单剂量富血小板血浆和透明质酸治疗膝关节骨关节炎的比较分析:一项为期12周的随访研究。

Northern clinics of Istanbul Pub Date : 2025-04-22 eCollection Date: 2025-01-01 DOI:10.14744/nci.2024.89587
Caglar Karabas, Ezgi Akyildiz Tezcan
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引用次数: 0

摘要

目的:骨关节炎(OA)是一种普遍和致残的关节疾病,影响全球数百万人,特别是膝关节,并且它的治疗选择有限。富血小板血浆(PRP)和透明质酸(HA)已成为有前途的关节内治疗方法。本研究旨在比较单剂量PRP和HA在12周的随访期间对膝关节OA患者疼痛、功能和僵硬的影响。方法:对2021年12月至2022年6月期间接受单剂量关节内HA或PRP治疗的64例膝关节OA患者进行回顾性分析。使用视觉模拟量表(VAS)和西安大略大学和麦克马斯特大学骨关节炎指数(WOMAC)评分评估疼痛和功能结局。采用李克特量表评估患者满意度。进行适当的统计分析来比较治疗结果和结果:在12周的随访期间,PRP和HA治疗均显著改善了疼痛、功能和僵硬。两组VAS疼痛评分均显著降低,但HA组降低幅度更大。此外,HA组在第4周时的WOMAC身体功能评分有明显改善(p=0.047)。结论:本研究是对膝关节OA的PRP和HA治疗文献的又一新颖贡献,其中我们强调了单剂量HA在减轻疼痛和增强身体功能方面的潜在益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative analysis of single-dose platelet-rich plasma and hyaluronic acid therapies in knee osteoarthritis: A 12-week follow-up study.

Objective: Osteoarthritis (OA) is a prevalent and disabling joint condition that affects millions worldwide, particularly in the knee joint, and it presents limited therapeutic options. Platelet-rich plasma (PRP) and hyaluronic acid (HA) have emerged as promising intra-articular treatments. This study aimed to compare the effects of single-dose PRP and HA on pain, functionality, and stiffness in patients with knee OA over a 12-week follow-up period.

Methods: A retrospective analysis was conducted on 64 patients who underwent single-dose intra-articular HA or PRP treatment for knee OA between December 2021 and June 2022. Pain and functional outcomes were assessed using the Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores. Patient satisfaction was evaluated using a Likert scale. Appropriate statistical analyses were performed to compare treatment outcomes and p<0.05 was considered statistically significant.

Results: Both PRP and HA treatments led to significant improvements in pain, functionality, and stiffness over the 12-week follow-up period. VAS pain scores decreased significantly in both groups, but a greater reduction was observed in the HA group. Additionally, the HA group exhibited superior improvement in the WOMAC physical function score at the 4-week mark (p=0.047).

Conclusion: This study is another novel contribution to the growing literature on treatment of PRP and HA treatments for knee OA, where we highlighted the potential benefits of single-dose HA in alleviating pain and enhancing physical function.

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