Northern clinics of Istanbul最新文献

{"title":"Do NEUT-RI, NEUT-GI, RE-LYMP, and AS-LYMP provide diagnostic value in differentiating acute cholecystitis from biliary colic?","authors":"Umit Ozdemir, Selin Yildiz","doi":"10.14744/nci.2026.63904","DOIUrl":"10.14744/nci.2026.63904","url":null,"abstract":"<p><strong>Objective: </strong>In the differential diagnosis of biliary colic and acute cholecystitis, physical examination, non-specific biochemical tests, and imaging methods are used. The aim of this study was to investigate the differential diagnostic power of NEUT-RI, NEUT-GI, RE-LYMP, and AS-LYMP parameters, which show neutrophil and lymphocyte activation, and are obtained with fluorescence flow cytometry during full blood count.</p><p><strong>Methods: </strong>In this prospective cohort study, patients presenting with right upper quadrant pain were separated into two groups according to the diagnoses of acute cholecystitis and biliary colic. The conventional inflammatory markers and the NEUT-RI, NEUT-GI, RE-LYMP, and AS-LYMP values were compared. Receiver Operating Characteristics (ROC) Curve analysis was performed to investigate the diagnostic power of the inflammatory markers.</p><p><strong>Results: </strong>In the acute cholecystitis group, C-reactive protein, white blood cells, neutrophil, monocyte, and immature granulocyte counts were higher, and the lymphocyte count was lower. The NEUT-RI and NEUT-GI values were significantly higher, and the RE-LYMP value was significantly lower in the acute cholecystitis group. The AS-LYMP values were similar in both groups. In the ROC analyses, the AUC values were 0.914 for CRP, 0.842 for WBC, 0.873 for neutrophils, and 0.823 for immature granulocyte count. A poor diagnostic performance was determined for NEUT-RI and NEUT-GI with AUC values of 0.662 and 0.612, respectively. The AUC for RE-LYMP and lymphocyte count was non-significant at <0.6.</p><p><strong>Conclusion: </strong>The results showed that NEUT-RI and NEUT-GI have limited diagnostic power in the differential diagnosis of acute cholecystitis from biliary colic, and RE-LYMP and AS-LYMP are insufficient diagnostically.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"171-178"},"PeriodicalIF":0.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and symptomatology of anemia in young adults: A cross-sectional study.","authors":"Efe Karakaya, Basak Kokdere, Selin Ece Parmaksizoglu, Sevval Rodoplu, Bilge Ada Ozcan, Seyhan Hidiroglu, Muhammet Ozbilen, Gokhan Tazegul","doi":"10.14744/nci.2026.64188","DOIUrl":"10.14744/nci.2026.64188","url":null,"abstract":"<p><strong>Objective: </strong>Anemia is a prevalent public health issue characterized by a reduction in hemoglobin concentration, often accompanied by nonspecific symptoms that overlap with various other medical conditions. Despite its high global and national prevalence, especially among women, the diagnostic value of clinical symptoms in identifying anemia remains uncertain. In this study, we aimed to determine the prevalence of anemia and evaluate the frequency and severity of anemia-related symptoms.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among medical students aged 18-35 between February and May 2025. Participants completed a detailed symptom questionnaire encompassing 44 anemia-related symptoms and underwent capillary hemoglobin measurement. Statistical analyses included group comparisons and regression analyses to explore the association between symptoms and anemia status.</p><p><strong>Results: </strong>A total of 251 participants (150 women, 101 men; median age: 22 Years) were included. The overall prevalence of anemia was 28.3%, significantly higher in women (35.3%) than in men (17.8%, p=0.025). The most frequently reported symptoms among anemic participants included fatigue (87.3%), malaise (85.9%), and attention deficit (78.9%). No statistically significant differences were observed in the frequency or severity of symptoms between anemic (median: 18 Symptoms) and non-anemic participants (median: 19 Symptoms)(all p>0.05). Regression analyses did not identify any predictive model for anemia based on symptomatology.</p><p><strong>Conclusion: </strong>Anemia was found to be prevalent even among young and otherwise healthy individuals. Anemia-related symptoms were common and similar across both anemic and non-anemic participants, suggesting that such nonspecific complaints may reflect underlying physiological processes or nutritional deficiencies rather than anemia alone.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"185-193"},"PeriodicalIF":0.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LuminaConsent: AI-driven standardization and quality enhancement of urological informed consent documentation.","authors":"Ibrahim Topcu, Tuncay Soylu, Muhammed Fatih Simsekoglu, Esra Melis Tuzcu, Zeynep Salman, Perihan Demir, Beyzanur Kac, M Yusuf Kartal, Serhat Suzan, M Ihsan Karaman","doi":"10.14744/nci.2026.93296","DOIUrl":"10.14744/nci.2026.93296","url":null,"abstract":"<p><strong>Objective: </strong>Informed consent is the cornerstone of modern medical ethics, but current documentation systems negatively impact patient autonomy and clinical quality due to deficiencies in readability, comprehensibility, and standardization. These issues hinder patient participation and require innovative solutions. This study introduces the AI-powered LuminaConsent system to address standard deficiencies, comprehensibility issues, and efficiency constraints in urological informed consent documents.</p><p><strong>Methods: </strong>In a three-armed comparative study, LuminaConsent (artificial intelligence), Turkish Urological Surgery Association standard forms, and expert-developed documents were evaluated in 10 urological procedures. The system is based on the RAG architecture, which uses OpenAI's GPT-4o-mini model and a special knowledge base consisting of 12 clinical publications. Three independent urology specialists conducted a blind evaluation using a 100-point scale across five areas: scientific content accuracy, patient communication effectiveness, quality of risk-benefit information, perioperative guidance, and legal-ethical compliance.</p><p><strong>Results: </strong>LuminaConsent achieved higher performance with mean scores of 82.33 points (SD±4.2) versus 78.77 points (SD±6.1) for professional society standards and 57.43 points (SD±3.8) for specialist documentation, representing statistically significant improvements of 43.3% over specialist practices (p<0.001) and 4.5% over professional society standards (p<0.05). The system demonstrated consistent high-quality output across all procedures while generating comprehensive documentation within 96-180 seconds compared to traditional processes requiring multiple days.</p><p><strong>Conclusion: </strong>LuminaConsent offers a pioneering model for systematic AI integration in clinical practice with its evidence-based content generation and bilingual processing capabilities. The findings support the potential to empower patient autonomy, reduce application variations, and improve ethical standards.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"230-242"},"PeriodicalIF":0.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The gut-kidney axis in calcium oxalate nephrolithiasis: Nutritional and microbial insights.","authors":"Mahdi Marzi, Goksel Sener, Tarik Emre Sener","doi":"10.14744/nci.2026.64392","DOIUrl":"10.14744/nci.2026.64392","url":null,"abstract":"<p><p>Calcium oxalate (CaOx) nephrolithiasis is the most common type of kidney stone disease worldwide. Recent studies show that its development cannot be explained solely by renal solute handling; instead, it reflects a broader interaction between dietary habits, the intestinal microbiota, and host metabolic responses. Intestinal absorption of calcium and oxalate-two central drivers of lithogenesis-is shaped by both microbial composition and dietary patterns. Although Oxalobacter formigenes was initially regarded as the main oxalate-degrading organism, newer studies indicate that a wider disturbance of the gut microbiota, especially the loss of short-chain fatty acid (SCFA)-producing species, may increase susceptibility to stone formation. In this review, nutritional, microbial, and mechanistic evidence is brought together to examine how diet-particularly salt, animal protein, calcium, oxalate, fruits, vegetables, and water intake-modulates the gut-kidney axis. Diets high in salt or animal protein tend to shift the microbiota toward more pro-inflammatory and acidogenic profiles, while fiber-rich, plant-based diets and adequate hydration appear to support microbial diversity, SCFA production, and epithelial barrier integrity. Probiotic and synbiotic interventions have also gained attention as potential strategies to reduce stone recurrence by targeting gut microbial function. Taken together, current findings suggest that the gut-kidney axis is a dynamic metabolic link between diet, microbial ecology, and renal physiology. Future studies combining multi-omics methods with personalized nutritional approaches may help develop more effective microbiota-based prevention and treatment strategies for CaOx nephrolithiasis.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"252-262"},"PeriodicalIF":0.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of physical examination, laboratory and radiologic findings in the diagnosis of acute appendicitis.","authors":"Ozgur Ekinci, Furkan Kilic, Muhammet Ali Aydemir, Ihsan Metin Leblebici, Cem Ilgın Erol, Ayse Nur Toksoz Yildirim, Tunc Eren, Hasan Guclu, Orhan Alimoglu","doi":"10.14744/nci.2026.99975","DOIUrl":"10.14744/nci.2026.99975","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the present study was to compare the diagnostic performance of physical examination, routinely used laboratory markers, and radiological imaging modalities in adult patients with suspected acute appendicitis (AA), and to evaluate the relative contribution of each diagnostic tool under real-world clinical conditions.</p><p><strong>Methods: </strong>This prospective observational study included 665 consecutive adult patients who underwent appendectomy for AA. Preoperative laboratory parameters, including white blood cell count, C-reactive protein, neutrophil count, neutrophil percentage, total bilirubin, and indirect bilirubin, were recorded. Radiological findings from computed tomography and ultrasonography were documented. Physical examinations were independently performed without access to laboratory or imaging results by both a general surgery resident and a specialist general surgeon. Physical examination findings were categorized as compatible, suspicious, or incompatible with AA. Histopathological examination of all specimens served as the reference standard.</p><p><strong>Results: </strong>Of the 665 patients, 242 (36.4%) were women, and 423 (63.6%) were men, with a mean age of 34.9±14.2 years. The negative appendectomy rate was 5.8%. Resident physical examination demonstrated the highest sensitivity (95.2%) and overall diagnostic accuracy (88.9%). Among laboratory markers, neutrophil count showed high sensitivity (87.9%), while total and indirect bilirubin demonstrated the highest specificity (89.7% and 94.7%, respectively). Computed tomography achieved a sensitivity of 85.7%, whereas ultrasonography showed lower diagnostic performance, particularly in specificity.</p><p><strong>Conclusion: </strong>Physical examination remains a highly effective diagnostic tool for AA when performed systematically and should be integrated with laboratory and selective imaging rather than replaced by them.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"214-220"},"PeriodicalIF":0.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic ultrasonography-guided biopsy: Radiological and radiometabolic factors affecting diagnostic success.","authors":"Coskun Dogan, Murat Asik, Goksel Menek, Zeynep Nihal Kazci, Nur Karaburun, Gonul Seven Yalcin, Serkan Gungor, Ramazan Guney","doi":"10.14744/nci.2025.92488","DOIUrl":"10.14744/nci.2025.92488","url":null,"abstract":"<p><strong>Objective: </strong>Investigate radiologic and radiometabolic features affecting the diagnostic success of transthoracic biopsy (TTB) procedures guided by Thoracic Ultrasonography (TUS).</p><p><strong>Methods: </strong>The electronic medical records of all patients who underwent TUS-guided TTB procedures (TUS-TBB) were retrospectively reviewed. Patients with a final diagnosis of primary lung cancer (LC), established via TUS-TBB or other diagnostic modalities, were included in the study. The cohort was stratified into two groups: those in whom the TUS-TBB procedure was diagnostic and those in whom it was non-diagnostic. Clinical, demographic, radiological [Chest Computed Tomography (CT)], and radiometabolic (PET-CT) characteristics were compared between the two groups.</p><p><strong>Results: </strong>A total of 107 patients with a final diagnosis of lung cancer were included in the study. Of these, 91 (85%) were male, with a mean age of 67.8±11.4 years. The mean maximum diameter of the mass lesion on chest CT was 68.2±31 millimeters (mm), and the mean maximum standardized uptake value (SUV_max) on PET-CT was 14.1±6.9. A necrotic component/ametabolic area within the lesion on PET-CT was present in 43 (40.2%) patients and absent in 64 (59.8%). The most frequent histopathological subtype was adenocarcinoma, observed in 46 (42.9%) cases. While 41 (38.3%) patients underwent transthoracic fine-needle aspiration biopsy (TTFNAB) under TUS guidance, 66 (61.7%) patients underwent tru-cut biopsy (TCB). The TUS-TBB procedure was diagnostically successful in 87 (81.3%) of the cases. The presence of a necrotic component within the lesion on PET-CT was identified as the sole independent risk factor significantly impacting the diagnostic success of the procedure (p=0.010).</p><p><strong>Conclusion: </strong>TUS-TBB procedures demonstrate high diagnostic success. In carefully selected patients, pre-procedural evaluation of lesion metabolic activity using PET-CT may enhance the diagnostic success of the biopsy.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"139-147"},"PeriodicalIF":0.9,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Metapneumovirus (HMPV): A comprehensive review of its virology, epidemiology, clinical features, and advances in diagnosis and prevention.","authors":"Osman Ozsahin, Arat Hulikyan, Hayriye Kirkoyun Uysal","doi":"10.14744/nci.2025.90422","DOIUrl":"10.14744/nci.2025.90422","url":null,"abstract":"<p><p>Human Metapneumovirus (HMPV) is a leading viral cause of respiratory infections worldwide, particularly affecting children, elderly adults, and immunocompromised individuals. Since its discovery in 2001, HMPV has been recognized as a significant pathogen responsible for both upper and lower respiratory tract infections, often manifesting as bronchiolitis, pneumonia, and wheezing in infants, as well as acute respiratory distress syndrome (ARDS) in older adults and immunocompromised patients. Although it shares clinical features with Respiratory Syncytial Virus (RSV), HMPV is genetically distinct, posing unique challenges for diagnosis, treatment, and prevention. This review provides a comprehensive analysis of HMPV, focusing on its virus structure, genetic makeup, taxonomy, clinical features, and epidemiology. It also explores advances in diagnosis, prevention, and therapeutic strategies, highlighting the urgent need for continued research to address the global burden of HMPV.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"243-251"},"PeriodicalIF":0.9,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of body mass index on progression-free survival and endocrine immune-related adverse events in advanced NSCLC patients treated with nivolumab: A retrospective cohort study.","authors":"Sila Oksuz, Sedat Yildirim, Hacer Sahika Yildiz, Hatice Odabas, Neslihan Buyukmurat, Nedim Turan","doi":"10.14744/nci.2026.65391","DOIUrl":"10.14744/nci.2026.65391","url":null,"abstract":"<p><strong>Objective: </strong>Body mass index (BMI) is a well-established prognostic factor in many cancer types. While BMI has been paradoxically associated with improved outcomes under immune checkpoint inhibitors (ICIs), its role in toxicity risk remains underexplored. This study examines the relationship between BMI and both progression-free survival (PFS) and immune-related adverse events (irAEs) in patients with advanced non-small cell lung cancer (NSCLC) receiving second-line treatment with nivolumab.</p><p><strong>Methods: </strong>This retrospective study examined 305 patients with histologically confirmed stage IV NSCLC who experienced progression after platinum-based chemotherapy. Patients were grouped based on whether their BMI was above or below the median value of 24.8 kg/m². PFS was assessed using Kaplan-Meier analysis. Frequencies of endocrine, hematologic, gastrointestinal, hepatic, and pulmonary toxicities were compared between BMI groups. Statistical significance was set at p<0.05.</p><p><strong>Results: </strong>No statistically significant difference in PFS was observed between BMI groups (<24.8: 7.53 months vs. ≥24.8: 8.30 months, p>0.05). Endocrine irAEs, however, occurred more frequently in patients with a higher BMI (p=0.034). No significant associations were found between BMI and hematologic (p=0.637), hepatic, gastrointestinal, or pulmonary irAEs. BMI was not predictive of PFS but was associated with endocrine toxicity.</p><p><strong>Conclusion: </strong>These findings suggest that BMI may serve as a simple indicator for toxicity risk stratification in immunotherapy settings.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"202-208"},"PeriodicalIF":0.9,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aesthetic perception of head shapes: Exploring awareness, preferences, and implications for surgery.","authors":"Seyda Guray, Ugur Kaan Kalem","doi":"10.14744/nci.2026.56588","DOIUrl":"10.14744/nci.2026.56588","url":null,"abstract":"<p><strong>Objective: </strong>Although much is known about facial aesthetics, the role of head shape remains underexplored. Understanding individuals' awareness, preferences, and interest in cranial aesthetic interventions may guide future approaches.This study aimed to assess Turkish individuals' perception of dolichocephalic, mesocephalic, and brachycephalic head shapes, along with their self-awareness, satisfaction, interest in correction, and preferred methods.</p><p><strong>Methods: </strong>We surveyed 100 participants (52 women, 48 men), excluding healthcare professionals, those with cranial surgery histories, and certain bald men. Preoperative lateral profile photographs of a female and a male facial aesthetic surgery patient were obtained. After measuring biparietal distances and establishing cranial indices, these images were digitally modified to represent each head shape type. Using these images, participants evaluated their head shape, satisfaction, awareness, and preferred interventions if considering surgery. Each participant's cranial index was also objectively measured by adjusting posterior cranial measurements for classification. Statistical analyses (SPSS v22) used chi-square tests (p<0.05).</p><p><strong>Results: </strong>Cranial index analysis showed 53% were brachycephalic. Overall, 65% were satisfied, 18% dissatisfied, and 17% never considered their head shape. Awareness differed significantly between attentive and non-attentive groups (p<0.001). Mesocephalic identification accuracy (87.88%) exceeded brachycephalic (p<0.00001) and dolichocephalic (p<0.000001). Only 11% considered cosmetic correction (p<0.001), with fat transfer preferred by 50% (p=1.0).</p><p><strong>Conclusion: </strong>Head shape influences aesthetic perception. Mesocephalic shapes are favored, while brachycephalic shapes correlate with greater dissatisfaction, potentially raising interest in occipital augmentation. Despite significant awareness differences, low intervention interest suggests the need for broader education and larger, diverse studies to clarify evolving preferences and guide future craniofacial aesthetic practice.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"148-153"},"PeriodicalIF":0.9,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal serum serotonin, serotonin transporter, and umbilical cord arterial serotonin levels in obese versus non-obese pregnancies.","authors":"Subhan Arif Rahman, Yusrawati","doi":"10.14744/nci.2026.86300","DOIUrl":"10.14744/nci.2026.86300","url":null,"abstract":"<p><strong>Objective: </strong>Maternal obesity correlates with metabolic and inflammatory alterations that may affect biomarkers of the serotonin system. Serotonin is also thought to influence the fetal neurobehavioral system. This research analyzed the levels of maternal serum serotonin, maternal serum serotonin transporter (SERT), and umbilical cord arterial serotonin in obese versus non-obese pregnant women.</p><p><strong>Methods: </strong>Maternal serum serotonin, maternal serum serotonin transporter (SERT), and umbilical cord arterial serotonin levels were compared between obese and non-obese pregnant women. A total of pregnant women undergoing cesarean delivery were included. The levels of serotonin and SERT in maternal serum and umbilical cord arterial blood were measured, and statistical analyses were performed to compare the groups.</p><p><strong>Results: </strong>Maternal serum serotonin was higher in the obese group than in the non-obese group (440.34 [275.26-542.40] ng/mL vs 237.00 [167.05-368.36] ng/mL; p=0.003). Umbilical cord arterial serotonin was higher in the obese group (188.17 [101.10-243.36] ng/mL vs 118.19 [64.32-189.71] ng/mL; p=0.019).No significant maternal serum SERT was observed.</p><p><strong>Conclusion: </strong>Obese and non-obese pregnant women undergoing cesarean delivery showed differences in maternal and umbilical cord arterial serotonin levels. No significant difference was observed in maternal serum SERT levels. These findings suggest that maternal obesity affects serotonin biomarkers, which may have implications for fetal neurobehavioral development.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 2","pages":"209-213"},"PeriodicalIF":0.9,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}