Northern clinics of Istanbul最新文献

{"title":"Cytotoxic effect of famotidine in breast adenocarcinoma cells line.","authors":"Mert Kaskal, Oguzcan Kinikoglu, George Zelhof, Emine Kubra Bilir","doi":"10.14744/nci.2026.55899","DOIUrl":"10.14744/nci.2026.55899","url":null,"abstract":"<p><strong>Objective: </strong>Breast cancer remains a leading cause of cancer-related mortality among women worldwide. Famotidine, a histamine H₂-receptor antagonist commonly prescribed for gastric conditions, has demonstrated potential anticancer effects through mechanisms unrelated to acid suppression. The study aims to evaluate the cytotoxic of famotidine on breast adenocarcinoma (MCF)-7 cell line through in vitro assays.</p><p><strong>Methods: </strong>MCF-7 cells were treated with varying concentrations of famotidine (0.364-20 mg/mL) for 24 hours. Cell viability and cytotoxicity were assessed using the MTT assay and Live/Dead fluorescence staining. Morphological changes were evaluated under phase-contrast and fluorescence microscopy. The statistical comparisons were performed using ANOVA statistical analysis.</p><p><strong>Results: </strong>Famotidine treatment resulted in a dose-dependent reduction in cell viability. Higher concentrations (≥5 mg/mL) led to substantial cytotoxicity, with viability falling below 20%. Live/Dead assays confirmed these results, showing increased red (dead cell) fluorescence at higher doses. Morphological analysis revealed change in cell morphology which is consistent with non-specific cytotoxic injury.</p><p><strong>Conclusion: </strong>Famotidine exhibits physiologically cytotoxic effects in MCF-7 breast cancer cells in vitro.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"58-63"},"PeriodicalIF":0.9,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multidimensional tool in disaster medicine: Development of the disaster anxiety scale.","authors":"Fatih Cemal Tekin, Yasemin Durduran, Yusuf Cokunlu","doi":"10.14744/nci.2025.29560","DOIUrl":"10.14744/nci.2025.29560","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop a multidimensional scale to assess disaster-related anxiety, addressing the limitations of generic and disaster-specific anxiety instruments. The new tool, the Multidimensional Disaster Anxiety Scale (MDAS), was designed to enable a comprehensive and practical evaluation of anxiety across all disaster types, with the potential to improve identification of vulnerable groups and inform psychosocial interventions.</p><p><strong>Methods: </strong>The methodological study followed a systematic process: item pool development, pilot testing, data collection, and assessment of reliability and validity. The initial item pool was generated through literature review and expert consultations, resulting in a draft with 30 items. These were reviewed for content validity by multidisciplinary experts, and items with low Content Validity Ratio (CVR) or deemed irrelevant were excluded. The sample, determined as 600 individuals, was selected using the cluster sampling method. After performing the Exploratory Factor Analysis (EFA), the sample was equally divided into two groups in order to collect data for the Confirmatory Factor Analysis (CFA). Statistical analyses included item-total correlations, Cronbach's alpha, split-half reliability, EFA, CFA, composite reliability (CR), and average variance extracted (AVE).</p><p><strong>Results: </strong>After validity and reliability analyses, the MDAS was finalized with 18 items across two subdimensions: Cognitive (Ideational) and Reactive. EFA revealed two factors, accounting for 57.1% of the total variance, with all factor loadings above 0.50. Cronbach's alpha demonstrated high internal consistency for the total scale (0.917), as well as the Cognitive (0.909) and Reactive (0.899) subscales. CFA confirmed the two-factor model with good fit indices (CFI=0.99, TLI=0.99, RMSEA=0.071, SRMR=0.071). CR and AVE values exceeded recommended thresholds for construct reliability and validity. The scale uses a 5-point Likert response format; scores range from 18 to 90, with higher scores indicating greater disaster anxiety.</p><p><strong>Conclusion: </strong>The MDAS is a valid, reliable, and sensitive instrument for the multidimensional assessment of disaster-related anxiety in the general population. Its generic structure allows application across various disaster contexts, supporting its utility in disaster preparedness, response, and recovery phases. The scale facilitates identification of individuals at risk, evaluation of intervention effectiveness, and clinical follow-up after disasters. Future research should further assess its psychometric properties, diagnostic performance, and establish cut-off values for clinical use.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"87-97"},"PeriodicalIF":0.9,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic submucosal dissection in gastrointestinal lesions: Clinical outcomes from a single center.","authors":"Huseyin Aykut, Emin Pala, Suleyman Sayar, Oguzhan Ozturk, Resul Kahraman, Kamil Ozdil","doi":"10.14744/nci.2025.37108","DOIUrl":"10.14744/nci.2025.37108","url":null,"abstract":"<p><strong>Objective: </strong>Endoscopic Submucosal Dissection (ESD) is increasingly utilized for en bloc resection of superficial gastrointestinal neoplasms, providing accurate histopathological evaluation and potential curative treatment. Despite its widespread use in Eastern Asia, clinical data from Turkiye remain limited. In this study, we aimed to retrospectively analyze clinical parameters such as technical success, complication rates, histopathological findings and local recurrence rates observed during follow-up in ESD procedures performed at our center.</p><p><strong>Methods: </strong>We retrospectively analyzed 147 patients who underwent ESD or hybrid ESD at a tertiary center between January 2020 and January 2025. Demographic characteristics, lesion features, procedural outcomes, complications, and follow-up results were evaluated.</p><p><strong>Results: </strong>En bloc resection was achieved in 99.3% of cases, with R0 resection in 93.9%. Invasive adenocarcinoma was detected in 7 patients; 3 patients with invasive adenocarcinoma and 1 patient with incomplete resection were referred for surgery. Intra-procedural complications (mainly bleeding) occurred in 3.4%, while post-procedural complications (post-ESD coagulation syndrome or microperforation) occurred in 4.7%. All complications were managed conservatively, and none required surgery. Median hospital stay was 1 day. Recurrence was rare and successfully managed either endoscopically or surgically.</p><p><strong>Conclusion: </strong>ESD is a safe and effective treatment for superficial gastrointestinal neoplasms in appropriately selected patients when performed by an experienced team. High technical success and low complication rates can be achieved in experienced centers. Future prospective, multicenter studies are warranted to establish standardized ESD practice in Turkiye.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"19-27"},"PeriodicalIF":0.9,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic symptoms in hydatid cyst; common or rare?","authors":"Ozge Atik, Ali Can, Mehmet Gokturk Kaban, Yusuf Kayar","doi":"10.14744/nci.2026.34437","DOIUrl":"10.14744/nci.2026.34437","url":null,"abstract":"<p><strong>Objective: </strong>Hydatid cyst infections may follow a different course, ranging from asymptomatic to life-threatening conditions. The rupture of a hydatid cyst can lead to a variety of allergic reactionsfromurticaria to anaphylactic shock. This study aimed to investigate the frequency and diversity of allergic symptoms in patients with hydatid cysts and to explore their relationship between clinical and laboratory findings.</p><p><strong>Methods: </strong>This study included 106 patients diagnosed with hydatid cysts of the liverbetween January 2017 and February 2024.The demographic characteristics such as age, gender, clinical symptoms and laboratory results were recorded. The characteristics of patients with allergic symptoms were analyzedin addition to cyst rupture.</p><p><strong>Results: </strong>The median age of patients was 33 and 77% were male. Allergic symptoms were present in one out of every ten patients. Allergic symptoms were pruritus in 5 patients, acute urticaria in 2 patients, and anaphylaxis in 3 patients. Only 22% (n=23) of the patients had eosinophilia. The characteristics of ruptured and non-ruptured patients were compared and it was observed that hemoglobin level was lower and γ-glutamyl transferase (GGT) level was higher in ruptured patients (p=0.032, p=0.015 respectively).</p><p><strong>Conclusion: </strong>Although allergic symptoms are not very common in hydatid cysts, life-threatening events such as anaphylaxis may still occur. This risk should always be considered, especially in cysts at risk of rupture.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"64-71"},"PeriodicalIF":0.9,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approach to the treatment of precocious puberty in small-for-gestational-age girls with normal growth catch-up.","authors":"Pinar Atla, Heves Kirmizibekmez, Gulcan Seymen, Fatma Dursun","doi":"10.14744/nci.2025.25478","DOIUrl":"10.14744/nci.2025.25478","url":null,"abstract":"<p><strong>Objective: </strong>Clinical observations show that the development of puberty occurs earlier, and the course is accelerated in children born small for gestational age (SGA) compared to peers born average for gestational age (AGA). The aim of this study was to investigate the response to GnRH analogue (GnRAa) treatment in SGA and AGA girls with central precocious puberty (CPP).</p><p><strong>Methods: </strong>This study included 16 SGA and 137 AGA girls who were receiving GnRHa treatment due to onset of central puberty before the age of eight. SGA group included girls who exhibited normal growth and did not receive growth hormone GH treatment. The response to treatment parameters were compared at the 12^th month and at the end of the treatment.</p><p><strong>Results: </strong>The mean age at the onset of puberty, anthropometric data, bone age, difference between bone age and decimal age were not different between SGA and AGA groups, as well as baseline luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol, stimulated LH and LH/FSH ratio. Height SDS, BMI SDS, and predicted adult height at presentation, at 12^th month and at the end of the treatment were not different in SGA girls. A significant difference was detected only in BMI parameter which increased in 12^th month in AGA girls.</p><p><strong>Conclusion: </strong>The findings of our study indicate that SGA girls with precocious puberty who have achieved growth catch-up and lack additional risk factors require a similar approach to AGA girls when initiating and modifying treatment during the follow-up period.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"45-50"},"PeriodicalIF":0.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Scapular morphometry in Hill-Sachs Lesions-an important step toward individualized instability care.","authors":"Soner Kocak","doi":"10.14744/nci.2026.40221","DOIUrl":"10.14744/nci.2026.40221","url":null,"abstract":"","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"128-129"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Reply.","authors":"Abdullah Ors, Tuncay Colak, Neslihan Buyukmurat, Cengiz Erdemir, Birkan Kibar","doi":"10.14744/nci.2025.32170","DOIUrl":"10.14744/nci.2025.32170","url":null,"abstract":"","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"129"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of mode of delivery on intestinal wall microvascularity in healthy newborns is studied using Superb Microvascular Imaging Doppler technique.","authors":"Gul Arga, Gulten Alioglu, Derya Buyukkayhan, Ali Yikilmaz","doi":"10.14744/nci.2025.77528","DOIUrl":"10.14744/nci.2025.77528","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate whether the mode of delivery influences intestinal microperfusion in healthy term neonates and to evaluate the utility of Superb Microvascular Imaging (SMI) in assessing neonatal intestinal microcirculation.</p><p><strong>Methods: </strong>A total of 45 healthy term neonates born between 38 and 40 weeks of gestation were prospectively enrolled. Twenty-six infants were delivered by cesarean section (C/S) and 19 by normal spontaneous vaginal delivery (NSVD). Intestinal microperfusion was assessed within the first 48 hours of life using monochrome SMI (mSMI) and color SMI (cSMI). Conventional Doppler techniques, including Color Doppler Imaging (CDI), Power Doppler Imaging (PDI), and Advanced Dynamic Flow (ADF), were also performed. Intestinal vascularity was semi-quantitatively scored and compared between groups.</p><p><strong>Results: </strong>No significant difference in intestinal microperfusion was observed between neonates delivered by C/S and NSVD using either mSMI (p=0.507) or cSMI (p=0.720). Similarly, no significant differences were detected using CDI, PDI, or ADF. However, mSMI demonstrated significantly higher detection of intestinal vascularity compared to cSMI (p<0.0001) and conventional Doppler modalities, which failed to detect vascular signals in a substantial proportion of cases.</p><p><strong>Conclusion: </strong>Mode of delivery does not appear to significantly affect early intestinal microperfusion in healthy term neonates. Superb Microvascular Imaging, particularly mSMI, provides a sensitive and non-invasive method for visualizing neonatal intestinal microcirculation. These findings support the potential role of SMI in establishing reference perfusion patterns and in the early detection of gastrointestinal perfusion abnormalities in neonates.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"51-57"},"PeriodicalIF":0.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of short and long-term outcomes of intracorporeal vs extracorporeal anastomosis in laparoscopic right hemicolectomy for colon cancer: A multicentric study.","authors":"Ersin Gundogan, Yunus Emre Altuntas, Selcuk Kaya, Murat Alkan, Fikri Kundes, Fatih Sumer, Gokcen Alinak Gundogan, Sedat Carkit, Metin Kement, Cuneyt Kayaalp","doi":"10.14744/nci.2025.67424","DOIUrl":"10.14744/nci.2025.67424","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate and compare the short- and long-term outcomes of intracorporeal versus extracorporeal anastomosis techniques in patients who underwent laparoscopic right hemicolectomy for colon cancer.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients who underwent laparoscopic right colectomy between January 2012 and June 2017 at two different centers. Groups were compared based on demographic data, preoperative clinical features, intraoperative and postoperative variables, pathological findings, and long-term follow-up outcomes.</p><p><strong>Results: </strong>The study included n=50 patients, with n=24 assigned to the intracorporeal anastomosis group and n=26 to the extracorporeal group. Intraoperative assessment showed that the intracorporeal group had significantly lower estimated blood loss (47±31.1 vs. 92.9±63.8 mL, p=0.01) and shorter total incision length (8.6±5.2 vs. 22.8±13.1 cm, p=0.001). During the early postoperative period, earlier oral intake (2.2±1.4 vs. 4±1.1 days, p=0.001) and shorter hospital stay (5.3±2.1 vs. 7.9±3.2 days, p=0.01) were observed in the intracorporeal group, while ıntensive care unit (ICU) stay was longer (1.1±0.4 vs. 0.3±0.6 days, p=0.001). Pathological evaluation confirmed adequate lymph node dissection (≥12 nodes) in all patients; however, the extracorporeal group demonstrated a higher total lymph node yield (31.9±13.3 vs. 23.3±7.3, p=0.04).</p><p><strong>Conclusion: </strong>Intracorporeal anastomosis in laparoscopic right hemicolectomy may provide certain perioperative benefits, including lower intraoperative blood loss, faster return to oral intake, and reduced hospitalization time. Despite this, the extracorporeal technique yielded a higher number of harvested lymph nodes, although oncological adequacy was achieved in both groups.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"113-117"},"PeriodicalIF":0.9,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of family physicians' knowledge about scabies: An example from a district in Istanbul.","authors":"Merve Yuzbasioglu, Bekir Aktura, Nazli Caf, Cansu Erden Cengiz, Hulya Akan","doi":"10.14744/nci.2025.39112","DOIUrl":"10.14744/nci.2025.39112","url":null,"abstract":"<p><strong>Objective: </strong>Scabies is a highly contagious and itchy skin disease that poses a public health problem due to its high prevalence in developing and underdeveloped countries. The aim of this study is to assess the knowledge level of family physicians working in a district of Istanbul regarding scabies and to identify their current awareness level and educational needs.</p><p><strong>Methods: </strong>This descriptive, cross-sectional study was conducted between August 1, 2023, and August 1, 2024. The population consisted of 123 active family physicians, and 103 volunteers participated in the study. Participants completed a 27-item online questionnaire assessing their sociodemographic characteristics and knowledge level regarding scabies. Data were analyzed using IBM SPSS 27.0 software. Categorical variables were compared using the chi-square test, with p<0.05 considered statistically significant.</p><p><strong>Results: </strong>The mean age of participants was 38.99±10.98 years, and 67% were female. 97.1% of physicians had previously seen a scabies case, and 88.3% had experience with >10 cases. The average knowledge score was 10.4±1.61 (min. 7- max. 13). 63.8% of physicians had a satisfactory level of knowledge. 59.2% of participants knew that scabies could be transmitted through sexual contact, 41.7% knew that it could not be transmitted from pets, and 95.1% knew about the use of 5% topical permethrin in treatment. Physicians with ≥10-case experience showed significantly higher accuracy regarding uncomplicated scabies treatment (p=0.01).</p><p><strong>Conclusion: </strong>Although family physicians' general knowledge level about scabies is acceptable, there are deficiencies in the transmission routes and treatment details. Increasing the knowledge level through online and face-to-face training organized within the scope of continuing medical education will improve early diagnosis and treatment success.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"98-104"},"PeriodicalIF":0.9,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}