European heart journal. Imaging methods and practice最新文献

{"title":"Radioprotection in interventional cardiology: a step-by-step 'call to action' to promote gender equity.","authors":"Chiara Bernelli, Stefania Angela Di Fusco, Roxana Mehran, Furio Colivicchi","doi":"10.1093/ehjimp/qyaf074","DOIUrl":"10.1093/ehjimp/qyaf074","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf074"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of missed stab wound to the right heart diagnosed by cardiac imaging.","authors":"Ruchika Meel, Ricardo Gonçalves","doi":"10.1093/ehjimp/qyaf078","DOIUrl":"https://doi.org/10.1093/ehjimp/qyaf078","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf078"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiological and prognostic relevance of exercise CMR-derived pulmonary artery compliance in patients with suspected diastolic dysfunction and normal right ventricular function.","authors":"Alexander Schulz, Lara Kuttenkeuler, Sören J Backhaus, Torben Lange, Jonas Otto, Judith Gronwald, Ruben Evertz, Johannes T Kowallick, Gerd Hasenfuß, Andreas Schuster","doi":"10.1093/ehjimp/qyaf077","DOIUrl":"10.1093/ehjimp/qyaf077","url":null,"abstract":"<p><strong>Aims: </strong>Right ventricular (RV) dysfunction has been associated with worse prognosis in patients with diastolic dysfunction, highlighting the importance of early detection. Main pulmonary artery (MPA) compliance may indicate adverse biventricular coupling prior to emerging RV function.</p><p><strong>Methods and results: </strong>Sixty-eight patients with suspected diastolic dysfunction (New York Heart Association ≥ II, LV EF ≥ 50%, E/e' ≥ 8) were prospectively recruited and underwent rest and stress right heart catheterization, echocardiography, and cardiovascular magnetic resonance imaging (CMR) within 24 h. Maximum (<i>A</i> <sub>max</sub>) and minimum (<i>A</i> <sub>min</sub>) MPA vessel area and stroke volume (RVSV) were obtained from CMR real-time phase-contrast images at rest and during exercise stress. Compliance was calculated as pulsatility <math><mrow><mi>MP</mi></mrow> <msub><mrow><mi>A</mi></mrow> <mrow><mrow><mi>Puls</mi></mrow> </mrow> </msub> <mo>=</mo> <mrow><mo>(</mo> <mrow> <mrow> <mfrac> <mrow><msub><mi>A</mi> <mrow><mrow><mi>max</mi></mrow> </mrow> </msub> <mo>-</mo> <msub><mi>A</mi> <mrow><mrow><mi>min</mi></mrow> </mrow> </msub> </mrow> <mrow><msub><mi>A</mi> <mrow><mrow><mi>min</mi></mrow> </mrow> </msub> </mrow> </mfrac> </mrow> </mrow> <mo>)</mo></mrow> <mo>×</mo> <mn>100</mn></math> and capacitance <math><mrow><mi>MP</mi></mrow> <msub><mrow><mi>A</mi></mrow> <mrow><mrow><mi>Cap</mi></mrow> </mrow> </msub> <mo>=</mo> <mrow> <mfrac> <mrow><mrow><mi>MP</mi></mrow> <msub><mrow><mi>A</mi></mrow> <mrow><mrow><mi>Puls</mi></mrow> </mrow> </msub> </mrow> <mrow><mrow><mi>RVSV</mi></mrow> </mrow> </mfrac> </mrow> </math> . Patients had systematic follow-up after 48 months. Occurrence of cardiovascular events was defined as the primary endpoint. A total of 63 patients [66 ± 9 years, 39 (61.9%) female] were eligible for final analyses. MPA<sub>Puls</sub> and MPA<sub>Cap</sub> were lower during exercise stress compared with rest (20% vs. 17.5%, <i>P</i> = 0.034 and 0.26%/mL vs. 0.20%/mL, <i>P</i> = 0.001). Subgroups with and without heart failure with preserved ejection fraction (HFpEF) had similar MPA compliance at rest, however, HFpEF patients had a steeper decrease of compliance during exercise stress (MPA<sub>Puls</sub> 13% vs. 20%; <i>P</i> < 0.001 MPA<sub>Cap</sub> 0.16%/mL vs. 0.25%/mL, <i>P</i> = 0.018). Decreasing MPA<sub>Puls</sub> and MPA<sub>Cap</sub> during exercise stress correlated with markers of diastolic dysfunction including pulmonary capillary wedge pressure, E/e', and HFA-PEFF score. Patients with decreased MPA<sub>Puls</sub> (HR 6.0; <i>P</i> = 0.016) and MPA<sub>Cap</sub> (HR 11.3; <i>P</i> = 0.015) had worse outcomes independent from conventional markers of diastolic dysfunction.</p><p><strong>Conclusion: </strong>In patients with suspected diastolic dysfunction and preserved RV function, exercise-stress testing unmasked decreasing CMR-derived MPA compliance, associated with LV diastolic dysfu","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf077"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superior aortic strain and ventriculoarterial coupling in older women are moderately correlated with Framingham 10-year risk.","authors":"Jie Jun Wong, Hongzhou Zhang, Shuang Leng, Fei Gao, Xiaodan Zhao, Kieran Tan, Ru-San Tan, Liang Zhong, Angela S Koh","doi":"10.1093/ehjimp/qyaf075","DOIUrl":"10.1093/ehjimp/qyaf075","url":null,"abstract":"<p><strong>Aims: </strong>Traditional risk factors do not fully characterize cardiovascular aging and are less helpful in assessing sex differences in cardiovascular risk. Using a novel cardiovascular magnetic resonance (CMR) method, we determined sex differences in aortic global longitudinal strain (AOGLS) and ventriculoarterial coupling (VAC) with correlations to Framingham risk scores.</p><p><strong>Methods and results: </strong>Community older adults without cardiovascular disease underwent CMR. AOGLS was the maximal absolute Lagrangian strain between the brachiocephalic artery and aortic annulus. VAC was aortic pulse wave velocity (AAPWV) divided by LVGLS. Among 202 participants (46.0% female, 70.2 ± 8.8 years), women had lower diastolic blood pressure (DBP) (70.5 ± 10.8 mmHg vs. 78.1 ± 9.5 mmHg, <i>P</i> < 0.001), body surface area (BSA) (1.52 ± 0.12 m² vs. 1.70 ± 0.14 m², <i>P</i> < 0.001), and fewer smokers (3.2% vs. 25.7% <i>P</i> < 0.001) than men, despite similar ages. Women had better AAPWV (8.41 ± 2.73 m/s vs. 9.13 ± 3.18 m/s, adj. <i>P</i> = 0.020), AOGLS (6.16 ± 2.44% vs. 5.21 ± 1.74%, adj. <i>P</i> = 0.030), LVGLS (-21.93 ± 2.59 vs. -20.06 ± 2.79%, adj. <i>P</i> = 0.021), VAC (-0.39 ± 0.15 vs. -0.47 ± 0.21, adj. <i>P</i> = 0.006), and smaller indexed cardiac volumes. Female sex was associated with better AOGLS (<i>β</i> = 0.838, adj. <i>P</i> = 0.030; <i>R</i> ² = 0.103) and VAC (<i>β</i> = -0.093, adj. <i>P</i> = 0.006; <i>R</i> ² = 0.113) independent of smoking, DBP, and BSA. Among women, AOGLS was moderately correlated with 10-year risks (<i>r</i> = -0.400 <i>P</i> = <0.001) and VAC was associated with 10-year risks (<i>β</i> = -6.915, adj. <i>P</i> = 0.017; <i>R</i> ² = 0.145).</p><p><strong>Conclusion: </strong>Novel CMR-derived aortic longitudinal strain differentiated ventriculo-aortic aging between the sexes. Women had superior AOGLS and VAC, independent of body size and DBP, that correlated better with Framingham risk scores compared to men. Impaired AOGLS and VAC may be useful in differentiating individuals at intermediate from low-borderline cardiovascular risk. <b>Trial registration</b>: ClinicalTrials.gov Identifier: NCT02791139.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf075"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging features of Takayasu arteritis in a young male.","authors":"Maria Ana Estevens, Ana Coutinho Santos, Duarte Saraiva Martins, Carla Saraiva","doi":"10.1093/ehjimp/qyaf076","DOIUrl":"https://doi.org/10.1093/ehjimp/qyaf076","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf076"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of party balloon inflation manoeuvre for haemodynamic provocation: a pilot study in healthy volunteers.","authors":"Kento Kito, Akihisa Kataoka, Maki Okamoto, Satoshi Nakada, Kazuyo Shirakura, Hanako Kobayashi, Ikumi Chikuda, Junichi Nishikawa, Yosei Iseki, Taiga Katayama, Hideyuki Kawashima, Takeyuki Sajima, Hirosada Yamamoto, Yusuke Watanabe, Naoyuki Yokoyama, Ken Kozuma","doi":"10.1093/ehjimp/qyaf071","DOIUrl":"10.1093/ehjimp/qyaf071","url":null,"abstract":"<p><strong>Aims: </strong>Left ventricular outflow tract (LVOT) obstruction is a key feature of hypertrophic obstructive cardiomyopathy (HOCM), whereas patent foramen ovale (PFO) obstruction is associated with cryptogenic stroke and other conditions. The Valsalva manoeuvre (VM) is a standard technique for diagnosing these conditions; however, its inconsistent execution can limit diagnostic accuracy. We aimed to evaluate the party balloon inflation manoeuvre (PBIM) as an alternative to VM for diagnosing HOCM and PFO by comparing their haemodynamic effects.</p><p><strong>Methods and results: </strong>In this single-centre pilot study, we conducted <i>in vitro</i> and <i>in vivo</i> experiments. The pressure characteristics of the two balloon sizes were measured in the <i>in vitro</i> experiment. In the <i>in vivo</i> study, we assessed haemodynamic changes in 25 healthy volunteers using transthoracic echocardiography. The endpoints included the left ventricular diastolic dimension (LVDd) for HOCM and the right ventricular inflow velocity-time integral (RV inflow-VTI) for PFO. PBIM significantly reduced LVDd compared with VM, indicating greater LVOT obstruction provocation (<i>P</i> < 0.01). The RV inflow-VTI was also significantly higher with PBIM, suggesting increased venous return and enhanced right-to-left shunting (<i>P</i> < 0.01). The heart rate and perceived exertion scores were higher with the PBIM, reflecting a greater physiological load.</p><p><strong>Conclusion: </strong>PBIM is a simple, effective, and reliable alternative to VM for diagnosing HOCM and PFO, offering clear visual feedback and improved diagnostic performance. Further research in patient populations is required to confirm these findings. <b>Trial registration number:</b> UMIN000054423.(https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&recptno=R000062098&type=summary&language=J).</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf071"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term cardiovascular consequences of cancer therapy-related cardiac dysfunction: insights from ventricular-arterial coupling and myocardial work.","authors":"Anthony F Yu, Jessica M Scott, Jessica Flynn, Chaya S Moskowitz, Chau T Dang, Lee W Jones, Richard M Steingart, Jennifer E Liu","doi":"10.1093/ehjimp/qyaf072","DOIUrl":"10.1093/ehjimp/qyaf072","url":null,"abstract":"<p><strong>Aims: </strong>Ventricular-arterial (VA) coupling and myocardial work can assess the interaction between the left ventricle and the arterial system and provide insight into cancer-therapy-related cardiac dysfunction (CTRCD). This study assessed the relationship between VA coupling and myocardial work indices with CTRCD in breast cancer (BC) survivors.</p><p><strong>Methods and results: </strong>In this cross-sectional case-control study, 42 human epidermal growth factor receptor 2-positive BC survivors [22 with a history of CTRCD (TOX), 20 without CTRCD (NOTOX)] and 15 age-matched healthy controls (HC) prospectively underwent echocardiography and cardiopulmonary exercise testing. VA coupling measures were arterial elastance (Ea) and end-systolic elastance (Ees), with increased Ea/Ees indicating ventricular-arterial uncoupling. Myocardial work measures included global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE). Linear regression models assessed associations between VA coupling and myocardial work indices with cardiorespiratory fitness, measured by peak oxygen consumption (VO_2peak). Ea and Ea/Ees were elevated in TOX [Ea: 2.00 (interquartile range (IQR), 1.83-2.25) mmHg/mL, <i>P</i> = 0.006; Ea/Ees: 1.48 (1.05-1.66), <i>P</i> = 0.002], but not NOTOX [Ea: 1.68 (1.36-1.95) mmHg/mL, <i>P</i>  <i>=</i> 0.8]; [Ea/Ees: 1.15 (1.03-1.28), <i>P</i> = 0.2] participants, compared to HC [Ea, 1.65 (1.50-1.73) mmHg/mL; Ea/Ees, 1.07 (0.89-1.19)]. GWW was increased and GWE was reduced in TOX [GWW: 86 (59-132) mmHg%, <i>P</i> = 0.009; GWE: 95 (94-96) %, <i>P</i> = 0.003] but not NOTOX [GWW: 64 (44-94) mmHg%, <i>P</i> = 0.3; GWE: 96 (96-97) %, <i>P</i>  <i>=</i> 0.003] participants, compared to HC [GWW: 46 (38-60) mmHg%; GWE: 97 (97-98) %]. Higher Ea (β=-0.16, <i>P</i> = 0.005) was associated with impaired VO_2peak in BC survivors.</p><p><strong>Conclusion: </strong>CTRCD is associated with VA uncoupling in BC survivors, the mechanism of which may be increased arterial load. Studies to evaluate whether reducing arterial load can mitigate VA uncoupling are needed.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf072"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based segmentation and strain analysis of left heart chambers from long-axis CMR images.","authors":"Jonas Leite, Emilie Bollache, Vincent Nguyen, Moussa Gueda Moussa, Thomas Wallet, Mikaël Prigent, Khaoula Bouazizi, Mohamed Zarai, Jérôme Lamy, Perrine Marsac, Niki Procopi, Michel Zeitouni, Alban Redheuil, Antonio Gallo, Elie Mousseaux, Gilles Montalescot, Thomas Dietenbeck, Nadjia Kachenoura","doi":"10.1093/ehjimp/qyaf070","DOIUrl":"10.1093/ehjimp/qyaf070","url":null,"abstract":"<p><strong>Aims: </strong>Feature tracking (FT) is increasingly used on dynamic cardiac magnetic resonance (CMR) images for myocardial strain evaluation but often requires manual initialization, which is tedious and source of variability, especially on the challenging long-axis (LAX) images. Accordingly, we designed a pipeline combining deep learning (DL) with FT for left ventricular (LV) and left atrial (LA) longitudinal myocardial strain estimation.</p><p><strong>Methods and results: </strong>We studied a multivendor database of 684 individuals divided into: training = 845, tuning = 281, and testing = 116 LAX-CMR cine 2- and/or 4-chamber views. Images were centre cropped. Then, a 2D- and 3D-ResUnet, which considers time as the third dimension, were designed for LV/LA segmentation and used to (i) estimate LV and LA strains (Full 2D-/3D-DL) and (ii) initialize an FT algorithm and further derive LV and LA strains (FT-initialized by 2D-/3D-DL). Left ventricular and LA contours and strain peaks were compared against reference standard (RS) measures performed by an expert using a semiautomated software. Intraclass-correlation-coefficient (ICC) was used to study reproducibility. 3D-DL outperformed 2D-DL segmentation (Dice-scores: 0.94 ± 0.02 vs. 0.90 ± 0.09, <i>P</i> = 0.002) and was stable across vendors, field strengths and imaging views. The added value of combining DL with FT was revealed by higher correlations and lower Bland-Altman biases against RS for FT initialized by 3D-DL strains (r ≥ 0.91, |mean-bias|≤0.65%) than for full 3D-DL strains (r ≤ 0.80, |mean-bias|<3.07%). Semiautomated human vs. FT initialized by 3D-DL (ICC ≥ 0.76) and inter-human strain reproducibility was equivalent.</p><p><strong>Conclusion: </strong>Generalizable DL-based LV and LA segmentation on LAX-CMR images was proposed. Its combination with FT resulted in fully automated and reliable LV and LA strain measures, reaching human reproducibility.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 4","pages":"qyaf070"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision medicine and mitral valve assessment.","authors":"Edgar Argulian, Julia Grapsa","doi":"10.1093/ehjimp/qyaf073","DOIUrl":"10.1093/ehjimp/qyaf073","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf073"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"False-positive phenomenon in microbubble testing: unveiling the underlying mechanism.","authors":"Yumi Yamamoto, Yasuhide Mochizuki, Saaya Ichikawa-Ogura, Rumi Hachiya, Hiroto Fukuoka, Toshiro Shinke","doi":"10.1093/ehjimp/qyaf056","DOIUrl":"https://doi.org/10.1093/ehjimp/qyaf056","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyaf056"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}