{"title":"全层直肠活检诊断巨结肠疾病：单一中心13年的经验。","authors":"Neslihan Gulcin, Furkan Ersoy, Gurkan Erkoc, Ali Ihsan Anadolulu, Meltem Caglar, Sidika Seyma Ozkanli, Cigdem Ulukaya Durakbasa","doi":"10.14744/nci.2025.97455","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>An experience regarding full-thickness rectal biopsies (FTRB) indications and results is presented.</p><p><strong>Methods: </strong>The records of patients who underwent FTRB between January 2010 and January 2022 were retrospectively reviewed.</p><p><strong>Results: </strong>107 patients were included. There were 66 men (61.6%) and 41 women (38.3%). The median age at biopsy was 15 (1-196) months. FTRB was performed in 81 patients who were unable to pass meconium in the first 48 hours or had intractable constipation. A stoma was performed in 26 patients before the rectal biopsy. Contrast colon radiography was conducted in 61 patients and/or anorectal manometry in 32 patients. Of the biopsies, 74 were full-thickness while 33 were not. Biopsies were repeated in 12 patients. Of the 49 (45%) patients with aganglionic specimens, data about nerve hypertrophy was reported in 37. Among these, 33 had nerve hypertrophy and 4 did not. A definitive surgery was performed in 44 of the 49 patients diagnosed with Hirschsprung disease (HD). Complications were observed in 7 (6.5%) of the patients.</p><p><strong>Conclusion: </strong>HD was histopathologically diagnosed. Biopsies that are not full-thickness can be of value when using immunohistochemistry stains.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 1","pages":"138-143"},"PeriodicalIF":0.9000,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364466/pdf/","citationCount":"0","resultStr":"{\"title\":\"Full-thickness rectal biopsies in diagnosis of Hirschsprung disease: 13 years of experience of a single center.\",\"authors\":\"Neslihan Gulcin, Furkan Ersoy, Gurkan Erkoc, Ali Ihsan Anadolulu, Meltem Caglar, Sidika Seyma Ozkanli, Cigdem Ulukaya Durakbasa\",\"doi\":\"10.14744/nci.2025.97455\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>An experience regarding full-thickness rectal biopsies (FTRB) indications and results is presented.</p><p><strong>Methods: </strong>The records of patients who underwent FTRB between January 2010 and January 2022 were retrospectively reviewed.</p><p><strong>Results: </strong>107 patients were included. There were 66 men (61.6%) and 41 women (38.3%). The median age at biopsy was 15 (1-196) months. FTRB was performed in 81 patients who were unable to pass meconium in the first 48 hours or had intractable constipation. A stoma was performed in 26 patients before the rectal biopsy. Contrast colon radiography was conducted in 61 patients and/or anorectal manometry in 32 patients. Of the biopsies, 74 were full-thickness while 33 were not. Biopsies were repeated in 12 patients. Of the 49 (45%) patients with aganglionic specimens, data about nerve hypertrophy was reported in 37. Among these, 33 had nerve hypertrophy and 4 did not. A definitive surgery was performed in 44 of the 49 patients diagnosed with Hirschsprung disease (HD). Complications were observed in 7 (6.5%) of the patients.</p><p><strong>Conclusion: </strong>HD was histopathologically diagnosed. Biopsies that are not full-thickness can be of value when using immunohistochemistry stains.</p>\",\"PeriodicalId\":94347,\"journal\":{\"name\":\"Northern clinics of Istanbul\",\"volume\":\"12 1\",\"pages\":\"138-143\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2025-02-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364466/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Northern clinics of Istanbul\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14744/nci.2025.97455\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Northern clinics of Istanbul","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14744/nci.2025.97455","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Full-thickness rectal biopsies in diagnosis of Hirschsprung disease: 13 years of experience of a single center.
Objective: An experience regarding full-thickness rectal biopsies (FTRB) indications and results is presented.
Methods: The records of patients who underwent FTRB between January 2010 and January 2022 were retrospectively reviewed.
Results: 107 patients were included. There were 66 men (61.6%) and 41 women (38.3%). The median age at biopsy was 15 (1-196) months. FTRB was performed in 81 patients who were unable to pass meconium in the first 48 hours or had intractable constipation. A stoma was performed in 26 patients before the rectal biopsy. Contrast colon radiography was conducted in 61 patients and/or anorectal manometry in 32 patients. Of the biopsies, 74 were full-thickness while 33 were not. Biopsies were repeated in 12 patients. Of the 49 (45%) patients with aganglionic specimens, data about nerve hypertrophy was reported in 37. Among these, 33 had nerve hypertrophy and 4 did not. A definitive surgery was performed in 44 of the 49 patients diagnosed with Hirschsprung disease (HD). Complications were observed in 7 (6.5%) of the patients.
Conclusion: HD was histopathologically diagnosed. Biopsies that are not full-thickness can be of value when using immunohistochemistry stains.
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