European heart journal. Imaging methods and practice最新文献

{"title":"Haemodynamic and hyperaemic effects of adenosine in patients with atrial fibrillation undergoing quantitative myocardial perfusion cardiovascular magnetic resonance.","authors":"Simran Shergill, Charley A Budgeon, Mohamed Elshibly, Peter Kellman, Anvesha Singh, Gerry P McCann, Gaurav S Gulsin, J Ranjit Arnold","doi":"10.1093/ehjimp/qyae127","DOIUrl":"10.1093/ehjimp/qyae127","url":null,"abstract":"<p><strong>Aims: </strong>Patients with atrial fibrillation (AF) are thought to have an attenuated response to adenosine during vasodilator stress testing. We sought to investigate the haemodynamic and hyperaemic effects of adenosine in patients with AF undergoing adenosine-stress cardiovascular magnetic resonance (CMR) assessment.</p><p><strong>Methods and results: </strong>We retrospectively examined 318 patients referred for clinical adenosine-stress CMR (AF <i>n</i> = 158, sinus rhythm [SR] <i>n</i> = 160). Baseline and peak heart rate (HR) and quantitative myocardial perfusion were compared between groups. At peak stress, the haemodynamic response was blunted in patients with AF (HR increase 7 ± 10bpm vs. 17 ± 11bpm in SR, <i>P</i> < 0.001). Fewer patients in AF met the threshold for a satisfactory HR response ≥10bpm (40% in AF vs. 76% in SR, <i>P</i> < 0.001). There were no intergroup differences in hyperaemic myocardial blood flow (1.52 ± 0.65 mL/min/g in AF vs. 1.55 ± 0.65 mL/min/g in SR, <i>P</i> = 0.670) or myocardial perfusion reserve (2.66 ± 1.11 in AF vs. 2.66 ± 1.08 in SR, <i>P</i> = 0.981). AF (odds ratio [OR], 0.29 [0.17-0.50], <i>P</i> < 0.001) and left ventricular ejection fraction (OR 1.03 [1.00-1.05], <i>P</i> = 0.023) were independently associated with achieving a satisfactory HR response on multivariable analysis, but only ejection fraction (OR 1.05 [1.02-1.09], <i>P</i> = 0.003) predicted a satisfactory hyperaemic response.</p><p><strong>Conclusion: </strong>The heart rate response during adenosine-stress CMR is blunted in AF patients. Despite this, the majority of patients with AF generate a sufficient hyperaemic response with a standard adenosine-stress protocol. Further work is needed to determine the diagnostic accuracy of adenosine-stress CMR in patients with AF.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae127"},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison between 64-projection and 32-projection myocardial perfusion scintigraphy.","authors":"Seyed Mohammad Abedi, Erfan Ghadirzadeh, Hanie Karimi, Pedram Nezhadnaderi, Seyede Sepide Daryabari, Amir Moradi, Alireza Khorrami Moghaddam, Seyed Jalal Hosseinimehr, Morteza Taghavi, Samad Golshani, Ali Asghar Farsavian, Alireza Mardanshahi, Ali Mostafavinia","doi":"10.1093/ehjimp/qyae142","DOIUrl":"10.1093/ehjimp/qyae142","url":null,"abstract":"<p><strong>Aims: </strong>While most clinical guidelines recommend using a 64-projection view technique, some protocols do not specify a preference between 32-projection and 64-projection methods for conducting myocardial perfusion scintigraphy (MPS), which shows the lack of consensus in this matter. Nevertheless, these guidelines and protocols have not provided us with compelling evidence to support why the 64-projection technique is usually chosen. Thus, we aimed to determine if there is a significant difference between them in the assessment of cardiac perfusion and functional indices.</p><p><strong>Methods and results: </strong>Sixty-nine patients were included in this pilot prospective, cross-sectional, cross-over, same patient control protocol study and underwent 32- and 64-projection MPS at both stress and rest phases after injecting 740-925 MBq of 99mTc-MIBI for every patient. Then, cardiac indices, including summed stress, rest, and difference scores, extent-stress and rest, left ventricular volumes and ejection-fraction, peak filling rate (PFR), and time to peak filling rate (TTPF) were recorded. Lin's concordance correlation coefficient was used to assess the agreement between protocols, and a paired sample <i>t</i>-test was used to compare the means of variables where appropriate. Findings revealed no significant difference as well as excellent/good agreement between the two methods in either the stress or rest state, except for the TTPF and PFR.</p><p><strong>Conclusion: </strong>The findings suggest that lower-projection techniques could be adequate for routine clinical assessments without sacrificing diagnostic accuracy. However, the poor agreement for PFR and TTPF indicates that the 32-projection method may not reliably assess diastolic function, implying that the 64-projection protocol is preferable when precise evaluations are necessary.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyae142"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between adverse childhood experiences and adult cardiac function in the UK Biobank.","authors":"Juan C Quiroz, Jackie Cooper, Celeste McCracken, Mohammed Y Khanji, Liliana Laranjo, Nay Aung, Aaron Mark Lee, Judit Simon, Theodore Murphy, Luca Biasiolli, Stefan K Piechnik, Pal Maurovich-Horvat, Steffen E Petersen, Zahra Raisi-Estabragh","doi":"10.1093/ehjimp/qyae139","DOIUrl":"10.1093/ehjimp/qyae139","url":null,"abstract":"<p><strong>Aims: </strong>The importance of early life factors in determining health in later adulthood is increasingly recognized. This study evaluated the association of adverse childhood experiences (ACEs) with cardiovascular magnetic resonance (CMR) phenotypes.</p><p><strong>Methods and results: </strong>UK Biobank participants who had completed CMR and the self-reported questionnaire on traumatic childhood experiences were included. Images were analysed using automated pipelines to extract measures of left and right ventricular (LV and RV) structure and function, myocardial character, and arterial compliance. Multivariable linear regression was used to estimate the association of childhood adversity with CMR phenotypes adjusting for age, sex, deprivation, education, obesity, smoking, alcohol intake, exercise level, diabetes, hypertension, and hypercholesterolaemia. Amongst 30 814 participants analysed, 6023 (19.5%) experienced physical abuse, 2746 (8.9%) sexual abuse, 4685 (15.2%) emotional abuse, 6822 (22.1%) emotional neglect, and 4534 (14.7%) physical neglect. Except for physical abuse, women reported greater rates of childhood adversity than men. Collectively, all types of childhood adversity were associated with smaller LV and RV volumes, greater LV mass, a concentric pattern of LV remodelling, poorer LV and RV function, lower aortic compliance, and greater arterial stiffness. Sexual abuse was associated with unhealthy CMR phenotypes in age- and sex-adjusted models, but these relationships were attenuated in fully adjusted models. Physical neglect had the most prominent pattern of adverse cardiovascular remodelling.</p><p><strong>Conclusion: </strong>ACEs were associated with unhealthy cardiovascular remodelling in adulthood, independent of traditional cardiovascular risk factors. These findings support the consideration of early life factors in cardiovascular disease risk assessment.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae139"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11686440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of valvular regurgitation by transthoracic 3D high pulse repetition frequency Doppler echocardiography.","authors":"Erik Andreas Rye Berg, Stefano Fiorentini, Jørgen Avdal, Bjørnar Grenne, Knut Haakon Stensæth, Peter Thomas While, Torvald Espeland, Rune Wiseth, Hans Torp, Svend Aakhus","doi":"10.1093/ehjimp/qyae138","DOIUrl":"10.1093/ehjimp/qyae138","url":null,"abstract":"<p><strong>Aims: </strong>To improve quantification of valvular regurgitation, a 3D high-pulse repetition frequency Doppler (3D HPRFD) method was developed for regurgitant volume (RVol) estimation from transthoracic echocardiography (TTE). Although successfully applied <i>in vitro</i> and in selected clinical cases, a systematic clinical validation of 3D HPRFD has not been published. Hence, our aims were to investigate (i) feasibility of 3D HPRFD and (ii) correlation between 3D HPRFD and RVol estimates obtained by the 2D proximal isovelocity surface area (PISA) method and cardiac magnetic resonance (CMR) in patients with either aortic regurgitation (AR) or mitral regurgitation (MR).</p><p><strong>Methods and results: </strong>We included 45 patients with AR (42% mild, 40% moderate, and 18% severe) and 45 with MR (67% mild, 24% moderate, and 9% severe). Median time between start of TTE and start of CMR was 1.5 h, minimizing changes in load. Overall feasibility of 3D HPRFD was 56% in AR and 44% in MR. Feasibility was only 25% in patients with severe regurgitation. In AR, estimated RVol from 3D HPRF did not correlate with estimated RVol from PISA or CMR [Spearman <i>rho</i> = 0.06 (<i>P</i> = 0.78) and 0.04 (<i>P</i> = 0.4), respectively]. In MR, RVol estimates from 3D HPRFD correlated with PISA (<i>rho</i> = 0.72, <i>P</i> < 0.001) but not with CMR (<i>rho</i> = 0.31, <i>P</i> = 0.43).</p><p><strong>Conclusion: </strong>Regurgitant volume estimation by 3D HPRFD had a low feasibility, especially in severe regurgitation, and in general correlated poorly with PISA and CMR estimates. In its current state, 3D HPRFD is not ready for clinical use.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae138"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Image reconstruction impacts haemodynamic parameters derived from 4D flow magnetic resonance imaging with compressed sensing.","authors":"Pia Sjöberg, Tania Lala, Johan Wittgren, Ning Jin, Erik Hedström, Johannes Töger","doi":"10.1093/ehjimp/qyae137","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae137","url":null,"abstract":"<p><strong>Aims: </strong>4D blood flow measurements by cardiac magnetic resonance imaging (CMR) can be used to simplify blood flow assessment. Compressed sensing (CS) can provide better flow measurements than conventional parallel imaging (PI), but clinical validation is needed. This study aimed to validate stroke volume (SV) measurements by 4D-CS in healthy volunteers and patients while also investigating the influence of the CS image reconstruction parameter <i>λ</i> on haemodynamic parameters.</p><p><strong>Methods and results: </strong>Healthy participants (<i>n</i> = 9; 20-62 years) underwent CMR with 2D, 4D-CS, and 4D-PI flow. Patients (<i>n</i> = 30, 17 with congenital heart defect; 2-75 years) had 4D-CS added to their clinical examination. Impact of <i>λ</i> was assessed by reconstructing 4D-CS data for six different <i>λ</i> values. In healthy volunteers, 4D-CS and 4D-PI SV differed by 0.4 ± 6.5 mL [0.6 ± 9.1%; intraclass correlation coefficient (ICC) 0.98], and 4D-CS and 2D flow by 0.9 ± 7.0 mL (0.9 ± 10.6%; ICC 0.98). In patients, 4D-CS and 2D flow differed by -1.3 ± 6.0 mL (-7.2 ± 20%; ICC 0.97). SV was not dependent on <i>λ</i> in patients (<i>P</i> = 0.75) but an increase in <i>λ</i> by 0.001 led to increased differences between 4D-CS and 4D-PI of -0.4% (<i>P</i> = 0.0021) in healthy participants. There were significant differences for ventricular kinetic energy (systole: <i>P</i> < 0.0001; diastole: <i>P</i> < 0.0001) and haemodynamic forces (systole: <i>P</i> < 0.0001; diastole: <i>P</i> < 0.0001), where error increased with increasing <i>λ</i> values in both healthy participants and patients.</p><p><strong>Conclusion: </strong>4D flow CMR with CS can be used clinically to assess SV in paediatric and adult patients. Ventricular kinetic energy and haemodynamic forces are however sensitive to the change in reconstruction parameter <i>λ</i>, and it is therefore important to validate advanced blood flow measurements before comparing data between scanners and centres.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 4","pages":"qyae137"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing diagnosis in a cardiac arrest case and suspected MINOCA: the complementary roles of imaging, biopsy, and genetic testing.","authors":"Giuseppe Ciliberti, Paolo Compagnucci, Michela Casella, Francesco Schiavone, Monica De Gaspari, Stefania Rizzo, Cristina Basso, Andrea Giovagnoni, Federico Guerra, Giada Tortora, Antonio Dello Russo","doi":"10.1093/ehjimp/qyae135","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae135","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae135"},"PeriodicalIF":0.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements and applications of artificial intelligence in cardiovascular imaging: a comprehensive review.","authors":"Federico Fortuni, Giuseppe Ciliberti, Benedetta De Chiara, Edoardo Conte, Luca Franchin, Francesca Musella, Enrica Vitale, Francesco Piroli, Stefano Cangemi, Stefano Cornara, Michele Magnesa, Antonella Spinelli, Giovanna Geraci, Federico Nardi, Domenico Gabrielli, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva","doi":"10.1093/ehjimp/qyae136","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae136","url":null,"abstract":"<p><p>Artificial intelligence (AI) is transforming cardiovascular imaging by offering advancements across multiple modalities, including echocardiography, cardiac computed tomography (CCT), cardiovascular magnetic resonance (CMR), interventional cardiology, nuclear medicine, and electrophysiology. This review explores the clinical applications of AI within each of these areas, highlighting its ability to improve patient selection, reduce image acquisition time, enhance image optimization, facilitate the integration of data from different imaging modality and clinical sources, improve diagnosis and risk stratification. Moreover, we illustrate both the advantages and the limitations of AI across these modalities, acknowledging that while AI can significantly aid in diagnosis, risk stratification, and workflow efficiency, it cannot replace the expertise of cardiologists. Instead, AI serves as a powerful tool to streamline routine tasks, allowing clinicians to focus on complex cases where human judgement remains essential. By accelerating image interpretation and improving diagnostic accuracy, AI holds great potential to improve patient care and clinical decision-making in cardiovascular imaging.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 4","pages":"qyae136"},"PeriodicalIF":0.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional assessment of ascending aortic stiffness, motion, and growth in ascending thoracic aortic aneurysm.","authors":"Nicasius S Tjahjadi, Taeouk Kim, Prabhvir S Marway, Carlos Alberto Campello Jorge, Timothy J Baker, Constantijn Hazenberg, Joost A van Herwaarden, Himanshu J Patel, C Alberto Figueroa, Nicholas S Burris","doi":"10.1093/ehjimp/qyae133","DOIUrl":"10.1093/ehjimp/qyae133","url":null,"abstract":"<p><strong>Aims: </strong>Aortic wall stiffening in ascending thoracic aortic aneurysm (aTAA) is common. However, the spatial and temporal relationships between stiffness, aortic size, and growth in aTAA remain unclear.</p><p><strong>Methods and results: </strong>In this single-centre retrospective study, we utilized vascular deformation mapping to extract multi-directional aortic motion, aortic distensibility, and aortic growth in a multi-planar fashion from multi-phasic ECG-gated computed tomography angiograms. Aortic displacement and stiffness metrics were compared between patients with sporadic ascending aortic dilation (Dilated), individuals without thoracic aortic dilation, and patients with Marfan syndrome. A total of 96 patients were included. Total and axial aortic root motion was significantly decreased in the Dilated group (<i>n</i> = 49) compared with the Non-dilated group (<i>n</i> = 38) and Marfan group (<i>n</i> = 16). Aortic distensibility was significantly lower in the Dilated group compared with the Non-dilated group and exhibited a more diffuse pattern of stiffening compared with the Marfan group in which stiffening was localized to the root. In Dilated group, aortic distensibility was moderately and positively associated with aortic growth rate (<i>R</i> = 0.34, <i>P</i> = 0.02). The moderate-to-strong association between age and aortic stiffness in non-dilated segments was either significantly blunted or absent in dilated segments.</p><p><strong>Conclusion: </strong>Vascular deformation mapping provides multi-level stiffness assessments of the ascending aorta using multi-phasic computed tomography angiography. Ascending aortic stiffening is a spatially heterogeneous process with stiffening tending to increase with degree of regional dilation and age, whereas lower stiffness was associated with faster growth of the mid-ascending aorta in those with sporadic aTAA.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"3 1","pages":"qyae133"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic red flags in transthyretin amyloid cardiomyopathy: all that glitters is not gold.","authors":"Laura De Michieli, Giulio Sinigiani, Stefano Nistri, Alberto Cipriani","doi":"10.1093/ehjimp/qyae114","DOIUrl":"10.1093/ehjimp/qyae114","url":null,"abstract":"","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae114"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproducibility of quantitative myocardial perfusion and coronary flow capacity by positron emission tomography: 3D digital silicon photomultiplier solid state vs. legacy 2D analogue systems for clinical practice and trials.","authors":"Amanda Roby, Lindsey Harmon, Kelly Sander, Linh Bui, Danai Kitkungvan, Monica Patel, Jagat Narula, Nils P Johnson, K Lance Gould","doi":"10.1093/ehjimp/qyae115","DOIUrl":"10.1093/ehjimp/qyae115","url":null,"abstract":"<p><strong>Aims: </strong>Quantitative rest-stress myocardial perfusion in millilitres per minute per gram among multiple 2D and 3D positron emission tomography-computed tomography (PET-CT) scanners is essential for personalized cardiac management and clinical trials. Accordingly, this study reports the accuracy and precision of quantitative rest-stress millilitres per minute per gram and coronary flow capacity among 2D and two different digital 3D silicon photomultiplier (SiPM) PET-CT scanners for quantifying the severity of coronary pathophysiology for clinical trials or guiding interventions vs. medical treatment.</p><p><strong>Methods and results: </strong>One hundred seventy-one participants underwent 748 paired serial rest or stress PET perfusion imaging in the same person on 'same day' or 'different days' using rubidium-82 (Rb-82) pharmacologic stress on 2D and two different digital 3D SiPM PET-CT scanners for global myocardial perfusion in millilitres per minute per gram. For methodological variability of 66 'same-day' serial paired PETs in the same person by 2D and two different 3D SiPM PET-CT scanners, rest-stress global myocardial millilitres per minute per gram had no significant bias (<i>P</i> = 0.464, mean difference 0.014 ± 0.21 mL/min/g) with coefficient of variation (COV) of ±14%. For methodological plus biological variability of 154 'different-day' serial paired PETs, rest-stress global perfusion had no significant bias (<i>P</i> = 0.136), mean difference (0.028 ± 0.33), and COV of ±20%. Coronary flow reserve had a small bias of 0.095 ± 0.57 (<i>P</i> = 0.041) and COV of ±20%. Coronary flow capacity was not different by Kolmogorov-Smirnov test (<i>P</i> = 0.99).</p><p><strong>Conclusion: </strong>For quantifying myocardial perfusion in the same person on 'same day' or 'different days' using Rb-82, 3D SiPM PET-CT is comparably reproducible to analogue 2D PET-CT with the HeartSee perfusion model as the basis for quantifying physiologic severity of coronary heart disease to guide clinical decision-making or randomized clinical trials confirming these outcomes.</p>","PeriodicalId":94317,"journal":{"name":"European heart journal. Imaging methods and practice","volume":"2 3","pages":"qyae115"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}