npj aging最新文献_第2页

Wearable sleep recording augmented by artificial intelligence for Alzheimer's disease screening. 人工智能增强的可穿戴睡眠记录用于阿尔茨海默病筛查。

IF 4.1

npj aging Pub Date : 2025-05-09 DOI: 10.1038/s41514-025-00219-y

Elisabeth R M Heremans, Astrid Devulder, Pascal Borzée, Rik Vandenberghe, François-Laurent De Winter, Mathieu Vandenbulcke, Maarten Van Den Bossche, Bertien Buyse, Dries Testelmans, Wim Van Paesschen, Maarten De Vos

{"title":"Wearable sleep recording augmented by artificial intelligence for Alzheimer's disease screening.","authors":"Elisabeth R M Heremans, Astrid Devulder, Pascal Borzée, Rik Vandenberghe, François-Laurent De Winter, Mathieu Vandenbulcke, Maarten Van Den Bossche, Bertien Buyse, Dries Testelmans, Wim Van Paesschen, Maarten De Vos","doi":"10.1038/s41514-025-00219-y","DOIUrl":"https://doi.org/10.1038/s41514-025-00219-y","url":null,"abstract":"The recent emergence of wearable devices will enable large scale remote brain monitoring. This study investigated whether multimodal wearable sleep recordings could help screening for Alzheimer's disease (AD). Measurements were acquired simultaneously from polysomnography and a wearable device, measuring electroencephalography (EEG) and accelerometry (ACM) in 67 elderly without cognitive symptoms and 35 AD patients. Sleep staging was performed using an AI model (SeqSleepNet), followed by feature extraction from hypnograms and physiological signals. Using these features, a multi-layer perceptron was trained for AD detection, with elastic net identifying key features. The wearable AD detection model achieved an accuracy of 0.90 (0.76 for prodromal AD). Single-channel EEG and ACM physiological features captured sufficient information for AD detection and outperformed the hypnogram features, highlighting these physiological features as promising discriminative markers for AD. We conclude that wearable sleep monitoring augmented by AI shows promise towards non-invasive screening for AD in the older population.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"34"},"PeriodicalIF":4.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing large language model performance related to aging in genetic conditions. 评估遗传条件下与衰老相关的大型语言模型性能。

IF 4.1

npj aging Pub Date : 2025-05-03 DOI: 10.1038/s41514-025-00226-z

Amna A Othman, Kendall A Flaharty, Suzanna E Ledgister Hanchard, Ping Hu, Dat Duong, Rebekah L Waikel, Benjamin D Solomon

{"title":"Assessing large language model performance related to aging in genetic conditions.","authors":"Amna A Othman, Kendall A Flaharty, Suzanna E Ledgister Hanchard, Ping Hu, Dat Duong, Rebekah L Waikel, Benjamin D Solomon","doi":"10.1038/s41514-025-00226-z","DOIUrl":"https://doi.org/10.1038/s41514-025-00226-z","url":null,"abstract":"Most genetic conditions are described in pediatric populations, leaving a gap in understanding their clinical progression and management in adulthood. Motivated by other applications of large language models (LLMs), we evaluated whether Llama-2-70b-chat (70b) and GPT-3.5 (GPT) could generate plausible medical vignettes, patient-geneticist dialogues and management plans for a hypothetical child and adult patients across 282 genetic conditions (selected by prevalence and categorized based on age-related characteristics). Results showed that LLMs provided appropriate age-based responses in both child and adult outputs based on Correctness and Completeness scores graded by clinicians. Sub-analysis of metabolic conditions including those typically presents neonatally with crisis also showed age-appropriate LLM responses. However 70b and GPT obtained low Correctness and Completeness scores at producing plausible management plans (55-66% for 70b and a wider range, 50-90%, for GPT). This suggests that LLMs still have some limitations in clinical applications.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"33"},"PeriodicalIF":4.1,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Adaptation of the Spalax galili transcriptome to hypoxia may underlie the complex phenotype featuring longevity and cancer resistance. 作者更正：Spalax galili转录组对缺氧的适应可能是长寿和抗癌的复杂表型的基础。

IF 4.1

npj aging Pub Date : 2025-05-03 DOI: 10.1038/s41514-025-00225-0

Gesa Poetzsch, Luca Jelacic, Leon Dammer, Sören Lukas Hellmann, Michelle Balling, Miguel Andrade-Navarro, Aaron Avivi, Imad Shams, Anne Bicker, Thomas Hankeln

引用次数: 0

Single-cell profiling unveils a geroprotective role of Procyanidin C1 in hematopoietic immune system via senolytic and senomorphic effects. 单细胞分析揭示了原花青素C1在造血免疫系统中通过衰老和同源效应的老年保护作用。

IF 4.1

npj aging Pub Date : 2025-05-02 DOI: 10.1038/s41514-025-00222-3

Xiuxing Liu, Yidan Liu, Yuehan Gao, Chun Zhang, Chenyang Gu, Jianjie Lv, Junying Wu, Wenru Su

{"title":"Single-cell profiling unveils a geroprotective role of Procyanidin C1 in hematopoietic immune system via senolytic and senomorphic effects.","authors":"Xiuxing Liu, Yidan Liu, Yuehan Gao, Chun Zhang, Chenyang Gu, Jianjie Lv, Junying Wu, Wenru Su","doi":"10.1038/s41514-025-00222-3","DOIUrl":"https://doi.org/10.1038/s41514-025-00222-3","url":null,"abstract":"Aging of hematopoietic and immune system (HIS) leads to cellular senescence and immune dysregulation, contributing to age-related diseases. Here, we show that Procyanidin C1 (PCC1), a compound with both senolytic and senomorphic properties, can counteract aging-related changes in HIS. Using single-cell RNA sequencing and validation experiments, we found that aging induced cellular senescence, inflammation, and immune dysregulation in the bone marrow and spleen tissues of mice. Long-term PCC1 treatment improved key physiological parameters especially the grip strength of aged mice. Further single-cell analysis revealed PCC1's broad geroprotective effects on HIS, including an increase in the proportion of B cells (BCs) and hematopoietic stem cells (HSCs), suppression of senescence-associated markers, and restoration of normal immune processes. Specifically, PCC1 mitigated inflammation and restored immune homeostasis in BCs by suppressing Cebpb expression and age-associated BCs. Moreover, PCC1 reversed aging-induced alterations in HSCs through upregulating Nedd4 and CD62L-Ca2+ axis expression. Finally, we identified senescent cells (SnCs) using machine learning and gene set enrichment analysis, revealing that PCC1 induced apoptosis of SnCs and regulated their metabolic processes, particularly in granulocytes and myeloid cells. The experimental validation further confirmed the senolytic and senomorphic effects of PCC1 both in vivo and in vitro. Overall, PCC1 holds potential as a therapeutic agent for alleviating immune dysfunction and promoting healthy aging via senolytic and senomorphic effects.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"31"},"PeriodicalIF":4.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic determinants of proteomic aging. 蛋白质组老化的遗传决定因素。

IF 4.1

npj aging Pub Date : 2025-04-26 DOI: 10.1038/s41514-025-00205-4

Alexander Mörseburg, Yajie Zhao, Katherine A Kentistou, John R B Perry, Ken K Ong, Felix R Day

{"title":"Genetic determinants of proteomic aging.","authors":"Alexander Mörseburg, Yajie Zhao, Katherine A Kentistou, John R B Perry, Ken K Ong, Felix R Day","doi":"10.1038/s41514-025-00205-4","DOIUrl":"https://doi.org/10.1038/s41514-025-00205-4","url":null,"abstract":"Changes in the proteome and its dysregulation have long been known to be a hallmark of aging. We derived a proteomic aging trait using data on 1459 plasma proteins from 44,435 UK Biobank individuals measured using an antibody-based assay. This metric is strongly associated with four age-related disease outcomes, even after adjusting for chronological age. Survival analysis showed that one-year older proteomic age, relative to chronological age, increases all-cause mortality hazard by 13 percent. We performed a genome-wide association analysis of proteomic age acceleration (proteomic aging trait minus chronological age) to identify its biological determinants. Proteomic age acceleration showed modest genetic correlations with four epigenetic clocks (Rg = 0.17 to 0.19) and telomere length (Rg = -0.2). Once we removed associations that were explained by a single pQTL, we were left with three signals mapping to BRCA1, POLR2A and TET2 with apparent widespread effects on plasma proteomic aging. Genetic variation at these three loci has been shown to affect other omics-related aging measures. Mendelian randomisation analyses showed causal effects of higher BMI and type 2 diabetes on faster proteomic age acceleration. This supports the idea that obesity and other features of metabolic syndrome have an adverse effect on the processes of human aging.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"30"},"PeriodicalIF":4.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LinAge2: providing actionable insights and benchmarking with epigenetic clocks. LinAge2：通过表观遗传时钟提供可操作的见解和基准。

IF 4.1

npj aging Pub Date : 2025-04-23 DOI: 10.1038/s41514-025-00221-4

Sheng Fong, Kirill A Denisov, Anastasiia A Nefedova, Brian K Kennedy, Jan Gruber

引用次数: 0

Relationship between physical activity and DNA methylation-predicted epigenetic clocks. 体育活动与DNA甲基化预测表观遗传时钟的关系。

IF 4.1

npj aging Pub Date : 2025-04-12 DOI: 10.1038/s41514-025-00217-0

Yanwei You, Yuquan Chen, Hao Ding, Qiyu Liu, Rui Wang, Kailin Xu, Qingyuan Wang, Danijela Gasevic, Xindong Ma

{"title":"Relationship between physical activity and DNA methylation-predicted epigenetic clocks.","authors":"Yanwei You, Yuquan Chen, Hao Ding, Qiyu Liu, Rui Wang, Kailin Xu, Qingyuan Wang, Danijela Gasevic, Xindong Ma","doi":"10.1038/s41514-025-00217-0","DOIUrl":"https://doi.org/10.1038/s41514-025-00217-0","url":null,"abstract":"This study investigates the relationship between physical activity (PA) levels and DNA methylation (DNAm)-predicted epigenetic clocks in a U.S. population sample (n = 948, mean age 62, 49% female). Eight epigenetic clocks were analyzed, revealing that higher PA levels were significantly associated with younger biological ages across all indicators, with the strongest effects observed for SkinBloodAge and LinAge. Multivariable linear regression models, adjusted for sociodemographic and lifestyle factors, highlighted the potential of PA to reduce biological ageing. Subgroup analyses indicated that these associations were more pronounced among non-Hispanic whites, individuals with a BMI of 25-30, and former smokers, suggesting that the impact of PA varies across different groups. These findings emphasize the role of PA in slowing biological ageing and reducing age-related health risks. Promoting regular PA, especially among older adults and those with higher BMI, could improve well-being and lifespan, highlighting PA as a modifiable factor in healthy ageing and age-related disease prevention.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"27"},"PeriodicalIF":4.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug safety in healthy aging. 健康老龄化中的药物安全。

IF 4.1

npj aging Pub Date : 2025-04-12 DOI: 10.1038/s41514-025-00220-5

Nikola Panajotovikj, Adrià Fernández-Torras, Jordi Mestres

引用次数: 0

1H-NMR-based metabolomics identifies disrupted betaine metabolism as distinct serum signature of pre-frailty. 基于1h - nmr的代谢组学鉴定出甜菜碱代谢紊乱是虚弱前的明显血清特征。

IF 4.1

npj aging Pub Date : 2025-04-12 DOI: 10.1038/s41514-025-00218-z

Carmen Marino, Alberto Imarisio, Clara Gasparri, Enza Napolitano, Anna Di Maio, Micol Avenali, Gabriele Buongarzone, Caterina Galandra, Marta Picascia, Manuela Grimaldi, Francesco Errico, Mariangela Rondanelli, Anna Maria D'Ursi, Enza Maria Valente, Alessandro Usiello

引用次数: 0

Vegetarian diet and healthy aging among Chinese older adults: a prospective study. 素食与中国老年人的健康老龄化：一项前瞻性研究。

IF 4.1

npj aging Pub Date : 2025-04-01 DOI: 10.1038/s41514-025-00213-4

Guliyeerke Jigeer, Kaiyue Wang, Yuebing Lv, Katherine L Tucker, Xiuhua Shen, Fan Chen, Liang Sun, Xiaoming Shi, Yaqi Li, Xiang Gao

{"title":"Vegetarian diet and healthy aging among Chinese older adults: a prospective study.","authors":"Guliyeerke Jigeer, Kaiyue Wang, Yuebing Lv, Katherine L Tucker, Xiuhua Shen, Fan Chen, Liang Sun, Xiaoming Shi, Yaqi Li, Xiang Gao","doi":"10.1038/s41514-025-00213-4","DOIUrl":"10.1038/s41514-025-00213-4","url":null,"abstract":"Vegetarian diets are increasingly popular worldwide, but their impact on healthy aging in older adults remains unclear. This study examined the association between vegetarian diets and healthy aging among 2,888 healthy older Chinese adults from the Chinese Longitudinal Healthy Longevity Survey. Dietary patterns (vegan, ovo-vegetarian, pesco-vegetarian, omnivorous) were derived from a simplified non-quantitative food frequency questionnaire. Over a median follow-up of 6 years, after accounting for sociodemographic and lifestyle factors, vegetarians had lower odds of achieving healthy aging compared to omnivores (adjusted OR = 0.65, 95% CI: 0.47-0.89), with consistent results across sensitivity analyses and individual health components. Additionally, the health effects of vegetarian diets may vary depending on diet quality, with vegetarians of higher diet quality not significantly differing in terms of overall healthy aging and individual outcomes when compared to omnivores. Accordingly, this finding highlights modest inclusion of animal-based foods may improve the overall health status of healthy older adults.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"11 1","pages":"25"},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0