Dan M Dorobantu, Curtis A Wadey, Ben Berryman, Nurul H Amir, Lynsey Forsythe, A Graham Stuart, Guido E Pieles, Craig A Williams
{"title":"A new protocol for a single-stage combined cardiopulmonary and echocardiography exercise test: a pilot study.","authors":"Dan M Dorobantu, Curtis A Wadey, Ben Berryman, Nurul H Amir, Lynsey Forsythe, A Graham Stuart, Guido E Pieles, Craig A Williams","doi":"10.1093/ehjimp/qyae021","DOIUrl":"10.1093/ehjimp/qyae021","url":null,"abstract":"<p><strong>Aims: </strong>The value of cardiopulmonary exercise testing (CPET) and exercise stress echocardiography (ESE) in managing cardiac disease is well known, but no standard CPET-ESE protocol is currently recommended. This pilot study aims to compare feasibility and cardiac function responses between a new high-intensity single-stage combined test (CPET-hiESE) and a standard maximal ESE (smESE).</p><p><strong>Methods and results: </strong>After screening and maximal CPET, all volunteers (<i>n</i> = 21) underwent three ESE modalities: (i) based on the gas exchange threshold (hiESE-GET, 40% of peak-GET, 6 min), (ii) based on heart rate (HR) (hiESE-HR, 80% of peak HR, 6 min), and (iii) smESE (85% of predicted peak HR for age, 3 min). Speckle tracking echocardiography (STE) and tissue Doppler imaging (TDI) were measured at each step. There was superior image quality and data completeness for the right ventricle strain for both hiESE modalities compared with smESE (71.4 and 76.2 vs. 42.9%, <i>P</i> = 0.07). Left ventricular STE data completeness was similar for all three conditions. Despite systematically higher HR, work rate and levels of exertion in the smESE compared with hiESE, STE and TDI parameters were not systematically different. Concordance correlation coefficients ranged from 0.56 to 0.88, lowest for strain rate parameters and mean difference from -0.34 to 1.53, highest for TDI measurements.</p><p><strong>Conclusion: </strong>The novel CPET-hiESE protocol allowed for better data completeness, at lower levels of exertion compared with smESE, without systematically different cardiac reserve measurements in healthy participants. This single-stage protocol can be individualized to clinical populations, which would provide practical advantages to standard testing.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11195695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roberta Lo Giudice, Alessia Gimelli, Marianna Venditti
{"title":"Enhancing cardiovascular imaging department efficiency through robust quality systems and effective risk management.","authors":"Roberta Lo Giudice, Alessia Gimelli, Marianna Venditti","doi":"10.1093/ehjimp/qyae012","DOIUrl":"10.1093/ehjimp/qyae012","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11195758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amro Sehly, Albert He, Jacob Agris, John Konstantopoulos, Jack Joyner, Julien Flack, Simon Kwok, Benjamin J W Chow, Brian Ko, Michael Ridner, Abdul Rahman Ihdayhid, Girish Dwivedi
{"title":"Deep learning-based computed tomography quantification of left ventricular mass.","authors":"Amro Sehly, Albert He, Jacob Agris, John Konstantopoulos, Jack Joyner, Julien Flack, Simon Kwok, Benjamin J W Chow, Brian Ko, Michael Ridner, Abdul Rahman Ihdayhid, Girish Dwivedi","doi":"10.1093/ehjimp/qyad043","DOIUrl":"10.1093/ehjimp/qyad043","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11195721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
YuZhi Phuah, Ying Xin Tan, Sheref Zaghloul, Sharmaine Sim, Joshua Wong, Saba Usmani, Lily Snell, Karish Thavabalan, Carmen Lucia García-Pérez, Niraj S Kumar, Hannah Glatzel, Reubeen Rashid Ahmad, Luciano Candilio, Jonathan J H Bray, Mahmood Ahmed, Rui Providencia
{"title":"A systematic review and meta-analysis of transthoracic echocardiogram vs. cardiac magnetic resonance imaging for the detection of left ventricular thrombus.","authors":"YuZhi Phuah, Ying Xin Tan, Sheref Zaghloul, Sharmaine Sim, Joshua Wong, Saba Usmani, Lily Snell, Karish Thavabalan, Carmen Lucia García-Pérez, Niraj S Kumar, Hannah Glatzel, Reubeen Rashid Ahmad, Luciano Candilio, Jonathan J H Bray, Mahmood Ahmed, Rui Providencia","doi":"10.1093/ehjimp/qyad041","DOIUrl":"10.1093/ehjimp/qyad041","url":null,"abstract":"<p><p>Transthoracic echocardiography (TTE) is the most commonly used imaging modality to diagnose left ventricular thrombus (LVT), however, cardiac magnetic resonance (CMR) remains the gold standard investigation. A comparison of the diagnostic performance between two modalities is needed to inform guidelines on a diagnostic approach towards LVT. We performed a systematic review and meta-analysis to investigate the diagnostic performance of three methods of TTE (non-contrast, contrast, and apical wall motion scoring) for the detection of LVT compared to CMR as a reference test. Studies comprising 2113 patients investigated for LVT using both TTE and CMR were included in the meta-analysis. For non-contrast TTE, pooled sensitivity and specificity were 47% [95% confidence interval (CI): 32-62%], and 98% (95% CI: 96-99%), respectively. In contrast, TTE pooled sensitivity and specificity values were 58% (95% CI: 46-69%), and 98% (95% CI: 96-99%), respectively. Apical wall motion scoring on non-contrast TTE yielded a sensitivity of 100% [95% CI: 93-100%] and a specificity of 54% (95% CI: 42-65%). The area under the curve (AUC) values from our summary receiver operating characteristic curve (SROC) for non-contrast and contrast TTE were 0.87 and 0.86 respectively, with apical wall motion studies having the highest AUC of 0.93. Despite high specificity, routine contrast and non-contrast TTE are likely to miss a significant number of LVT, making it a suboptimal screening tool. The addition of apical wall motion scoring provides a promising method to reliably identify patients requiring further investigations for LVT, whilst excluding others from unnecessary testing.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11240154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sigbjorn Sabo, David Pasdeloup, Hakon Neergaard Pettersen, Erik Smistad, Andreas Østvik, Sindre Hellum Olaisen, Stian Bergseng Stølen, Bjørnar Leangen Grenne, Espen Holte, Lasse Lovstakken, Havard Dalen
{"title":"Real-time guidance by deep learning of experienced operators to improve the standardization of echocardiographic acquisitions.","authors":"Sigbjorn Sabo, David Pasdeloup, Hakon Neergaard Pettersen, Erik Smistad, Andreas Østvik, Sindre Hellum Olaisen, Stian Bergseng Stølen, Bjørnar Leangen Grenne, Espen Holte, Lasse Lovstakken, Havard Dalen","doi":"10.1093/ehjimp/qyad040","DOIUrl":"10.1093/ehjimp/qyad040","url":null,"abstract":"<p><strong>Aims: </strong>Impaired standardization of echocardiograms may increase inter-operator variability. This study aimed to determine whether the real-time guidance of experienced sonographers by deep learning (DL) could improve the standardization of apical recordings.</p><p><strong>Methods and results: </strong>Patients (<i>n</i> = 88) in sinus rhythm referred for echocardiography were included. All participants underwent three examinations, whereof two were performed by sonographers and the third by cardiologists. In the first study period (Period 1), the sonographers were instructed to provide echocardiograms for the analyses of the left ventricular function. Subsequently, after brief training, the DL guidance was used in Period 2 by the sonographer performing the second examination. View standardization was quantified retrospectively by a human expert as the primary endpoint and the DL algorithm as the secondary endpoint. All recordings were scored in rotation and tilt both separately and combined and were categorized as standardized or non-standardized. Sonographers using DL guidance had more standardized acquisitions for the combination of rotation and tilt than sonographers without guidance in both periods (all <i>P</i> ≤ 0.05) when evaluated by the human expert and DL [except for the apical two-chamber (A2C) view by DL evaluation]. When rotation and tilt were analysed individually, A2C and apical long-axis rotation and A2C tilt were significantly improved, and the others were numerically improved when evaluated by the echocardiography expert. Furthermore, all, except for A2C rotation, were significantly improved when evaluated by DL (<i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>Real-time guidance by DL improved the standardization of echocardiographic acquisitions by experienced sonographers. Future studies should evaluate the impact with respect to variability of measurements and when used by less-experienced operators.</p><p><strong>Clinicaltrialsgov identifier: </strong>NCT04580095.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11195719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amélie Marang, Marc Bonnet, Thomas Rees, Jonathan Bentz, Sébastien Gerelli
{"title":"An unusual cause of reversible complete heart block: Right sinus of Valsalva rupture and compressive pseudo- aneurysm","authors":"Amélie Marang, Marc Bonnet, Thomas Rees, Jonathan Bentz, Sébastien Gerelli","doi":"10.1093/ehjimp/qyad038","DOIUrl":"https://doi.org/10.1093/ehjimp/qyad038","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xu Wang, Steele C Butcher, Rinchyenkhand Myagmardorj, Sophie IE Liem, Victoria Delgado, Jeroen J Bax, Jeska K De Vries-Bouwstra, Nina Ajmone Marsan
{"title":"Epicardial adipose tissue in patients with systemic sclerosis","authors":"Xu Wang, Steele C Butcher, Rinchyenkhand Myagmardorj, Sophie IE Liem, Victoria Delgado, Jeroen J Bax, Jeska K De Vries-Bouwstra, Nina Ajmone Marsan","doi":"10.1093/ehjimp/qyad037","DOIUrl":"https://doi.org/10.1093/ehjimp/qyad037","url":null,"abstract":"Abstract Aims Epicardial adipose tissue (EAT) has emerged as a mediator between systemic inflammatory disorders and cardiovascular disease, and may therefore play a role in the pathophysiology of cardiac involvement in systemic sclerosis (SSc). The aim of this study was to assess the correlation between EAT and left ventricular (LV) function, and to determine the prognostic value of EAT in patients with SSc. Methods and results Consecutive patients with SSc who underwent non-contrast thorax computed tomography and echocardiography were included. EAT mass was quantified using dedicated software. The study endpoint was all-cause mortality. A total of 230 SSc patients [age 53±15 years, 14% male] were included. The median value of EAT mass was 67g (IQR: 45-101g). Patients with increased EAT mass (≥67g) showed more impaired LV diastolic function as compared to patients with less EAT mass (&lt;67g), and even after adjusting for age and comorbidities, EAT mass was independently associated with LV diastolic function parameters. During a median follow-up of 8 years, 42 deaths occurred. Kaplan-Meier analysis showed that patients with increased EAT mass had higher all-cause mortality rate as compared to patients with less EAT mass (29% vs 7 %; P&lt;0.001). In the multivariable analysis, EAT was independently associated with all-cause mortality after adjusting for important covariates (HR:1.006; 95%CI:1.001-1.010). Conclusion In patients with SSc, EAT is independently associated with LV diastolic dysfunction and higher mortality rate.","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135874668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Per M Arvidsson, Peregrine G Green, William D Watson, Mayooran Shanmuganathan, Einar Heiberg, Giovanni Luigi De Maria, Håkan Arheden, Neil Herring, Oliver J Rider
{"title":"Non-invasive left ventricular pressure-volume loops from cardiovascular magnetic resonance imaging and brachial blood pressure: validation using pressure catheter measurements.","authors":"Per M Arvidsson, Peregrine G Green, William D Watson, Mayooran Shanmuganathan, Einar Heiberg, Giovanni Luigi De Maria, Håkan Arheden, Neil Herring, Oliver J Rider","doi":"10.1093/ehjimp/qyad035","DOIUrl":"10.1093/ehjimp/qyad035","url":null,"abstract":"<p><strong>Aims: </strong>Left ventricular (LV) pressure-volume (PV) loops provide gold-standard physiological information but require invasive measurements of ventricular intracavity pressure, limiting clinical and research applications. A non-invasive method for the computation of PV loops from magnetic resonance imaging and brachial cuff blood pressure has recently been proposed. Here we evaluated the fidelity of the non-invasive PV algorithm against invasive LV pressures in humans.</p><p><strong>Methods and results: </strong>Four heart failure patients with EF < 35% and LV dyssynchrony underwent cardiovascular magnetic resonance (CMR) imaging and subsequent LV catheterization with sequential administration of two different intravenous metabolic substrate infusions (insulin/dextrose and lipid emulsion), producing eight datasets at different haemodynamic states. Pressure-volume loops were computed from CMR volumes combined with (i) a time-varying elastance function scaled to brachial blood pressure and temporally stretched to match volume data, or (ii) invasive pressures averaged from 19 to 30 sampled beats. Method comparison was conducted using linear regression and Bland-Altman analysis. Non-invasively derived PV loop parameters demonstrated high correlation and low bias when compared to invasive data for stroke work (R<sup>2</sup> = 0.96, <i>P</i> < 0.0001, bias 4.6%), potential energy (R<sup>2</sup> = 0.83, <i>P</i> = 0.001, bias 1.5%), end-systolic pressure-volume relationship (R<sup>2</sup> = 0.89, <i>P</i> = 0.0004, bias 5.8%), ventricular efficiency (R<sup>2</sup> = 0.98, <i>P</i> < 0.0001, bias 0.8%), arterial elastance (R<sup>2</sup> = 0.88, <i>P</i> = 0.0006, bias -8.0%), mean external power (R<sup>2</sup> = 0.92, <i>P</i> = 0.0002, bias 4.4%), and energy per ejected volume (R<sup>2</sup> = 0.89, <i>P</i> = 0.0001, bias 3.7%). Variations in estimated end-diastolic pressure did not significantly affect results (<i>P</i> > 0.05 for all). Intraobserver analysis after one year demonstrated 0.9-3.4% bias for LV volumetry and 0.2-5.4% for PV loop-derived parameters.</p><p><strong>Conclusion: </strong>Pressure-volume loops can be precisely and accurately computed from CMR imaging and brachial cuff blood pressure in humans.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}