npj aging最新文献_第2页

Deep learning of conversation-based 'filmstrips' for robust Alzheimer's disease detection. 基于对话的深度学习“电影条”用于稳健的阿尔茨海默病检测。

IF 6

npj aging Pub Date : 2025-08-29 DOI: 10.1038/s41514-025-00267-4

Arthur Trognon, Coralie Duman, Gwladys Vittart, Natacha Stortini, Loann Mahdar-Recorbet, Hamza Altakroury

引用次数: 0

Modulating biological aging with food-derived signals: a systems and precision nutrition perspective. 用食物来源的信号调节生物衰老：一个系统和精确营养的观点。

IF 6

npj aging Pub Date : 2025-08-20 DOI: 10.1038/s41514-025-00266-5

Carsten Carlberg, Andreas Blüthner, Irini Schoeman-Giziakis, Annemarie Oosting, Luca Cocolin

引用次数: 0

Epigenetic age acceleration and midlife cognition: joint evidence from observational study and Mendelian randomization. 表观遗传年龄加速与中年认知：来自观察性研究和孟德尔随机化的联合证据。

IF 6

npj aging Pub Date : 2025-08-18 DOI: 10.1038/s41514-025-00265-6

Yang Pan, Zhijie Huang, Xiao Sun, Ileana De Anda-Duran, Ruiyuan Zhang, Wei Chen, Changwei Li, Ana W Capuano, Kristine Yaffe, Jinying Zhao, David A Bennett, Owen T Carmichael, Lydia A Bazzano, Tanika N Kelly

{"title":"Epigenetic age acceleration and midlife cognition: joint evidence from observational study and Mendelian randomization.","authors":"Yang Pan, Zhijie Huang, Xiao Sun, Ileana De Anda-Duran, Ruiyuan Zhang, Wei Chen, Changwei Li, Ana W Capuano, Kristine Yaffe, Jinying Zhao, David A Bennett, Owen T Carmichael, Lydia A Bazzano, Tanika N Kelly","doi":"10.1038/s41514-025-00265-6","DOIUrl":"10.1038/s41514-025-00265-6","url":null,"abstract":"The relationship between epigenetic age acceleration (EAA) and midlife cognitive function remains unclear, with limited causal evidence. We investigated this association in 1252 Black and White middle-aged adults from the Bogalusa Heart Study (BHS) and conducted a two-sample Mendelian randomization (MR) analysis using GWAS summary statistics for EAA (N = 34,710) and cognition (N ≤ 106,162). In BHS, higher Hannum age acceleration, PhenoAge acceleration, and GrimAge acceleration (GrimAA) were each associated with slower processing speed (p < 0.05). Additionally, GrimAA was linked to lower global cognition scores (p < 0.001), independent of covariates. MR analysis suggested a potential link, showing that genetically predicted GrimAA was nominally associated with slower processing speed (p = 0.05). These findings suggest that epigenetic aging, particularly GrimAA, is independently associated with lower cognitive function in midlife and may play an important role in cognitive impairment, especially in processing speed.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"75"},"PeriodicalIF":6.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Identification of markers for neurescence through transcriptomic profiling of postmortem human brains. 作者更正：通过对死后人类大脑的转录组学分析鉴定神经新生标志物。

IF 6

npj aging Pub Date : 2025-08-12 DOI: 10.1038/s41514-025-00262-9

Shiva Kazempour Dehkordi, Sogand Sajedi, Amirreza Heshmat, Miranda E Orr, Habil Zare

引用次数: 0

IF 6

npj aging Pub Date : 2025-08-06 DOI: 10.1038/s41514-025-00263-8

Megan C Hall, Maggie P Rempe, Chloe C Casagrande, Ryan J Glesinger, Nathan M Petro, Grant M Garrison, Jason A John, Sarah M Dietz, Mikki Schantell, Hua Bai, Yasra Arif, Christine M Embury, Seth Bashford, Hannah J Okelberry, Aubrie J Petts, Elizabeth L Keifer, Pamela E May-Weeks, Giorgia Picci, Elizabeth Heinrichs-Graham, Tony W Wilson

{"title":"Age-related alterations in alpha and beta oscillations support preservation of semantic processing in healthy aging.","authors":"Megan C Hall, Maggie P Rempe, Chloe C Casagrande, Ryan J Glesinger, Nathan M Petro, Grant M Garrison, Jason A John, Sarah M Dietz, Mikki Schantell, Hua Bai, Yasra Arif, Christine M Embury, Seth Bashford, Hannah J Okelberry, Aubrie J Petts, Elizabeth L Keifer, Pamela E May-Weeks, Giorgia Picci, Elizabeth Heinrichs-Graham, Tony W Wilson","doi":"10.1038/s41514-025-00263-8","DOIUrl":"10.1038/s41514-025-00263-8","url":null,"abstract":"Semantic processing remains relatively preserved during healthy aging, but the mechanisms are poorly understood. Herein, we use dynamic functional mapping based on magnetoencephalography to examine the neural oscillations serving semantic processing across the adult lifespan (N = 154; 21-87 years). Task-related oscillatory dynamics were imaged using a beamformer and whole-brain linear mixed-effects (LME) models were calculated with age and task condition (semantically-related or -unrelated) as factors. LMEs revealed significant age-by-condition interactions on alpha and beta activity in multiple regions, which generally reflected stronger responses with increasing age and/or in the semantically-related condition across regions (p values < 0.005, corrected). Follow-up mediation analyses of these interaction clusters indicated that left perisylvian alpha responses suppressed the effect of age on verbal fluency (p = 0.014), with larger conditional differences in this region supporting preserved fluency with increasing age. Our findings provide novel insight on age-related neurophysiological adaptations that support preservation of semantic processing.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"73"},"PeriodicalIF":6.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endo180 and basement membrane stiffness induce OXPHOS and neoplastic transformation in aging prostate epithelia. 内皮180和基底膜刚度诱导老化前列腺上皮氧化磷酸化和肿瘤转化。

IF 6

npj aging Pub Date : 2025-08-02 DOI: 10.1038/s41514-025-00259-4

Lucia Pastro, Jennyfer Martínez, Santiago Fontenla, Ana C Chiale, Agustina Faulord, María P Frade, Andrea S Díaz, Rodrigo Martino-Kunsch, Laura Castro, Lysann Schenk, Celia Quijano, Justin Sturge, Mercedes Rodríguez-Teja

{"title":"Endo180 and basement membrane stiffness induce OXPHOS and neoplastic transformation in aging prostate epithelia.","authors":"Lucia Pastro, Jennyfer Martínez, Santiago Fontenla, Ana C Chiale, Agustina Faulord, María P Frade, Andrea S Díaz, Rodrigo Martino-Kunsch, Laura Castro, Lysann Schenk, Celia Quijano, Justin Sturge, Mercedes Rodríguez-Teja","doi":"10.1038/s41514-025-00259-4","DOIUrl":"10.1038/s41514-025-00259-4","url":null,"abstract":"During prostate aging collagen-IV is modified by advanced glycation end-products, inducing crosslinking of the basement membrane surrounding glandular acini. Basement membrane stiffness sensed by Endo180 disrupts its suppressor complex with CD147, triggering epithelial-to-mesenchymal transition and limiting survival in prostate cancer patients. Here we report basement membrane stiffness and Endo180 cooperate in rewiring epithelia for mitochondrial oxidative phosphorylation (OXPHOS) and growth suppressor evasion, cell proliferation promotion, cell death resistance, inflammation, invasion and metastasis without affecting genome instability, highlighting a non-oncogenic biomechanical event in age-related neoplasia. Endo180-CD147 complex coupled to OXPHOS in Gleason 6 and in Gleason ≥7 tumors Endo180 uncoupled from CD147-OXPHOS, identifying a bio-switch for invasive cancer. Endo180 correlated with patient age in normal tissue, Gleason 6 and 7, but not Gleason 8 tumors, suggesting biological age unleashes its suppression of tumorigenesis. Application of Endo180-based diagnostics in age-related glandular cancers could inform treatment decisions, improving quality of life and survival.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"72"},"PeriodicalIF":6.0,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 2-year calorie restriction intervention may reduce glycomic biological age biomarkers - a pilot study. 一项初步研究表明，2年的卡路里限制干预可能会降低糖糖生物年龄生物标志物。

IF 6

npj aging Pub Date : 2025-08-01 DOI: 10.1038/s41514-025-00254-9

Tea Pribić, Jayanta K Das, Lovorka Đerek, Daniel W Belsky, Melissa Orenduff, Kim M Huffman, William E Kraus, Helena Deriš, Jelena Šimunović, Tamara Štambuk, Azra Frkatović-Hodžić, Virginia B Kraus, Sai Krupa Das, Susan B Racette, Nirad Banskota, Luigi Ferrucci, Carl Pieper, Nathan E Lewis, Gordan Lauc, Sridevi Krishnan

{"title":"A 2-year calorie restriction intervention may reduce glycomic biological age biomarkers - a pilot study.","authors":"Tea Pribić, Jayanta K Das, Lovorka Đerek, Daniel W Belsky, Melissa Orenduff, Kim M Huffman, William E Kraus, Helena Deriš, Jelena Šimunović, Tamara Štambuk, Azra Frkatović-Hodžić, Virginia B Kraus, Sai Krupa Das, Susan B Racette, Nirad Banskota, Luigi Ferrucci, Carl Pieper, Nathan E Lewis, Gordan Lauc, Sridevi Krishnan","doi":"10.1038/s41514-025-00254-9","DOIUrl":"10.1038/s41514-025-00254-9","url":null,"abstract":"In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants (n = 26) were evaluated for the effects of 2 years of 25% calorie restriction (CR) on N-glycosylation of IgG, plasma, and complement C3, as well as IgG-based biological age (GlycAge). Plasma samples were collected at baseline (BL), 12 (12mo), and 24 months (24mo). IgG galactosylation was higher at 24mo compared to BL (p = 0.051) and increased from 12mo to 24mo (p = 0.016); GlycAge decreased over the same period (p = 0.027). GlycAge was positively associated with TNF-α (p = 0.030) and ICAM-1 (p = 0.017). Between BL and 24mo, plasma high-branched glycans declined (p = 0.013), bisecting GlcNAcs increased in both plasma (p < 0.001) and IgG (p = 0.01), complement C3 protein (p < 0.001), C3-Man9 (p < 0.001), and C3-Man9Glc1C3 (p = 0.046) were reduced. The absence of a control group warrants cautious interpretation.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"71"},"PeriodicalIF":6.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel deep learning-based brain age prediction framework for routine clinical MRI scans. 一种新的基于深度学习的常规临床MRI扫描脑年龄预测框架。

IF 6

npj aging Pub Date : 2025-07-29 DOI: 10.1038/s41514-025-00260-x

Hyunwoong Kim, Seongbeom Park, Sang Won Seo, Duk L Na, Hyemin Jang, Jun Pyo Kim, Hee Jin Kim, Sung Hoon Kang, Kichang Kwak

{"title":"A novel deep learning-based brain age prediction framework for routine clinical MRI scans.","authors":"Hyunwoong Kim, Seongbeom Park, Sang Won Seo, Duk L Na, Hyemin Jang, Jun Pyo Kim, Hee Jin Kim, Sung Hoon Kang, Kichang Kwak","doi":"10.1038/s41514-025-00260-x","DOIUrl":"10.1038/s41514-025-00260-x","url":null,"abstract":"Physiological brain aging is associated with cognitive impairment and neuroanatomical changes. Brain age prediction of routine clinical 2D brain MRI scans were understudied and often unsuccessful. We developed a novel brain age prediction framework for clinical 2D T1-weighted MRI scans using a deep learning-based model trained with research grade 3D MRI scans mostly from publicly available datasets (N = 8681; age = 51.76 ± 21.74). Our model showed accurate and fast brain age prediction on clinical 2D MRI scans from cognitively unimpaired (CU) subjects (N = 175) with MAE of 2.73 years after age bias correction (Pearson's r = 0.918). Brain age gap of Alzheimer's disease (AD) subjects was significantly greater than CU subjects (p < 0.001) and increase in brain age gap was associated with disease progression in both AD (p < 0.05) and Parkinson's disease (p < 0.01). Our framework can be extended to other MRI modalities and potentially applied to routine clinical examinations, enabling early detection of structural anomalies and improve patient outcome.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"70"},"PeriodicalIF":6.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local radiotherapy for cancer patients is associated with mosaic loss of chromosome Y, a hallmark of male aging. 癌症患者的局部放疗与Y染色体镶嵌丢失有关，这是男性衰老的标志。

IF 6

npj aging Pub Date : 2025-07-29 DOI: 10.1038/s41514-025-00261-w

Takuro Kobayashi, Tsuyoshi Hachiya, Yan Lu, Yoshihiro Ikehata, Toshiyuki China, Haruna Kawano, Masayoshi Nagata, Hisamitsu Ide, Shuji Isotani, Shuko Nojiri, Takuro Iwami, Shunsuke Uchiyama, Yasushi Okazaki, Hidewaki Nakagawa, Takayuki Morisaki, Koichi Matsuda, Yoichiro Kamatani, Chikashi Terao, Shigeo Horie

{"title":"Local radiotherapy for cancer patients is associated with mosaic loss of chromosome Y, a hallmark of male aging.","authors":"Takuro Kobayashi, Tsuyoshi Hachiya, Yan Lu, Yoshihiro Ikehata, Toshiyuki China, Haruna Kawano, Masayoshi Nagata, Hisamitsu Ide, Shuji Isotani, Shuko Nojiri, Takuro Iwami, Shunsuke Uchiyama, Yasushi Okazaki, Hidewaki Nakagawa, Takayuki Morisaki, Koichi Matsuda, Yoichiro Kamatani, Chikashi Terao, Shigeo Horie","doi":"10.1038/s41514-025-00261-w","DOIUrl":"10.1038/s41514-025-00261-w","url":null,"abstract":"Mosaic loss of chromosome Y (mLOY) is the most common somatic mutation in hematopoietic cells of aging men and is linked to cancer risk and mortality. However, its relationship with treatment modalities remains unclear. In 348 prostate cancer patients at Juntendo University Hospital, local radiotherapy was associated with a higher prevalence of mLOY (OR = 2.55, 95% CI: 1.08-6.50, P = 0.04), whereas surgery and endocrine therapy were not. We then examined BioBank Japan data from over 30,000 patients with prostate, lung, colorectal, and gastric cancers. Fixed-effect meta-analysis across these sites showed a significant association between radiotherapy and mLOY (OR = 1.48, 95% CI: 1.11-1.98, P = 0.01). No significant effect heterogeneity was observed across cancer types (Q = 0.36, I² = 0%, P = 0.95). Our findings suggest that radiotherapy may exacerbate genomic instability, indicating a potential vulnerability in certain cancer patients to DNA damage induced by radiation therapy.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"69"},"PeriodicalIF":6.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying people with potentially undiagnosed dementia with Lewy bodies using natural language processing. 使用自然语言处理识别可能患有路易体痴呆的人。

IF 4.1

npj aging Pub Date : 2025-07-18 DOI: 10.1038/s41514-025-00252-x

Mohamed Heybe, Lucy Gibson, Annabel C Price, Rudolf N Cardinal, John T O'Brien, Robert Stewart, Christoph Mueller

引用次数: 0