IF 13

npj aging Pub Date : 2026-10-15 DOI: 10.1038/s41514-026-00546-8

Nazib M Seidu, Olof Lindberg, Silke Kern, Lina Rydén, Lars-Olof Wahlund, Margda Waern, Rosaleena Mohanty, Nira Cedres, Henrik Zetterberg, Kaj Blennow, Hanna Falk Erhag, Anna Zettergren, Eric Westman, Henne Holstege, Ingmar Skoog

{"title":"Polygenic scores for longevity in relation to brain MRI measures in a cohort of 70-year-olds.","authors":"Nazib M Seidu, Olof Lindberg, Silke Kern, Lina Rydén, Lars-Olof Wahlund, Margda Waern, Rosaleena Mohanty, Nira Cedres, Henrik Zetterberg, Kaj Blennow, Hanna Falk Erhag, Anna Zettergren, Eric Westman, Henne Holstege, Ingmar Skoog","doi":"10.1038/s41514-026-00546-8","DOIUrl":"10.1038/s41514-026-00546-8","url":null,"abstract":"Population-based studies on the relation between polygenic longevity scores (PGLSs) and specific brain regions on magnetic resonance imaging (MRI) are few. We aimed to investigate this relationship in a population of 70-year-olds from Gothenburg, Sweden (N = 675). We constructed two PGLSs (one with and one without the APOE locus) using longevity GWAS summary statistics. MRI outcomes included total grey matter, white matter (WM), WM hyperintensities (WMHs), subcortical volumes, small vessel disease (SVD) score, cortical thicknesses, and fractional anisotropy (FA) fibre tracts. We adjusted for sex, age, principal components, and sex interactions, and corrected for multiple comparisons. We found no associations in the total sample. In males, both PGLSs were associated with smaller WMHs volume and lower SVD burden, and a thicker cortex of pars triangularis, pars opercularis, and insula. Our findings suggest a possible link between genetic propensity for longevity and lower cerebrovascular burden and certain cortical grey matter areas in males.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"12 1","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation and refinement of a biomarker panel for frailty assessment and prediction of muscle weakness in older adults. 验证和改进用于老年人衰弱评估和肌肉无力预测的生物标志物面板。

IF 13

npj aging Pub Date : 2026-09-17 DOI: 10.1038/s41514-026-00488-1

Akiko Yamakawa, Tohru Hosoyama, Marie Takemura, Shumpei Niida, Kouichi Ozaki, Shosuke Satake, Daichi Shigemizu

{"title":"Validation and refinement of a biomarker panel for frailty assessment and prediction of muscle weakness in older adults.","authors":"Akiko Yamakawa, Tohru Hosoyama, Marie Takemura, Shumpei Niida, Kouichi Ozaki, Shosuke Satake, Daichi Shigemizu","doi":"10.1038/s41514-026-00488-1","DOIUrl":"10.1038/s41514-026-00488-1","url":null,"abstract":"Frailty is a complex geriatric syndrome characterized by age-related declines in physiological function and cognitive reserve. To promote early prevention and intervention, minimally invasive and objective biomarkers that can detect frailty progression are required. We aimed to identify biomarkers associated with frailty progression and to elucidate their relevance to the Japanese version of the Cardiovascular Health Study (J-CHS) criteria, consist of five components (unintentional weight loss, self-reported exhaustion, muscle weakness, slow walking speed, and low physical activity). A total of 168 individuals (61 robust, 25 pre-frail, and 82 frail) enrolled in the NCGG (National Center for Geriatrics and Gerontology) Biobank were analyzed. Clinical information, blood-test data, aging-related factors, and gene-expression data were integrated for the analysis. First, linear regression identified one clinical factor, five aging-related factors, and 251 gene-expression factors associated with frailty. Subsequent logistic regression analyses examining each J-CHS components highlighted six candidate biomarkers. Cross-validation further suggested that three of these biomarkers-SMI, apelin, and GDF15-may represent potential biomarkers. Finally, retrospective and prospective analyses further demonstrated that those biomarkers were predictive of future muscle weakness, yielding a concordance index of 0.70. In conclusion, we validated and refined a biomarker panel consisting of SMI, apelin, and GDF15 that is associated with frailty, particularly muscle weakness (a major J-CHS component). These biomarkers may be useful for frailty assessment. Longitudinal analyses further suggested that they may be associated with the future development of muscle weakness in initially robust older adults, although validation in larger prospective cohorts is warranted.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"12 1","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering senescence-associated mechanisms through cell painting & transcriptomics. 通过细胞绘画和转录组学解读衰老相关机制。

IF 13

npj aging Pub Date : 2026-09-17 DOI: 10.1038/s41514-026-00500-8

Yuliana Tan, Anika Liu, Emily Larkin, Revati Wani, Alec Dick, Stefano Patassini, Patrik Erlmann

引用次数: 0

IF 13

npj aging Pub Date : 2026-09-17 DOI: 10.1038/s41514-026-00478-3

Yiling Mai, Henriette Zimmeck, Cagdas Guducu, Thomas Hummel

{"title":"Age-related changes in olfactory function: electrophysiological recordings from the olfactory mucosa and human brain.","authors":"Yiling Mai, Henriette Zimmeck, Cagdas Guducu, Thomas Hummel","doi":"10.1038/s41514-026-00478-3","DOIUrl":"10.1038/s41514-026-00478-3","url":null,"abstract":"Age-related olfactory decline in humans is well-documented, yet the underlying peripheral neural mechanisms remain poorly understood. We investigated age-related olfactory decline across psychophysical, nasal mucosal, and central neural levels in 73 healthy adults across the lifespan. Participants underwent Sniffin' Sticks testing and simultaneous recordings of mucosal electro-olfactograms (EOG) and cerebral chemosensory event-related potentials (CERP) in response to olfactory and trigeminal stimulation. Older adults exhibited significantly lower psychophysical olfactory scores, prolonged CERP P2 latencies, and reduced spectral power across theta, delta, and beta bands at peripheral (EOG) and cerebral (Fz, Cz, and Pz) sites. These findings demonstrate a systemic decline of olfactory function. Although the olfactory mucosa remains functionally active, diminished neural recruitment and oscillatory power, coupled with slower central processing, characterize olfactory aging. These objective electrophysiological markers provide a comprehensive profile of sensory decline in the aging population.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"12 1","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a three-month exercise programme on cognition, mood and neurogenesis: the NeuroFit randomised controlled trial. 为期三个月的运动计划对认知、情绪和神经发生的影响：NeuroFit随机对照试验。

IF 13

npj aging Pub Date : 2026-09-17 DOI: 10.1038/s41514-026-00439-w

Sahand Farmand, Curie Kim, Andrea Du Preez, André O Werneck, Lucia Batzu, Dominic Pearce, Kirsten Brady, Markos Khir, Sarah Nicolas, John F Cryan, Yvonne M Nolan, Brendon Stubbs, Sandrine Thuret

{"title":"Effects of a three-month exercise programme on cognition, mood and neurogenesis: the NeuroFit randomised controlled trial.","authors":"Sahand Farmand, Curie Kim, Andrea Du Preez, André O Werneck, Lucia Batzu, Dominic Pearce, Kirsten Brady, Markos Khir, Sarah Nicolas, John F Cryan, Yvonne M Nolan, Brendon Stubbs, Sandrine Thuret","doi":"10.1038/s41514-026-00439-w","DOIUrl":"10.1038/s41514-026-00439-w","url":null,"abstract":"Middle age represents a critical window for mental and cognitive change, yet it remains relatively understudied as a target period for preventative lifestyle interventions. We conducted a three-month randomised controlled trial in healthy middle-aged adults in the UK (n = 52) to examine the effects of exercise on pattern separation, cognition and well-being, blood-based biomarkers, and hippocampal neurogenesis, using an in vitro parabiosis assay. No significant intervention-by-time effect was observed for the primary outcome, pattern separation (β = 0.33, p = 0.26). However, significant intervention-by-time effects were detected for depressive symptoms, as measured by the PHQ-9 (β = -1.18, adjusted p = 0.011), and for the percentage of proliferative cells in vitro (β = -0.23, adjusted p = 0.02), suggesting that exercise remodels the circulating milieu in ways that directly influence hippocampal progenitor biology. Overall, our findings suggest that a structured, instructor-led, live online exercise programme in midlife is feasible and may produce temporally staged adaptations, with early effects on mood, intermediate systemic biological changes influencing hippocampal progenitor dynamics, and cognitive benefits that may require longer exposure to emerge. The trial was prospectively registered at Clinicaltrials.gov ( NCT05397990 ).","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"12 1","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of physical fitness with brain structure, pathology and cognition in cognitively normal older adults. 认知正常老年人身体健康与大脑结构、病理和认知的关系。

IF 13

npj aging Pub Date : 2026-09-16 DOI: 10.1038/s41514-026-00512-4

Svenja Schwarck, Niklas Behrenbruch, Beate Schumann-Werner, Eóin N Molloy, Berta Garcia-Garcia, Anne Hochkeppler, Larissa Fischer, Anna-Therese Büchel, Enise I Incesoy, Jose Bernal, Roberto Duarte Coello, Maria D C Valdés-Hernández, Joanna M Wardlaw, Niklas Vockert, Patrick Müller, Gusalija Behnisch, Barbara Morgado, Hermann Esselmann, Constanze I Seidenbecher, Björn H Schott, Henryk Barthel, Osama Sabri, Jens Wiltfang, Michael C Kreissl, Emrah Düzel, Anne Maass

{"title":"Associations of physical fitness with brain structure, pathology and cognition in cognitively normal older adults.","authors":"Svenja Schwarck, Niklas Behrenbruch, Beate Schumann-Werner, Eóin N Molloy, Berta Garcia-Garcia, Anne Hochkeppler, Larissa Fischer, Anna-Therese Büchel, Enise I Incesoy, Jose Bernal, Roberto Duarte Coello, Maria D C Valdés-Hernández, Joanna M Wardlaw, Niklas Vockert, Patrick Müller, Gusalija Behnisch, Barbara Morgado, Hermann Esselmann, Constanze I Seidenbecher, Björn H Schott, Henryk Barthel, Osama Sabri, Jens Wiltfang, Michael C Kreissl, Emrah Düzel, Anne Maass","doi":"10.1038/s41514-026-00512-4","DOIUrl":"10.1038/s41514-026-00512-4","url":null,"abstract":"The role of physical fitness in cognitive reserve and brain maintenance remains unclear. We investigated the associations of muscular and aerobic fitness (VO2max) with markers of brain health and cognition in 353 cognitively unimpaired older adults (mean age = 72.77 ± 7.95 years; 177 females). Muscular fitness comprised handgrip strength, appendicular skeletal muscle mass, and Timed-Up-and-Go performance. Blood biomarkers of Alzheimer's pathology (Aβ1-42/Aβ1-40, p-tau217, GFAP) and neuroplasticity (BDNF, VEGF, Cathepsin-B), gray matter (GM) volume and thickness, medial temporal lobe (MTL) tau burden ([¹⁸F]PI-2620 PET), white matter hyperintensities, and perivascular spaces (PVS) were assessed. Higher muscular capacity was associated with lower basal ganglia PVS volume, whereas aerobic fitness was related to greater MTL thickness and GM volume. Although fitness did not moderate pathology-cognition associations, VO₂max explained additional variance in verbal memory beyond tau. These findings indicate distinct associations of fitness with brain health, while providing limited support for cognitive reserve. Trial Registration: The study was registered in the German Clinical Trials Register (DRKS00032449; date of registration: 2025-05-07; recruiting ongoing).","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"12 1","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13582920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148984404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspectives on cardiovascular longevity and economic prosperity in the Association of Southeast Asian Nations (ASEAN). 东南亚国家联盟（ASEAN）心血管寿命与经济繁荣的观点。

IF 13

npj aging Pub Date : 2026-09-09 DOI: 10.1038/s41514-026-00511-5

Muhammad Daniel Azlan Bin Mahadzir, Daniel J Lim, Angela S Koh

引用次数: 0

How age and sex interaction is associated with immune aging with implications for vaccines and age-related autoimmunity. 年龄和性别相互作用与免疫老化的关系及其对疫苗和年龄相关自身免疫的影响

IF 13

npj aging Pub Date : 2026-08-22 DOI: 10.1038/s41514-026-00491-6

Reza Gheitasi, Mahnaz Rezaei, Parvaneh Nafisi Fard, Daniela Roel, Sabine Baumgart, Diana Dudziak, Norman Rose, Simon M Petzinna, Thomas Kamradt, Carsten Watzl, Mathias W Pletz, Valentin S Schäfer

引用次数: 0

Exploring the link between body physiology and cognition: the role of the brain and aging. 探索身体生理和认知之间的联系：大脑和衰老的作用。

IF 13

npj aging Pub Date : 2026-07-31 DOI: 10.1038/s41514-026-00456-9

Irina Buianova, Narun Pat

引用次数: 0

FOSL2-driven SASP in endometrial stroma promotes the inflammation of endometriosis. 子宫内膜基质中fosl2驱动的SASP促进了子宫内膜异位症的炎症。

IF 13

npj aging Pub Date : 2026-07-24 DOI: 10.1038/s41514-026-00447-w

Weiwei Shi, Xinyi Tang, Fei Yang, Han Yin, Quan Zhou, Fangyue Sun, Shanbo Ding, Udo Jeschke, Lin Peng

{"title":"FOSL2-driven SASP in endometrial stroma promotes the inflammation of endometriosis.","authors":"Weiwei Shi, Xinyi Tang, Fei Yang, Han Yin, Quan Zhou, Fangyue Sun, Shanbo Ding, Udo Jeschke, Lin Peng","doi":"10.1038/s41514-026-00447-w","DOIUrl":"10.1038/s41514-026-00447-w","url":null,"abstract":"Endometriosis (EMs) is characterized by chronic pelvic inflammation, but the etiology of this inflammation remains poorly understood. The senescence-associated secretory phenotype (SASP), whereby senescent cells secrete pro-inflammatory cytokines, is a potential mechanism. This study investigates the pro-inflammatory SASP in EMs and its underlying influences. Through molecular assays and single-cell RNA-seq analysis, we found a subgroup of endometrial stromal cells (ESCs) marked by SASP in both eutopic endometrium and endometriotic lesions of EMs patients. The transcription factor FOSL2 was aberrantly overexpressed in this ESC subgroup; its overexpression induced cellular senescence and the secretion of SASP factors, while FOSL2 knockdown reversed these effects. Conditioned medium from ESCs with high FOSL2 expression promoted M2 macrophage polarization and recruitment. Mechanistically, FOSL2 overexpression in ESCs was regulated by the PGE2/cAMP/PKA signaling pathway, and FOSL2 modulated SASP through the activation of NF-κB signaling. In conclusion, the SASP in ESCs, regulated by FOSL2, contributes to chronic pelvic inflammation and immune system disruption in EMs patients. Targeting FOSL2 to reverse the SASP may offer a promising therapeutic strategy for EMs.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"12 1","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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