评估克里门刚果出血热患者的流行病学、临床、实验室和治疗特点:十年分析结果。

Northern clinics of Istanbul Pub Date : 2024-06-25 eCollection Date: 2024-01-01 DOI:10.14744/nci.2023.09815
Mustafa Arslan, Senol Comoglu
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引用次数: 0

摘要

目标:克里米亚-刚果出血热(CCHF克里米亚-刚果出血热(CCHF)是一种由蜱虫传播的病毒性人畜共患病,病程急且严重,可伴有发热、出血、肌肉酸痛、头痛、腹泻、虚弱和类似的非特异性症状。本研究旨在根据地区、流行病学、临床、实验室和治疗特点,确定该病流行的阿马西亚省的 CCHF 病例分布情况:回顾性评估了 2013 年 1 月至 2023 年 1 月期间本诊所收治的 88 例 18 岁以上 CCHF 病例的特征。通过扫描患者档案,获得患者的年龄、性别、职业、居住地区、蜱虫接触史、疾病潜伏期、疾病发展期(月、年)、住院时间、症状、体格检查和实验室检查结果、应用的血液制品替代疗法、康复和死亡状况等人口统计学数据:88 例患者的平均年龄(± 标准差)为 48±18 岁,其中 53 例(60.2%)为男性。患者中有 68 人(77.3%)从事农业和畜牧业,79 人(89.7%)居住在村庄和村落。塔索瓦区的发病率最高,有 29 名患者(32.9%)。6 月是最常见的发病月份,有 31 例(35.2%)患者。入院时最常见的症状是疲劳,比例为 93%。其他症状包括肌痛和关节痛(83.2%)、发热(65%)、头痛(64.4%)、恶心呕吐(43.5%)、结膜充血(35.2%)和腹泻(21.7%)。在临床随访中,有 15 例(17.04%)患者漏诊出血。入院时,血小板减少(92%)、白细胞减少(84.1%)、天门冬氨酸氨基转移酶和丙氨酸氨基转移酶(86.3%)、肌酐磷酸激酶(71.6%)和乳酸脱氢酶(76.1%)水平升高。所有患者均未接受利巴韦林治疗。3名患者的死亡率为3.40%:结论:阿马西亚及其所有地区都是慢性阻塞性肺疾病的流行区。在我省的春夏季节,应询问门诊,尤其是急诊中发热主诉患者的蜱虫接触史和农牧业职业。如果在这些患者中发现血小板减少症,则应注意慢性阻塞性肺病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of epidemiological, clinical, laboratory and treatment characteristics of Crimen Congo hemorrhagic fever patients: Results of a 10-year analysis.

Objective: Crimean-Congo hemorrhagic fever (CCHF) is a viral zoonosis transmitted by ticks and may have an acute and severe course with fever, bleeding, muscle aches, headache, diarrhea, weakness, and similar non-specific symptoms. This study aimed to determine the distribution of CCHF cases in Amasya province, which is endemic for this disease, according to districts, epidemiological, clinical, laboratory, and treatment characteristics.

Methods: The characteristics of 88 CCHF cases over 18 who were admitted to our clinic and treated between January 2013 and January 2023 were evaluated retrospectively. Demographic data such as age, gender, occupation, district of residence, history of tick contact, the incubation period of the disease, period of development of the disease (months, years), length of hospital stay, symptoms, physical examination and laboratory findings, blood product replacement therapies applied, recovery and mortality status of the patients were reached by scanning the patient files.

Results: The mean age (±standard deviation) of 88 cases was 48±18 years, and 53 (60.2%) were male. Of the patients, 68 (77.3%) were engaged in farming and animal husbandry, and 79 (89.7%) lived in villages and hamlets. Tasova district had the highest frequency of cases, with 29 (32.9%) patients. June was the most common month for the disease, with 31 (35.2%) cases. The most common symptom on admission was fatigue, with a rate of 93%. Other symptoms included myalgia and arthralgia (83.2%), fever (65%), headache (64.4%), nausea-vomiting (43.5%), conjunctival hyperemia (35.2%), and diarrhea (21.7%). In clinical follow-up, bleeding was missed in 15 (17.04%) patients. On admission to the hospital, there were elevated levels of thrombocytopenia (92%), leukopenia (84.1%), aspartate aminotransferase and alanine aminotransferase (86.3%), creatinine phosphokinase (71.6%), and lactate dehydrogenase (76.1%). None of the patients were given ribavirin treatment. Our mortality rate was 3.40% with three patients.

Conclusion: Amasya is an endemic area for CCHF with all its districts. In our province's spring and summer months, tick contact history and the farming-livestock profession should be questioned in patients with fever complaints in clinic admissions, especially emergency services. In the case of the detection of thrombocytopenia in these patients, CCHF should be kept in mind.

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