IF 4.1

npj aging Pub Date : 2025-06-23 DOI: 10.1038/s41514-025-00246-9

Ruin Moaddel, Chad Sanehira, Gregory Keyes, Chang-Yi Cui, Reza Ahmadkhaniha, Julián Candia, Nathan L Price, Sarah Eckroth, Bryce Middleton, Mohammed Khadeer, Caio H Mazucanti, Ross A McDevitt, Myriam Gorospe, Rafael de Cabo, Josephine M Egan, Christopher E Ramsden, Luigi Ferrucci

引用次数: 0

Multinational evaluation of AnthropoAge as a measure of biological age in the USA, England, Mexico, Costa Rica, and China: a population-based longitudinal study. 在美国、英国、墨西哥、哥斯达黎加和中国，对AnthropoAge作为生物年龄测量的多国评估：一项基于人口的纵向研究。

IF 4.1

npj aging Pub Date : 2025-06-21 DOI: 10.1038/s41514-025-00232-1

Carlos A Fermín-Martínez, Daniel Ramírez-García, Neftali Eduardo Antonio-Villa, Jerónimo Perezalonso Espinosa, Diego Aguilar-Ramírez, Carmen García-Peña, Luis Miguel Gutiérrez-Robledo, Jacqueline A Seiglie, Omar Yaxmehen Bello-Chavolla

{"title":"Multinational evaluation of AnthropoAge as a measure of biological age in the USA, England, Mexico, Costa Rica, and China: a population-based longitudinal study.","authors":"Carlos A Fermín-Martínez, Daniel Ramírez-García, Neftali Eduardo Antonio-Villa, Jerónimo Perezalonso Espinosa, Diego Aguilar-Ramírez, Carmen García-Peña, Luis Miguel Gutiérrez-Robledo, Jacqueline A Seiglie, Omar Yaxmehen Bello-Chavolla","doi":"10.1038/s41514-025-00232-1","DOIUrl":"10.1038/s41514-025-00232-1","url":null,"abstract":"We validated AnthropoAge, a biological age (BA) metric, for prediction of mortality and age-related outcomes using harmonized data from the US, England, Mexico, Costa Rica, and China. We estimated AnthropoAge and AnthropoAgeAccel as proxies of BA and age acceleration using body mass index and waist-to-height ratio. We compared mortality prediction of AnthropoAge vs. chronological age (CA) using Cox models and assessed its association with age-related outcomes with generalized estimating equations. Among 57,080 participants aged 50-94 years, AnthropoAgeAccel (c-statistic 0.806) improved mortality prediction of CA (0.803) and identified distinct aging trends for each country. Accelerated aging (AnthropoAgeAccel>0) increased mortality risk by ~37% independently of age and covariates, and predicted health deterioration, new deficits in activities of daily living, and age-related diseases. AnthropoAge is a robust BA metric with potential applications in identifying functional deficits, health decline, and mortality risk. However, it requires further validation and potential recalibration for broader applicability in underrepresented populations like Latin America.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"52"},"PeriodicalIF":4.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food insecurity modifies the association between the gut microbiome and the risk of cognitive impairment in adults. 粮食不安全改变了肠道微生物群与成人认知障碍风险之间的关系。

IF 4.1

npj aging Pub Date : 2025-06-18 DOI: 10.1038/s41514-025-00241-0

Shoshannah Eggers, Zachary E Hoggarth, Kiran Nagdeo, Maria J Banas, Jamil M Lane, Elza Rechtman, Chris Gennings, Elizabeth O'Neal, Paul E Peppard, Ajay K Sethi, Nasia Safdar, Kristen Mc Malecki, Amy A Schultz, Vishal Midya

{"title":"Food insecurity modifies the association between the gut microbiome and the risk of cognitive impairment in adults.","authors":"Shoshannah Eggers, Zachary E Hoggarth, Kiran Nagdeo, Maria J Banas, Jamil M Lane, Elza Rechtman, Chris Gennings, Elizabeth O'Neal, Paul E Peppard, Ajay K Sethi, Nasia Safdar, Kristen Mc Malecki, Amy A Schultz, Vishal Midya","doi":"10.1038/s41514-025-00241-0","DOIUrl":"10.1038/s41514-025-00241-0","url":null,"abstract":"This study investigated the role of food insecurity as an effect modifier between the gut microbiome, including groups of microbes (cliques), and risk of cognitive impairment (RCI). The analytical sample (n = 360) included adult participants of the Survey of the Health of Wisconsin with complete data on food insecurity, RCI, and 16S rRNA sequencing from stool samples. Microbial cliques associated with RCI were identified using an interpretable machine-learning-based algorithm. All analyses were stratified by food insecurity level, and adjusted for relevant confounders. We identified two cliques whose associations with RCI were modified by food insecurity status. The presence of the clique with either Eisenbergiella or Eubacterium was more strongly associated with RCI for the food-insecure group (β = 0.29, p < 0.0001). A clique representing the presence of Ruminococcus torques, Bacteroides, CAG-352F, and/or Eubacterium had a stronger association with RCI for the food-secure group (β = 0.1, p < 0.0001). Findings suggest food security be considered in RCI etiology.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"47"},"PeriodicalIF":4.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise alters transcriptional profiles of senescence and gut barrier integrity in intestinal crypts of aging mice. 运动改变衰老小鼠肠隐窝中衰老和肠屏障完整性的转录谱。

IF 4.1

npj aging Pub Date : 2025-06-13 DOI: 10.1038/s41514-025-00242-z

Hyeonuk Jeon, Siyeon Lee, Yumin Kim, Yeongmin Kim, Soyeon Shin, Yoseob Lee, Minki Kim, Eunbin Ko, Eunsu Lee, Brian Min Song, Hojeong Choi, Nahee Hwang, Se-Eun Han, Byungjin Hwang, Jae-Woo Kim, Chang-Myung Oh, Sungsoon Fang

{"title":"Exercise alters transcriptional profiles of senescence and gut barrier integrity in intestinal crypts of aging mice.","authors":"Hyeonuk Jeon, Siyeon Lee, Yumin Kim, Yeongmin Kim, Soyeon Shin, Yoseob Lee, Minki Kim, Eunbin Ko, Eunsu Lee, Brian Min Song, Hojeong Choi, Nahee Hwang, Se-Eun Han, Byungjin Hwang, Jae-Woo Kim, Chang-Myung Oh, Sungsoon Fang","doi":"10.1038/s41514-025-00242-z","DOIUrl":"10.1038/s41514-025-00242-z","url":null,"abstract":"Senescence is the gradual process of aging in tissues and cells, and a primary cause of aging-associated diseases. Among them, intestinal stem cells (ISCs) experience exhaustion during aging, leading to reduced regenerative capacity in the intestinal crypt, which impairs intestinal function and contributes to systemic health issues. Given the critical role ISCs play in maintaining intestinal homeostasis, preventing their senescence is essential for preserving intestinal function. Among the various strategies proposed to slow cellular senescence, regular exercise has emerged as one of the most well-known and widely accepted interventions. Here, we examined how exercise affects the small intestine in an aging mouse model. Using single-cell RNA sequencing, we found that signaling pathways and gene expression related to DNA replication and cell cycle progression were upregulated in ISCs. Additionally, genes promoting ribosome biogenesis showed increased expression in both ISCs and transit amplifying cells. Exercise also recovered Wnt signaling inhibition, potentially influencing ISC differentiation. Furthermore, exercise increased Reg3g expression in Paneth cells and improved gut barrier function, contrasting with findings from a diet-induced obese mouse model. This suggests that regular exercise helps inhibit the aging of ISCs in multiple ways, contributing to the maintenance of intestinal homeostasis.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"51"},"PeriodicalIF":4.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating EEG complexity and spectral signatures in Alzheimer's disease and frontotemporal dementia: evidence for rostrocaudal asymmetry. 评估阿尔茨海默病和额颞叶痴呆的脑电图复杂性和频谱特征：背侧-尾侧不对称的证据。

IF 4.1

npj aging Pub Date : 2025-06-09 DOI: 10.1038/s41514-025-00243-y

Kassra Ghassemkhani, Kevin S Saroka, Blake T Dotta

引用次数: 0

The role of physical activity in mitigating age-related changes in the neuromuscular control of gait. 体力活动在减轻与年龄相关的步态神经肌肉控制变化中的作用。

IF 4.1

npj aging Pub Date : 2025-06-09 DOI: 10.1038/s41514-025-00239-8

M N Núñez-Lisboa, A H Dewolf

{"title":"The role of physical activity in mitigating age-related changes in the neuromuscular control of gait.","authors":"M N Núñez-Lisboa, A H Dewolf","doi":"10.1038/s41514-025-00239-8","DOIUrl":"10.1038/s41514-025-00239-8","url":null,"abstract":"Exercise induces neural and muscular adaptations, improving muscle mass and function in older adults. We investigated its impact on gait neuromuscular control in young and older adults, classified as more active (young: n = 15, 5185 ± 1471 MET-min/week; old: n = 14, 6481 ± 4846 MET-min/week) or less active (young: n = 14, 1265 ± 965 MET-min/week; old: n = 14, 1473 ± 859 MET-min/week). Isometric maximal voluntary torques were assessed for proximal (knee) and distal (ankle) extensors, and muscle mechanical properties of these muscles were assessed using Myoton. Gait was analysed using ground reaction forces, motion capture, and electromyography. Less active older adults exhibited shorter steps, higher mechanical cost, and greater collision at heel strike. These differences were linked to altered neuromuscular control, wider activation of lumbar and sacral motor pools, different activation timing, and reduced muscle-tendon stiffness. Our findings highlight that physical activity preserves neuromuscular control, muscle mechanical properties, and gait efficiency, mitigating age-related decline.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"49"},"PeriodicalIF":4.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STEMI-OP in-hospital mortality prediction algorithms: Frailty-integrated machine learning in older patients undergoing primary PCI. STEMI-OP住院死亡率预测算法：接受初级PCI的老年患者虚弱综合机器学习

IF 4.1

npj aging Pub Date : 2025-06-06 DOI: 10.1038/s41514-025-00238-9

Tan Van Nguyen, Quyen The Nguyen, Huong Quynh Nguyen, Nghia Thuong Nguyen, Khai Duc Luong, Lan Hoang Do Thi, Tu Cam Nguyen, Thuan Hoang Vo, Phan Huu Le, Phuc Thien Tran, Thanh Dinh Le

{"title":"STEMI-OP in-hospital mortality prediction algorithms: Frailty-integrated machine learning in older patients undergoing primary PCI.","authors":"Tan Van Nguyen, Quyen The Nguyen, Huong Quynh Nguyen, Nghia Thuong Nguyen, Khai Duc Luong, Lan Hoang Do Thi, Tu Cam Nguyen, Thuan Hoang Vo, Phan Huu Le, Phuc Thien Tran, Thanh Dinh Le","doi":"10.1038/s41514-025-00238-9","DOIUrl":"10.1038/s41514-025-00238-9","url":null,"abstract":"Despite advances in medical care, older patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) currently face high in-hospital mortality rates. Traditional prognostic models, primarily developed in Caucasian populations with fewer older participants and using classical statistical approaches, may not perform well in Southeast Asian settings. This study explores the need for artificial intelligence-based risk assessment models-the STEMI-OP algorithms-designed explicitly for STEMI patients aged 60 and older following primary PCI in Vietnam. Machine learning (ML) models were developed and validated using pre- and post-PCI features, with advanced feature selection techniques to identify key predictors. SHapley Additive exPlanations and Causal Random Forests were employed to improve interpretability and causal relationships between features and outcomes, highlighting the key factors, including the Killip classification, the Clinical Frailty Scale, glucose levels, and creatinine levels in predicting in-hospital mortality. The CatBoost model with ElasticNet regression for pre-PCI prediction and the Random Forest model with Ridge regression post-PCI prediction demonstrated significantly superior performance compared to traditional risk scores, achieving AUC values of 92.16% and 95.10%, respectively, outperforming the GRACE 2.0 score (83.48%) and the CADILLAC score (87.01%). By incorporating frailty and employing advanced ML techniques, the STEMI-OP algorithms produced more precise, personalized risk assessments that could enhance clinical decision-making and improve outcomes for older STEMI patients undergoing primary PCI.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"48"},"PeriodicalIF":4.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ageing is associated with exaggerated overstaying in foraging behaviour. 衰老与觅食行为中过度停留有关。

IF 4.1

npj aging Pub Date : 2025-05-30 DOI: 10.1038/s41514-025-00240-1

Noham Wolpe, Daniel N Scott, Mordechai L Salomon, Matthew R Nassar, Paul C Fletcher, Emilio Fernandez-Egea

{"title":"Ageing is associated with exaggerated overstaying in foraging behaviour.","authors":"Noham Wolpe, Daniel N Scott, Mordechai L Salomon, Matthew R Nassar, Paul C Fletcher, Emilio Fernandez-Egea","doi":"10.1038/s41514-025-00240-1","DOIUrl":"10.1038/s41514-025-00240-1","url":null,"abstract":"People constantly decide how much time to invest in rewarding activities. Foraging tasks assess this decision-making by measuring when individuals switch between contexts. People typically perform suboptimally in these tasks, largely due to overstaying, but it remains unclear whether this tendency changes with age independently of cognitive abilities and mental health factors. Previous research showing increased sensitivity to the opportunity cost of time in older adults predicts less overstaying, whereas a hypothesised shift towards exploitative behaviour predicts more overstaying. In an online foraging task, 350 young and older adults decided when to switch between contexts with varying reward conditions. We also assessed cognitive performance and self-reported motivation and depression. Participants consistently overstayed, and this behaviour was strongly associated with sensitivity to reward changes. Despite this, older adults selectively overstayed more without increased reward-based adaptation. Our findings show ageing is associated with exaggerated overstaying, supporting increased exploitative behaviour in old age.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"46"},"PeriodicalIF":4.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Senolytic effects of a modified Gingerenone A. 改性姜酮a的抗衰老作用。

IF 4.1

npj aging Pub Date : 2025-05-30 DOI: 10.1038/s41514-025-00230-3

Ruin Moaddel, Chad Sanehira, Gregory Keyes, Chang-Yi Cui, Reza Ahmadkhaniha, Julián Candia, Nathan L Price, Sarah Eckroth, Bryce Middleton, Mohammed Khadeer, Caio H Mazucanti, Ross A McDevitt, Myriam Gorospe, Rafael de Cabo, Josephine M Egan, Christopher E Ramsden, Luigi Ferrucci

{"title":"Senolytic effects of a modified Gingerenone A.","authors":"Ruin Moaddel, Chad Sanehira, Gregory Keyes, Chang-Yi Cui, Reza Ahmadkhaniha, Julián Candia, Nathan L Price, Sarah Eckroth, Bryce Middleton, Mohammed Khadeer, Caio H Mazucanti, Ross A McDevitt, Myriam Gorospe, Rafael de Cabo, Josephine M Egan, Christopher E Ramsden, Luigi Ferrucci","doi":"10.1038/s41514-025-00230-3","DOIUrl":"10.1038/s41514-025-00230-3","url":null,"abstract":"Senescent cells accumulate with aging and are associated with several age-associated diseases and functional declines. Eliminating senescent cells with senolytics improves aging phenotypes in mouse models and may improve the health of people with chronic diseases. To date, very few senotherapeutic (senolytics and senomorphics) compounds have been identified. In a recent study, we reported that gingerenone A (GinA) has a senolytic effect via mechanisms including the activation of caspase-3 activity and apoptotic cell death. In this study, we investigated whether GinA has senotherapeutic properties in a mouse model of senescence. Moreover, we modified GinA with eicosapentaenoic acid (EPA) esters (GinA-EPA) or docosahexaenoic acid (DHA) esters (GinA-DHA) to generate modified gingerenone A (modGinA) that could enhance GinA effects. We found that both GinA and modGinA induced biochemical and histological changes consistent with anti-inflammatory, senolytic, and senomorphic effects, leading to improved metabolic and mitochondrial functions.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"45"},"PeriodicalIF":4.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subcortical brain volumetric differences related to white matter lesion volume and cognition in healthy aging. 健康衰老中白质损伤体积与认知的皮质下脑容量差异。

IF 4.1

npj aging Pub Date : 2025-05-28 DOI: 10.1038/s41514-025-00234-z

Hyun Song, Pradyumna K Bharadwaj, Matthew D Grilli, David A Raichlen, Christian G Habeck, Matthew J Huentelman, Georg A Hishaw, Theodore P Trouard, Gene E Alexander

{"title":"Subcortical brain volumetric differences related to white matter lesion volume and cognition in healthy aging.","authors":"Hyun Song, Pradyumna K Bharadwaj, Matthew D Grilli, David A Raichlen, Christian G Habeck, Matthew J Huentelman, Georg A Hishaw, Theodore P Trouard, Gene E Alexander","doi":"10.1038/s41514-025-00234-z","DOIUrl":"10.1038/s41514-025-00234-z","url":null,"abstract":"White matter hyperintensity (WMH) lesions associated with small vessel cerebrovascular disease (CVD) are common structural neuroimaging findings in older adults. Greater global brain WMH burden related to aging has been implicated in dementia but has also been linked to brain atrophy and cognitive dysfunction in old age. We sought to investigate the regionally distributed association of global WMH lesion load with subcortical gray matter (SGM) volumes using a multivariate network analysis method in 178 community-dwelling, healthy older adults (mean age = 69.77 ± 10.22 years). We additionally applied mediation models with WMH-related subcortical volumetric differences as a mediator to evaluate a potential global WMH-related vascular risk pathway leading to cognitive aging. Global WMH burden was associated with a regionally distributed pattern of SGM atrophy involving bilateral putamen and left nucleus accumbens, with relative volume increases in bilateral caudate nucleus. Mediation analyses revealed that increasing age predicted greater WMH-SGM pattern expression, which then predicted slowed processing speed that was, in turn, associated with decrements in other age-sensitive cognitive domains of memory, executive functioning, and fine motor function. These results suggest that the multivariate WMH-SGM pattern and its association with processing speed may provide an important early indicator of age-related decrements in higher-order cognitive processes, reflecting a potential link between CVD and broader cognitive dysfunction across multiple domains in healthy aging.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"44"},"PeriodicalIF":4.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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