npj aging最新文献_第2页

The impact of blood pressure lowering agents on the risk of worsening frailty among patients with diabetes mellitus: a cohort study. 降压药对糖尿病患者衰弱恶化风险的影响：一项队列研究。

IF 4.1

npj aging Pub Date : 2024-10-07 DOI: 10.1038/s41514-024-00173-1

Jui Wang, Szu-Ying Lee, Chia-Ter Chao, Jenq-Wen Huang, Kuo-Liong Chien

{"title":"The impact of blood pressure lowering agents on the risk of worsening frailty among patients with diabetes mellitus: a cohort study.","authors":"Jui Wang, Szu-Ying Lee, Chia-Ter Chao, Jenq-Wen Huang, Kuo-Liong Chien","doi":"10.1038/s41514-024-00173-1","DOIUrl":"https://doi.org/10.1038/s41514-024-00173-1","url":null,"abstract":"Patients with diabetes mellitus (DM) are at risk of developing frailty, but studies rarely addressed risk factors for frailty worsening. We investigated whether blood pressure (BP)-lowering agents influenced such risk in these patients. Adults with type 2 DM were identified from National Taiwan University Hospital, with the primary outcome, the worsening of frailty by ≧1 score increase of FRAIL scale determined. We used the Cox proportional hazards analysis to derive the risk of worsening frailty associated with BP-lowering agents. Among 41,440 patients with DM, 27.4% developed worsening frailty after 4.09 years of follow-up. Cox regression revealed that diuretics (hazard ratio (HR) 1.12, 95% confidence interval (CI) 1.06-1.18) and α-blocker (HR 1.14, 95% CI 1.06-1.23) users had a significantly higher risk of worsening frailty than non-users, whereas the risk was lower among β-blocker users (HR 0.93, 95% CI 0.88-0.98). It would be therefore prudent to weigh the advantages and disadvantages of using specific BP-lowering agent classes.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"44"},"PeriodicalIF":4.1,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of Klotho and sirtuins in sleep-related cardiovascular diseases: a review study. Klotho和sirtuins在睡眠相关心血管疾病中的作用：综述研究。

IF 4.1

npj aging Pub Date : 2024-10-02 DOI: 10.1038/s41514-024-00165-1

Farzaneh Rostamzadeh, Siyavash Joukar, Mahboobeh Yeganeh-Hajahmadi

{"title":"The role of Klotho and sirtuins in sleep-related cardiovascular diseases: a review study.","authors":"Farzaneh Rostamzadeh, Siyavash Joukar, Mahboobeh Yeganeh-Hajahmadi","doi":"10.1038/s41514-024-00165-1","DOIUrl":"10.1038/s41514-024-00165-1","url":null,"abstract":"The prevalence of sleep disorders has been reported from 1.6% to 56.0%, worldwide. Sleep deprivation causes cardiovascular diseases (CVDs) including atherosclerosis, vascular aging, hypertension, heart dysfunction, reduced heart rate variability, and cardiac arrhythmia. Reduced tissue oxygen causes various CVDs by activating pro-inflammatory factors and increasing oxidative stress. Sleep disorders are more important and prevalent in older people and cause more severe cardiovascular complications. On the other hand, the reduction of Klotho level, an age-dependent protein whose expression decreases with age, is associated with age-related diseases. Sirtuins, class III histone deacetylases, also are among the essential factors in postponing cellular aging and increasing the lifespan of organisms, and they do this by regulating different pathways in the cell. Sirtuins and Klotho play an important role in the pathophysiology of CVDS and both have anti-oxidative stress and anti-inflammatory activity. Studies have shown that the levels of Klotho and sirtuins are altered in sleep disorders. In this article, alterations of Klotho and sirtuins in sleep disorders and in the development of sleep-related CVDs were reviewed and the possible signaling pathways were discussed. The inclusion criteria were studies with keywords of different types of sleep disorders and CVDs, klotho, SIRT1-7, and sirtuins in PubMed, Scopus, Embase، Science Direct، Web of Sciences and Google Scholar by the end of 2023. The studies revealed there is a bidirectional relationship between sleep disorders and the serum and tissue levels of Klotho and sirtuins and sleep related-CVDs.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"43"},"PeriodicalIF":4.1,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal exposure to undernutrition is associated with a specific lipid profile predicting future brain aging. 产前营养不良与预测未来大脑衰老的特定脂质特征有关。

IF 4.1

npj aging Pub Date : 2024-09-30 DOI: 10.1038/s41514-024-00169-x

Stuart G Snowden, Albert Koulman, Christian Gaser, Susanne E la Fleur, Tessa J Roseboom, Aniko Korosi, Susanne R de Rooij

{"title":"Prenatal exposure to undernutrition is associated with a specific lipid profile predicting future brain aging.","authors":"Stuart G Snowden, Albert Koulman, Christian Gaser, Susanne E la Fleur, Tessa J Roseboom, Aniko Korosi, Susanne R de Rooij","doi":"10.1038/s41514-024-00169-x","DOIUrl":"10.1038/s41514-024-00169-x","url":null,"abstract":"Prenatal adversity affects cognitive and brain aging. Both lipid and leptin concentrations may be involved. We investigated if prenatal undernutrition is associated with a specific blood lipid profile and/or leptin concentrations, and if these relate to cognitive function and brain aging. 801 plasma samples of members of the Dutch famine birth cohort were assessed for lipidomics and leptin at age 58. Cognitive performance was measured with a Stroop task at 58, and MRI-based BrainAGE was derived in a subsample at 68. Out of 259 lipid signals, a signature of five identified individuals who were undernourished prenatally. These five lipids were not associated with cognitive performance, but three were predictive of BrainAGE. Leptin was not associated with prenatal famine exposure, Stroop performance, or BrainAGE. In conclusion, prenatal undernutrition was associated with an altered lipid profile predictive of BrainAGE 10 years later, demonstrating the potential of lipid profiles as early biomarkers for accelerated brain aging.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"42"},"PeriodicalIF":4.1,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The paradox of senescent-marker positive cancer cells: challenges and opportunities. 衰老标记阳性癌细胞的悖论：挑战与机遇。

IF 4.1

npj aging Pub Date : 2024-09-14 DOI: 10.1038/s41514-024-00168-y

Emily A O'Sullivan, Ryan Wallis, Federica Mossa, Cleo L Bishop

引用次数: 0

Monitoring reaction time to digital device in the very-old to detect early cognitive decline. 监测老年人对数字设备的反应时间，以发现早期认知功能衰退。

IF 4.1

npj aging Pub Date : 2024-09-06 DOI: 10.1038/s41514-024-00167-z

Yukari Yamada, Tadahisa Okuda, Tomoe Uchida, Tatsuyoshi Ikenoue, Shingo Fukuma

引用次数: 0

Aging insights from heterochronic parabiosis models. 从异时同种异体移植模型中了解衰老。

IF 4.1

npj aging Pub Date : 2024-08-17 DOI: 10.1038/s41514-024-00166-0

Francisco Alejandro Lagunas-Rangel

引用次数: 0

Precious2GPT: the combination of multiomics pretrained transformer and conditional diffusion for artificial multi-omics multi-species multi-tissue sample generation. Precious2GPT：多组学预训练变换器与条件扩散相结合，用于人工多组学多物种多组织样本生成。

IF 4.1

npj aging Pub Date : 2024-08-08 DOI: 10.1038/s41514-024-00163-3

Denis Sidorenko, Stefan Pushkov, Akhmed Sakip, Geoffrey Ho Duen Leung, Sarah Wing Yan Lok, Anatoly Urban, Diana Zagirova, Alexander Veviorskiy, Nina Tihonova, Aleksandr Kalashnikov, Ekaterina Kozlova, Vladimir Naumov, Frank W Pun, Alex Aliper, Feng Ren, Alex Zhavoronkov

{"title":"Precious2GPT: the combination of multiomics pretrained transformer and conditional diffusion for artificial multi-omics multi-species multi-tissue sample generation.","authors":"Denis Sidorenko, Stefan Pushkov, Akhmed Sakip, Geoffrey Ho Duen Leung, Sarah Wing Yan Lok, Anatoly Urban, Diana Zagirova, Alexander Veviorskiy, Nina Tihonova, Aleksandr Kalashnikov, Ekaterina Kozlova, Vladimir Naumov, Frank W Pun, Alex Aliper, Feng Ren, Alex Zhavoronkov","doi":"10.1038/s41514-024-00163-3","DOIUrl":"10.1038/s41514-024-00163-3","url":null,"abstract":"Synthetic data generation in omics mimics real-world biological data, providing alternatives for training and evaluation of genomic analysis tools, controlling differential expression, and exploring data architecture. We previously developed Precious1GPT, a multimodal transformer trained on transcriptomic and methylation data, along with metadata, for predicting biological age and identifying dual-purpose therapeutic targets potentially implicated in aging and age-associated diseases. In this study, we introduce Precious2GPT, a multimodal architecture that integrates Conditional Diffusion (CDiffusion) and decoder-only Multi-omics Pretrained Transformer (MoPT) models trained on gene expression and DNA methylation data. Precious2GPT excels in synthetic data generation, outperforming Conditional Generative Adversarial Networks (CGANs), CDiffusion, and MoPT. We demonstrate that Precious2GPT is capable of generating representative synthetic data that captures tissue- and age-specific information from real transcriptomics and methylomics data. Notably, Precious2GPT surpasses other models in age prediction accuracy using the generated data, and it can generate data beyond 120 years of age. Furthermore, we showcase the potential of using this model in identifying gene signatures and potential therapeutic targets in a colorectal cancer case study.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"37"},"PeriodicalIF":4.1,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shared whole environmental etiology between Alzheimer's disease and age-related macular degeneration. 阿尔茨海默病和老年性黄斑变性具有共同的整体环境病因。

IF 4.1

npj aging Pub Date : 2024-08-05 DOI: 10.1038/s41514-024-00162-4

Siting Ye, Shuo Ma, Shunming Liu, Yu Huang, Dantong Li, Min Li, Ting Su, Jing Luo, Chi Zhang, Danli Shi, Lianting Hu, Lei Zhang, Honghua Yu, Mingguang He, Xianwen Shang, Xueli Zhang

{"title":"Shared whole environmental etiology between Alzheimer's disease and age-related macular degeneration.","authors":"Siting Ye, Shuo Ma, Shunming Liu, Yu Huang, Dantong Li, Min Li, Ting Su, Jing Luo, Chi Zhang, Danli Shi, Lianting Hu, Lei Zhang, Honghua Yu, Mingguang He, Xianwen Shang, Xueli Zhang","doi":"10.1038/s41514-024-00162-4","DOIUrl":"10.1038/s41514-024-00162-4","url":null,"abstract":"The comorbidity of Alzheimer's disease (AD) and age-related macular degeneration (AMD) has been established in clinical and genetic studies. There is growing interest in determining the shared environmental factors associated with both conditions. Recent advancements in record linkage techniques enable us to identify the contributing factors to AD and AMD from a wide range of variables. As such, we first constructed a knowledge graph based on the literature, which included all statistically significant risk factors for AD and AMD. An environment-wide association study (EWAS) was conducted to assess the contribution of various environmental factors to the comorbidity of AD and AMD based on the UK biobank. Based on the conditional Q-Q plots and Bayesian algorithm, several shared environmental factors were identified, which could be categorized into the domains of health condition, biological sample parameters, body index, and attendance availability. Finally, we generated a shared etiology landscape for AD and AMD by combining existing knowledge with our novel findings.","PeriodicalId":94160,"journal":{"name":"npj aging","volume":"10 1","pages":"36"},"PeriodicalIF":4.1,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of cellular senescence in ovarian aging. 细胞衰老在卵巢衰老中的作用。

IF 4.1

npj aging Pub Date : 2024-07-20 DOI: 10.1038/s41514-024-00157-1

Jéssica D Hense, José V V Isola, Driele N Garcia, Larissa S Magalhães, Michal M Masternak, Michael B Stout, Augusto Schneider

引用次数: 0

Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention. 通过 PEPITEM 干预，使老龄小鼠的白细胞贩运恢复活力。

IF 4.1

npj aging Pub Date : 2024-07-18 DOI: 10.1038/s41514-024-00160-6

Sophie J Hopkin, Poppy Nathan, Laleh Pezhman, Jenefa Begum, Julia E Manning, Lauren M Quinn, G Ed Rainger, Helen M McGettrick, Asif J Iqbal, Myriam Chimen

引用次数: 0