npj aging最新文献

{"title":"Anti-aging properties of the aminosterols of the dogfish shark.","authors":"Denise Barbut, Michele Perni, Michael Zasloff","doi":"10.1038/s41514-024-00188-8","DOIUrl":"https://doi.org/10.1038/s41514-024-00188-8","url":null,"abstract":"<p><p>The development of anti-aging drugs is challenged by both the apparent complexity of the physiological mechanisms involved in aging and the likelihood that many of these mechanisms remain unknown. As a consequence, the development of anti-aging compounds based on the rational targeting of specific pathways has fallen short of the goal. To date, the most impressive compound is rapamycin, a natural bacterial product initially identified as an antifungal, and only subsequently discovered to have anti-aging properties. In this review, we focus on two aminosterols from the dogfish shark, Squalus acanthias, that we discovered initially as broad-spectrum anti-microbial agents. This review is the first to gather together published studies conducted both in vitro and in numerous vertebrate species to demonstrate that these compounds target aging pathways at the cellular level and provide benefits in multiple aging-associated conditions in relevant animal models and in humans. The dogfish aminosterols should be recognized as potential anti-aging drugs.</p>","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"62"},"PeriodicalIF":4.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age- and sex-related variations in extracellular vesicle profiling for the assessment of cardiovascular risk: the EVaging index.","authors":"Jacopo Burrello, Jessica Goi, Alessio Burrello, Elena Vacchi, Azucena Rendon-Angel, Edoardo Lazzarini, Giovanni Bianco, Vittorio Limongelli, Giuseppe Vassalli, Carlo W Cereda, Silvia Monticone, Paolo Mulatero, Benedetta Bussolati, Andrea Alimonti, Giovanni G Camici, Giorgia Melli, Elena Osto, Giovanni Pedrazzini, Barile Lucio","doi":"10.1038/s41514-024-00189-7","DOIUrl":"https://doi.org/10.1038/s41514-024-00189-7","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) offer valuable diagnostic and prognostic insights for cardiovascular (CV) diseases, but the influence of age-related chronic inflammation (\"inflammaging\") and sex differences on EV profiles linked to CV risk remains unclear. This study aimed to use EV profiling to predict age and stratify patients by CV risk. We developed an EVaging index by analyzing surface antigen profiles of serum EVs from 625 participants, aged 20 to 94 years, across varying CV risk groups. The EVaging index was associated with age in healthy individuals and distinguished CV risk profiles in patients, correlating with CV outcomes and likelihood of fatal CV events according to the European Society of Cardiology (ESC) SCORE, and reflecting age-associated comorbidities. While changes in disease-related EV fingerprint adds complexity in CV patients, EV profiling may help assess biological aging and CV risk, emphasizing EVs' roles in inflammaging.</p>","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"63"},"PeriodicalIF":4.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Mediterranean diet in cancer incidence and mortality in the older adults.","authors":"Giulia Giordano, Luca Mastrantoni, Roberta Terranova, Giuseppe Ferdinando Colloca, Giuseppe Zuccalà, Francesco Landi","doi":"10.1038/s41514-024-00186-w","DOIUrl":"10.1038/s41514-024-00186-w","url":null,"abstract":"<p><p>The magnitude of benefit of Mediterranean diet in cancer prevention and mortality in older adults is still unclear, therefore we conducted a systematic review and meta-analysis. Outcomes considered were cancer incidence and cancer mortality. In studies evaluating cancer incidence as a time-to-event endpoint and adherence as quantiles, HR was 0.885 (95% CI 0.773-1.013, I² = 44%). Including ORs, exploratory pooled effect size was 0.876 (0.794-0.966, I² = 34%), consistently with results of studies evaluating ORs for adherence as one-point increase (OR 0.744, 0.570-0.972, I² = 90%). No clear benefit was observed on cancer mortality, with pooled HR of 0.935 (0.800-1.093, I² = 0%). Significant differences were observed for ORs according to cancer type but not between medium and high adherence for both outcomes. Certainty of evidence was low. Our findings suggest that MD could play a protective role in cancer incidence in advanced age, but no clear effect on cancer mortality was observed.</p>","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"61"},"PeriodicalIF":4.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SenMayo transcriptomic senescence panel highlights glial cells in the ageing mouse and human retina.","authors":"Samyuktha Suresh, Gayathri Karthik, John F Ouyang, Vicki Chrysostomou, See Aik Tang, Enrico Petretto, Jonathan G Crowston, Katharina C Bell","doi":"10.1038/s41514-024-00187-9","DOIUrl":"https://doi.org/10.1038/s41514-024-00187-9","url":null,"abstract":"<p><p>There is a growing need to better characterise senescent cells in the CNS and retina. The recently published SenMayo gene panel was developed to identify transcriptomic signatures of senescence across multiple organ systems, but the retina was not included. While other approaches have identified senescent signatures in the retina, these have largely focused on experimental models in young animals. We therefore conducted a detailed single-cell RNA-seq analysis to identify senescent cell populations in the retina of different aged mice and compared these with five comprehensive human and mouse retina and brain transcriptome datasets. Transcriptomic signatures of senescence were most apparent in mouse and human retinal glial cells, with IL4, 13 and 10 and the AP1 pathway being the most prominent markers involved. Similar levels of transcriptional senescence were observed in the retinal glia of young and old mice, whereas the human retina showed significantly increased enrichment scores with advancing age.</p>","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"60"},"PeriodicalIF":4.1,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrated single-cell atlas of blood immune cells in aging.","authors":"Igor Filippov, Leif Schauser, Pärt Peterson","doi":"10.1038/s41514-024-00185-x","DOIUrl":"10.1038/s41514-024-00185-x","url":null,"abstract":"<p><p>Recent advances in single-cell technologies have facilitated studies on age-related alterations in the immune system. However, previous studies have often employed different marker genes to annotate immune cell populations, making it challenging to compare results. In this study, we combined seven single-cell transcriptomic datasets, comprising more than a million cells from one hundred and three donors, to create a unified atlas of human peripheral blood mononuclear cells (PBMC) from both young and old individuals. Using a consistent set of marker genes for immune cell annotation, we standardized the classification of immune cells and assessed their prevalence in both age groups. The integrated dataset revealed several consistent trends related to aging, including a decline in CD8⁺ naive T cells and MAIT cells and an expansion of non-classical monocyte compartments. However, we observed significant variability in other cell types. Our analysis of the long non-coding RNA MALAT1^hi T cell population, previously implicated in age-related T cell exhaustion, showed that this population is highly heterogeneous with a mixture of naïve-like and memory-like cells. Despite substantial variation among the datasets when comparing gene expression between age groups, we identified a high-confidence signature of CD8⁺ naive T cell aging marked by an increased expression of pro-inflammatory genes. In conclusion, our study emphasizes the importance of standardizing existing single-cell datasets to enable the comprehensive examination of age-related cellular changes across multiple datasets.</p>","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"59"},"PeriodicalIF":4.1,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11606963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimorbidity is associated with myocardial DNA damage, nucleolar stress, dysregulated energy metabolism, and senescence in cardiovascular disease.","authors":"Kristina Tomkova, Marius Roman, Adewale S Adebayo, Sophia Sheikh, Syabira Yusoff, Melanie Gulston, Lathishia Joel-David, Florence Y Lai, Antonio Murgia, Bryony Eagle-Hemming, Hardeep Aujla, Tom Chad, Gavin D Richardson, Julian L Griffin, Gavin J Murphy, Marcin J Woźniak","doi":"10.1038/s41514-024-00183-z","DOIUrl":"10.1038/s41514-024-00183-z","url":null,"abstract":"<p><p>This study investigates why individuals with multimorbidity-two or more chronic conditions-are more prone to adverse outcomes after surgery. In our cohort, ninety-eight of 144 participants had multimorbidity. The myocardial transcriptome and metabolites involved in energy production were measured in 53 and 57 sequential participants, respectively. Untargeted analysis of the metabolome in blood and myocardium was performed in 30 sequential participants. Mitochondrial respiration in circulating mononuclear cells was measured in 70 participants. Results highlighted four main biological processes associated with multimorbidity: DNA damage with epigenetic changes, mitochondrial energy disruption, cellular aging (senescence) and innate immune response. Histone 2B, its ubiquitination enzymes and AKT3 were upregulated in the multimorbid group. Plasma senescence-associated proteins (IL-1β, GM-CSF) increased with more comorbidities. DNA damage and nucleolar instability were specifically apparent in multimorbid myocardium. We conclude that multimorbidity in cardiovascular patients accelerates biological aging, making them more vulnerable to metabolic stress.</p>","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"58"},"PeriodicalIF":4.1,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics.","authors":"Abhijeet Venkataraman, Ivan Kordic, JiaXun Li, Nicholas Zhang, Nivik Sanjay Bharadwaj, Zhou Fang, Sandip Das, Ahmet F Coskun","doi":"10.1038/s41514-024-00178-w","DOIUrl":"10.1038/s41514-024-00178-w","url":null,"abstract":"<p><p>Aging has profound effects on the body, most notably an increase in the prevalence of several diseases. An important aging hallmark is the presence of senescent cells that no longer multiply nor die off properly. Another characteristic is an altered immune system that fails to properly self-surveil. In this multi-player aging process, cellular senescence induces a change in the secretory phenotype, known as senescence-associated secretory phenotype (SASP), of many cells with the intention of recruiting immune cells to accelerate the clearance of these damaged senescent cells. However, the SASP phenotype results in inducing secondary senescence of nearby cells, resulting in those cells becoming senescent, and improper immune activation resulting in a state of chronic inflammation, called inflammaging, in many diseases. Senescence in immune cells, termed immunosenescence, results in further dysregulation of the immune system. An interdisciplinary approach is needed to physiologically assess aging changes of the immune system at the cellular and tissue level. Thus, the intersection of biomaterials, microfluidics, and spatial omics has great potential to collectively model aging and immunosenescence. Each of these approaches mimics unique aspects of the body undergoes as a part of aging. This perspective highlights the key aspects of how biomaterials provide non-cellular cues to cell aging, microfluidics recapitulate flow-induced and multi-cellular dynamics, and spatial omics analyses dissect the coordination of several biomarkers of senescence as a function of cell interactions in distinct tissue environments. An overview of how senescence and immune dysregulation play a role in organ aging, cancer, wound healing, Alzheimer's, and osteoporosis is included. To illuminate the societal impact of aging, an increasing trend in anti-senescence and anti-aging interventions, including pharmacological interventions, medical procedures, and lifestyle changes is discussed, including further context of senescence.</p>","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"57"},"PeriodicalIF":4.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between gut microbiota and locomotive syndrome risk in healthy Japanese adults: a cross-sectional study.","authors":"Minami Nishiyama, Sho Nakamura, Taizo Matsuki, Hiroto Narimatsu","doi":"10.1038/s41514-024-00184-y","DOIUrl":"10.1038/s41514-024-00184-y","url":null,"abstract":"<p><p>This cross-sectional study examined the association between gut microbiota composition and locomotive syndrome in 568 healthy Japanese adults (36.8% male, median age 58.5 years) using data from the Kanagawa \"ME-BYO\" Prospective Cohort Study. Locomotive syndrome was assessed using the 5-question Geriatric Locomotive Function Scale (GLFS-5). Linear discriminant analysis effect size showed an enrichment of Actinobacteria and depletion of Firmicutes in GLFS-5 positive individuals. Classification tree analysis identified three terminal nodes as GLFS-5 positive, with one node involving Holdemania. Participants aged ≥70.0 and <78.0 years who did not consume probiotic foods and had ≥0.04% relative abundance of Holdemania were classified as at risk for locomotive syndrome. Our findings suggest a potential association between gut microbiota, particularly higher Holdemania abundance, and locomotive syndrome in older adults. This study provides insights into the complex relationship between gut microbiome composition and musculoskeletal health in aging populations. However, the cross-sectional design limits causal inference.</p>","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"55"},"PeriodicalIF":4.1,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting poor performance on cognitive tests among older adults using wearable device data and machine learning: a feasibility study.","authors":"Collin Sakal, Tingyou Li, Juan Li, Xinyue Li","doi":"10.1038/s41514-024-00177-x","DOIUrl":"10.1038/s41514-024-00177-x","url":null,"abstract":"<p><p>Timely implementation of interventions to slow cognitive decline among older adults requires accurate monitoring to detect changes in cognitive function. Factors known to be associated with cognition that can be gathered from accelerometers, user interfaces, and other sensors within wearable devices could be used to train machine learning models and develop wearable-based cognitive monitoring systems. Using data from over 2400 older adults in the National Health and Nutrition Examination Survey (NHANES) we developed prediction models to differentiate older adults with normal cognition from those with poor cognition based on outcomes from three cognitive tests measuring different domains of cognitive function. During repeated cross-validation CatBoost, XGBoost, and Random Forest models performed best when predicting poor cognition based on tests measuring processing speed, working memory, and attention (median AUCs ≥0.82) compared to immediate and delayed recall (median AUCs ≥0.72) and categorical verbal fluency (median AUC ≥ 0.68). Activity and sleep parameters were also more strongly associated with poor cognition based on tests assessing processing speed, working memory, and attention compared to other cognitive subdomains. Our work provides proof of concept that data collatable through wearable devices such as age, education, sleep parameters, activity summaries, and light exposure metrics could be used to differentiate between older adults with normal versus poor cognition. We further identified metrics that could be targets in future causal studies seeking to better understand how sleep and activity parameters influence cognitive function among older adults.</p>","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"56"},"PeriodicalIF":4.1,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging modulates the impact of cognitive interference subtypes on dynamic connectivity across a distributed motor network.","authors":"Jake J Son, Yasra Arif, Hannah J Okelberry, Hallie J Johnson, Madelyn P Willett, Alex I Wiesman, Tony W Wilson","doi":"10.1038/s41514-024-00182-0","DOIUrl":"10.1038/s41514-024-00182-0","url":null,"abstract":"<p><p>Research has shown age-related declines in cognitive control in the context of interference, but these studies have focused on frontoparietal networks and less is known about impacts on motor response-related dynamics in the face of distractors. Thus, we examined whether healthy aging affected connectivity between attention networks and motor circuitry using a multisource interference task and magnetoencephalography in 72 healthy-aging participants (28-63 years-old). Our results indicated stronger beta connectivity with increasing age between bilateral primary motor (M1) and occipital cortices, as well as stronger gamma fronto-motor connectivity during flanker-type interference. Regarding Simon-type interference, stronger beta interactions were observed between left M1 and right temporal and right M1 and left parietal with increasing age. Finally, the superadditivity effect (flanker + Simon presented simultaneously) indicated weaker beta connectivity between right M1 and left premotor with increasing age. These findings suggest exhaustion of age-related compensatory adaptations in the fronto-parieto-motor network with greater interference.</p>","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"54"},"PeriodicalIF":4.1,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}