Full-thickness rectal biopsies in diagnosis of Hirschsprung disease: 13 years of experience of a single center.

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Northern clinics of Istanbul Pub Date : 2025-02-05 eCollection Date: 2025-01-01 DOI:10.14744/nci.2025.97455

Neslihan Gulcin, Furkan Ersoy, Gurkan Erkoc, Ali Ihsan Anadolulu, Meltem Caglar, Sidika Seyma Ozkanli, Cigdem Ulukaya Durakbasa

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Abstract

Objective: An experience regarding full-thickness rectal biopsies (FTRB) indications and results is presented.

Methods: The records of patients who underwent FTRB between January 2010 and January 2022 were retrospectively reviewed.

Results: 107 patients were included. There were 66 men (61.6%) and 41 women (38.3%). The median age at biopsy was 15 (1-196) months. FTRB was performed in 81 patients who were unable to pass meconium in the first 48 hours or had intractable constipation. A stoma was performed in 26 patients before the rectal biopsy. Contrast colon radiography was conducted in 61 patients and/or anorectal manometry in 32 patients. Of the biopsies, 74 were full-thickness while 33 were not. Biopsies were repeated in 12 patients. Of the 49 (45%) patients with aganglionic specimens, data about nerve hypertrophy was reported in 37. Among these, 33 had nerve hypertrophy and 4 did not. A definitive surgery was performed in 44 of the 49 patients diagnosed with Hirschsprung disease (HD). Complications were observed in 7 (6.5%) of the patients.

Conclusion: HD was histopathologically diagnosed. Biopsies that are not full-thickness can be of value when using immunohistochemistry stains.

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全层直肠活检诊断巨结肠疾病：单一中心13年的经验。

目的：介绍直肠全层活检（FTRB）的适应症和结果。方法：回顾性分析2010年1月至2022年1月间行FTRB的患者资料。结果：纳入107例患者。男性66例（61.6%），女性41例（38.3%）。活检时的中位年龄为15（1-196）个月。对81例在48小时内无法排出胎便或有顽固性便秘的患者进行了FTRB。26例患者在直肠活检前行造口术。61例患者行结肠造影，32例患者行肛肠测压。在活检中，74例为全层切片，33例为非全层切片。12例患者重复活检。在49例（45%）有神经节标本的患者中，37例报告了神经肥大的数据。其中神经肥大33例，无神经肥大4例。确诊为巨结肠病（HD）的49例患者中有44例进行了最终手术。7例（6.5%）患者出现并发症。结论：HD经组织病理学诊断。当使用免疫组织化学染色时，非全层活检是有价值的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Northern clinics of Istanbul

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