European heart journal. Imaging methods and practice最新文献

{"title":"How to behave with paediatric myocarditis: imaging methods and clinical considerations.","authors":"Rosalba De Sarro, Nunzia Borrelli, Giulia Pelaia, Alessia Mendicino, Sara Moscatelli, Isabella Leo, Giulia La Vecchia, Giuseppe Mazza, Lucy Castaldo, Antonio Strangio, Martina Avesani, Salvatore De Rosa, Daniele Torella, Giovanni Di Salvo, Jolanda Sabatino","doi":"10.1093/ehjimp/qyaf025","DOIUrl":"10.1093/ehjimp/qyaf025","url":null,"abstract":"<p><p>Paediatric myocarditis is a challenging and heterogeneous condition, with varied clinical presentations ranging from mild symptoms to life-threatening complications such as heart failure, arrhythmias, and sudden cardiac death. Effective management hinges on early diagnosis, appropriate treatment, and ongoing monitoring, which can be significantly enhanced through multimodal imaging techniques. This review emphasizes the crucial role of advanced imaging in the diagnosis, prognostication, and management of paediatric myocarditis. While traditional echocardiography remains the first-line imaging tool, it is often insufficient in detecting subtle myocardial changes and it does not allow the identification of myocardial inflammation and fibrosis, particularly in cases with preserved left ventricular function. Recent advancements, including speckle-tracking echocardiography, provide enhanced sensitivity for detecting early signs of myocardial dysfunction, even in the absence of overt abnormalities. Cardiovascular magnetic resonance (CMR) has emerged as a cornerstone in the non-invasive evaluation of myocarditis, offering unparalleled tissue characterization. Indeed, CMR provides critical insights into myocardial oedema, necrosis, and fibrosis, which are essential for confirming the diagnosis, stratifying prognosis, and guiding therapy. Parametric mapping techniques allow for highly accurate detection of myocardial fibrosis (native T1 mapping) and inflammation (T2 mapping), even in the absence of gadolinium contrast, making it particularly valuable in paediatric patients. In conclusion, multimodality imaging, integrating echocardiography and CMR, allows for a comprehensive understanding of disease severity, guiding treatment decisions and optimizing long-term outcomes. This review underscores the importance of a tailored, imaging-driven approach to managing paediatric myocarditis, ensuring the best possible care for this special population.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf025"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial non-inflammatory, non-atherosclerotic vasculopathy presented with acute coronary syndrome.","authors":"Hikaru Masuda, Riku Arai, Yuki Nakajima, Yutaka Koyama, Nobuhiro Murata, Yasuo Okumura, Masashi Tanaka, Hiroyuki Hao","doi":"10.1093/ehjimp/qyaf039","DOIUrl":"https://doi.org/10.1093/ehjimp/qyaf039","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf039"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution automated free-breathing coronary magnetic resonance angiography in comparison with coronary computed tomography angiography.","authors":"Gregory Wood, Alexandra Uglebjerg Pedersen, Bjarne Linde Nørgaard, Christian Alcaraz Frederiksen, Jesper Møller Jensen, Karl-Philipp Kunze, Radhouene Neji, Jens Wetzl, Claudia Prieto, René M Botnar, Won Yong Kim","doi":"10.1093/ehjimp/qyaf037","DOIUrl":"https://doi.org/10.1093/ehjimp/qyaf037","url":null,"abstract":"<p><strong>Aims: </strong>Clinical implementation of coronary magnetic resonance angiography (CMRA) is limited due to variability in image quality. A protocol utilizing an image navigator (iNAV) integrated with automated scan planning has been developed to facilitate consistent diagnostic image quality. The aim of this study was to evaluate the agreement of automated iNAV CMRA compared with coronary computed tomography angiography (CCTA) using Coronary Artery Disease-Reporting and Data System (CAD-RADS) to classify coronary artery disease (CAD).</p><p><strong>Methods and results: </strong>Ninety-five individuals underwent automated iNAV CMRA at a resolution of 0.7 mm³ with a deep learning-assisted automated scan planning and trigger-delay detection protocol. CMRA and CCTA data sets were analysed using CAD-RADS to classify the per-patient severity of CAD. Additionally, the accuracy of both imaging modalities in predicting referral for invasive coronary angiography (ICA) and coronary revascularization was assessed. CMRA classification for CAD-RADS ≥ 1, ≥2, ≥3, and ≥4 agreed with CCTA for 80%, 73%, 63%, and 70% of cases, respectively. The area under the receiver operating characteristic curves with CAD-RADS ≥ 4 and ≥3 for CMRA and CCTA were comparable in predicting ICA referral (0.75 vs. 0.70, <i>P</i> = 0.687, and 0.70 vs. 0.70, <i>P</i> = 0.945) and revascularization (0.72 vs. 0.74, <i>P</i> = 0.811, and 0.68 vs. 0.76, <i>P</i> = 0.089).</p><p><strong>Conclusion: </strong>A novel automated iNAV CMRA protocol was implemented, investigating individuals at risk of CAD. Using the CAD-RADS classification, there was moderate to good agreement between CMRA and CCTA. In patients with CAD-RADS ≥ 4 and ≥3, CMRA was as effective as CCTA in predicting ICA referral and revascularization.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf037"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding statistical analysis in randomized trials: tips and tricks for effective review.","authors":"Paolo Frumento, Alessia Gimelli","doi":"10.1093/ehjimp/qyaf036","DOIUrl":"10.1093/ehjimp/qyaf036","url":null,"abstract":"<p><p>This review explores the critical role of statistical analysis in interpreting randomized controlled trials (RCTs), focusing on how these methods are used to evaluate the efficacy and safety of clinical interventions. RCTs are considered the gold standard in clinical research, yet their statistical complexity can make interpretation challenging. Understanding key statistical concepts, such as <i>P</i>-values, hazard ratios, and confidence intervals, is essential for distinguishing between statistical significance and clinical relevance. It is important to assess study design elements, including randomization methods, sample size calculations, and the handling of missing data, as these factors directly influence the validity of the findings. Additionally, the analysis plan-whether it follows an intention-to-treat approach or uses per-protocol analysis-can impact the interpretation of trial outcomes. Readers should also be aware of the distinction between pre-specified and <i>post hoc</i> analyses, as the latter can increase the risk of false positives. The appropriate interpretation of these elements ensures a balanced understanding of trial results, allowing clinicians and researchers to make evidence-based decisions.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf036"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tips and tricks to evaluate the impact of ChatGPT in scientific writing.","authors":"Alessia Gimelli, Stefano Nistri","doi":"10.1093/ehjimp/qyaf035","DOIUrl":"https://doi.org/10.1093/ehjimp/qyaf035","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf035"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear wave elastography to unmask differences in myocardial stiffness between athletes and sedentary non-athletes.","authors":"Karim Taha, Youri Bekhuis, Ruben de Bosscher, Christophe Dausin, Marta Orlowska, Ahmed S Youssef, Stéphanie Bézy, Véronique Cornelissen, Lieven Herbots, Rik Willems, Jens-Uwe Voigt, Jan D'hooge, Guido Claessen","doi":"10.1093/ehjimp/qyaf023","DOIUrl":"10.1093/ehjimp/qyaf023","url":null,"abstract":"<p><strong>Aims: </strong>Myocardial stiffening naturally occurs with aging and contributes to diastolic dysfunction. Assessing myocardial stiffness non-invasively could improve the sensitivity of diastolic function evaluation in clinical practice. Shear wave (SW) elastography is a non-invasive tool for quantifying myocardial stiffness, where higher SW velocities indicate increased stiffness. We investigated whether SW elastography could detect differences in myocardial stiffness between athletes and sedentary non-athletes and, during exercise, reveal differences in operational stiffness that may indicate diastolic dysfunction.</p><p><strong>Methods and results: </strong>We enrolled 20 master athletes (median age 60 [IQR 59-66] years) and 17 sedentary non-athletes (median age 58 [IQR 52-71] years). Standard exercise echocardiography revealed no significant differences in diastolic function between the groups. Additionally, ultra-high frame rate imaging was used to measure SW velocities after mitral valve closure (MVC) and aortic valve closure (AVC) at rest and during exercise. At rest, athletes had lower SW velocities after MVC compared to sedentary non-athletes (3.2 ± 0.4 m/s vs. 3.9 ± 0.7 m/s, respectively, <i>P</i> = 0.003). During exercise, SW velocities after AVC significantly increased in sedentary non-athletes but not in athletes (+1.6 ± 1.6 cm/s increase per 1% power output increase vs. 0.0 ± 0.8 cm/s, respectively, <i>P</i> = 0.006). An inverse correlation was found between the increase of SW velocity after AVC during exercise and VO₂max (<i>r</i> = -0.51, <i>P</i> = 0.003).</p><p><strong>Conclusion: </strong>SW elastography reveals reduced myocardial stiffness in athletes compared to sedentary non-athletes at rest and during exercise, which is not detected by conventional echocardiographic measurements. Exercise-induced changes in SW velocities after AVC may potentially serve as an early marker for detecting diastolic dysfunction.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 4","pages":"qyaf023"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D play: from bench to hybrid catheterization laboratory.","authors":"Simona Celi, Katia Capellini, Benigno Marco Fanni, Alessandra Pizzuto, Giuseppe Santoro, Emanuele Gasparotti","doi":"10.1093/ehjimp/qyaf034","DOIUrl":"https://doi.org/10.1093/ehjimp/qyaf034","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf034"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in cardiac remodelling in ischaemic cardiomyopathy and functional mitral regurgitation: impact on prognosis.","authors":"Duygu Kocyigit Burunkaya, Nancy A Obuchowski, Natalie Ho, Zoran B Popovic, David Chen, Christopher Nguyen, W H Wilson Tang, Deborah H Kwon","doi":"10.1093/ehjimp/qyaf021","DOIUrl":"10.1093/ehjimp/qyaf021","url":null,"abstract":"<p><strong>Aims: </strong>Sex differences in prognosis of functional mitral regurgitation (FMR) associated with ischaemic cardiomyopathy (ICM) demonstrate the need to identify sex differences in cardiac remodelling. This study aimed to characterize sex differences in cardiac remodelling associated with FMR in the setting of ICM, sex interactions with cardiac remodelling and FMR severity, and predictors of all-cause mortality or heart transplantation using cardiac magnetic resonance (CMR) imaging.</p><p><strong>Methods and results: </strong>Consecutive patients with ICM referred to CMR between 2002 and 2017 were reviewed. Eligible 790 patients [mean age: 62.0 (standard deviation = 11.2] years and 24.7% females] were evaluated over a median follow-up of 5.8 years. There were 773 subjects with complete data for survival analysis, with 449 primary events. Coronary artery disease risk factors, medications, and previous coronary revascularization were similar in females and males (all <i>P</i> > 0.05). Indexed left ventricular and right ventricular (LV and RV) volumes were larger in males (<i>P</i> < or =0.005 for all comparisons) with similar slope of increasing LV and RV volumes in the setting of increasing FMR (all <i>P</i> > 0.05, for interactions). However, indexed left atrial volume was similar in males and females (<i>P</i> = 0.696), after adjusting for FMR severity. After adjusting for medical risk factors and post-CMR procedural interventions, females demonstrated increased risk of primary clinical composite point with enlarging LV volumes [hazard ratio: 1.04 (95% confidence interval: 1.01-1.06), <i>P</i> = 0.034].</p><p><strong>Conclusion: </strong>Because females with increasing LV size and FMR severity demonstrated significantly increased risk of adverse outcomes, our findings suggest the importance of deriving sex-specific CMR selection criteria for therapeutic management of FMR in the setting of ICM.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf021"},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The five times sit-to-stand test predicts achievable exercise intensity during stress echocardiography.","authors":"Yasuhide Mochizuki, Yui Kuroki, Mina Shibakai, Ayaka Oda, Sakiko Gohbara, Yumi Yamamoto, Saaya Ichikawa-Ogura, Rumi Hachiya, Eiji Toyosaki, Hiroto Fukuoka, Toshiro Shinke","doi":"10.1093/ehjimp/qyaf030","DOIUrl":"10.1093/ehjimp/qyaf030","url":null,"abstract":"<p><strong>Aims: </strong>Exercise stress echocardiography (ESE) is becoming increasingly important in assessing heart failure and valvular diseases; however, determining optimal exercise intensity remains challenging, particularly in patients with physical disorders.</p><p><strong>Methods and results: </strong>A total of 94 patients scheduled for ESE were enrolled in the study. Physical capability was assessed using the five times sit-to-stand test (5-STS), Clinical Frailty Scale, acronyms of the five components, namely strength, assistance with walking, rising from a chair, climbing stairs, and falls (SARC-F) questionnaire, grip strength test, and bioelectrical impedance analysis. In the derivation cohort (<i>n</i> = 43), we determined the 5-STS cut-off value to achieving a 25 W load. The effectiveness of this cut-off value was prospectively evaluated in a validation cohort (<i>n</i> = 51). In the derivation cohort, the 5-STS predicted achieving a 25 W load using a cut-off of 11.7 s with 91% sensitivity and 70% specificity. In the validation cohort, using 12.0 s as the cut-off demonstrated 98% sensitivity and 88% specificity. The multivariate analysis identified age, sex (female), brain natriuretic peptide, SARC-F, and 5-STS as independent predictors of maximum achieved load. In a multivariate model including bioelectrical impedance parameters, lower limb muscle mass independently influenced maximum achievable load, regardless of age. Patients with optimized 5-STS-based load selection achieved significantly higher peak heart rates and maximum loads than those without.</p><p><strong>Conclusion: </strong>Sarcopenia-related indices, particularly the 5-STS, effectively and simply predicted achievable exercise intensity during ESE, independent of age and sex. The use of these indices to determine the initial load may help optimize ESE protocols for individual patients.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf030"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic coronary syndrome with suspected Takayasu's arteritis.","authors":"Adriana Złahoda-Huzior, Maria Kundzierewicz, Katarzyna Kołodziej, Robert Banys, Jacek Godlewski, Dariusz Dudek, Małgorzata Urbańczyk-Zawadzka","doi":"10.1093/ehjimp/qyaf028","DOIUrl":"https://doi.org/10.1093/ehjimp/qyaf028","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf028"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}