IF 4.1

npj aging Pub Date : 2025-04-01 DOI: 10.1038/s41514-025-00213-4

Guliyeerke Jigeer, Kaiyue Wang, Yuebing Lv, Katherine L Tucker, Xiuhua Shen, Fan Chen, Liang Sun, Xiaoming Shi, Yaqi Li, Xiang Gao

{"title":"Vegetarian diet and healthy aging among Chinese older adults: a prospective study.","authors":"Guliyeerke Jigeer, Kaiyue Wang, Yuebing Lv, Katherine L Tucker, Xiuhua Shen, Fan Chen, Liang Sun, Xiaoming Shi, Yaqi Li, Xiang Gao","doi":"10.1038/s41514-025-00213-4","DOIUrl":"10.1038/s41514-025-00213-4","url":null,"abstract":"Vegetarian diets are increasingly popular worldwide, but their impact on healthy aging in older adults remains unclear. This study examined the association between vegetarian diets and healthy aging among 2,888 healthy older Chinese adults from the Chinese Longitudinal Healthy Longevity Survey. Dietary patterns (vegan, ovo-vegetarian, pesco-vegetarian, omnivorous) were derived from a simplified non-quantitative food frequency questionnaire. Over a median follow-up of 6 years, after accounting for sociodemographic and lifestyle factors, vegetarians had lower odds of achieving healthy aging compared to omnivores (adjusted OR = 0.65, 95% CI: 0.47-0.89), with consistent results across sensitivity analyses and individual health components. Additionally, the health effects of vegetarian diets may vary depending on diet quality, with vegetarians of higher diet quality not significantly differing in terms of overall healthy aging and individual outcomes when compared to omnivores. Accordingly, this finding highlights modest inclusion of animal-based foods may improve the overall health status of healthy older adults.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"25"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian vascular aging: a hidden driver of mid-age female fertility decline.

IF 4.1

npj aging Pub Date : 2025-03-30 DOI: 10.1038/s41514-025-00216-1

Ge Wang, Ruobing Yang, Hua Zhang

引用次数: 0

Pan-PTM profiling identifies post-translational modifications associated with exceptional longevity and preservation of skeletal muscle function in Drosophila.

IF 4.1

npj aging Pub Date : 2025-03-30 DOI: 10.1038/s41514-025-00215-2

Suresh Poudel, Chia-Lung Chuang, Him K Shrestha, Fabio Demontis

{"title":"Pan-PTM profiling identifies post-translational modifications associated with exceptional longevity and preservation of skeletal muscle function in Drosophila.","authors":"Suresh Poudel, Chia-Lung Chuang, Him K Shrestha, Fabio Demontis","doi":"10.1038/s41514-025-00215-2","DOIUrl":"10.1038/s41514-025-00215-2","url":null,"abstract":"Skeletal muscle weakness is a major component of age-associated frailty, but the underlying mechanisms are not completely understood. Drosophila has emerged as a useful model for studying skeletal muscle aging. In this organism, previous lab-based selection established strains with increased longevity and reduced age-associated muscle functional decline compared to a parental strain. Here, we have applied a computational pipeline (JUMPptm) for retrieving information on 8 post-translational modifications (PTMs) from the skeletal muscle proteomes of 2 long-lived strains and the corresponding parental strain in young and old age. This pan-PTM analysis identified 2470 modified sites (acetylation, carboxylation, deamidation, dihydroxylation, mono-methylation, oxidation, phosphorylation, and ubiquitination) in several classes of proteins, including evolutionarily conserved muscle contractile proteins and metabolic enzymes. PTM consensus sequences further highlight the amino acids that are enriched adjacent to the modified site, thus providing insight into the flanking residues that influence distinct PTMs. Altogether, these analyses identify PTMs associated with muscle functional decline during aging and that may underlie the longevity and negligible functional senescence of lab-evolved Drosophila strains.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"23"},"PeriodicalIF":4.1,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting all-cause mortality with machine learning among Brazilians aged 50 and over: results from The Brazilian Longitudinal Study of Ageing (ELSI-Brazil).

IF 4.1

npj aging Pub Date : 2025-03-28 DOI: 10.1038/s41514-025-00210-7

Felipe Mendes Delpino, Alexandre Dias Porto Chiavegatto Filho, Juliana Lustosa Torres, Fabíola Bof de Andrade, Maria Fernanda Lima-Costa, Bruno Pereira Nunes

{"title":"Predicting all-cause mortality with machine learning among Brazilians aged 50 and over: results from The Brazilian Longitudinal Study of Ageing (ELSI-Brazil).","authors":"Felipe Mendes Delpino, Alexandre Dias Porto Chiavegatto Filho, Juliana Lustosa Torres, Fabíola Bof de Andrade, Maria Fernanda Lima-Costa, Bruno Pereira Nunes","doi":"10.1038/s41514-025-00210-7","DOIUrl":"https://doi.org/10.1038/s41514-025-00210-7","url":null,"abstract":"We aimed to develop a machine-learning model to predict all-cause mortality among Brazilians aged 50 and over, incorporating demographic, health, and lifestyle characteristics as predictors. We analyzed data from the Brazilian Longitudinal Study of Aging (ELSI-Brazil), waves 1 and 2 (2015-2021), a nationally representative sample from 70 municipalities across Brazil's five regions. Nine algorithms, including Random Forest, Gradient Boosting, XGBOOST, and Logistic Regression, were tested on 9412 participants (54.6% female), with 970 deaths recorded over approximately five years. Using 59 predictor variables, we assessed performance with metrics like AUC, accuracy, precision, and F1-Score. Random Forest excelled with an AUC of 0.92 (95% CI: 0.90-0.94). SHAP analysis highlighted age, sex, BMI, medication use, and physical activity as top predictors. Integrating these models into healthcare systems can improve policy planning and enable targeted interventions, ultimately fostering better health outcomes for aging populations.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"22"},"PeriodicalIF":4.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Butylphthalide identified via Samul-tang-induced transcriptomic signatures improves oocyte quality in aged mice.

IF 4.1

npj aging Pub Date : 2025-03-26 DOI: 10.1038/s41514-025-00214-3

Hyejin Shin, Haeseung Lee, Musun Park, Kyuwon Son, Myunggyo Lee, Ami Lee, Seongwon Cha, Sooseong You

{"title":"Butylphthalide identified via Samul-tang-induced transcriptomic signatures improves oocyte quality in aged mice.","authors":"Hyejin Shin, Haeseung Lee, Musun Park, Kyuwon Son, Myunggyo Lee, Ami Lee, Seongwon Cha, Sooseong You","doi":"10.1038/s41514-025-00214-3","DOIUrl":"10.1038/s41514-025-00214-3","url":null,"abstract":"Samul-tang (SM) is a traditional prescription widely used in clinical practice for the management of gynecological diseases, especially for menstrual regulation and infertility treatment. We previously reported its efficacy in increasing mature oocyte production and improving ovarian reserves, potentially regulated by rat sarcoma virus (Ras) signaling in the ovaries of aged mice. Although the main ingredients of SM are known, the bioactive compounds responsible for protecting ovarian function during aging remain unidentified. This study aimed to identify the active compounds that significantly contribute to the therapeutic potential of SM against age-related decline in ovarian function. The combination of butylphthalide and oleanolic acid improved mature oocyte production similar to that in SM-administered aged mice. Subsequently, we identified butylphthalide as an active compound that mimicked SM's effect on enhancing ovarian reserve. This study introduces a novel strategy for identifying active compounds in multi-component herbal medicines by evaluating compound combinations in an in vivo model, offering promising therapeutic avenues for age-related female infertility through targeted gene expression modulation.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"21"},"PeriodicalIF":4.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing metabolic health with digital twins.

IF 4.1

npj aging Pub Date : 2025-03-24 DOI: 10.1038/s41514-025-00211-6

Chengxun Su, Peter Wang, Nigel Foo, Dean Ho

引用次数: 0

Author Correction: The annual rate of coronary artery calcification with combination therapy with a PCSK9 inhibitor and a statin is lower than that with statin monotherapy. 作者更正：采用 PCSK9 抑制剂和他汀类药物联合疗法的冠状动脉钙化年发生率低于他汀类药物单药疗法。

IF 4.1

npj aging Pub Date : 2025-03-19 DOI: 10.1038/s41514-025-00208-1

Yuichi Ikegami, Ikuo Inoue, Kaiji Inoue, Yuichi Shinoda, Shinichiro Iida, Seiichi Goto, Takanari Nakano, Akira Shimada, Mitsuhiko Noda

引用次数: 0

Atg5 in microglia regulates sex-specific effects on postnatal neurogenesis in Alzheimer's disease.

IF 4.1

npj aging Pub Date : 2025-03-16 DOI: 10.1038/s41514-025-00209-0

Ellen Walter, Gabrielle Angst, Justin Bollinger, Linh Truong, Elena Ware, Eric S Wohleb, Yanbo Fan, Chenran Wang

引用次数: 0

The role of inhibitory and excitatory neurometabolites in age-related differences in action selection.

IF 4.1

npj aging Pub Date : 2025-03-13 DOI: 10.1038/s41514-025-00204-5

Geraldine Rodríguez-Nieto, Amirhossein Rasooli, Hong Li, Stefan Sunaert, Dante Mantini, Mark Mikkelsen, Richard A E Edden, Sima Chalavi, Stephan P Swinnen

引用次数: 0

Adaptation of the Spalax galili transcriptome to hypoxia may underlie the complex phenotype featuring longevity and cancer resistance.

IF 4.1

npj aging Pub Date : 2025-03-06 DOI: 10.1038/s41514-025-00206-3

Gesa Poetzsch, Luca Jelacic, Leon Dammer, Sören Lukas Hellmann, Michelle Balling, Miguel Andrade-Navarro, Aaron Avivi, Imad Shams, Anne Bicker, Thomas Hankeln

{"title":"Adaptation of the Spalax galili transcriptome to hypoxia may underlie the complex phenotype featuring longevity and cancer resistance.","authors":"Gesa Poetzsch, Luca Jelacic, Leon Dammer, Sören Lukas Hellmann, Michelle Balling, Miguel Andrade-Navarro, Aaron Avivi, Imad Shams, Anne Bicker, Thomas Hankeln","doi":"10.1038/s41514-025-00206-3","DOIUrl":"10.1038/s41514-025-00206-3","url":null,"abstract":"In the subterranean rodent (Nanno)spalax galili, evolutionary adaptation to hypoxia is correlated with longevity and tumor resistance. Adapted gene-regulatory networks of Spalax might pinpoint strategies to maintain health in humans. Comparing liver, kidney and spleen transcriptome data from Spalax and rat at hypoxia and normoxia, we identified differentially expressed gene pathways common to multiple organs in both species. Body-wide interspecies differences affected processes like cell death, antioxidant defense, DNA repair, energy metabolism, immune response and angiogenesis, which may play a crucial role in Spalax's adaptation to environmental hypoxia. In all organs, transcription of genes for genome stability maintenance and DNA repair was elevated in Spalax versus rat, accompanied by lower expression of aerobic energy metabolism and proinflammatory genes. These transcriptomic changes might account for the extraordinary lifespan of Spalax and its cancer resistance. The identified gene networks present candidates for further investigating the molecular basis underlying the complex Spalax phenotype.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"16"},"PeriodicalIF":4.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

npj aging最新文献