IF 6

npj aging Pub Date : 2025-10-09 DOI: 10.1038/s41514-025-00275-4

Yang Chen, Feifei Dai, Shulun Huang, Daoda Qi, Chengyi Peng, Aijia Zhang, Yuan Wang, Yan Gu, Jingjing Guo

引用次数: 0

The dissipation theory of aging: a quantitative analysis using a cellular aging map. 老化的耗散理论：使用细胞老化图的定量分析。

IF 6

npj aging Pub Date : 2025-10-09 DOI: 10.1038/s41514-025-00277-2

Farhan Khodaee, Rohola Zandie, Louis-Alexandre Leger, Yufan Xia, Pakaphol Thadawasin, Elazer R Edelman

引用次数: 0

Spine age estimation using deep learning in lateral spine radiographs and DXA VFA to predict incident fracture and mortality. 使用深度学习侧位脊柱x线片和DXA VFA来估计脊柱年龄，以预测意外骨折和死亡率。

IF 6

npj aging Pub Date : 2025-10-09 DOI: 10.1038/s41514-025-00271-8

Sang Wouk Cho, Namki Hong, Kyoung Min Kim, Young Han Lee, Chang Oh Kim, Hyeon Chang Kim, Yumie Rhee, Brian H Chen, William D Leslie, Steven R Cummings

{"title":"Spine age estimation using deep learning in lateral spine radiographs and DXA VFA to predict incident fracture and mortality.","authors":"Sang Wouk Cho, Namki Hong, Kyoung Min Kim, Young Han Lee, Chang Oh Kim, Hyeon Chang Kim, Yumie Rhee, Brian H Chen, William D Leslie, Steven R Cummings","doi":"10.1038/s41514-025-00271-8","DOIUrl":"https://doi.org/10.1038/s41514-025-00271-8","url":null,"abstract":"Spine age estimated from lateral spine radiographs and DXA VFAs could be associated with fracture and mortality risk. In the VERTE-X cohort (n = 10,341, derivation set) and KURE cohort (n = 3517; external test set), spine age discriminated prevalent vertebral fractures and osteoporosis better than chronological age. Predicted age difference was associated with overall (adjusted HR [aHR] 1.22 per 1 SD increment, p < 0.001), vertebral, non-vertebral incident fractures, and mortality (aHR 1.31, p = 0.001) during a median 6.6 years follow-up in KURE, independent of chronological age and covariates. Spine age to estimate FRAX hip fracture probabilities, instead of chronological age, improved the discriminatory performance for incident hip fracture (AUROC 0.83 vs. 0.78, p = 0.027). Shorter height, lower femoral neck BMD, diabetes, vertebral fractures, and surgical prosthesis were associated with higher predicted age difference, explaining 40% of variance. Spine age estimated from lateral spine radiographs and DXA VFA enhanced fracture risk assessment and mortality prediction over chronological age.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"83"},"PeriodicalIF":6.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timing and duration of calorie restriction determine its impact on ovarian aging in female mice. 卡路里限制的时间和持续时间决定了其对雌性小鼠卵巢衰老的影响。

IF 6

npj aging Pub Date : 2025-10-09 DOI: 10.1038/s41514-025-00276-3

Juliane B Prosczek, Jéssica D Hense, Driele N Garcia, Shara P Sodré, Gabriela A Blanco, César A Pinzón-Osorio, Larissa S Magalhães, Giulia C Pereira, Bianka M Zanini, Renata P Ramirez, Luis A X Cruz, Rafael G Mondadori, Augusto Schneider

{"title":"Timing and duration of calorie restriction determine its impact on ovarian aging in female mice.","authors":"Juliane B Prosczek, Jéssica D Hense, Driele N Garcia, Shara P Sodré, Gabriela A Blanco, César A Pinzón-Osorio, Larissa S Magalhães, Giulia C Pereira, Bianka M Zanini, Renata P Ramirez, Luis A X Cruz, Rafael G Mondadori, Augusto Schneider","doi":"10.1038/s41514-025-00276-3","DOIUrl":"https://doi.org/10.1038/s41514-025-00276-3","url":null,"abstract":"This study investigated how the timing and duration of 30% caloric restriction (CR) affect ovarian aging in mice. Mice were assigned to one of four groups: ad libitum (AL) control, long-term CR (3-11 months; CR/CR), early short-term CR (3-7 months; CR/AL), and late short-term CR (7-11 months; AL/CR). Long-term CR reduced body mass, improved insulin sensitivity, preserved the ovarian primordial follicle reserve, and attenuated ovarian macrophage infiltration compared to AL-fed mice. Metabolic benefits from CR were quickly reversed upon returning to AL feeding. Short-term CR, whether initiated early or late, did not preserve the ovarian reserve. Some benefits were observed with an early start CR, including reduced ovarian collagen deposition at 7 months and reduced macrophage infiltration at 11 months. Our findings indicate that only long-term CR preserves the ovarian reserve. Short-term CR positive effects on other ovarian aging hallmarks depended on an early age of onset.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"87"},"PeriodicalIF":6.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of biological aging acceleration in capturing transitions of atrial fibrillation and dementia: a population-based study. 利用生物老化加速捕捉心房颤动和痴呆的转变：一项基于人群的研究。

IF 6

npj aging Pub Date : 2025-10-09 DOI: 10.1038/s41514-025-00274-5

Yufan Liu, Chenglong Li

引用次数: 0

Age-specific tumor-associated macrophage biomarkers underlie metastasis and immune dysregulation in thyroid cancer. 年龄特异性肿瘤相关巨噬细胞生物标志物是甲状腺癌转移和免疫失调的基础。

IF 6

npj aging Pub Date : 2025-10-09 DOI: 10.1038/s41514-025-00270-9

Tianyao Chu, Shenglong Xu, Hongyan Chen, Xinlei Zhang, Yan Zhao, Peng Zhang

引用次数: 0

A centenarian single nucleotide polymorphism in collagen gene COL25A1 promotes longevity in C. elegans. 胶原蛋白基因COL25A1的百岁单核苷酸多态性促进秀丽隐杆线虫的寿命。

IF 6

npj aging Pub Date : 2025-09-30 DOI: 10.1038/s41514-025-00264-7

Anita Goyala, Cyril Statzer, Ji Young Cecilia Park, Ines Neundorf, Michael R MacArthur, Jan M Gebauer, Collin Y Ewald

{"title":"A centenarian single nucleotide polymorphism in collagen gene COL25A1 promotes longevity in C. elegans.","authors":"Anita Goyala, Cyril Statzer, Ji Young Cecilia Park, Ines Neundorf, Michael R MacArthur, Jan M Gebauer, Collin Y Ewald","doi":"10.1038/s41514-025-00264-7","DOIUrl":"10.1038/s41514-025-00264-7","url":null,"abstract":"Before human genome sequencing, a genome-wide study of sibling centenarian pairs identified a longevity-associated locus on chromosome 4. Here, we mapped the genes in this locus and identified a collagen gene, COL25A1. Introducing an SNP linked to longevity that changes a serine predicted to be phosphorylated to leucine in COL25A1, into col-99, the C. elegans ortholog, extended lifespan. These col-99(gk694263[S106L]) SNP-mutants exhibited enhanced innate immune-related transcriptional responses, and their lifespan extension was abolished by inhibiting the p38 MAPK pathway. YAP-1, a transcriptional co-activator responsive to extracellular matrix changes, was essential for this longevity. Mechanistically, we find that this SNP modifies furin-mediated cleavage of this transmembrane collagen in vitro, and expressing the cleaved extracellular domain of COL-99 alone was sufficient to prolong C. elegans' lifespan. These findings reveal a potential mechanism by which a human centenarian-associated SNP in COL25A1 influences furin cleavage and shedding of the collagen ectodomain to promote healthy longevity.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"81"},"PeriodicalIF":6.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding skin aging: the role of KNG1 in collagen and elastic fibre degradation. 解码皮肤老化：KNG1在胶原蛋白和弹性纤维降解中的作用。

IF 6

npj aging Pub Date : 2025-09-26 DOI: 10.1038/s41514-025-00268-3

Xinyue Zhang, Xinyu Yang, Xiaoran Liu, Jianyuan Huang, Yarui Zhang, Xunhong Xu, Qimei Chen, Shan Zhao, Tianyi Huang, Min Zhang, Lin Zhang, Xueer Wang

{"title":"Decoding skin aging: the role of KNG1 in collagen and elastic fibre degradation.","authors":"Xinyue Zhang, Xinyu Yang, Xiaoran Liu, Jianyuan Huang, Yarui Zhang, Xunhong Xu, Qimei Chen, Shan Zhao, Tianyi Huang, Min Zhang, Lin Zhang, Xueer Wang","doi":"10.1038/s41514-025-00268-3","DOIUrl":"10.1038/s41514-025-00268-3","url":null,"abstract":"Kininogen-1 (KNG1) is an important pro-inflammatory and pro-oxidant factor, but its precise role in skin aging remains inadequately elucidated. Quantitative 4D proteomic-sequencing analysis identified upregulated KNG1 in 3- and 15-month-old C57BL/6J mouse skin, with immunohistochemical staining corroborating its increase in intrinsic aging. KNG1 overexpression in murine skin reduced dermal thickness, collagen fibre content, elastic fibre density, aging marker Lamin B1, and increased oxidative stress marker 8-hydroxy-2'-deoxyguanosine (8-OHdG), while KNG1 knockdown ameliorated these aging-associated phenotypes. Protein-protein interaction analysis revealed the underlying mechanisms. KNG1 regulates elastic fibre degradation through membrane metallo-endopeptidase (MME) activity, modulates collagen fibre degradation via matrix metallopeptidase 1 (MMP1) and matrix metallopeptidase 9 (MMP9), and elevates oxidative stress through epoxide hydrolase 2 (EPHX2). Thus, KNG1 may serve as an intrinsic skin aging biomarker, promoting collagen fibre degradation through MMP1/MMP9, elastic fibre breakdown through MME, and oxidative stress through EPHX2. KNG1 downregulation may represent a prospective anti-aging target.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"80"},"PeriodicalIF":6.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial respiratory chain deficiency is associated with an impaired skeletal muscle regenerative response and fibrosis in older men with HIV. 线粒体呼吸链缺陷与老年男性HIV患者骨骼肌再生反应受损和纤维化有关。

IF 6

npj aging Pub Date : 2025-09-23 DOI: 10.1038/s41514-025-00273-6

Matthew Hunt, Amy E Vincent, Megan M McNiff, Gareth Ettridge, Caroline Sabin, Alan Winston, Brendan Ai Payne

{"title":"Mitochondrial respiratory chain deficiency is associated with an impaired skeletal muscle regenerative response and fibrosis in older men with HIV.","authors":"Matthew Hunt, Amy E Vincent, Megan M McNiff, Gareth Ettridge, Caroline Sabin, Alan Winston, Brendan Ai Payne","doi":"10.1038/s41514-025-00273-6","DOIUrl":"10.1038/s41514-025-00273-6","url":null,"abstract":"Despite suppressive anti-retroviral therapy (ART), some older people with HIV show adverse ageing phenotypes, and the underlying mechanisms remain incompletely understood. We recruited 30 men with HIV aged ≥ 50 years and 15 well-matched men without HIV and performed histological analyses on skeletal muscle biopsies and plasma biomarker measurement, in combination with clinical and functional assessments. Men with HIV showed higher frequencies of frailty, pre-frailty, sarcopenia, and pre-sarcopenia when compared to men without HIV. When assessing skeletal muscle, men with HIV had decreased mitochondrial complex I and IV protein abundance and myofibre regeneration, whilst fibrosis was increased, and plasma TNFα and MCP-4 levels were elevated. Spearman correlation analyses suggested that inflammation and mitochondrial respiratory chain deficiency may result in a damage response in skeletal muscle with resolution by fibrosis rather than regeneration. These findings thus provide plausible rationales for adverse ageing phenotypes in older men with HIV, including frailty and sarcopenia.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"79"},"PeriodicalIF":6.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global epidemiology and burden of osteoporosis among postmenopausal women: insights from the Global Burden of Disease Study 2021. 绝经后妇女骨质疏松症的全球流行病学和负担：来自2021年全球疾病负担研究的见解

IF 6

npj aging Pub Date : 2025-09-01 DOI: 10.1038/s41514-025-00269-2

Haofeng Liang, Shibo Chen, Meiling Shi, Jialiang Xu, Chenxi Zhao, Bingsheng Yang, Sikuan Zheng, Jianye Tan

{"title":"Global epidemiology and burden of osteoporosis among postmenopausal women: insights from the Global Burden of Disease Study 2021.","authors":"Haofeng Liang, Shibo Chen, Meiling Shi, Jialiang Xu, Chenxi Zhao, Bingsheng Yang, Sikuan Zheng, Jianye Tan","doi":"10.1038/s41514-025-00269-2","DOIUrl":"10.1038/s41514-025-00269-2","url":null,"abstract":"Osteoporosis, primarily characterized by low bone mineral density (LBMD), is a major skeletal disorder among postmenopausal women (PMW), yet its global burden remains poorly quantified. Leveraging data from the Global Burden of Disease (GBD) Study 2021, we assessed the LBMD burden in PMW across 204 countries and territories between 1990 and 2021. Metrics included deaths, disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs), with temporal trends evaluated via estimated annual percentage change (EAPC). We found that in 2021, LBMD was responsible for 219,552 deaths and 7.76 million DALYs in PMW globally, with age-standardized DALY rates reaching 979.2 per 100,000 population. Compared to premenopausal women, PMW experienced a 15.17-fold higher mortality, a 5.84-fold higher burden in DALYs, and a 6.29-fold higher burden in YLDs. While age-standardized rates (ASR) for deaths and DALYs showed slight declines from 1990 to 2021, the absolute number of LBMD-related deaths more than doubled, increasing from 91,941 in 1990 to 219,552 in 2021, largely driven by global population aging. South Asia experienced the greatest burden, with India reporting the highest DALYs rates. The burden was highest in women aged ≥80 years and increased most rapidly in those aged ≥95. Regions with a high Socio-demographic Index (SDI) exhibited lower mortality rates but disproportionately higher levels of disability, whereas low-SDI regions bore a greater burden of mortality. Projections to 2045 suggest a sustained rise in deaths and disability, despite modest rate reductions. These findings underscore the urgent need for age-tailored, equity-focused interventions to mitigate fracture risk and improve musculoskeletal health among aging female populations worldwide.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"78"},"PeriodicalIF":6.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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