Relationship between physical activity and DNA methylation-predicted epigenetic clocks.

IF 4.1 Q2 GERIATRICS & GERONTOLOGY
Yanwei You, Yuquan Chen, Hao Ding, Qiyu Liu, Rui Wang, Kailin Xu, Qingyuan Wang, Danijela Gasevic, Xindong Ma
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引用次数: 0

Abstract

This study investigates the relationship between physical activity (PA) levels and DNA methylation (DNAm)-predicted epigenetic clocks in a U.S. population sample (n = 948, mean age 62, 49% female). Eight epigenetic clocks were analyzed, revealing that higher PA levels were significantly associated with younger biological ages across all indicators, with the strongest effects observed for SkinBloodAge and LinAge. Multivariable linear regression models, adjusted for sociodemographic and lifestyle factors, highlighted the potential of PA to reduce biological ageing. Subgroup analyses indicated that these associations were more pronounced among non-Hispanic whites, individuals with a BMI of 25-30, and former smokers, suggesting that the impact of PA varies across different groups. These findings emphasize the role of PA in slowing biological ageing and reducing age-related health risks. Promoting regular PA, especially among older adults and those with higher BMI, could improve well-being and lifespan, highlighting PA as a modifiable factor in healthy ageing and age-related disease prevention.

体育活动与DNA甲基化预测表观遗传时钟的关系。
本研究调查了美国人群样本(n = 948,平均年龄62岁,49%为女性)中体力活动(PA)水平与DNA甲基化(DNAm)预测表观遗传时钟之间的关系。研究人员分析了8个表观遗传时钟,发现PA水平越高,所有指标的生物年龄越年轻,其中对皮肤血液年龄和血统年龄的影响最大。多变量线性回归模型,调整了社会人口和生活方式因素,强调了PA减少生物衰老的潜力。亚组分析表明,这些关联在非西班牙裔白人、BMI在25-30之间的个体和前吸烟者中更为明显,这表明PA的影响在不同的群体中有所不同。这些发现强调了PA在减缓生物衰老和减少与年龄相关的健康风险方面的作用。提倡定期PA,特别是在老年人和BMI较高的人群中,可以改善幸福感和寿命,强调PA是健康老龄化和年龄相关疾病预防的可改变因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
8.90
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