Institution in Turkiye.</p><p><strong>Methods: </strong>This comparative, real-life, retrospective cohort study included treatment-naïve nAMD patients treated starting with three loading doses of IVB, switched to three loading doses of IVR and IVA due to treatment failure after IVB loading, and followed up one year with a treat-and-extend (T&E) protocol with 2-week extension/shortening intervals. The primary outcomes were changes in best-corrected visual acuity (BCVA; logMAR) and central macular thickness (CMT, µm) one year after the switch, and the secondary outcomes were maximum treatment intervals, number of injections, and disease activity rates.</p><p><strong>Results: </strong>The mean age (72.9±8.2 and 72.2±6.7, p=0.677) and gender (60.0% and 47.4% females, p=0.398) were similar among the IVR (35 eyes/patients) and IVA (38 eyes/patients) groups. The median BCVA and CMT were significantly improved during the study period (p<0.001) with no significant intergroup differences. The ratio of 4-, 6-, 8-, 10-, and 12-week maximum treatment intervals were 28.6%, 17.1%, 14.3%, 8.6%, and 31.4% in the IVR, and 13.2%, 15.8%, 21.1%, 15.8%, and 34.2% in the IVA group (p=0.492). The median (IQR) number of injections in the IVA group (8 [7-9]) was significantly lower than the IVR group (9 [8-12]) during the one-year T&E period (p=0.026). The disease activity rates were 34.3% and 26.4% one month (p=0.610) and 37.1% and 21.1% one year (p=0.195) after the switch in IVR and IVA groups.</p><p><strong>Conclusion: </strong>This real-life comparison study indicates that, after the treatment failure with three loading doses of IVB, switching to either on-label anti-VEGF agent can be regarded as comparable considering functional and anatomical results. However, although maximum treatment intervals were not significantly different, fewer injections were required with aflibercept during the one-year T&E follow-up period.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"451-459"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental investigation of the effect of thymoquinone on the viability of random patterned skin flaps.","authors":"Gulsum Cebi, Tugba Feryal Yildiz, Eda Merve Kurtulus, Yagmur Aydin, Merdan Serin","doi":"10.14744/nci.2024.51482","DOIUrl":"10.14744/nci.2024.51482","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study is to demonstrate the potential effects of thymoquinone, a well-known antioxidant agent, on random flap viability and thus to improve the clinical use of these flaps.</p><p><strong>Methods: </strong>In this study, 24 Sprague Dawley female albino rats weighing between 200-250 grams were used. Three groups consisting of randomly selected 8 rats were formed, as study, sham and control groups. Modified McFarlane flap model sized 3x9 cm. was used. In control group, only local wound care was carried out for ten days after flap elevation. In sham group, daily intraperitoneal dimethyl sulfoxide (DMSO) solution was injected in the post-operative 10-day period. In the study group thymoquinone and DMSO solution were injected intraperitoneally together. 10 days later, the study was terminated and flaps were photographed for necrotic area measurements, tissue and blood samples were taken out for biochemical and histopathological studies. In biochemical studies, tissue and serum total antioxidant capacity (TAC) and thiobarbituric acid reactive substrates (TBARS) levels were measured. Histopathological studies included inflammatory cell infiltration, collagen, fibroblast formation and angiogenesis.</p><p><strong>Results: </strong>There was significant decrease in the necrotic areas of flaps in the study group. Serum and tissue antioxidant levels were significantly high and TBARS levels were significantly low. Histopathological examination showed no significant difference in inflammatory cell infiltration, fibroblast formation or angiogenesis between the groups. However, collagen density in the study group was found to be more than the other groups and the structure was better formed.</p><p><strong>Conclusion: </strong>Thymoquinone increases the flap viability due to its antioxidant properties and it has a positive contribution to wound healing, although it has no significant anti-inflammatory or anjiogenetic activity. In the future, we think that it can be clinically useful for preventing distal flap necrosis in patients with high risk.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"440-450"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the effectiveness of a virtual service /patient-based education program on patient care and clinical decision-making in nursing: A quasi-experimental study.","authors":"Taner Onay, Mehmet Ali Gulpinar, Merve Saracoglu, Esra Akdeniz","doi":"10.14744/nci.2024.78095","DOIUrl":"10.14744/nci.2024.78095","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to determine the effectiveness of a virtual service/patient-based program (vSPBP) developed for nursing education and its effect on the development of care plan preparation and clinical decision-making skills.</p><p><strong>Methods: </strong>The study was conducted in a quasi-experimental design with a sample of fourth-year nursing students. Participants were assigned to the intervention group (n=44) and control group (n=51). The intervention group participated in a full-day vSPBP in addition to clinical training, whereas the control group received only the clinical training. Both groups were evaluated at the end of the intervention for care planning skills and at the beginning, middle, and end of the academic year for clinical decision-making skills. The Modified Simulation Effectiveness Tool (mSET) and focused group interview were used to evaluate the effectiveness of the vSPBP; nursing students' Clinical Decision-Making in Nursing Scale (CDM-NS) and Care Plan Evaluation Form were used to evaluate learning outcomes. Quantitative data were analyzed using the t-test and ANOVA. Qualitative data were analyzed by three researchers, and themes were identified. Ethical permissions were obtained from the relevant units.</p><p><strong>Results: </strong>The total score of the Turkish Version of the mSET was 84.39±12.08 (51-95) and the education program was found to be highly effective. The mean care plan preparation skills scores of the intervention and control groups were 44.84±2.77 and 27.75±4.28 (0-50), respectively, and the total scores of the CDM-NS (at the last measurement) were 147.90±11.28 and 146.42±12.21. While there was a significant difference between the intervention and control groups in the ability to prepare a care plan (p=0.001), there was no difference between the groups in clinical decision-making skills over time (p=0.433), between the second and third measurements over time (p>0.05), but both measurements increased significantly compared with the first measurement (p=0.000).</p><p><strong>Conclusion: </strong>The vSPBP was determined to be an effective learning activity for the development of care plan preparation and clinical reasoning skills, as well as effective in closing the gap between theoretical and clinical knowledge and adaptation to the nursing process when applied in an integrated manner with the existing nursing program.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"422-433"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male breast cancer in a single-center experience: Diagnosis, clinicopathological features, and treatment strategies.","authors":"Deniz Isik, Oguzcan Kinikoglu, Ezgi Turkoglu, Heves Surmeli, Neslihan Buyukmurat","doi":"10.14744/nci.2024.32815","DOIUrl":"10.14744/nci.2024.32815","url":null,"abstract":"<p><strong>Objective: </strong>Although breast cancer is the most common cancer type in women worldwide, it is a rare tumor in men, accounting for less than 1% of all male cancers. Therefore, the characteristics of the tumor, the management of the disease, and our overall survival data are quite limited.</p><p><strong>Methods: </strong>We retrospectively analyzed the data of 51 male patients diagnosed and treated for breast cancer, whose follow-up processes continue, at our hospital. We examined in detail the patients' age, comorbid diseases, history of concomitant malignancies, family history, stage of the disease, tumor size, lymph node status, estrogen receptor (ER)/progesterone receptor (PR) along with Human Epidermal Growth Factor Receptor-2 (HER-2) status. Additionally, we analyzed the type of surgery, history of radiotherapy, and chemotherapy and hormonal treatments in the adjuvant and metastatic periods.</p><p><strong>Results: </strong>In our study, where we determined a median survival time of 122 months (29-214), we found that the stage at diagnosis, Eastern Cooperative Oncology Group (ECOG) performance status, and discontinuation of adjuvant endocrine therapy significantly affected survival. While the median survival was not reached in stage 1 patients at diagnosis, the median survival times for stage 2, 3, and 4 patients were 118, 83, and 39 months, respectively. The differences between the groups were statistically significant (p=0.005). Similarly, the median survival was not reached for patients with an ECOG performance status of 0, but it was 84 months for those with a status of 1 and 98 months for those with a status of 2. The differences among these three groups were also statistically significant (p=0.001). The median survival was not reached for patients who completed adjuvant endocrine therapy, whereas it was 83 months for those who discontinued the therapy, with the difference being statistically significant (p=0.021). Besides these data, the presence of perineural invasion was found to be a factor close to statistical significance in terms of survival (p=0.066). Histological subgroups, grade, lymphovascular invasion, adjuvant chemotherapy, and Ki-67 were not significant parameters for survival.</p><p><strong>Conclusion: </strong>Despite the differences in the stage at diagnosis, response to treatments, lower awareness of the disease, older age at diagnosis, and consequently, the increase in accompanying comorbid diseases, male breast cancer is managed according to studies and guideline recommendations for female breast cancer due to the lack of sufficient randomized studies. By presenting our clinical experience, we have emphasized the necessity for further studies in this field.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"434-439"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of school achievements in adolescents with primary hypertension.","authors":"Emre Leventoglu, Akif Kavgaci, Furkan Cagri Kavas, Fatma Canbeyli Hayvaci, Bahar Buyukkaragoz","doi":"10.14744/nci.2024.34438","DOIUrl":"10.14744/nci.2024.34438","url":null,"abstract":"<p><strong>Objective: </strong>Primary hypertension (HT) is a global public health problem with increasing prevalence in recent years. HT may have caused decreased neurocognitive functions and learning difficulties. In this study, clinical characteristics of adolescents with primary HT were examined and the relationship between semester grade point average (GPA) and HT was evaluated.</p><p><strong>Methods: </strong>This is an observational, cross-sectional, descriptive study conducted on adolescents with primary HT attending high school. Patient records (number of hospital visits, HT-related complaints, blood pressure measurements, and laboratory tests) were evaluated retrospectively. End-of-semester report card grades of Mathematics, Turkish Language and Literature and English courses were noted, and compared with the clinical characteristics of the patients.</p><p><strong>Results: </strong>The study included 83 patients with a mean age of 15.6±1.2 years. Patients with higher body mass index had lower grades in Mathematics (p=0.007) and Turkish Language and Literature (p=0.004). Patients with HT-related symptoms such as headache, epistaxis and palpitations had lower GPAs for all courses. Also, patients with hyperuricemia or proteinuria had lower semester GPAs compared to patients with normal serum uric acid levels or without proteinuria (p<0.05). GPAs for Mathematics (p=0.000) and Turkish Language and Literature (p=0.006) decrease as the number of hospital visits increases.</p><p><strong>Conclusion: </strong>HT may cause not only cardiovascular complications but also decreased neurocognitive functions through various mechanisms and may have a negative impact on academic skills. Therefore, HT should be followed up with a multidisciplinary approach and intensive efforts should be made to approach the goal of normotension.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"476-484"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evaluation of potential drug-drug interactions with antibiotics in hospitalized patients.","authors":"Nurten Nur Aydin, Murat Aydin","doi":"10.14744/nci.2023.82473","DOIUrl":"10.14744/nci.2023.82473","url":null,"abstract":"<p><strong>Objective: </strong>Drug-drug interactions (DDIs) occur when one drug alters the effect of another drug. The aim of this study was to evaluate potential drug-drug interactions (pDDIs) associated with the use of systemic antibiotics in hospitalized patients.</p><p><strong>Methods: </strong>The study included patients over the age of 18 who were hospitalized in our hospital on 12.07.2022 and were using at least two systemic drugs concurrently, with at least one being a systemic antibiotic. The study was conducted using the point prevalence method. The patients' medication was evaluated for pDDIs using the UpToDate^®/Lexicomp^® database system. According to this screening tool, pDDIs were classified into 4 groups according to their severity: B, C, D, and X, ranging from mild to severe.</p><p><strong>Results: </strong>Out of the 296 patients included in the study, at least one pDDI was detected in 190 patients (64.2%). One hundred seventy-seven patients (59.8%) had at least one pDDI with non-antibiotic drugs. Fifty-seven patients (19.3%) had at least one pDDI with antibiotics. One hundred and six patients (35.8%) had no drug interactions. Patients with pDDIs related to antibiotics had significantly higher age, number of comorbidities, total number of medications and number of antibiotics (p=0.010, p=0.004, p<0.001, p<0.001, respectively) compared to patients without pDDIs related to antibiotics (n=239). For antibiotics, potential pDDIs were observed 25, 75, 6, and 6 times in groups B, C, D, and X, respectively. Out of the total of 398 antibiotics, penicillins (24.9%, n=99) and cephalosporins (24.4%, n=97) were the most frequently used. Respectively, eight and two pDDIs were detected with these drugs. While quinolones were used 47 times (11.8%), 74 pDDIs (59.7%) were identified with quinolones. Out of the 47 patients who used quinolones, 37 had pDDIs with antibiotics. The most frequent pDDI with antibiotics was associated with the use of quinolone systemic corticosteroids (15 patients). The second most prevalent interaction involves quinolone-angiotensin converting enzyme inhibitors or angiotensin 2 receptor blockers (13 patients).</p><p><strong>Conclusion: </strong>Antibiotics should be checked for pDDIs before being prescribed. While beta-lactam antibiotics are generally considered safer in terms of pDDIs, greater caution should be exercised, particularly when prescribing quinolones.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"11 5","pages":"398-405"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}