European heart journal. Imaging methods and practice最新文献

{"title":"Comprehensive 4D-flow cardiac magnetic resonance evaluation of the descending thoracic aorta in aortic regurgitation.","authors":"J Urmeneta Ulloa, A Álvarez Vázquez, V Martínez de Vega, L Martínez de Vega, C Andreu-Vázquez, I J Thuissard-Vasallo, M Recio Rodríguez, J A Cabrera","doi":"10.1093/ehjimp/qyaf002","DOIUrl":"10.1093/ehjimp/qyaf002","url":null,"abstract":"<p><strong>Aims: </strong>To assess the reproducibility of 4D-Flow cardiac magnetic resonance (CMR) parameters in the descending thoracic aorta-DTAo-(regurgitant fraction [RF], end-diastolic reverse flow [EDRF], and holodiastolic flow reversal [HDR]), and the relationship with RF in the sinotubular junction (STJ), and the left ventricular end-diastolic volume index (LVEDVI) in patients with chronic aortic regurgitation (AR).</p><p><strong>Methods and results: </strong>A descriptive study of these variables was conducted. A receiver operating characteristic curve was used to determine the optimal cut-off point. Thirty patients had severe AR (RF ≥ 30%, STJ) and 60 mild-to-moderate (RF < 30%). The mean age was 59 ± 17 years. Left ventricular ejection fraction (LVEF) was 56% (53-61%) and LVEDVI was 94 (76-128) mL/m². Flow in the DTAo at the left inferior pulmonary vein (LIPV) was easily identifiable and measurements were highly reproducible. The intraclass correlation coefficient was 0.969 (95% CI: 0.954-0.980) for RF and 0.929 (95% CI: 0.893-0.952) for EDRF. Flow parameters measured at the LIPV were all significantly greater in the severe AR group: RF (21% vs. 6%, <i>P</i> < 0.001), EDRF (20 vs. 4 mL/s; <i>P</i> < 0.001), and HDR (20% vs. 8%; <i>P</i> < 0.001). Three parameters-presence of HDR, RF ≥ 17%, and EDRF ≥ 7 mL/s at the LIPV-were associated with RF ≥ 30% in the STJ and elevated LVEDVI.</p><p><strong>Conclusion: </strong>4D-flow CMR can reproducibly assess flow in the DTAo in patients with chronic AR. An RF ≥ 17%, EDRF ≥ 7 mL/s, and/or the presence of HDR in the DTAo (LIPV) were associated with an RF ≥ 30% in STJ and elevated LVEDVI.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf002"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac manifestations of autosomal dominant polycystic kidney disease.","authors":"Franja Dugar, Maurice Pradella, Arnheid Kessel-Schaefer, Paul Kettnaker, Philip Haaf","doi":"10.1093/ehjimp/qyaf003","DOIUrl":"https://doi.org/10.1093/ehjimp/qyaf003","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf003"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Ex vivo</i> imaging of subacute myocardial infarction with ultra-short echo time 3D quantitative T₁- and T_1<i>ρ</i> -mapping magnetic resonance imaging in mice.","authors":"Iida Räty, Antti Aarnio, Mikko J Nissi, Sanna Kettunen, Anna-Kaisa Ruotsalainen, Svetlana Laidinen, Seppo Ylä-Herttuala, Elias Ylä-Herttuala","doi":"10.1093/ehjimp/qyae131","DOIUrl":"10.1093/ehjimp/qyae131","url":null,"abstract":"<p><strong>Aims: </strong>The aim of this study was to develop an ultra-short echo time 3D magnetic resonance imaging (MRI) method for imaging subacute myocardial infarction (MI) quantitatively and in an accelerated way. Here, we present novel 3D T₁- and T_1<i>ρ</i> -weighted Multi-Band SWeep Imaging with Fourier Transform and Compressed Sensing (MB-SWIFT-CS) imaging of subacute MI in mice hearts <i>ex vivo</i>.</p><p><strong>Methods and results: </strong>Relaxation time-weighted and under-sampled 3D MB-SWIFT-CS MRI were tested with manganese chloride (MnCl₂) phantom and mice MI model. MI was induced in C57BL mice, and the hearts were collected 7 days after MI and then fixated. The hearts were imaged with T₁ and adiabatic T_1<i>ρ</i> relaxation time-weighted 3D MB-SWIFT-CS MRI, and the contrast-weighted image series were estimated with a locally low-rank regularized subspace constrained reconstruction. The quantitative parameter maps, T₁ and T_1<i>ρ</i> , were then obtained by performing non-linear least squares signal fitting on the image estimates. For comparison, the hearts were also imaged using 2D fast spin echo-based T₂ and T_1<i>ρ</i> mapping methods. The relaxation rates varied linearly with the MnCl₂ concentration, and the T₁ and T_1<i>ρ</i> relaxation time values were elevated in the damaged areas. The ischaemic areas could be observed visually in the 3D T₁, 3D T_1<i>ρ</i> , and 2D MRI maps. The scar tissue formation in the anterior wall of the left ventricle and inflammation in the septum were confirmed by histology, which is in line with the results of MRI.</p><p><strong>Conclusion: </strong>MI with early fibrosis, increased inflammatory activity, and interstitial oedema were determined simultaneously with T₁ and T_1<i>ρ</i> relaxation time constants within the myocardium by using the 3D MB-SWIFT-CS method, allowing quantitative isotropic 3D assessment of the entire myocardium.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyae131"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning model to diagnose cardiac amyloidosis from haematoxylin/eosin-stained myocardial tissue.","authors":"Takeshi Tohyama, Takeshi Iwasaki, Masataka Ikeda, Masato Katsuki, Tatsuya Watanabe, Kayo Misumi, Keisuke Shinohara, Takeo Fujino, Toru Hashimoto, Shouji Matsushima, Tomomi Ide, Junji Kishimoto, Koji Todaka, Yoshinao Oda, Kohtaro Abe","doi":"10.1093/ehjimp/qyae141","DOIUrl":"10.1093/ehjimp/qyae141","url":null,"abstract":"<p><strong>Aims: </strong>Amyloid deposition in myocardial tissue is a definitive feature for diagnosing cardiac amyloidosis, though less invasive imaging modalities such as bone tracer cardiac scintigraphy and cardiac magnetic resonance imaging have been established as first steps for its diagnosis. This study aimed to develop a deep learning model to support the diagnosis of cardiac amyloidosis from haematoxylin/eosin (HE)-stained myocardial tissue.</p><p><strong>Methods and results: </strong>This single-centre retrospective observational study enrolled 166 patients who underwent myocardial biopsies between 2008 and 2022, including 76 patients diagnosed with cardiac amyloidosis and 90 with other diagnoses. A deep learning model was developed to output the probabilities of cardiac amyloidosis for all the small patches cutout from each myocardial specimen. The developed model highlighted the area in the stained images as highly suspicious, corresponding to where Dylon staining marked amyloid deposition, and discriminated the patches in the evaluation dataset with an area under the curve of 0.965. Provided that the diagnostic criterion for cardiac amyloidosis was defined as a median probability of cardiac amyloidosis >50% in all patches, the model achieved perfect performance in discriminating patients with cardiac amyloidosis from those without it, with an area under the curve of 1.0.</p><p><strong>Conclusion: </strong>A deep learning model was developed to diagnose cardiac amyloidosis from HE-stained myocardial tissue accurately. Although further prospective validation of this model using HE-stained myocardial tissues from multiple centres is needed, it may help minimize the risk of missing cardiac amyloidosis and maximize the utility of histological diagnosis in clinical practice.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyae141"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haemodynamic and hyperaemic effects of adenosine in patients with atrial fibrillation undergoing quantitative myocardial perfusion cardiovascular magnetic resonance.","authors":"Simran Shergill, Charley A Budgeon, Mohamed Elshibly, Peter Kellman, Anvesha Singh, Gerry P McCann, Gaurav S Gulsin, J Ranjit Arnold","doi":"10.1093/ehjimp/qyae127","DOIUrl":"10.1093/ehjimp/qyae127","url":null,"abstract":"<p><strong>Aims: </strong>Patients with atrial fibrillation (AF) are thought to have an attenuated response to adenosine during vasodilator stress testing. We sought to investigate the haemodynamic and hyperaemic effects of adenosine in patients with AF undergoing adenosine-stress cardiovascular magnetic resonance (CMR) assessment.</p><p><strong>Methods and results: </strong>We retrospectively examined 318 patients referred for clinical adenosine-stress CMR (AF <i>n</i> = 158, sinus rhythm [SR] <i>n</i> = 160). Baseline and peak heart rate (HR) and quantitative myocardial perfusion were compared between groups. At peak stress, the haemodynamic response was blunted in patients with AF (HR increase 7 ± 10bpm vs. 17 ± 11bpm in SR, <i>P</i> < 0.001). Fewer patients in AF met the threshold for a satisfactory HR response ≥10bpm (40% in AF vs. 76% in SR, <i>P</i> < 0.001). There were no intergroup differences in hyperaemic myocardial blood flow (1.52 ± 0.65 mL/min/g in AF vs. 1.55 ± 0.65 mL/min/g in SR, <i>P</i> = 0.670) or myocardial perfusion reserve (2.66 ± 1.11 in AF vs. 2.66 ± 1.08 in SR, <i>P</i> = 0.981). AF (odds ratio [OR], 0.29 [0.17-0.50], <i>P</i> < 0.001) and left ventricular ejection fraction (OR 1.03 [1.00-1.05], <i>P</i> = 0.023) were independently associated with achieving a satisfactory HR response on multivariable analysis, but only ejection fraction (OR 1.05 [1.02-1.09], <i>P</i> = 0.003) predicted a satisfactory hyperaemic response.</p><p><strong>Conclusion: </strong>The heart rate response during adenosine-stress CMR is blunted in AF patients. Despite this, the majority of patients with AF generate a sufficient hyperaemic response with a standard adenosine-stress protocol. Further work is needed to determine the diagnostic accuracy of adenosine-stress CMR in patients with AF.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae127"},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison between 64-projection and 32-projection myocardial perfusion scintigraphy.","authors":"Seyed Mohammad Abedi, Erfan Ghadirzadeh, Hanie Karimi, Pedram Nezhadnaderi, Seyede Sepide Daryabari, Amir Moradi, Alireza Khorrami Moghaddam, Seyed Jalal Hosseinimehr, Morteza Taghavi, Samad Golshani, Ali Asghar Farsavian, Alireza Mardanshahi, Ali Mostafavinia","doi":"10.1093/ehjimp/qyae142","DOIUrl":"10.1093/ehjimp/qyae142","url":null,"abstract":"<p><strong>Aims: </strong>While most clinical guidelines recommend using a 64-projection view technique, some protocols do not specify a preference between 32-projection and 64-projection methods for conducting myocardial perfusion scintigraphy (MPS), which shows the lack of consensus in this matter. Nevertheless, these guidelines and protocols have not provided us with compelling evidence to support why the 64-projection technique is usually chosen. Thus, we aimed to determine if there is a significant difference between them in the assessment of cardiac perfusion and functional indices.</p><p><strong>Methods and results: </strong>Sixty-nine patients were included in this pilot prospective, cross-sectional, cross-over, same patient control protocol study and underwent 32- and 64-projection MPS at both stress and rest phases after injecting 740-925 MBq of 99mTc-MIBI for every patient. Then, cardiac indices, including summed stress, rest, and difference scores, extent-stress and rest, left ventricular volumes and ejection-fraction, peak filling rate (PFR), and time to peak filling rate (TTPF) were recorded. Lin's concordance correlation coefficient was used to assess the agreement between protocols, and a paired sample <i>t</i>-test was used to compare the means of variables where appropriate. Findings revealed no significant difference as well as excellent/good agreement between the two methods in either the stress or rest state, except for the TTPF and PFR.</p><p><strong>Conclusion: </strong>The findings suggest that lower-projection techniques could be adequate for routine clinical assessments without sacrificing diagnostic accuracy. However, the poor agreement for PFR and TTPF indicates that the 32-projection method may not reliably assess diastolic function, implying that the 64-projection protocol is preferable when precise evaluations are necessary.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyae142"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between adverse childhood experiences and adult cardiac function in the UK Biobank.","authors":"Juan C Quiroz, Jackie Cooper, Celeste McCracken, Mohammed Y Khanji, Liliana Laranjo, Nay Aung, Aaron Mark Lee, Judit Simon, Theodore Murphy, Luca Biasiolli, Stefan K Piechnik, Pal Maurovich-Horvat, Steffen E Petersen, Zahra Raisi-Estabragh","doi":"10.1093/ehjimp/qyae139","DOIUrl":"10.1093/ehjimp/qyae139","url":null,"abstract":"<p><strong>Aims: </strong>The importance of early life factors in determining health in later adulthood is increasingly recognized. This study evaluated the association of adverse childhood experiences (ACEs) with cardiovascular magnetic resonance (CMR) phenotypes.</p><p><strong>Methods and results: </strong>UK Biobank participants who had completed CMR and the self-reported questionnaire on traumatic childhood experiences were included. Images were analysed using automated pipelines to extract measures of left and right ventricular (LV and RV) structure and function, myocardial character, and arterial compliance. Multivariable linear regression was used to estimate the association of childhood adversity with CMR phenotypes adjusting for age, sex, deprivation, education, obesity, smoking, alcohol intake, exercise level, diabetes, hypertension, and hypercholesterolaemia. Amongst 30 814 participants analysed, 6023 (19.5%) experienced physical abuse, 2746 (8.9%) sexual abuse, 4685 (15.2%) emotional abuse, 6822 (22.1%) emotional neglect, and 4534 (14.7%) physical neglect. Except for physical abuse, women reported greater rates of childhood adversity than men. Collectively, all types of childhood adversity were associated with smaller LV and RV volumes, greater LV mass, a concentric pattern of LV remodelling, poorer LV and RV function, lower aortic compliance, and greater arterial stiffness. Sexual abuse was associated with unhealthy CMR phenotypes in age- and sex-adjusted models, but these relationships were attenuated in fully adjusted models. Physical neglect had the most prominent pattern of adverse cardiovascular remodelling.</p><p><strong>Conclusion: </strong>ACEs were associated with unhealthy cardiovascular remodelling in adulthood, independent of traditional cardiovascular risk factors. These findings support the consideration of early life factors in cardiovascular disease risk assessment.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae139"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex endocarditis in a young patient.","authors":"Marie-Luise Dikou, Abigail Gowland, Sara Volpi, Julia Grapsa, Gianluca Lucchese","doi":"10.1093/ehjimp/qyae132","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae132","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyae132"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aberration correction-impact on image quality and chamber quantification in transthoracic echocardiography.","authors":"Erik Andreas Rye Berg, Torvald Espeland, Håvard Dalen, Bjørnar Grenne, Tore Grüner Bjåstad, Espen Holte, Svein-Erik Måsøy","doi":"10.1093/ehjimp/qyae140","DOIUrl":"10.1093/ehjimp/qyae140","url":null,"abstract":"<p><strong>Aims: </strong>To improve image quality (IQ) in echocardiography, an aberration correction (AC) algorithm has recently been implemented in commercial scanners. We aimed to study (i) the correlation of a subjective IQ-score and an objective IQ-metric [global image coherence (GIC)], (ii) if AC improved IQ; (iii) if AC affected average values and interobserver agreement of left ventricular (LV) size, LV longitudinal strain, and left atrial (LA) volume.</p><p><strong>Methods and results: </strong>From 50 adult patients, where 45 (90%) had cardiovascular disease, unprocessed image data (channel data) were acquired from six standard transthoracic views. The data were processed with and without AC, resulting in 300 pairs of cine-loops. The cine-loops were randomly presented one-by-one to two blinded raters experienced in echocardiography. Both raters scored IQ subjectively from 1 (poor) to 4 (very good) and quantified LV dimensions, volumes and longitudinal strain, and LA volume. IQ-score correlated with GIC, Spearman <i>rho</i> 0.72, <i>P</i> < 0.001. AC improved median IQ-score from 2.5 to 3.0 (Wilcoxon signed rank: <i>P</i> < 0.001). The differences in average values of LV size, LV longitudinal strain, or LA volume with and without AC were not statistically significant and numerically minimal. Measured by intraclass correlation, interobserver agreement of these values was not significantly affected by AC.</p><p><strong>Conclusion: </strong>Image quality-score strongly correlated with GIC. Aberration correction improved IQ. However, AC did not lead to statistically significant changes in average values or interobserver agreement of LV size, LV longitudinal strain or LA volume quantification. Likely, the major benefit of AC is enhanced visualization of anatomical details.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyae140"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of valvular regurgitation by transthoracic 3D high pulse repetition frequency Doppler echocardiography.","authors":"Erik Andreas Rye Berg, Stefano Fiorentini, Jørgen Avdal, Bjørnar Grenne, Knut Haakon Stensæth, Peter Thomas While, Torvald Espeland, Rune Wiseth, Hans Torp, Svend Aakhus","doi":"10.1093/ehjimp/qyae138","DOIUrl":"10.1093/ehjimp/qyae138","url":null,"abstract":"<p><strong>Aims: </strong>To improve quantification of valvular regurgitation, a 3D high-pulse repetition frequency Doppler (3D HPRFD) method was developed for regurgitant volume (RVol) estimation from transthoracic echocardiography (TTE). Although successfully applied <i>in vitro</i> and in selected clinical cases, a systematic clinical validation of 3D HPRFD has not been published. Hence, our aims were to investigate (i) feasibility of 3D HPRFD and (ii) correlation between 3D HPRFD and RVol estimates obtained by the 2D proximal isovelocity surface area (PISA) method and cardiac magnetic resonance (CMR) in patients with either aortic regurgitation (AR) or mitral regurgitation (MR).</p><p><strong>Methods and results: </strong>We included 45 patients with AR (42% mild, 40% moderate, and 18% severe) and 45 with MR (67% mild, 24% moderate, and 9% severe). Median time between start of TTE and start of CMR was 1.5 h, minimizing changes in load. Overall feasibility of 3D HPRFD was 56% in AR and 44% in MR. Feasibility was only 25% in patients with severe regurgitation. In AR, estimated RVol from 3D HPRF did not correlate with estimated RVol from PISA or CMR [Spearman <i>rho</i> = 0.06 (<i>P</i> = 0.78) and 0.04 (<i>P</i> = 0.4), respectively]. In MR, RVol estimates from 3D HPRFD correlated with PISA (<i>rho</i> = 0.72, <i>P</i> < 0.001) but not with CMR (<i>rho</i> = 0.31, <i>P</i> = 0.43).</p><p><strong>Conclusion: </strong>Regurgitant volume estimation by 3D HPRFD had a low feasibility, especially in severe regurgitation, and in general correlated poorly with PISA and CMR estimates. In its current state, 3D HPRFD is not ready for clinical use.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae138"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}