Sex-specific insights into drug-induced lifespan extension and weight loss in mice.

Abstract

The DrugAge database serves as a comprehensive resource for studying compounds that increase lifespan in model organisms. In the latest version of DrugAge, we implemented multiple updates, predominantly focusing on mouse studies to enhance data accuracy and consistency. Key improvements include re-recording of mouse data from original sources, standardization of drug dosages to parts per million, and recording of administration routes, treatment initiation ages, and lifespans of controls. The user interface was also upgraded. Additionally, weight change data were included to address the potential impact of caloric restriction induced by drug administration on lifespan. Our analysis revealed significant correlations between weight loss and lifespan extension in male mice, particularly in studies conducted by the Interventions Testing Program, highlighting the importance of considering weight changes in lifespan studies. We also observed notable sex-related differences in lifespan and weight change responses, underscoring the need for sex-specific analyses in aging research.