Nuclear receptor protein: REV-ERB.

Northern clinics of Istanbul Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI:10.14744/nci.2023.49225
Mahmud Esad Pence
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Abstract

REV-ERB α/β proteins play critical roles in circadian rhythm regulation and are considered to be specialized members of the nuclear receptor family. These so-called "orphan" proteins, whose endogenous ligands were initially unidentified, have become exogenously interferable through synthetic agents with the discovery of their endogenous ligands. This feature has made them an important target for clinical research in recent years. Unlike other nuclear receptors, the unique structure of REV-ERB proteins allows them to perform only transcription inhibition, which makes them even more intriguing. This review summarizes the structural features of REV-ERB α/β proteins and their role in the circadian cycle. We also discuss findings in the literature on the function of REV-ERB α/β proteins in the metabolic and immune systems, emphasizing their importance in these systems.

核受体蛋白:REV-ERB。
REV-ERB α/β蛋白在昼夜节律调节中起关键作用,被认为是核受体家族的特殊成员。这些所谓的“孤儿”蛋白,其内源性配体最初是不确定的,随着内源性配体的发现,已经通过合成剂成为外源性可干扰的。这一特点使其成为近年来临床研究的重要对象。与其他核受体不同,REV-ERB蛋白的独特结构允许它们只执行转录抑制,这使它们更加有趣。本文综述了REV-ERB α/β蛋白的结构特征及其在昼夜周期中的作用。我们还讨论了有关REV-ERB α/β蛋白在代谢和免疫系统中的功能的文献发现,强调了它们在这些系统中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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