npj aging最新文献_第6页

Evaluation of equation as a classifier for kidney function in domestic cats: a proof-of-concept study. 评估方程作为一个分类器的肾功能在家猫：一个概念验证研究。

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npj aging Pub Date : 2026-05-25 DOI: 10.1038/s41514-026-00417-2

Qinghong Li, Linxing Yao

{"title":"Evaluation of equation as a classifier for kidney function in domestic cats: a proof-of-concept study.","authors":"Qinghong Li, Linxing Yao","doi":"10.1038/s41514-026-00417-2","DOIUrl":"10.1038/s41514-026-00417-2","url":null,"abstract":"In human medicine, estimated glomerular filtration rate (eGFR) is routinely used to assess renal function. In cats, reliable eGFR formulas are not yet available. To test the hypothesis that a human eGFR equation with four metabolites can effectively distinguish cats with different renal functions, two cohorts of cats were retrospectively enrolled. Cohort 1 included 34 colony cats and cohort 2 had 29 client-owned cats. The metabolite markers were quantified in cat serum and renal function was estimated using the adapted equation (eRFfel). Receiver Operating Characteristic Area Under the Curve for eRFfel as a binary classifier were 0.9714 and 0.9958, and 0.9731 and 0.9643 as a ternary classifier for cohort 1 and cohort 2, respectively. In cohort 1, eRFfel was 1.30 ± 0.04 (Mean ± SEM, mL/min/kg), 0.78 ± 0.06, and 0.36 ± 0.05 for healthy control, IRIS Chronic Kidney Disease (CKD) stages 1 and 2 (CKD1/2), and stages 3 and 4 (CKD3/4), respectively, and 1.30 ± 0.06, 0.72 ± 0.05, and 0.47 ± 0.04 for healthy control, CKD stage 2, and CKD stage 3 in cohort 2, respectively (both P < 0.0001). Although the original equation was trained on human data, eRFfel was associated positively with urine specific gravity, but negatively with serum symmetric dimethylarginine and creatinine in cats (all P < 0.0001). The preliminary results demonstrated the effectiveness of eRFfel as a classifier for feline renal function.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13578686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum uric acid, gout, cardiometabolic diseases, and multimorbidity: a prospective cohort study using multi-state model. 血清尿酸、痛风、心脏代谢疾病和多种疾病：一项使用多状态模型的前瞻性队列研究

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npj aging Pub Date : 2026-05-25 DOI: 10.1038/s41514-026-00413-6

Chuanghai Wu, Guowei Zhong, Ying Yang, Baizhao Peng, Dexian Li, Zihao Jiang, Wen Fang, Shuai Ji, Xinghong Zhou, Hiu Yee Kwan, Yanyan Liu, Xiaoshan Zhao

{"title":"Serum uric acid, gout, cardiometabolic diseases, and multimorbidity: a prospective cohort study using multi-state model.","authors":"Chuanghai Wu, Guowei Zhong, Ying Yang, Baizhao Peng, Dexian Li, Zihao Jiang, Wen Fang, Shuai Ji, Xinghong Zhou, Hiu Yee Kwan, Yanyan Liu, Xiaoshan Zhao","doi":"10.1038/s41514-026-00413-6","DOIUrl":"10.1038/s41514-026-00413-6","url":null,"abstract":"Multimorbidity, particularly cardiometabolic multimorbidity (CMM), is a growing global health challenge, defined by the co-occurrence of cardiometabolic diseases (CMDs) like type 2 diabetes, ischemic heart disease, and stroke. While serum uric acid (SUA) and gout have been linked to various chronic conditions, their roles in multimorbidity and the CMM trajectory remain unexplored in large populations. Using data from over 400,000 UK Biobank participants, we explored the associations between SUA, gout, 36 chronic conditions, and multimorbidity. A multi-state model was applied to investigate SUA and gout's roles in the CMM trajectory, including transitions from CMD-free status to first CMD (FCMD), CMM, and death. Analyses were conducted for the overall population and stratified by sex. We observed that higher SUA levels and gout were associated with a higher likelihood of multimorbidity and multiple chronic conditions, particularly CMDs. Multi-state analysis revealed that both SUA and gout increased the risk of most transitions. Classifying FCMDs by specific CMDs further revealed distinct roles of SUA/gout in disease-specific transitions, even at the same stage. Sex-specific analyses showed a stronger impact in females compared to males. These findings highlight the importance of managing SUA levels and gout to prevent multimorbidity and slow CMM progression, particularly in females.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-restricted feeding improves functional capacity of adipose-derived stem cells with activation of OSK-associated transcriptional programs. 限时喂养通过激活osk相关转录程序提高脂肪源性干细胞的功能能力。

IF 13

npj aging Pub Date : 2026-05-25 DOI: 10.1038/s41514-026-00411-8

Rui Zhang, Xingxiang Duan, Wanyang Zhong, Yan Deng, Ziping Wang, Junnan Wang, Yan He, Shuang Rong, Qingsong Ye

{"title":"Time-restricted feeding improves functional capacity of adipose-derived stem cells with activation of OSK-associated transcriptional programs.","authors":"Rui Zhang, Xingxiang Duan, Wanyang Zhong, Yan Deng, Ziping Wang, Junnan Wang, Yan He, Shuang Rong, Qingsong Ye","doi":"10.1038/s41514-026-00411-8","DOIUrl":"10.1038/s41514-026-00411-8","url":null,"abstract":"Time-restricted feeding (TRF), a circadian-based dietary intervention, has emerged as a promising strategy to counteract metabolic and age-related dysfunctions. However, how TRF can reverse stem cell aging and restore tissue regenerative potential remains unclear. In this study, we investigated the effects of long-term TRF on senescent adipose-derived stem cells (ADSCs) in a high-fat diet (HFD) induced aged mice model. Mice were assigned to standard or HFD diets under ad libitum or TRF (8 h/day) regimens for 7 months. TRF effectively attenuated HFD-induced weight gain and metabolic inflexibility. Functionally, TRF preserved ADSC morphology and mitochondrial integrity, restored proliferation and migration capacity. Restored balanced lineage differentiation and markedly reduced senescence markers, reactive oxygen species, and inflammatory cytokines. TRF was associated with increased expression of Oct4, Sox2, and Klf4 (OSK) in ADSCs. Lentiviral overexpression of OSK partially recapitulated restoration-associated phenotypes in vitro. However, while OSK overexpression was sufficient to induce these changes, the present data do not establish a necessary role for OSK in mediating TRF-induced effects. Analysis of adipose tissue was consistent with the cell assay, confirming that TRF alleviated fibrosis and inflammation in aged adipose tissue. We find TRF as a noninvasive, physiologically safe intervention to restore aged stem cell function and tissue homeostasis during aging.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age- and sex-dependent transcriptomic network alterations in sepsis. 脓毒症中年龄和性别依赖的转录组网络改变。

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npj aging Pub Date : 2026-05-25 DOI: 10.1038/s41514-026-00416-3

Collins K Boahen, Andrian Fratea, Anca-Lelia Riza, Ioana Streata, Andra Grigorescu, Mihai G Netea, Vinod Kumar

{"title":"Age- and sex-dependent transcriptomic network alterations in sepsis.","authors":"Collins K Boahen, Andrian Fratea, Anca-Lelia Riza, Ioana Streata, Andra Grigorescu, Mihai G Netea, Vinod Kumar","doi":"10.1038/s41514-026-00416-3","DOIUrl":"10.1038/s41514-026-00416-3","url":null,"abstract":"Sepsis arises from a dysregulated immune response to infection, causing systemic inflammation and high mortality. Its nonspecific symptoms and complex molecular mechanisms make early diagnosis and therapeutic development challenging. The contribution of host factors to this heterogeneity is not fully understood. We investigated whether baseline gene co-expression networks are preserved or reorganized in sepsis and whether age and sex influence these networks by analyzing RNA-seq data from Peripheral Blood Mononuclear Cells (PBMCs) of healthy Romanian individuals and sepsis patients. Sixteen co-expression modules were identified in healthy controls. Most were preserved in sepsis, but four exhibited disrupted organization, indicating selective network reprogramming. Notably, the green module was strongly associated with age, sex, and sepsis. Within this module, 13 age-associated and 20 sex-associated hub genes were identified. Individual hub genes showed modest discriminative ability, whereas a multigene model achieved high accuracy (AUC = 0.988). Transcription factor motif enrichment highlighted STAT family and AP-1-related signals, while functional enrichment implicated chromatin remodeling, DNA repair, and immune pathways, consistent with hallmarks of aging. These results suggest that age and sex shape the molecular architecture of sepsis, emphasizing the need for demography-aware approaches to understand its biology and prioritize pathways and regulators for validation towards precision diagnostics and therapeutics.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13483464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Life's essential 8 and longevity: the sustained impact of cardiovascular health on mortality from middle age to centenarians. 生命的本质与长寿：心血管健康对中年至百岁老人死亡率的持续影响。

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npj aging Pub Date : 2026-05-25 DOI: 10.1038/s41514-026-00395-5

Shimin Chen, Shengshu Wang, Bin He, Shanshan Yang, Ke Han, Yueting Shi, Huaihao Li, Yinghui Bao, Junhan Yang, Wenchang Wang, Shengyan Du, Xiaoxin Ye, Yanhao Wan, Jianhua Wang, Yali Zhao, Yizhi Chen, Qiao Zhu, Chaoxue Ning, Yujian Chen, Shihui Fu, Xiangyang Zheng, Dianjianyi Sun, Miao Liu, Yao He

{"title":"Life's essential 8 and longevity: the sustained impact of cardiovascular health on mortality from middle age to centenarians.","authors":"Shimin Chen, Shengshu Wang, Bin He, Shanshan Yang, Ke Han, Yueting Shi, Huaihao Li, Yinghui Bao, Junhan Yang, Wenchang Wang, Shengyan Du, Xiaoxin Ye, Yanhao Wan, Jianhua Wang, Yali Zhao, Yizhi Chen, Qiao Zhu, Chaoxue Ning, Yujian Chen, Shihui Fu, Xiangyang Zheng, Dianjianyi Sun, Miao Liu, Yao He","doi":"10.1038/s41514-026-00395-5","DOIUrl":"10.1038/s41514-026-00395-5","url":null,"abstract":"While Life's Essential 8 (LE8) provides a comprehensive measure of cardiovascular health (CVH), its association with mortality among the oldest-old, including centenarians, remains unclear. This study evaluated the relationship between LE8-defined CVH and all-cause mortality across adulthood using data from the China Kadoorie Biobank (Hainan cohort) and the China Hainan Centenarian Cohort Study, including 31,473 individuals aged 30-116. Participants were categorized by life stage and CVH score (low, moderate, high). Higher CVH scores were associated with significantly reduced mortality risk at all life stages, including among centenarians, who experienced a 54.8% lower risk with high CVH. A near-linear dose-response relationship was observed. Population-attributable fractions for mortality reached 36.8% in centenarians. Physical activity and body mass were particularly important in reducing mortality among centenarians. These findings challenge therapeutic nihilism in the oldest-old while underscoring the need for age-specific strategies tailored to distinct physiological profiles is crucial for extending healthy lifespan across the adult life course.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteocalcin is a compensatory hormone to protect the nervous system in ovariectomized mice. 骨钙素是一种保护去卵巢小鼠神经系统的代偿性激素。

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npj aging Pub Date : 2026-05-23 DOI: 10.1038/s41514-026-00410-9

Yiting Kang, Yaoyao Yao, Zeguo Feng, Xiaohang Gao, Yifei Song, Qianyu Zhang, Xiaohui Di, Lei Huang, Wei Han, Jianbao Zhang

{"title":"Osteocalcin is a compensatory hormone to protect the nervous system in ovariectomized mice.","authors":"Yiting Kang, Yaoyao Yao, Zeguo Feng, Xiaohang Gao, Yifei Song, Qianyu Zhang, Xiaohui Di, Lei Huang, Wei Han, Jianbao Zhang","doi":"10.1038/s41514-026-00410-9","DOIUrl":"10.1038/s41514-026-00410-9","url":null,"abstract":"Undercarboxylated osteocalcin (ucOCN), a bone-derived hormone, modulates neurocognition and emotional regulation. Its concentration declines with aging but rises secondarily in females with estrogen deficiency caused by ovarian decline. Using an ovariectomized (OVX) mouse model, we found serum ucOCN sharply increased in early OVX stages with normal behavioral performance, whereas prolonged estrogen loss decreased ucOCN and induced cognitive and emotional impairments. Ocn knockout mice failed to exhibit OVX-triggered ucOCN elevation and displayed severe synaptic damage and behavioral deficits at the early stage, which were rescued by exogenous ucOCN supplementation. Furthermore, long-term ucOCN administration ameliorated behavioral impairments induced by sustained estrogen deficiency, upregulated the expression of synaptic proteins, and restored hippocampal synaptic plasticity. Collectively, dynamic alterations in ucOCN are correlated with neurobehavioral changes under estrogen deficiency. As a time-dependent neurocompensatory mediator, ucOCN maintains hippocampal synaptic integrity. Long-term ucOCN intervention may provide a promising therapeutic strategy for estrogen deficiency-related cognitive and emotional disorders.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148007780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multimodal ocular aging index reveals proteomic pathways and predicts incident age-related eye diseases. 多模态眼衰老指数揭示蛋白质组学途径并预测与年龄相关的眼病。

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npj aging Pub Date : 2026-05-22 DOI: 10.1038/s41514-026-00418-1

Jia-Yan Kai, Shi-Yi Gong, Dan-Lin Li, Carla Lanca, Andrzej Grzybowski, Chaofu Ke, Chen-Wei Pan

{"title":"A multimodal ocular aging index reveals proteomic pathways and predicts incident age-related eye diseases.","authors":"Jia-Yan Kai, Shi-Yi Gong, Dan-Lin Li, Carla Lanca, Andrzej Grzybowski, Chaofu Ke, Chen-Wei Pan","doi":"10.1038/s41514-026-00418-1","DOIUrl":"10.1038/s41514-026-00418-1","url":null,"abstract":"Chronological age incompletely captures heterogeneity in biological aging. In this prospective study of 45,819 UK Biobank participants, we developed a multimodal ocular aging index (MOAI) by integrating ophthalmic phenotypes with plasma proteomic and metabolomic profiles using machine learning. The MOAI quantifies divergence between ocular biological and chronological age. Over 13.80 years of follow-up, accelerated ocular aging was significantly associated with higher risks of incident age-related macular degeneration and cataract, even after adjustment for chronological age and established risk factors. Incorporation of the MOAI significantly improved risk reclassification beyond traditional predictors. Explainable modeling and pathway enrichment analyses identified inflammation-related proteins and pathways, including cytokine-cytokine receptor interactions and PI3K-Akt signaling, as key drivers of accelerated ocular aging. These findings establish a multimodal framework for quantifying organ-specific biological aging, link ocular aging to systemic inflammatory processes, and highlight the eye as a sensitive readout of aging biology with implications for healthspan.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13469725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148007755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discordance between measured and perceived vision in older adults: the need for objective screening despite health consciousness. 老年人测量视力与感知视力之间的不一致：尽管有健康意识，但仍需要进行客观筛查。

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npj aging Pub Date : 2026-05-20 DOI: 10.1038/s41514-026-00403-8

Xueer Tu, Xun Wang, Lanqin Zhao, Duoru Lin, Weiming Huang, Jun Fu, Qiuping Zhong, Dongni Wang, Meimei Dongye, Zhenzhen Liu, Haotian Lin

{"title":"Discordance between measured and perceived vision in older adults: the need for objective screening despite health consciousness.","authors":"Xueer Tu, Xun Wang, Lanqin Zhao, Duoru Lin, Weiming Huang, Jun Fu, Qiuping Zhong, Dongni Wang, Meimei Dongye, Zhenzhen Liu, Haotian Lin","doi":"10.1038/s41514-026-00403-8","DOIUrl":"10.1038/s41514-026-00403-8","url":null,"abstract":"Perceived visual problems in older adults do not always align with measured vision, potentially delaying diagnosis and timely intervention. In this cross-sectional analysis of baseline data from the Proactive Ophthalmic Examination Cohort (Guangzhou, 2023-2024), we evaluated the prevalence and correlates of discordance between objective vision impairment (OVI, presenting visual acuity <20/40) and subjective visual disturbance (SVD, self-reported visual symptoms) among 829 health-conscious adults aged ≥65 years without prior intraocular interventions. Discordance was defined as two conditions: OVI without SVD or non-OVI with SVD. Associated factors were examined at the eye level using generalized linear mixed-effects models. Within this cohort, the prevalences of OVI and SVD were 42.8% and 44.6%, respectively (53.1% and 47.9% at the participant level). Discordance was substantial: 47.2% of OVI eyes did not report SVD, whereas 38.5% of non-OVI eyes reported SVD. SVD demonstrated limited accuracy for identifying OVI (sensitivity, 0.53; specificity, 0.64). The proportion of OVI eyes attributable to uncorrected refractive error was higher in OVI without SVD than in OVI with SVD (83.0% vs. 66.8%, p < 0.001). Higher income and lower Self-Rating Anxiety Scale (SAS) scores were associated with OVI without SVD, while lower income and higher SAS scores were linked to non-OVI with SVD; unilateral OVI was also associated with OVI without SVD. These findings indicate that SVD incompletely reflects OVI and underscore the need for routine objective vision screening in older populations, irrespective of perceived symptoms.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crosstalk between lipid metabolism and epigenetics in cellular senescence and age-related diseases. 细胞衰老和年龄相关疾病中脂质代谢与表观遗传学之间的串扰。

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npj aging Pub Date : 2026-05-20 DOI: 10.1038/s41514-026-00408-3

Xiao Yu, Fanke Huang, Menghui Hou, Nan Wang, Qianhui Ma, Minghe Li, Chang Zhang, Haiying Zhang, Yingai Shi, Xu He

引用次数: 0

Decidual aging in recurrent pregnancy Loss: from regulating networks to therapeutic interventions. 复发性妊娠丢失中的个体衰老：从调节网络到治疗干预。

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npj aging Pub Date : 2026-05-19 DOI: 10.1038/s41514-026-00407-4

Yu Liu, Wenyan Shi, Zhonglin Jiang, Yujie Xu, Meichen Wang, Xiuju Wang, Hongmei Yin, Dong Wang, Feibo Xu, Yuhui Hao, Dongdong Guan, Lei Han

引用次数: 0