Baseline macular structural and vascular changes as predictive markers of visual improvement in central retinal vein occlusion.

Northern clinics of Istanbul Pub Date : 2025-04-24 eCollection Date: 2025-01-01 DOI:10.14744/nci.2025.26932
Ulviye Kivrak, Guzide Akcay
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Abstract

Objective: This study aims to evaluate the changes in posterior segment parameters that affect visual prognosis in patients with central retinal vein occlusion (CRVO).

Methods: This retrospective study included 58 eyes of 58 CRVO patients. Best-corrected visual acuity (BCVA), intraocular pressure, central macular thickness (CMT), hyperreflective foci (HRF), ellipsoid zone (EZ) loss, disorganization of retinal inner layers (DRIL), intraretinal cystic changes, posterior vitreous detachment (PVD), and macular superficial and deep vascular density (VD), as well as superficial and deep foveal avascular zone (FAZ) areas, were assessed at baseline and 3 months follow-up after treatment. The treatments (intravitreal injections and laser) received were recorded.

Results: The mean age was 63.02±9.91 years, 37 (63.8%) were female, and 39 (67.3%) were classified as having non-ischemic CRVO. The mean baseline BCVA was 0.64±0.85 logMAR; at 3 months, it improved to 0.39±0.65 logMAR (p<0.001). The mean baseline CMT was 478.9±82.6 µm, and at 3 months, it reduced to 288.56±72.39 µm (p<0.001). At baseline, HRF in 31% of eyes, EZ disruption in 44.8% of eyes, DRIL in 17.2% of eyes, intraretinal cysts in 55.2% of eyes, and PVD in 43.1% of eyes. A significant decrease in BCVA was observed in patients with EZ loss (p<0.001), while the presence of intraretinal cysts had significant impact on CMT (p=0.007). Furthermore, a statistically significant negative correlation was observed between foveal and superior VD in both the superficial and deep capillary plexus (SCP, DCP) and changes in BCVA (logMAR). In contrast, a positive correlation was found between superficial FAZ area and BCVA (logMAR). Additionally, a statistically significant positive correlation was noted between foveal VD in both the SCP and DCP and changes in CMT.

Conclusion: The study emphasizes the importance of structural and vascular changes in predicting functional outcomes and suggests the utility of optical coherence tomography (OCT) and OCT angiography in early visual prognosis and treatment planning.

基线黄斑结构和血管变化作为视网膜中央静脉闭塞视力改善的预测标志。
目的:探讨视网膜中央静脉阻塞(CRVO)患者后段参数变化对视力预后的影响。方法:对58例CRVO患者58只眼进行回顾性研究。在基线和治疗后3个月随访时评估最佳矫正视力(BCVA)、眼压、黄斑中心厚度(CMT)、高反射灶(HRF)、椭球区(EZ)丧失、视网膜内层紊乱(DRIL)、视网膜内囊性改变、玻璃体后脱离(PVD)、黄斑浅深血管密度(VD)以及浅深中央凹无血管区(FAZ)区域。记录玻璃体内注射和激光治疗。结果:平均年龄63.02±9.91岁,女性37例(63.8%),非缺血性CRVO 39例(67.3%)。平均基线BCVA为0.64±0.85 logMAR;结论:本研究强调了结构和血管变化对预测功能结局的重要性,并提示光学相干断层扫描(OCT)和OCT血管造影在早期视觉预后和治疗计划中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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