Northern clinics of Istanbul最新文献

{"title":"Assessment of retinal and hearing impairments related to microvascular dysfunction in metabolic syndrome.","authors":"Emel Cetinkaya, Sema Basat, Yasar Sertbas, Meltem Sertbas","doi":"10.14744/nci.2025.82258","DOIUrl":"10.14744/nci.2025.82258","url":null,"abstract":"<p><strong>Objective: </strong>Metabolic syndrome (MetS) is a global health issue linked to both macrovascular and emerging microvascular complications. This study aimed to assess microvascular complications of MetS, including retinopathy and hearing loss.</p><p><strong>Methods: </strong>This cross-sectional study included 102 adults (70 with MetS, 32 controls) from an internal medicine clinic. Participants underwent metabolic profiling and standardized eye and hearing evaluations, including fundoscopy, audiometry, and symptom screening. Sensory complications were analyzed in relation to MetS and its components using regression models.</p><p><strong>Results: </strong>Retinal abnormalities were more common in the MetS group (50%) than in controls (18.7%) (p=0.007), with hypertension as the only independent predictor (OR=2.623, p=0.022). Sensorineural hearing loss affected 23.5% of participants and was linked to higher metabolic burden (p=0.038), though age and male sex were the main predictors. Tinnitus was more frequent in MetS patients (19% vs. 3%) (p=0.059), with triglycerides independently predicting its risk (OR=1.006, p=0.021). Vertigo occurred in 11.4% of MetS patients but not in controls (p=0.054), with hypertension showing borderline significance (OR=7.311, p=0.065).</p><p><strong>Conclusion: </strong>Metabolic syndrome, particularly hypertension and dyslipidemia, is associated with increased risk of retinopathy, hearing loss, tinnitus, and vertigo. These findings suggest systemic metabolic dysfunction may impair microvascular structures in the eye and inner ear. Routine sensory screening in MetS patients may enable early detection and prevention.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"8-18"},"PeriodicalIF":0.9,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review of de novo oligometastatic breast cancer: Current treatment options, surgical outcomes, and systemic therapy.","authors":"Bulent Citgez, Banu Yigit, Emir Capkinoglu","doi":"10.14744/nci.2025.96237","DOIUrl":"10.14744/nci.2025.96237","url":null,"abstract":"<p><p>De novo metastatic breast cancer (dnMBC) represents a biologically diverse malignancy, manifesting with variable clinical trajectories. While systemic therapy (ST) constitutes the primary modality in its treatment paradigm, the role of locoregional interventions such as surgery and radiotherapy is increasingly being explored, particularly in patients with oligometastatic breast cancer. This subset, defined by a limited number of metastatic sites, may follow a less aggressive course and thus become candidates for intensified multimodal therapeutic strategies. Although locoregional treatment (LRT) alone does not offer a curative outcome in the metastatic setting, it can provide meaningful benefits in terms of local disease control, palliation of symptoms, and overall improvement in quality of life. The survival benefit associated with surgical removal of the primary tumor in dnMBC remains a subject of ongoing investigation, with current evidence yielding inconclusive results regarding its effect on overall survival. Nevertheless, a range of individual parameters including the biological characteristics of the tumor, the extent of metastatic spread, response to ST, and the patient's overall functional status play a decisive role in guiding therapeutic choices. Employing a multidisciplinary framework is crucial to appropriately select patients who are most likely to benefit from the addition of LRT as part of an integrated treatment approach.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"13 1","pages":"118-127"},"PeriodicalIF":0.9,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of diuretic infusion in saline for percutaneous nephrostomy in non-dilated renal collecting systems: A single-center experience.","authors":"Ali Dablan, Omer Altun, Fatma Zeynep Arslan, Cagri Erdim, Ilhan Nahit Mutlu, Ozgur Kilickesmez","doi":"10.14744/nci.2023.23356","DOIUrl":"10.14744/nci.2023.23356","url":null,"abstract":"<p><strong>Objective: </strong>In this retrospective study, we aimed to investigate the etiology, success, and complication rate of percutaneous nephrostomy (PCN) in patients with non-dilated renal collecting system (NCT) using saline and diuretic agents.</p><p><strong>Methods: </strong>PCN was performed on 62 kidneys from 35 patients with NCT. Prior to the procedure, a combination of saline and furosemide infusion was administered. Several parameters were evaluated, including pre- and post-procedure levels of creatinine and blood urea nitrogen, fluoroscopy time, total air kerma (TAK), dose area product (DAP), puncture number, success rate, and complication rate.</p><p><strong>Results: </strong>Fistula was the most common etiology and was detected in 29 out of 62 kidneys. The other most common cause was ureteral injury, detected in 21 out of 62 kidneys. The success rate of our procedures was 96.7%, and the rate of minor complications was 1.7%. Transient macroscopic hematuria was one of the minor complications observed in one patient. No major complications were observed. During each procedure, the average number of needle passes was 1.44±0.5 (range: 1-3). The average duration of the complete procedure was 13.17±6.46 minutes (range: 8-31 minutes). The mean fluoroscopy time was 2.37 minutes (range: 0.8-11.6 minutes). In terms of radiation exposure, the mean DAP was 166.94±148.5 μGy•m² (range: 3.93-666.59 μGy•m²) with a median of 127.04 μGy•m², and the cumulative dose (TAK) was 72.43 mGy (range: 12-342 mGy) with a median of 42.05 mGy, respectively.</p><p><strong>Conclusion: </strong>Diuretic infusion in saline is a safe and beneficial method for PCN in NCT. With its low complication rate and high success rate, PCN provides rapid treatment for various etiologies with the potential to address conditions such as fistula, ureteral injury, and urosepsis in the collecting system, which may otherwise have devastating consequences.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 1","pages":"62-68"},"PeriodicalIF":0.9,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of magnesium prophylaxis in children with migraine without aura.","authors":"Elif Yuksel Karatoprak, Ceren Melis Ozkan, Mustafa Safa Tural, Seyma Sonmez Sahin","doi":"10.14744/nci.2025.64296","DOIUrl":"10.14744/nci.2025.64296","url":null,"abstract":"<p><strong>Objective: </strong>Migraine is one of the prevalent types of primary headache disorders in children and significantly affects their quality of life. Although pharmacological prophylaxis is often necessary, conventional treatments are frequently limited by adverse effects and modest efficacy. Magnesium, a vital intracellular cation involved in numerous neuronal and vascular functions, has been proposed as a safer alternative. However, data on its use in pediatric migraine remain limited. To investigate the effectiveness and safety profile of magnesium oxide prophylaxis in children diagnosed with migraine without aura.</p><p><strong>Methods: </strong>This retrospective study included pediatric patients aged 7-18 years with a diagnosis of migraine without aura, treated exclusively with magnesium oxide at a dosage of 6-9 mg/kg/day or a fixed dose of 365 mg/day for four months. Headache frequency, migraine-related disability (assessed by PedMIDAS), and quality of life (measured by HIT-6) were evaluated before and after four months of prophylaxis.</p><p><strong>Results: </strong>Following magnesium prophylaxis, a statistically significant reduction was observed in headache frequency, PedMIDAS scores, and HIT-6 scores (p<0.001 for all). Additionally, disability levels according to PedMIDAS grading improved significantly. No participants reported side effects during the study.</p><p><strong>Conclusion: </strong>Magnesium oxide appears to be a well-tolerated, safe, and potentially effective prophylactic option for children with migraine without aura. It was associated with a significant reduction in attack frequency, disability scores, and improved quality of life. Despite promising results, the absence of a control group and serum magnesium data are notable limitations. Further prospective, randomized controlled studies are required to confirm these findings and establish the most effective dosage, duration, and formulation of magnesium for pediatric use.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 6","pages":"724-729"},"PeriodicalIF":0.9,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of levetiracetam monotherapy on thyroid function in pediatric epilepsy patients.","authors":"Gulcan Seymen, Busra Isin Kutlubay","doi":"10.14744/nci.2025.43789","DOIUrl":"10.14744/nci.2025.43789","url":null,"abstract":"<p><strong>Objective: </strong>Childhood epilepsy requires long-term antiepileptic drug (AED) therapy, and its potential endocrine effects are a critical consideration. While the impact of AEDs on thyroid function is well documented in adults, data on pediatric populations remain scarce. Levetiracetam (LEV), a broad-spectrum AED widely prescribed for children, has an unclear influence on thyroid function. This study aims to evaluate the effects of LEV on thyroid function in children with epilepsy.</p><p><strong>Methods: </strong>A retrospective observational study was conducted at the Pediatric Neurology Clinic of Umraniye Hospital between 2020 and 2022. One hundred pediatric patients, aged 2.3 to 18 years, diagnosed with epilepsy and using LEV monotherapy for at least 12 months were included. Thyroid-stimulating hormone (TSH) and free thyroxine (fT4) levels were measured at baseline and at 3, 6, and 12 months. Statistical analyses were performed using paired t-tests, with a p-value <0.05 considered statistically significant.</p><p><strong>Results: </strong>The mean TSH levels increased from 1.46±0.3 mIU/L at baseline to 1.60±0.3 mIU/L at 12 months (p=0.0017). Despite the statistically significant rise, TSH levels remained within normal reference ranges, and no clinically significant hypothyroidism was observed. Changes in fT4 levels were not statistically significant, except for a borderline increase at 12 months (p=0.05). Four patients exhibited transient TSH elevations but did not require thyroid hormone replacement therapy.</p><p><strong>Conclusion: </strong>LEV monotherapy does not appear to significantly impact thyroid function in pediatric epilepsy patients. While a slight but statistically significant increase in TSH levels was observed, these changes were clinically insignificant. These findings suggest that LEV is a safe option regarding thyroid function in children with epilepsy. Further long-term prospective studies are warranted to confirm these results.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 6","pages":"707-711"},"PeriodicalIF":0.9,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic and histopathological findings in children with growth retardation.","authors":"Melike Arslan","doi":"10.14744/nci.2025.67790","DOIUrl":"10.14744/nci.2025.67790","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to describe the clinical characteristics, endoscopic and histopathological findings of children admitted to the paediatric gastroenterology outpatient clinic for growth retardation.</p><p><strong>Methods: </strong>The study was carried out with 90 patients aged 2-18 years who presented to our paediatric gastroenterology outpatient clinic with complaints of growth retardation and underwent oesophagogastroduodenoscopy (EGD) because growth retardation persisted despite adequate caloric support (at least 3 months).</p><p><strong>Results: </strong>The mean age of the patients was 11.11±4.27 years, 56 (62.2%) were female and 52 (57.8%) were under 12 years of age. Of the patients, 36.7% had mild, 47.8% moderate and 15.6% severe acute malnutrition, 22.2% stunting and 7.8% severe stunting. Associated dyspeptic symptoms were present in 34 (37.8%) patients and celiac antibodies were positive in 20 (22.2%) patients. Iron deficiency was present in 28.9% and B12 deficiency in 41.1% of the patients. The most common endoscopic findings were pangastritis (88.9%), duodenitis (61.1%), bile reflux (35.6%) and bulbitis (31.1%). Chronic Helicobacter pylori (H. pylori) gastritis was found in 72.2%, celiac disease in 20.0% and reflux oesophagitis in 17.8% of the patients. No association was found between chronic H. pylori gastritis and iron deficiency anaemia and vitamin B12 deficiency (p=0.90, p=0.89). There was no association between chronic H. pylori gastritis and height-for-age, weight-for-height and BMI z scores (0.31, 0.57, 0.43).</p><p><strong>Conclusion: </strong>In this study, positive endoscopic findings were found in all children with persistent growth retardation despite adequate caloric support, even in the absence of accompanying dyspeptic symptoms. More studies evaluating the usefulness of endoscopy in children with growth retardation are needed.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 6","pages":"719-723"},"PeriodicalIF":0.9,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal echocardiography: A nine-year experience at a single tertiary center.","authors":"Oyku Tosun","doi":"10.14744/nci.2025.79346","DOIUrl":"10.14744/nci.2025.79346","url":null,"abstract":"<p><strong>Objective: </strong>Fetal echocardiography is a vital diagnostic tool used during pregnancy to evaluate the structure and function of the fetal heart. It allows for the early detection of congenital heart diseases (CHDs) and fetal arrhythmias, enabling timely prenatal counseling, perinatal planning, and therapeutic interventions when necessary. While routine obstetric ultrasounds may detect basic structural anomalies, fetal echocardiography provides more detailed anatomical and functional information, particularly in high-risk pregnancies. This study presents a nine-year experience of fetal echocardiography at a tertiary center, focusing on diagnostic accuracy, clinical contribution, and postnatal outcomes.</p><p><strong>Methods: </strong>We retrospectively analyzed 405 fetuses who underwent fetal echocardiography between March 2016 and March 2025. All evaluations were performed by an experienced pediatric cardiologist using standard imaging protocols. Fetal cardiac findings and postnatal confirmation data were assessed.</p><p><strong>Results: </strong>Major structural cardiac anomalies were identified in 48 fetuses (11.9%), with the most common being Tetralogy of Fallot and Transposition of the Great Arteries. Minor findings such as echogenic intracardiac focus, premature atrial contractions, and small ventricular septal defects (VSDs) were seen in 104 cases (25.7%). Significant arrhythmias, including supraventricular tachycardia and complete heart block, were detected in 14 cases (3.5%).</p><p><strong>Conclusion: </strong>Fetal echocardiography is a reliable, non-invasive method for the early and accurate diagnosis of fetal cardiac anomalies. It facilitates appropriate prenatal referral and postnatal care planning, ultimately improving neonatal outcomes.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 6","pages":"712-718"},"PeriodicalIF":0.9,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo antioxidant and anti-inflammatory effects of Myrtus communis against ionizing radiation-induced gastrointestinal injury: TROD-GROG-002 study.","authors":"Melisa Bagci Kilic, Melike Pekyurek Varan, Ozum Atasoy, Nagehan Ozyilmaz, Seren Ede Pazarbasi, Busra Ertas, Ali Sen, Cemile Ceylan, Tugba Tunali Akbay, Feriha Ercan, Beste Melek Atasoy","doi":"10.14744/nci.2025.89588","DOIUrl":"10.14744/nci.2025.89588","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the in vivo radioprotective effects of Myrtus communis (MC) on the gastrointestinal system.</p><p><strong>Methods: </strong>A total of 30 female rats were divided into four groups: i) Control; ii) irradiation (IR) only; iii) MC-pretreated; and iv) MC-treated. The rats received oral MC extract (100 mg/kg/day) for 4 days before exposure to 10 Gy IR or continued until sacrifice. On the fourth day of IR exposure, the rats were sacrificed, and histopathological and biochemical analyses were performed on the ileum, pancreas, and liver tissues.</p><p><strong>Results: </strong>Malondialdehyde and myeloperoxidase levels decreased in both MC-treated groups, while glutathione levels and Na⁺-K⁺-ATPase activity increased (p<0.01), with significant histopathological improvements compared to the IR-only group.</p><p><strong>Conclusion: </strong>The results of this study demonstrate that MC significantly decreases ionizing radiation-induced oxidative and inflammatory damage in the gastrointestinal systems of rats. Therefore, it may be regarded as a new candidate with radioprotective potential for future clinical application.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 6","pages":"730-738"},"PeriodicalIF":0.9,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave ablation for hepatocellular carcinoma: A single-center experience and outcomes.","authors":"Mustafa Demir, Mehmet Taha Avci, Abdulbaki Agackiran, Sevdenur Emir, Aylin Acar, Tolga Canbak","doi":"10.14744/nci.2025.34101","DOIUrl":"10.14744/nci.2025.34101","url":null,"abstract":"<p><strong>Objective: </strong>Microwave ablation (MWA) has emerged as a minimally invasive treatment for hepatocellular carcinoma (HCC), offering a promising alternative for patients ineligible for surgical resection. This study aims to evaluate the efficacy, safety, and clinical outcomes of MWA in a single-center cohort, focusing on treatment success, recurrence rates, and long-term survival.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 54 patients who underwent percutaneous ultrasound-guided MWA for HCC between January 2019 and December 2023. Patient demographics, tumor characteristics, and procedural outcomes were assessed. Treatment success was defined as complete ablation confirmed by contrast-enhanced imaging one month post-procedure. Local tumor progression (LTP) and recurrence rates were evaluated during follow-up. Survival outcomes were analyzed based on follow-up data, considering overall survival and recurrence-free survival rate.</p><p><strong>Results: </strong>A total of 71 tumors were treated in 54 patients. Complete ablation was achieved in 91.5% of tumors following the initial or secondary procedure. LTP was observed in 16.6% of patients during follow-up. No major complications were reported. The median follow-up period was 36 months, and survival outcomes were comparable to those reported for other ablative techniques. No statistically significant correlation was found between tumor size and ablation success (p>0.05).</p><p><strong>Conclusion: </strong>MWA is an effective and safe treatment modality for HCC, demonstrating high technical success and acceptable recurrence rates. These findings support the continued integration of MWA in multidisciplinary HCC management, particularly for patients ineligible for surgery. Further research with larger cohorts and longer follow-up is needed to optimize patient selection and refine ablation strategies.</p>","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 6","pages":"700-706"},"PeriodicalIF":0.9,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug intoxications in the emergency department: Our 1-year experience.","authors":"Ersoy Oksuz, Bilgehan Demir","doi":"10.14744/nci.2025.23855","DOIUrl":"10.14744/nci.2025.23855","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Drug intoxication (DRI), which occurs due to accidental or suicidal use of high doses of drugs, has a high mortality and morbidity rate. emergency departments of hospitals are the units where these patients first come to the hospital, where the first interventions are performed and where the mortality rate is higher than other departments. therefore, DRI is a more important health problem for the emergency department (ED) than other departments of hospitals. In this study, we aimed to retrospectively investigate the demographic characteristics, drugs used and clinical course of patients admitted to the ED of our hospital with the diagnosis of DRI.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Patients admitted to the ED of Malatya Training and Research Hospital with the diagnosis of DRI were retrospectively screened from the hospital database. The patients' demographic characteristics, medications and clinical conditions were recorded. Patients over the age of 18 years who were diagnosed with DRI and whose medicationuse was identified were included in this study. Patients under the of 18 and those poisoned by other substances such as alcohol, illegal chemicals, or agricultural pesticides were excluded.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Demographic characteristics, type of intoxication and clinical course of the patients included in the study are shown in Table 1. In 2023, 282 patients were admitted to the emergency department of our hospital with the diagnosis of DRI. Of these, 60% were women and 40% were men (n=170, n=112, respectively) and there was no statistically significant difference between the numbers of men and women (p=0.156). Fifteen percent of the women were over 50 years of age and 85% were under 50 years of age. this ratio was 55% to 45% in men. there was no statistically significant difference in the age distribution between men and women (p=0.246, p=0.260, respectively), (Table 1). 77% of the patients used overdose drugs for suicidal purposes and 23% accidentally (n=217, n=65, respectively). There was no statistically significant difference in the type of DRI, total number of males and females and age distribution (p=0.26). While 60% of the patients were hospitalized, 25% were admitted to intensive care unit and 35% to service (n=70, n=100, respectively). There were statistically significantly more patients admitted to service (p=0.03).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The results of our study show that the number of female patients admitted to the ED of our hospital with the diagnosis of DRI, patients under 50 years of age and suicidal use are higher, the most commonly used drugs in these patients are NSAIDs, SSRIs and antipyschotics as a drug group and drugs used in psychiatric disorders. Our study has shown that frequently used and easily accessible drugs are more likely to be abused, and that questioning such drugs, especially in patients presenting to the emergency service with drug intoxication in this regi","PeriodicalId":94347,"journal":{"name":"Northern clinics of Istanbul","volume":"12 6","pages":"690-693"},"PeriodicalIF":0.9,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}